Regulation of Adenylate Cyclase Coupled β-Adrenergic Receptors

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

A STUDY OF THE ADRENOTROPIC RECEPTORS

1948 • 2,856 citations

Differentiation of Receptor Systems activated by Sympathomimetic Amines

1967 • 2,054 citations

Insulin-Dependent Regulation of Insulin Receptor Concentrations: A Direct Demonstration in Cell Culture

1974 • 1,037 citations

THE RELATION OF ADENOSINE-3', 5'-PHOSPHATE AND PHOSPHORYLASE TO THE ACTIONS OF CATECHOLAMINES AND OTHER HORMONES

1960 • 852 citations

The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver

1971 • 811 citations

Insulin interactions with its receptors: Experimental evidence for negative cooperativity

1973 • 717 citations

Acetylcholine Receptors in Muscle Fibres

1971 • 443 citations

PREPARATION AND CHARACTERIZATION OF A PLASMA MEMBRANE FRACTION FROM ISOLATED FAT CELLS

1970 • 402 citations

Identification of beta-adrenergic receptors in human lymphocytes by (-) (3H) alprenolol binding.

1976 • 398 citations

Catecholamine-induced subsensitivity of adenylate cyclase associated with loss of beta-adrenergic receptor binding sites.

1975 • 381 citations

The Cellular Location of Adenyl Cyclase in the Pigeon Erythrocyte

1963 • 293 citations

Peptide hormone binding to receptors: A review of direct studies in vitro

1973 • 286 citations

Identification of adenylate cyclase-coupled beta-adrenergic receptors in frog erythrocytes with (minus)-[3-H] alprenolol.

1975 • 248 citations

5′-Guanylylimidodiphosphate, A Potent Activator of Adenylate Cyclase Systems in Eukaryotic Cells

1974 • 244 citations

Subsensitivity of adenylate cyclase and decreased beta-adrenergic receptor binding after chronic exposure to (minus)-isoproterenol in vitro.

1975 • 235 citations

Stereospecific [3H](−)-alprenolol binding sites, β-adrenergic receptors and adenylate cyclase

1974 • 229 citations

A persistent active state of the adenylate cyclase system produced by the combined actions of isoproterenol and guanylyl imidodiphosphate in frog erythrocyte membranes.

1975 • 221 citations

β-Adrenergic receptors: Evidence for negative cooperativity

1975 • 200 citations

Properties of the Specific Binding of 125I-Nerve Growth Factor to Responsive Peripheral Neurons

1974 • 199 citations

Identification of cardiac beta-adrenergic receptors by (minus) [3H]alprenolol binding.

1975 • 185 citations

Stimulation and Desensitization of Macrophage Adenylate Cyclase by Prostaglandins and Catecholamines

1974 • 166 citations

Noradrenaline binding and the search for catecholamine receptors

1974 • 144 citations

Stimulation of Catecholamine-sensitive Adenylate Cyclase by 5′-Guanylyl-Imidodiphosphate

1974 • 139 citations

Solubilization of myocardial adenyl cyclase

1970 • 136 citations

The Effects of Nucleotides on the Expression of β-Adrenergic Adenylate Cyclase Activity in Membranes from Turkey Erythrocytes

1974 • 118 citations

Binding of 5′-Guanylyl-Imidodiphosphate to Turkey Erythrocyte Membranes and Effects on β-Adrenergic-activated Adenylate Cyclase

1974 • 103 citations

Heterogeneity of adenylate cyclase-coupled β-adrenergic receptors

1975 • 98 citations

Release of Neurotransmitters and Their Interaction with Receptors

1972 • 91 citations

Pineal beta adrenergic receptor: correlation of binding of 3H-l-alprenolol with stimulation of adenylate cyclase.

1976 • 84 citations

Membrane-bound enzymes

1975 • 74 citations

Hormone-induced Desensitisation of Hormonal Control of Cyclic AMP Levels in Human Diploid Fibroblasts

1973 • 72 citations

Characteristics of 5'-guanylyl imidodiphosphate-activated adenylate cyclase.

1975 • 72 citations

Identification of adenylate cyclase-coupled beta-adrenergic receptors with radiolabeled beta-adrenergic antagonists

1975 • 66 citations

The effect of catecholamines on the adenyl cyclase of frog and tadpole hemolysates

1968 • 62 citations

Receptors in pharmacology

1978 • 61 citations

Molecular aspects of membrane phenomena

1976 • 46 citations

Guanosine triphosphate binding sites in solubilized myocardium. Relation to adenylate cyclase activity.

1975 • 43 citations

Inhibition of carbonic anhydrase by parathyroid hormone and cyclic AMP in rat renal cortex in vitro.

1975 • 41 citations

Molecular pharmacology of beta-adrenergic receptors—A status report

1974 • 22 citations

Catecholamine stimulated myocardial adenylate cyclase: Effects of nucleotides

1975 • 16 citations