Anti-αgalactosyl (Anti-Gal) Antibody Damage Beyond Hyperacute Rejection

Man, apes, and Old World monkeys differ from other mammals in the expression of alpha-galactosyl epitopes on nucleated cells.

1988 • 924 citations

A unique natural human IgG antibody with anti-alpha-galactosyl specificity.

1984 • 696 citations

Interaction of the natural anti-Gal antibody with α-galactosyl epitopes: a major obstacle for xenotransplantation in humans

1993 • 645 citations

Identification of carbohydrate structures that bind human antiporcine antibodies: implications for discordant xenografting in humans.

1992 • 626 citations

Anti-pig IgM antibodies in human serum react predominantly with Gal(alpha 1-3)Gal epitopes.

1993 • 611 citations

The generation of transgenic pigs as potential organ donors for humans

1995 • 598 citations

Transplantation of porcine fetal pancreas to diabetic patients

1994 • 555 citations

Evolutionary relationship between the natural anti-Gal antibody and the Gal alpha 1----3Gal epitope in primates.

1987 • 544 citations

Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury

1995 • 538 citations

Interaction between human natural anti-alpha-galactosyl immunoglobulin G and bacteria of the human flora

1988 • 526 citations

Human natural anti-alpha-galactosyl IgG. II. The specific recognition of alpha (1----3)-linked galactose residues.

1985 • 417 citations

Oocyte Galα1,3Gal Epitopes Implicated in Sperm Adhesion to the Zona Pellucida Glycoprotein ZP3 Are Not Required for Fertilization in the Mouse

1995 • 399 citations

Enzymatic remodelling of the carbohydrate surface of a xenogenic cell substantially reduces human antibody binding and complement-mediated cytolysis

1995 • 318 citations

Gene sequences suggest inactivation of alpha-1,3-galactosyltransferase in catarrhines after the divergence of apes from monkeys.

1991 • 304 citations

Frameshift and nonsense mutations in a human genomic sequence homologous to a murine UDP-Gal:beta-D-Gal(1,4)-D-GlcNAc alpha(1,3)-galactosyltransferase cDNA.

1990 • 277 citations

Bovine α1→3-Galactosyltransferase: Isolation and Characterization of a cDNA Clone

1989 • 264 citations

Evolution and environment in the Hominoidea

1992 • 264 citations

One percent of human circulating B lymphocytes are capable of producing the natural anti-Gal antibody

1993 • 231 citations

Lytic anti-α-galactosyl antibodies from patients with chronic Chagas' disease recognize novel O-linked oligosaccharides on mucin-like glycosyl-phosphatidylinositol-anchored glycoproteins of Trypanosoma cruzi

1994 • 223 citations

The human natural anti-Gal IgG. III. The subtlety of immune tolerance in man as demonstrated by crossreactivity between natural anti-Gal and anti-B antibodies.

1987 • 220 citations

Characterization and affinity isolation of xenoreactive human natural antibodies.

1994 • 218 citations

Isolation of a cDNA encoding a murine UDPgalactose:beta-D-galactosyl- 1,4-N-acetyl-D-glucosaminide alpha-1,3-galactosyltransferase: expression cloning by gene transfer.

1989 • 217 citations

Evolution and pathophysiology of the human natural anti-?-galactosyl IgG (anti-Gal) antibody

1993 • 197 citations

A novel mechanism of retrovirus inactivation in human serum mediated by anti-alpha-galactosyl natural antibody.

1995 • 193 citations

Characterization of an alpha 1—-3-galactosyltransferase homologue on human chromosome 12 that is organized as a processed pseudogene.

1991 • 188 citations

Biosynthesis of terminal Gal alpha 1—-3Gal beta 1—-4GlcNAc-R oligosaccharide sequences on glycoconjugates. Purification and acceptor specificity of a UDP-Gal:N-acetyllactosaminide alpha 1—-3-galactosyltransferase from calf thymus.

1985 • 174 citations

Cardiac xenografts between primate species provide evidence for the importance of the alpha-galactosyl determinant in hyperacute rejection.

1995 • 156 citations

Anti‐Gal activity In diabetic patients transplanted with fetal porcine Islet cell clusters

1995 • 146 citations

INCREASED ANTI-GAL ACTIVITY IN DIABETIC PATIENTS TRANSPLANTED WITH FETAL PORCINE ISLET CELL CLUSTERS

1995 • 133 citations

EVIDENCE THAT INTRAVENOUSLY ADMINISTERED α-GALACTOSYL CARBOHYDRATES REDUCE BABOON SERUM CYTOTOXICITY TO PIG KIDNEY CELLS (PK15) AND TRANSPLANTED PIG HEARTS

1994 • 130 citations

PROTECTION OF PIG KIDNEY (PK15) CELLS FROM THE CYTOTOXIC EFFECT OF ANTI-PIG ANTIBODIES BY α-GALACTOSYL OLIGOSACCHARIDES1

1994 • 111 citations

Defining the minimal size of catalytically active primate α1,3 galactosyltransferase: structure-function studies on the recombinant truncated enzyme

1994 • 103 citations

Enzymatic Synthesis of a Blood Group B-related Pentaglycosylceramide by an α-Galactosyltransferase from Rabbit Bone Marrow

1973 • 98 citations

Anti-alpha-galactosyl immunoglobulin A (IgA), IgG, and IgM in human secretions

1995 • 94 citations

ANTIBODY-DEPENDENT CELL-MEDIATED CYTOTOXICITY AGAINST PORCINE ENDOTHELIUM INDUCED BY A MAJORITY OF HUMAN SERA

1994 • 94 citations

Major oligosaccharides in the glycoprotein of Friend murine leukemia virus: structure elucidation by one- and two-dimensional proton nuclear magnetic resonance and methylation analysis

1984 • 79 citations

Limited specificity of xenoantibodies in diabetic patients transplanted with fetal porcine islet cell clusters. Main antibody reactivity against α‐linked galactose‐containing epitopes

1994 • 67 citations

An alpha-D-galactosyltransferase activity in Ehrlich ascites tumor cells. Biosynthesis and characterization of a trisaccharide (alpha-D-galactose-(1 goes to 3)-N-acetyllactosamine).

1981 • 65 citations

cDNA sequence and chromosome localization of pig ?1,3 galactosyltransferase

1995 • 64 citations

Human anti-Gal heavy chain genes. Preferential use of VH3 and the presence of somatic mutations.

1995 • 62 citations

Specificity of human antibodies against gal?1-3gal carbohydrate epitope and distinction from natural antibodies reacting with gal?1-2gal or gal?1-4 gal

1990 • 60 citations

Variability of anti‐αGal antibodies in human serum and their relation to serum cytotoxicity against pig cells

1994 • 57 citations

The N-linked carbohydrate chain of the 85-kilodalton glycoprotein from Trypanosoma cruzi trypomastigotes contains sialyl, fucosyl and galactosyl (α1–3)galactose units

1990 • 51 citations

Differential Host-dependent Expression of -galactosyl Epitopes on Viral Glycoproteins: A Study of Eastern Equine Encephalitis Virus as a Model

1994 • 51 citations

Xenograft Tolerance

1994 • 50 citations

The α-galactosyl epitope on mammalian thyroid cells

1991 • 43 citations

Variations in Activity of the Human Natural Anti-Gal Antibody in Young and Elderly Populations

1995 • 43 citations

Suppression of α-galactosyl epitopes synthesis and production of the natural anti-Gal antibody: a major evolutionary event in ancestral Old World primates

1995 • 39 citations

CONTRIBUTION OF ANTI-GAL TO PRIMATE AND HUMAN IgG BINDING TO PORCINE ENDOTHELIAL CELLS

1995 • 21 citations

CONTRIBUTION OF ANTI-GAL TO PRIMATE AND HUMAN IgG BINDING TO PORCINE ENDOTHELIAL CELLS

1995 • 20 citations

Xenogeneic thyroid-stimulating hormone-like activity of the human natural anti-Gal antibody. Interaction of anti-Gal with porcine thyrocytes and with recombinant human thyroid-stimulating hormone receptors expressed on mouse cells.

1993 • 18 citations