A controlled study of Tourette syndrome. VII. Summary: a common genetic disorder causing disinhibition of the limbic system.

From motivation to action: Functional interface between the limbic system and the motor system

1980 • 2,292 citations

Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs

1976 • 2,224 citations

Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum

1975 • 1,741 citations

Cognitive Deficit Caused by Regional Depletion of Dopamine in Prefrontal Cortex of Rhesus Monkey

1979 • 1,496 citations

Efferent connections of the substantia nigra and ventral tegmental area in the rat

1979 • 1,278 citations

Biogenic Amines and the States of Sleep

1969 • 1,274 citations

Psychosomatic Disease and the "Visceral Brain"

1949 • 1,163 citations

(–)Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor

1980 • 1,091 citations

3H-baclofen and 3H-GABA bind to bicuculline-insensitive GABAB sites in rat brain

1981 • 1,044 citations

Selective activation of the mesocortical DA system by stress

1976 • 1,037 citations

A Family Study of Schizoaffective, Bipolar I, Bipolar II, Unipolar, and Normal Control Probands

1982 • 995 citations

The problem of the frontal lobe: A reinterpretation

1971 • 892 citations

Perseverative interference in monkeys following selective lesions of the inferior prefrontal convexity

1970 • 760 citations

An Anatomy of Schizophrenia?

1973 • 721 citations

A subpopulation of mesencephalic dopamine neurons projecting to limbic areas contains a cholecystokinin-like peptide: Evidence from immunohistochemistry combined with retrograde tracing

1980 • 717 citations

Selective 60HDA-induced destruction of mesolimbic dopamine neurons: Abolition of psychostimulant-induced locomotor activity in rats

1976 • 706 citations

Human autonomy and the frontal lobes. Part I: Imitation and utilization behavior: A neuropsychological study of 75 patients

1986 • 663 citations

Interchangeability of Stress and Amphetamine in Sensitization

1980 • 565 citations

Effect of lesion of cortical dopamine terminals on subcortical dopamine receptors in rats

1980 • 544 citations

INCREASED DOPAMINE-RECEPTOR SENSITIVITY IN SCHIZOPHRENIA

1978 • 513 citations

The Inheritance of Gilles de la Tourette's Syndrome and Associated Behaviors

1986 • 504 citations

Psychiatric Disorders in the Relatives of Probands With Affective Disorders

1984 • 494 citations

A Family Study of Panic Disorder

1983 • 490 citations

Pharmacology of mesocortical dopamine neurons.

1983 • 478 citations

The phenomenology of experimentally induced amphetamine psychosis--preliminary observations.

1970 • 475 citations

Human autonomy and the frontal lobes. Part II: Patient behavior in complex and social situations: The “environmental dependency syndrome”

1986 • 467 citations

The ?isolation syndrome? in mice

1973 • 417 citations

Organization of catecholamine neurons projecting to the frontal cortex in the rat

1978 • 415 citations

Syndrome of Klüver and Bucy

1955 • 402 citations

Selective Brain Dopamine Depletion in Developing Rats: An Experimental Model of Minimal Brain Dysfunction

1976 • 400 citations

Genetic and clinical implications of alcoholism and affective disorder

1986 • 390 citations

Go - No Go Learning After Frontal Lobe Lesions in Humans

1975 • 367 citations

Frontal cortex and behavior

1986 • 366 citations

Dopaminergic A10 neurones are involved in cognitive functions

1980 • 362 citations

Antipsychotic drug actions: a clue to the neuropathology of schizophrenia?

1973 • 336 citations

Studies on the Hyperactive Child

1971 • 335 citations

Inhibition of d-amphetamine-induced locomotor activity by injection of haloperidol into the nucleus accumbens of the rat

1975 • 332 citations

Blockade by benzodiazepines of the selective high increase in dopamine turnover induced by stress in mesocortical dopaminergic neurons of the rat

1979 • 328 citations

Peptide-monoamine coexistence: Studies of the actions of cholecystokinin-like peptide on the electrical activity of midbrain dopamine neurons

1981 • 321 citations

Alcoholism and Heredity

1979 • 319 citations

Response to stress of mesocortico-frontal dopaminergic neurones in rats after long-term isolation

1980 • 296 citations

Stress-induced increase in 3,4-dihydroxyphenylacetic acid (DOPAC) levels in the cerebral cortex and in n. accumbens: Reversal by diazepam

1978 • 291 citations

Cocaine psychoses: a continuum model

1975 • 290 citations

Dopamine Nerve Terminals in the Rat Limbic Cortex: Aspects of the Dopamine Hypothesis of Schizophrenia

1974 • 290 citations

Dextroamphetamine

1972 • 274 citations

Development of a New Pharmacological Seizure Model: Effects of Anticonvulsants on Cortical‐and Amygdala‐Kindled Seizures in the Rat

1980 • 261 citations

Relationship between the locomotor hyperactivity induced by A10 lesions and the destruction of the frontocortical dopaminergic innervation in the rat

1978 • 253 citations

Dopamine and norepinephrine innervated cells in the rat prefrontal cortex: Pharmacological differentiation using microiontophoretic techniques

1976 • 251 citations

Stimulant Medications Precipitate Tourette's Syndrome

1982 • 246 citations

Effect of 6‐Hydroxydopamine Lesions of the Medial Prefrontal Cortex on Neurotransmitter Systems in Subcortical Sites in the Rat

1980 • 242 citations

Stereotyped behaviour patterns and hyperactivity induced by amphetamine and apomorphine after discrete 6-hydroxydopamine lesions of extrapyramidal and mesolimbic nuclei

1977 • 225 citations

SCHIZOPHRENIA AND THE LIMBIC SYSTEM

1974 • 223 citations

Effect of septal lesions on thirst in the rat as indicated by water consumption and operant responding for water reward.

1965 • 222 citations

Amphetamine-Induced Dopaminergic Hypersensitivity in Guinea Pigs

1975 • 221 citations

Gilles de la Tourette's syndrome

1986 • 216 citations

Behavioral and neurochemical effects of neurotensin microinjection into the ventral tegmental area of the rat

1983 • 210 citations

Tourette's Syndrome and Attention Deficit Disorder with Hyper activity: Are They Genetically Related?

1984 • 198 citations

Cholecystokinin peptides produce marked reduction of dopamine turnover in discrete areas in the rat brain following intraventricular injection

1980 • 196 citations

Locomotor activation induced by infusion of endorphins into the ventral tegmental area: evidence for opiate-dopamine interactions.

1980 • 182 citations

Biogenic amine metabolism in tourette syndrome

1979 • 182 citations

Electrophysiological studies of neurons in the ventral tegmental area of tsai

1980 • 181 citations

Mental illness in the biological and adoptive relatives of schizophrenic adoptees: findings relevant to genetic and environmental factors in etiology

1983 • 170 citations

Paradoxical response to amphetamine in developing rats treated with 6-hydroxydopamine

1976 • 170 citations

Bombesin: Receptor distribution in brain and effects on nociception and locomotor activity

1980 • 169 citations

The behavioural effects of dopamine applied intracerebrally to areas of the mesolimbic system

1975 • 167 citations

Central Biogenic Amine Metabolism in Children with the Syndrome of Chronic Multiple Tics of Gilles de la Tourette: Norepinephrine, Serotonin, and Dopamine

1979 • 149 citations

Chronic, Multiple Tics of Gilles de la Tourette's Disease

1978 • 145 citations

Alternation behavior, spatial discrimination, and reversal disturbances following 6-hydroxydopamine lesions in the nucleus accumbens of the rat

1985 • 144 citations

Responses of intracellularly recorded cortical neurons to the iontophoretic application of dopamine

1982 • 139 citations

Age-dependent effects of 6-hydroxydopamine on locomotor activity in the rat

1979 • 137 citations

Role of endogenous substance P in stress-induced activation of mesocortical dopamine neurones

1983 • 134 citations

Increased spontaneous activity following substance P infusion into A10 dopaminergic area

1978 • 129 citations

The Dopamine Hypothesis: An Overview of Studies With Schizophrenic Patients

1982 • 126 citations

Behavioral changes following discrete lesions of temporal lobe structures

1958 • 123 citations

Detection of major gene for Gilles de la Tourette syndrome.

1984 • 120 citations

Neuroanatomy of Gilles de la Tourette's Syndrome Possible Midbrain Involvement

1983 • 119 citations

Behavioral analysis of the effect of substance P injected into the ventral mesencephalon on investigatory and spontaneous motor behavior in the rat

1985 • 116 citations

Gilles de la Tourette's syndrome: Tics and central nervous system stimulants in twins and nontwins

1986 • 113 citations

Behavioral study after local injection of 6-hydroxydopamine into the nucleus accumbens in the rat

1985 • 109 citations

Behavioral effects of lesions in the A10 dopaminergic area of the rat

1977 • 107 citations

Effects of Dopamine Agonists and Antagonists in Tourette's Disease

1979 • 106 citations

A study of pontine lesions suppressing deep sleep in the cat.

1965 • 105 citations

Performance of disturbed hyperactive and nonhyperactive children on an objective measure of hyperactivity

1984 • 99 citations

Behavioral implications of dopaminergic neurons in the mesolimbic system.

1977 • 95 citations

Magnitude and duration of hyperactivity following neonatal 6-hydroxydopamine is related to the extent of brain dopamine depletion

1981 • 94 citations

Methylphenidate in 6-Hydroxydopamine-Treated Developing Rat Pups

1978 • 92 citations

Comparative analysis of prefrontal learning functions in rats, cats, and monkeys.

1977 • 89 citations

MULTIPLE TIC SYNDROME (GILLES DE LA TOURETTEʼS SYNDROME)

1974 • 89 citations

Increased utilization of dopamine in the nucleus accumbens but not in the cerebral cortex after dorsal raphe lesion in the rat

1979 • 86 citations

Radiofrequency lesion of the ventral mesencephalic tegmentum: Neurological and behavioral considerations

1976 • 77 citations

GABAergic inhibition of neurons in the ventral tegmental area

1978 • 74 citations

Behavioral effects of local injection of 6-hydroxydopamine in the medial ventral tegmentum in the rat. Possible role of the mesolimbic dopaminergic system

1975 • 71 citations

Effects of lesions of the ventral medial tegmentum on locomotor activity, biogenic amines and response to amphetamine in rats

1980 • 66 citations

The effect of 6-ohda lesions of the lateral septum on schedule-induced polydipsia

1985 • 63 citations

Specific effect of haloperidol on dopamine turnover in the frontal cortex

1977 • 62 citations

Disappearance of hoarding and disorganization of eating behavior after ventral mesencephalic tegmentum lesions in rats.

1978 • 61 citations

EFFECT OF INDOMETHACIN ON ARTERIAL OXYGENATION IN CRITICALLY ILL PATIENTS WITH SEVERE BACTERIAL PNEUMONIA

1987 • 60 citations

Neuropsychiatric Disturbances following Brainstem Lesions

1981 • 50 citations

Bombesin-induced behavioural changes: Antagonism by neuroleptics

1983 • 48 citations

PSYCHIATRIC SYMPTOMS AND SYNDROMES IN PARKINSON'S DISEASE

1951 • 47 citations

An Independent Analysis of the Copenhagen Sample of the Danish Adoption Study of Schizophrenia

1981 • 38 citations

Bombesin-induced locomotor hyperactivity: evaluation of the involvement of the mesolimbic dopamine system

1984 • 34 citations

On the mechanism of go-no go symmetrically reinforced task in dogs.

1972 • 33 citations

The analysis of Schizophrenia family data

1986 • 30 citations

Human gastrin-releasing peptide gene is located on chromosome 18

1987 • 28 citations

Receptor maturation in pathogenesis and treatment of Tourette syndrome.

1982 • 28 citations

Small doses of apomorphine and chronic administration of d-amphetamine reduce locomotor hyperactivity produced by radiofrequency lesions of dopaminergic A10 neurons area.

1977 • 27 citations

Tourette syndrome in Japan: etiologic considerations based on associated factors and familial clustering.

1982 • 26 citations

Human gastrin-releasing peptide gene maps to chromosome band 18q21

1987 • 26 citations

Behavioural effects of methylphenidate in 6-hydroxydopamine-treated neonatal rats

1978 • 26 citations

An evaluation of the young dopamine-lesioned rat as an animal model for minimal brain dysfunction (MBD)

1980 • 23 citations

An Independent Analysis of the Copenhagen Sample of the Danish Adoption Study of Schizophrenia

1982 • 16 citations

Nonstriatal dopaminergic neurons: Section X. Morphine, amphetamine, and noncataleptogenic neuroleptics: Introduction: morphine, amphetamine, and noncataleptogenic neuroleptics.

1977 • 3 citations