Biology and biochemistry of platelet-activating factor

LEUKOCYTE-DEPENDENT HISTAMINE RELEASE FROM RABBIT PLATELETS

1972 • 1,214 citations

Platelet-activating factor. Evidence for 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine as the active component (a new class of lipid chemical mediators).

1979 • 1,203 citations

Hemodialysis leukopenia. Pulmonary vascular leukostasis resulting from complement activation by dialyzer cellophane membranes.

1977 • 1,004 citations

The physiological action of β‐iminazolylethylamine

1910 • 867 citations

Complement (C5-a)-induced granulocyte aggregation in vitro. A possible mechanism of complement-mediated leukostasis and leukopenia.

1977 • 696 citations

Antihypertensive activity of an alkyl ether analog of phosphatidylcholine

1979 • 562 citations

Physicochemical and Functional Identity of Rabbit Platelet-Activating Factor (PAF) Released in Vivo during IgE Anaphylaxis with PAF Released in Vitro from IgE Sensitized Basophils

1979 • 454 citations

A specific acetylhydrolase for 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (a hypotensive and platelet-activating lipid).

1981 • 440 citations

Platelet-activating factor induces a platelet-dependent bronchoconstriction unrelated to the formation of prostaglandin derivatives

1980 • 422 citations

Identification of platelet activating factor isolated from rabbit basophils as acetyl glyceryl ether phosphorylcholine.

1980 • 408 citations

The role of platelet-activating factor in platelet aggregation

1979 • 408 citations

Activation of human neutrophils with 1-O-hexadecyl/octadecyl-2-acetyl-sn-glycerol-3-phosphorylcholine (platelet activating factor).

1981 • 390 citations

BACKGROUND AND PRESENT STATUS OF RESEARCH ON PLATELET‐ACTIVATING FACTOR (PAF‐ACETHER)

1981 • 332 citations

Enzymatic synthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine, a hypotensive and platelet-aggregating lipid.

1980 • 321 citations

Platelet-activating factor, a new mediator of anaphylaxis and immune complex deposition from rabbit and human basophils

1974 • 279 citations

Structural analysis of purified platelet-activating factor by lipases

1977 • 262 citations

Human neutrophil-derived platelet activating factor.

1980 • 260 citations

Pathobiology of the intravenous infusion of acetyl glyceryl ether phosphorylcholine (AGEPC), a synthetic platelet-activating factor (PAF), in the rabbit.

1980 • 259 citations

Present concepts on the mechanisms of platelet aggregation

1981 • 248 citations

Platelet‐activating factor and macrophages. I. Evidence for the release from rat and mouse peritoneal macrophages and not from mastocytes

1979 • 244 citations

The release of histamine and 5‐hydroxytryptamine (serotonin) from platelets by antigen‐antibody reactions (in vitro)

1955 • 241 citations

1-O-Alkyl-sn-glyceryl-3-phosphorylcholines: a novel class of neutrophil stimulants.

1981 • 237 citations

Release of platelet-activating factor (PAF) and histamine. II. The cellular origin of human PAF: monocytes, polymorphonuclear neutrophils and basophils.

1981 • 225 citations

Aggregation of rabbit platelets by platelet-activating factor is independent of the release reaction and the arachidonate pathway and inhibited by membrane-active drugs.

1979 • 217 citations

The Release of a Platelet-Activating Factor by Stimulated Rabbit Neutrophils

1979 • 214 citations

Leukotriene B4: An inflammatory mediator In vivo

1981 • 213 citations

Preliminary studies of an acid-labile factor (ALF) in human sera that inactivates platelet-activating factor (PAF)

1980 • 207 citations

Biosynthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor and a hypotensive lipid) by cholinephosphotransferase in various rat tissues

1981 • 200 citations

Platelet‐Activating Factor (PAF‐Acether) Secretion from Platelets: Effect of Aggregating Agents

1980 • 195 citations

Platelet activating factor. Stimulation of the lipoxygenase pathway in polymorphonuclear leukocytes by 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine.

1982 • 194 citations

THE ANAPHYLACTIC REACTION OF PLAIN MUSCLE IN THE GUINEA-PIG

1913 • 191 citations

STUDIES ON THE MECHANISM OF THE SHWARTZMAN PHENOMENON

1951 • 189 citations

ACUTE IMMUNE COMPLEX DISEASE IN RABBITS

1971 • 188 citations

Release of platelet‐activating factor (PAF‐acether) from alveolar macrophages by the calcium ionophore A 23187 and phagocytosis

1980 • 186 citations

Biosynthesis of platelet-activating factor

1982 • 185 citations

Activities of enzymes that metabolize platelet-activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in neutrophils and eosinophils from humans and the effect of a calcium ionophore

1982 • 174 citations

RELEASE OF VASOACTIVE AMINES FROM RABBIT PLATELETS INDUCED BY SENSITIZED MONONUCLEAR LEUKOCYTES AND ANTIGEN

1970 • 170 citations

Neutrophil Aggregation and Swelling Induced by Chemotactic Agents

1977 • 166 citations

Activation of 1-alkyl-2-lysoglycero-3-phosphocholine. Acetyl-CoA transferase during phagocytosis in human polymorphonuclear leukocytes.

1982 • 158 citations

Novel effects of 1-0-hexadecyl-2-acyl-sn-glycero-3-phosphorylcholine mediators on human leukocyte function: Delineation of the specific roles of the acyl substituents

1980 • 150 citations

Semi-synthèse et structure proposée du facteur activant les plaquettes (P.A.F.): PAF-acether, un alkyl ether analogue de la lysophosphatidylcholine.

1979 • 149 citations

Platelet Aggregation and Release of ADP, Serotonin and Histamine Associated with Phagocytosis of Antigen-Antibody Complexes.

1965 • 146 citations

Intravascular Aggregation and Pulmonary Sequestration of Platelets during IgE-Induced Systemic Anaphylaxis in the Rabbit: Abrogation of Lethal Anaphylactic Shock by Platelet Depletion

1977 • 145 citations

Acyl dihydroxyacetone phosphate: Precursor of alkyl ethers

1970 • 144 citations

Biosynthesis of platelet-activating factor (PAF-acether) II. Involvement of phospholipase A2 in the formation of PAF-acether and lyso-PAF-acether from rabbit platelets

1982 • 142 citations

Activation and desensitization of platelets by platelet-activating factor (PAF) derived from IgE-sensitized basophils. I. Characteristics of the secretory response.

1976 • 132 citations

Physical and chemical properties of platelet-activating factor obtained from human neutrophils and monocytes and rabbit neutrophils and basophils

1980 • 131 citations

Respiratory and circulatory alterations induced by acetyl glyceryl ether phosphorylcholine, a mediator of IgE anaphylaxis in the rabbit.

1980 • 123 citations

Destruction of rabbit platelets in the allergic response of sensitized leukocytes. I. Demonstration of a fluid phase intermediate.

1971 • 121 citations

[Semi-synthesis and proposed structure of platelet-activating factor (P.A.F.): PAF-acether an alkyl ether analog of lysophosphatidylcholine].

1979 • 120 citations

Platelet activating factor (PAF‐acether): total synthesis of 1‐O‐octadecyl 2‐O‐acetyl sn‐glycero‐3‐phosphoryl choline

1980 • 120 citations

Mediators of Immune-Complex-Induced Aggregation of Polymorphonuclear Neutrophils

1981 • 118 citations

Biosynthetic labelling of platelet activating factor from radioactive acetate by stimulated platelets

1981 • 117 citations

Ether lipid content and fatty acid distribution in rabbit polymorphonuclear neutrophil phospholipids

1982 • 116 citations

THE PHYSIOLOGY OF THE IMMEDIATE REACTION OF ANAPHYLAXIS IN THE GUINEA-PIG

1910 • 115 citations

Monocyte aggregation and superoxide anion release in response to formyl-methionyl-leucyl-phenylalanine (FMLP) and platelet-activating factor (PAF).

1982 • 115 citations

Modification of the polar head group of acetyl glyceryl ether phosphorylcholine and subsequent effects upon platelet activation.

1981 • 114 citations

Release of platelet-activating factor and histamine. I. Effect of immune complexes, complement and neutrophils on human and rabbit mastocytes and basophils.

1977 • 114 citations

Effect of platelet-activating factor (PAF) on human platelets

1982 • 113 citations

The release of four mediators of immediate hypersensitivity from human leukemic basophils.

1975 • 111 citations

Effects of acetyl glyceryl ether phosphorylcholine on human platelet function in vitro

1981 • 109 citations

Release, purification, and characterization of platelet-activating factor (PAF)

1980 • 109 citations

Anaphylactic actions of platelet-activating factor.

1981 • 108 citations

AGEPC (platelet activating factor) induced stimulation of rabbit platelets: Effects on phosphatidylinositol, DI- and TRI-phosphoinositides and phosphatidic acid metabolism

1982 • 105 citations

Effect of intravascular complement activation on granulocyte adhesiveness and distribution

1978 • 102 citations

Platelet-activating factor in anaphylaxis and phagocytosis. I. Release from human peripheral polymorphonuclears and monocytes during the stimulation by ionophore A23187 and phagocytosis but not from degranulating basophils.

1980 • 102 citations

The Release of Four Mediators of Immediate Hypersensitivity from Human Leukemic Basophils

1975 • 96 citations

Production and release of platelet-activating factor (PAF); dissociation from degranulation and superoxide production in the human neutrophil.

1980 • 95 citations

Stereospecific activity of 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine and comparison of analogs in the degranulation of platelets and neutrophils

1981 • 95 citations

The Role of Micro-embolism in the Production of Irreversible Shock

1963 • 90 citations

New total synthesis and high resolution 1H NMR spectrum of platelet-activating factor, its enantiomer and racemic mixtures

1981 • 88 citations

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) stimulates calcium influx in rabbit platelets

1981 • 88 citations

Destruction of Rabbit Platelets in the Allergic Response of Sensitized Leukocytes

1971 • 85 citations

Microscopic observations on the behavior of living blood vessels of the rabbit during the reaction of anaphylaxis

1938 • 85 citations

Lipid mediators of inflammation and allergy.

1982 • 85 citations

Platelet-activating factor (PAF) in experimentally-induced rabbit acute serum sickness: role of basophil-derived PAF in immune complex deposition.

1982 • 85 citations

Inhibition of platelet adenylate cyclase by 1-O-alkyl-2-O-acetyl-sn-glyceryl-3-phosphorylcholine (platelet-activating factor).

1982 • 83 citations

Basophil-derived platelet-activating factor (PAF) as an in vivo mediator of acute allergic reactions: demonstration of specific desensitization of platelets to PAF during IgE-induced anaphylaxis in the rabbit.

1977 • 83 citations

Lysophosphatidic acid-induced aggregation of human and feline platelets: Structure-activity relationship

1981 • 83 citations

Platelet-activating factor acether (PAF-acether) involvement in acute inflammatory and pain processes

1981 • 83 citations

Induction of leukocytic infiltrates in rabbit skin by acetyl glyceryl ether phosphorylcholine.

1982 • 82 citations

Release of 1-O-alkylglyceryl 3-phosphorylcholine, O-deacetyl platelet-activating factor, from leukocytes: chemical ionization mass spectrometry of phospholipids.

1980 • 79 citations

Microscopic Observations on the Behavior of Living Blood Vessels of the Rabbit during the Reaction of Anaphylaxis

1938 • 78 citations

Structural analogs of platelet-activating factor (PAF-acether)

1981 • 78 citations

Effect of intravascular complement activation on granulocyte adhesiveness and distribution

1978 • 77 citations

Studies on the Chemistry of Anaphylaxis

1908 • 77 citations

The Role of Acyldihydroxyacetone Phosphate, Reduced Nicotinamide Adenine Dinucleotide, and Reduced Nicotinamide Adenine Dinucleotide Phosphate in the Biosynthesis of O-Alkyl Glycerolipids by Microsomal Enzymes of Ehrlich Ascites Tumor

1972 • 75 citations

Acetyl glyceryl ether phosphorylcholine. Intravascular alterations following intravenous infusion into the baboon.

1981 • 74 citations

Potent platelet stimulating activity of enantiomers of acetyl glyceryl ether phosphorylcholine and its methoxy analogues

1981 • 73 citations

In vivo metabolism of a new class of biologically active phospholipids: 1-alkyl-2-acetyl--glycero-3-phosphocholine, a platelet activating-hypotensive phospholipid

1981 • 71 citations

Requirement of Cytidine Derivatives in the Biosynthesis of O-Alkyl Phospholipids

1970 • 70 citations

Specificity of lysophospholipase D

1980 • 68 citations

Phorbol myristate acetate: in vivo effects upon neutrophils, platelets, and lung.

1980 • 67 citations

Selective desensitization of neutrophils: further studies with 1-O-alkyl-sn-glycero-3-phosphocholine analogues.

1981 • 64 citations

Influence of alkyl ether chain length of acetyl glyceryl ether phosphorylcholine and its ethanolamine analog on biological activity toward rabbit platelets

1981 • 63 citations

Circulatory and Ventilatory Effects of Induced Platelet Aggregation and Their Inhibition by Acetylsalicylic Acid

1972 • 62 citations

THE ROLE PLAYED BY LEUCOCYTES AND PLATELETS IN ANAPHYLACTIC AND PEPTONE SHOCK

1950 • 60 citations

Identification of O-Alkyldihydroxyacetone Phosphate, O-Alkyldihydroxyacetone, and Diacyl Glyceryl Ethers after Enzymic Synthesis

1970 • 59 citations

The role of PMN-leucocyte lysosomes in tissue injury, inflammation and hypersensitivity. VI. The participation of the PMN-leucocyte and the blood platelet in systemic aggregate anaphylaxis.

1968 • 58 citations

Substrate specificity in the biocleavage of the O-alkyl bond: 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (a hypotensive and platelet-activating lipid) and its metabolites

1981 • 58 citations

Evidence for 5,12-dihydroxy-6,8,10,14-eicosatetraenoate as a mediator of human neutrophil aggregation

1981 • 57 citations

IgE-Induced Release of A Platelet-Activating Factor from Rabbit Lung

1975 • 56 citations

Neutrophil-degranulating action of 5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid and 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine. Comparison with other degranulating agents.

1981 • 56 citations

IMMUNOLOGICAL INDUCTION OF INCREASED VASCULAR PERMEABILITY

1969 • 54 citations

Generation and release of platelet-activating factor (PAF) from enriched preparations of rabbit basophils; failure of human basophils to release PAF.

1980 • 53 citations

The role of platelets and the release of serotonin and histamine during anaphylaxis in the rabbit

1959 • 53 citations

Basophil-Derived Platelet-Activating Factor (PAF) as an in Vivo Mediator of Acute Allergic Reactions: Demonstration of Specific Desensitization of Platelets to PAF during IgE-Induced Anaphylaxis in the Rabbit

1977 • 52 citations

Release of platelet-activating factor in human pathology. I. Evidence for the occurrence of basophil degranulation and release of platelet-activating factor in systemic lupus erythematosus.

1981 • 49 citations

One, Two, Three or More Pathways for Platelet Aggregation

1980 • 48 citations

The binding of rabbit basophil-derived platelet-activating factor to rabbit platelets.

1980 • 47 citations

Immunologic Release in the Rat Peritoneal Cavity of Lipid Chemotactic and Chemokinetic Factors for Polymorphonuclear Leukocytes

1978 • 46 citations

Activation of platelets by platelet-activating factor (PAF) derived from IgE-sensitized basophils. II. The role of serine proteases, cyclic nucleotides, and contractile elements in PAF-induced secretion.

1976 • 44 citations

Neutrophil responses to platelet-activating factor

1981 • 43 citations

Effects on the Pulmonary Circulation of Suddenly Induced Intravascular Aggregation of Blood Platelets

1971 • 43 citations

Evidence for the involvement of IgE-basophil system in acute serum sickness.

1976 • 43 citations

Role of Prostaglandin Synthesis in Rabbit Platelet Activation Induced by Basophil-Derived Platelet-Activating Factor

1978 • 41 citations

IgE-induced respiratory and circulatory changes during systemic anaphylaxis in the rabbit.

1976 • 41 citations

Studies of Hemolytic Streptococcal Antibodies in Control Groups, Rheumatic Fever, and Rheumatoid Arthritis. I. The Incidence of Antistreptolysin " O," Antifibrinolysin, and Hemolytic Streptococcal Precipitating Antibodies in the Sera of Urban Control Groups.

1941 • 40 citations

Platelet-activating factor and analogues: comparative studies with human neutrophils and rabbit platelets.

1983 • 39 citations

Molecular pathobiology of acetyl glyceryl ether phosphorylcholine: evidence for the structural and functional identity with platelet-activating factor.

1980 • 38 citations

Microsomal Enzymes Involved in the Metabolism of Ether-Linked Glycerolipids and Their Precursors in Mammals

1976 • 38 citations

Effect of synthetic PAF-acether on human neutrophil function

1981 • 35 citations

Destruction of rabbit platelets in the allergic response of sensitized leukocytes. II. Evidence for basophil involvement.

1971 • 35 citations

Blood platelets in anaphylaxis

1941 • 34 citations

Platelet-activating factor effects on pulmonary ultrastructure in rabbits

1983 • 33 citations

Stimulation of human neutrophil degranulation with 1-0-octadecyl-2-0-acetyl-sn-glyceryl-3-phosphorylcholine: Modulation by inhibitors of arachidonic acid metabolism

1982 • 32 citations

Intravascular effects of IgE antibody upon basophils,, neutrophils, platelets and blood coagulation in the rabbit.

1975 • 31 citations

Thromboxane B2 (TxB2) release during IgE anaphylaxis in the rabbit.

1980 • 31 citations

Blood Platelets in Anaphylaxis

1941 • 30 citations

AN ELECTROCARDIOGRAPHIC STUDY OF THE ANAPHYLACTIC RABBIT

1913 • 30 citations

Blood Constituents During Anaphylactic Shock in the Monkey

1941 • 29 citations

Desensitization of the human neutrophil degranulation response: Studies with 5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid

1981 • 29 citations

Neutropenia induced by platelet-activating factor (PAF-acether) released from neutrophils: The inhibitory effect of prostacyclin (PGI2)

1981 • 29 citations

Release of a slow-reacting substance from rabbit platelets.

1981 • 29 citations

Neutropenia induced by systemic infusion of 5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid: correlation with its in vitro effects upon neutrophils.

1982 • 28 citations

Role of extracellular calcium and neutrophil degranulation responses to 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine.

1981 • 28 citations

In vivo observations of the vascular reactions to large doses of horse serum using the rabbit ear chamber technique.

1951 • 27 citations

The Release of Prostaglandin‐Like Substances during Platelet Aggregation and Pulmonary Microembolism

1975 • 27 citations

THE BEHAVIOUR OF PLATELETS IN VIVO

1965 • 26 citations

Destruction of Rabbit Platelets in the Allergic Response of Sensitized Leukocytes

1971 • 26 citations

Platelet-activating factor (PAF-acether): Present status

1981 • 26 citations

Platelet activating factor (1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine)

1982 • 25 citations

Haemodynamic changes resulting from thrombin induced intravascular coagulation

1970 • 25 citations

The immunological generation of a platelet-activating factor and a platet-lytic factor in the rat.

1979 • 24 citations

Pulmonary Responses to Intravascular Platelet Aggregation in the Cat

1974 • 24 citations

Pulmonary vascular responses to adenosine diphosphate.

1971 • 23 citations

Is platelet-activating factor (PAF-acether) synthesis by murine peritoneal cells (PC) a two-step process?

1981 • 23 citations

Pharmacological modulation of platelet-activating factor (PAF) release from rabbit leucocytes. I. Role of cAMP.

1980 • 22 citations

Role of granulocytes in immune complex-induced tissue injuries

1977 • 22 citations

THE INDUCED SUSCEPTIBILITY OF THE GUINEA-PIG TO THE TOXIC ACTION OF THE BLOOD SERUM OF THE HORSE

1908 • 22 citations

Bronchoconstriction induced by intratracheal administration of platelet-activating factor (PAF-acether) in baboons

1981 • 21 citations

Non-platelet-mediated vascular actions of 1-O-alkyl-2-acetyl-sn-3-glyceryl phosphorycholine (a synthetic PAF)

1981 • 20 citations

Release of platelet-activating factor (PAF-acether) and arachidonic acid metabolites from alveolar macrophages

1981 • 19 citations

Mechanisms of bronchoconstriction and of thrombocytopenia induced by collagen in the guinea pig

1979 • 18 citations

Studies on the Histamine-Content of the Blood and Tissues of the Rabbit During Anaphylactic Shock

1941 • 18 citations

Proceedings: Role of platelet aggregation in bronchoconstriction in guinea-pigs.

1975 • 16 citations

Intravascular Effects of IgE Antibody upon Basophils, Neutrophils, Splatelets and Blood Coagulation in the Rabbit

1975 • 15 citations

Studies on Heart Anaphylaxis

1972 • 15 citations

Studies on heart anaphylaxis. V. Cross-desensitisation between antigen, anaphylatoxin, and compound 48-80 in the guinea-pig papillary muscle.

1972 • 14 citations

Plasma- und Bluthistamin bei verschiedenen Schockformen des Meerschweinchens

1964 • 13 citations

IX. Specific Anaphylactic Shock

1917 • 13 citations

The binding of platelet-activating factor (PAF) to polymorphonuclear neutrophils (PMN) as a trigger for the immune-induced PMN aggregation.

1980 • 12 citations

Thrombin-induced formation of a polar lipid material within platelets that possesses platelet-activating activity

1980 • 12 citations

The Croonian Lectures ON THE BEHAVIOUR OF THE LEUCOCYTES IN INFECTION AND IMMUNITY.

1910 • 11 citations

Hemodynamic Changes of Adenosine Diphosphate, Adenosine Triphosphate, and Thrombin in Relation to Their Platelet-Aggregating Activity

1971 • 10 citations

Cardiac effects of acetyl glyceryl ether phosphorylcholine

1982 • 9 citations

[Platelet aggregation and platelet activating factor (author's transl)].

1980 • 6 citations

The Significance of Platelet Aggregation in Anaphylactic Shock in Rats

1969 • 1 citations