Reliability of high and low anxiety-related behaviour:

Validation of open : closed arm entries in an elevated plus-maze as a measure of anxiety in the rat

1985 • 5,596 citations

Depression: a new animal model sensitive to antidepressant treatments

1977 • 4,272 citations

The use of a plus-maze to measure anxiety in the mouse

1987 • 2,571 citations

Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation

1997 • 1,773 citations

Genetics of Mouse Behavior: Interactions with Laboratory Environment

1999 • 1,626 citations

A review of the validity and variability of the Elevated Plus-Maze as an animal model of anxiety

1996 • 1,160 citations

Ethologically-based animal models of anxiety disorders

1990 • 841 citations

Ethopharmacological analysis of rat behavior on the elevated plus-maze

1994 • 823 citations

Factor analysis of spatiotemporal and ethological measures in the murine elevated plus-maze test of anxiety

1995 • 773 citations

Animal models of anxiety: an ethological perspective

1997 • 648 citations

Stress and emotionality: a multidimensional and genetic approach

1997 • 508 citations

A multiple-test study of anxiety-related behaviours in six inbred rat strains

1997 • 497 citations

Why do people with anxiety disorders become depressed? A prospective‐longitudinal community study

2000 • 414 citations

Strain Differences in the Behavioral Effects of Antidepressant Drugs in the Rat Forced Swimming Test

2000 • 338 citations

Behavioural profiles of two Wistar rat lines selectively bred for high or low anxiety-related behaviour

1998 • 323 citations

The influence of open arm ledges and maze experience in the elevated plus-maze

1996 • 308 citations

Behavioural analysis of four mouse strains in an anxiety test battery

2000 • 261 citations

High vs low anxiety-related behavior rats: an animal model of extremes in trait anxiety.

2002 • 259 citations

Neurobehavioral studies of forced swimming: The role of learning and memory in the forced swim test

1990 • 231 citations

Inbred Roman High- and Low-Avoidance Rats

1999 • 221 citations

Hyper‐Reactive Hypothalamo‐Pituitary‐Adrenocortical Axis in Rats Bred for High Anxiety‐Related Behaviour

1999 • 198 citations

Experimental approaches to anxiety and depression

1993 • 192 citations

Structure of the mouse behaviour on the elevated plus-maze test of anxiety

1997 • 184 citations

Anxiety- and activity-related effects of diazepam and chlordiazepoxide in the rat light/dark and dark/light tests

1997 • 174 citations

Behavioral, Physiological, and Neuroendocrine Stress Responses and Differential Sensitivity to Diazepam in Two Wistar Rat Lines Selectively Bred for High- and Low-Anxiety–Related Behavior

1998 • 168 citations

Vasopressin Mediates the Response of the Combined Dexamethasone/CRH Test in Hyper-anxious Rats Implications for Pathogenesis of Affective Disorders

2002 • 168 citations

Reduction of Hypothalamic Vasopressinergic Hyperdrive Contributes to Clinically Relevant Behavioral and Neuroendocrine Effects of Chronic Paroxetine Treatment in a Psychopathological Rat Model

2002 • 164 citations

The anxiolytic effect of the CRH₁ receptor antagonist R121919 depends on innate emotionality in rats

2001 • 155 citations

Do anxiety and depression have a common pathophysiological mechanism?

2000 • 151 citations

Antidepressant-like behavioral effects of serotonin receptor agonists

1994 • 149 citations

Unconditioned anxiety and social behaviour in two rat lines selectively bred for high and low anxiety-related behaviour

2000 • 138 citations

Dimensions of emotionality in a rat model of innate anxiety.

2001 • 138 citations

Mixed anxiety and depression.

1991 • 136 citations

Are Wistar-Kyoto rats a genetic animal model of depression resistant to antidepressants?

1997 • 134 citations

Spatial reference memory and neocortical neurochemistry vary with the estrous cycle in C57BL/6 mice.

2001 • 133 citations

Does the behavioral “despair” test measure “despair”?

1986 • 121 citations

Influence of spatial and temporal manipulations on the anxiolytic efficacy of chlordiazepoxide in mice previously exposed to the elevated plus-maze

1999 • 121 citations

The modified hole board as a differential screen for behavior in rodents

2001 • 115 citations

Physiological correlates of the forced swim test in rats

1993 • 103 citations

Cross-fostering and cross-breeding of HAB and LAB rats: a genetic rat model of anxiety.

2001 • 80 citations

The relationship between anxiety and depression in animal models: a study using the forced swimming test and elevated plus-maze

1999 • 64 citations

Interindividual differences in active and passive behaviors in the forced-swimming test: implications for animal models of psychopathology

1999 • 63 citations

Idazoxan and 8-OH-DPAT Modify the Behavioral Effects Induced by Either NA, or 5-HT, or Dual NA/5-HT Reuptake Inhibition in the Rat Forced Swimming Test

2001 • 58 citations

Effects of diazepam and desipramine in the forced swimming test: influence of previous experience with the situation

1993 • 58 citations

Dehydroepiandrosterone Decreases Behavioral Despair in High-but not Low-Anxiety Rats

1997 • 53 citations

Opposite effects of diazepam and β-CCE on immobility and straw-climbing behavior of rats in a modified forced-swim test

1989 • 49 citations

Treatment of depression and concomitant anxiety

2000 • 43 citations

Towards a genetics of anxious temperament: from mice to men

1998 • 40 citations

The anxiolytic-like effect of MCI-225, a selective NA reuptake inhibitor with 5-HT3 receptor antagonism

2001 • 32 citations

Mixed Anxiety and Depression

1998 • 15 citations

A gene promotes anxiety in mice—and also in scientists

1999 • 8 citations