The Role of RecA Protein in Homologous Genetic Recombination

The double-strand-break repair model for recombination

1983 • 2,468 citations

Exchanges between DNA strands in ultraviolet-irradiated Escherichia coli

1971 • 582 citations

Role of RecA protein spiral filaments in genetic recombination

1984 • 362 citations

ENZYMES OF GENERAL RECOMBINATION

1987 • 333 citations

recA protein of Escherichia coli promotes branch migration, a kinetically distinct phase of DNA strand exchange.

1981 • 312 citations

The Single-Stranded DNA Phages

1975 • 301 citations

Single-stranded DNA phages

1980 • 278 citations

Genetic Recombination: Strand Transfer and Mismatch Repair

1978 • 270 citations

Replacement of potassium chloride by potassium glutamate dramatically enhances protein-DNA interactions in vitro

1987 • 267 citations

Structure of helical RecA-DNA complexes

1986 • 244 citations

The helicity of DNA in complexes with RecA protein

1982 • 217 citations

Characterization of complexes between recA protein and duplex DNA by electron microscopy

1982 • 212 citations

Persistence of pyrimidine dimers during post-replication repair in ultraviolet light-irradiated Escherichia coli K12

1974 • 210 citations

Directionality and polarity in recA protein-promoted branch migration.

1981 • 203 citations

The direction of RecA protein assembly onto single strand DNA is the same as the direction of strand assimilation during strand exchange.

1985 • 198 citations

recA protein-promoted DNA strand exchange. Stable complexes of recA protein and single-stranded DNA formed in the presence of ATP and single-stranded DNA binding protein.

1982 • 166 citations

Polarity of heteroduplex formation promoted by Escherichia coli recA protein.

1981 • 159 citations

Synapsis and the formation of paranemic joints by E. coli RecA protein

1983 • 150 citations

The topology of homologous pairing promoted by RecA protein

1980 • 146 citations

Electron microscopic visualization of RecA-DNA filaments: Evidence for a cyclic extension of duplex DNA

1982 • 146 citations

Insertions, deletions and mismatches in heteroduplex DNA made by recA protein

1983 • 145 citations

Models of specifically paired like (homologous) nucleic acid structures

1971 • 145 citations

Stable binding of recA protein to duplex DNA. Unraveling a paradox.

1987 • 140 citations

Heteroduplex formation by recA protein: polarity of strand exchanges.

1981 • 138 citations

Visualization of RecA protein and its association with DNA: A priming effect of single-strand-binding protein

1982 • 135 citations

Isolation and visualization of active presynaptic filaments of recA protein and single-stranded DNA.

1984 • 135 citations

Purification and characterization of an activity from Saccharomyces cerevisiae that catalyzes homologous pairing and strand exchange.

1987 • 132 citations

General mechanism for RecA protein binding to duplex DNA

1988 • 121 citations

recA protein-promoted ATP hydrolysis occurs throughout recA nucleoprotein filaments.

1987 • 121 citations

The Recombination of Genetic Material

1988 • 116 citations

Partial purification and characterization of a recombinase from human cells

1986 • 116 citations

Concerted strand exchange and formation of Holliday structures by E. coli RecA protein

1981 • 115 citations

MOLECULAR MECHANISMS IN GENETIC RECOMBINATION

1973 • 110 citations

Nick-free formation of reciprocal heteroduplexes: a simple solution to the topological problem.

1979 • 104 citations

Fibers of RecA protein and complexes of RecA protein and single-stranded φX174 DNA as visualized by negative-stain electron microscopy

1986 • 103 citations

recA protein promotes homologous-pairing and strand-exchange reactions between duplex DNA molecules.

1981 • 99 citations

Polar branch migration promoted by recA protein: effect of mismatched base pairs.

1982 • 97 citations

High salt activation of recA protein ATPase in the absence of DNA.

1988 • 96 citations

Topography of the interaction of recA protein with single-stranded deoxyoligonucleotides.

1986 • 92 citations

Control of UV induction of recA protein.

1983 • 91 citations

Exchange of recA protein between adjacent recA protein-single-stranded DNA complexes.

1986 • 91 citations

Mechanism of E. coli RecA protein directed strand exchanges in post-replication repair of DNA

1981 • 82 citations

The pairing activity of stable nucleoprotein filaments made from recA protein, single-stranded DNA, and adenosine 5'-(gamma-thio)triphosphate.

1985 • 82 citations

Formation of nascent heteroduplex structures by RecA protein and DNA

1982 • 81 citations

Properties of the duplex DNA-dependent ATPase activity of Escherichia coli RecA protein and its role in branch migration.

1987 • 77 citations

The formation of paranemic and plectonemic joints between DNA molecules by the recA and single-stranded DNA-binding proteins of Escherichia coli.

1985 • 77 citations

On the role of single-stranded DNA binding protein in recA protein-promoted DNA strand exchange.

1983 • 76 citations

Left-handed Z-DNA binding by the recA protein of Escherichia coli.

1987 • 76 citations

Electron microscopic visualization of the RecA protein-mediated pairing and branch migration phases of DNA strand exchange.

1987 • 74 citations

recA protein binding to the heteroduplex product of DNA strand exchange.

1987 • 73 citations

Biochemical Measure of the Time and Frequency of Radiation-induced Allelic Recombination in Ustilago

1971 • 71 citations

Dissociation pathway for recA nucleoprotein filaments formed on linear duplex DNA

1989 • 71 citations

Homology-dependent changes in adenosine 5'-triphosphate hydrolysis during recA protein-promoted DNA strand exchange: evidence for long paranemic complexes

1987 • 68 citations

Ionic inhibition of formation of RecA nucleoprotein networks blocks homologous pairing.

1985 • 62 citations

Extent of duplex DNA underwinding induced by RecA protein binding in the presence of ATP

1989 • 62 citations

Relationship of the physical and enzymic properties of Escherichia coli recA protein to its strand exchange activity

1986 • 59 citations

Recombinational bypass of pyrimidine dimers promoted by the recA protein of Escherichia coli.

1982 • 58 citations

Structure of helical RecA-DNA complexes

1988 • 52 citations

Patterns of nuclease protection during strand exchange. recA protein forms heteroduplex DNA by binding to strands of the same polarity.

1986 • 51 citations

Visualization of the paranemic joining of homologous DNA molecules catalyzed by the RecA protein of Escherichia coli.

1986 • 50 citations

Translocation of Escherichia coli recA protein from a single-stranded tail to contiguous duplex DNA.

1987 • 49 citations

The accessibility of DNA to dimethylsulfate in complexes with recA protein.

1987 • 48 citations

Mechanistic aspects of the DNA strand exchange activity of E. coli recA protein

1987 • 47 citations

Duplex-duplex interactions catalyzed by recA protein allow strand exchanges to pass double-strand breaks in DNA

1984 • 47 citations

Transduction versus "Conjuduction": Evidence for Multiple Roles for Exonuclease V in Genetic Recombination in Escherichia coli

1979 • 47 citations

The mechanics of winding and unwinding helices in recombination: Torsional stress associated with strand transfer promoted by RecA protein

1988 • 44 citations

Homology-dependent underwinding of duplex DNA in RecA protein generated paranemic complexes

1988 • 33 citations

DNase protection by recA protein during strand exchange. Asymmetric protection of the Holliday structure.

1988 • 31 citations

The binding of RecA protein to duplex DNA molecules is directional and is promoted by a single stranded region

1986 • 28 citations

Intermediates in Homologous Pairing Promoted by RecA Protein and Correlations of Recombination In Vitro and In Vivo

1984 • 27 citations

Negative complementation of recA protein by recA1 polypeptide: in vivo recombination requires a multimeric form of recA protein

1984 • 24 citations

Transfer of recA protein from one polynucleotide to another. Effect of ATP and determination of the processivity of ATP hydrolysis during transfer.

1987 • 20 citations

Unidirectional Branch Migration Promoted by Nucleoprotein Filaments of RecA Protein and DNA

1984 • 18 citations

Underwater Blood

1971 • 5 citations