Adenovirus-Based Expression Vectors and Recombinant Vaccines

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Characteristics of a Human Cell Line Transformed by DNA from Human Adenovirus Type 5

1977 • 4,801 citations

Isolation of a Cytopathogenic Agent from Human Adenoids Undergoing Spontaneous Degeneration in Tissue Culture

1953 • 1,059 citations

A simple technique for the rescue of early region I mutations into infectious human adenovirus type 5

1988 • 606 citations

Identification of a protein linked to the ends of adenovirus DNA

1977 • 502 citations

A role for exon sequences and splice-site proximity in splice-site selection

1986 • 494 citations

Mapping temperature-sensitive and host-range mutations of adenovirus type 5 by marker rescue

1978 • 408 citations

Development of adenovirus vectors for the expression of heterologous genes.

1988 • 386 citations

Adenovirus early region 4 encodes functions required for efficient DNA replication, late gene expression, and host cell shutoff

1985 • 383 citations

The Adenovirus E1B-55K Transforming Polypeptide Modulates Transport or Cytoplasmic Stabilization of Viral and Host Cell mRNAs

1986 • 301 citations

Role of early region 3 (E3) in pathogenesis of adenovirus disease.

1989 • 285 citations

THE VIRUS WATCH PROGRAM: A CONTINUING SURVEILLANCE OF VIRAL INFECTIONS IN METROPOLITAN NEW YORK FAMILIES

1969 • 284 citations

Molecular Epidemiology of Human Adenoviruses

1984 • 277 citations

BASIC AND CLINICAL IMMUNOLOGY

1988 • 246 citations

Use of Nondefective Adenovirus-Simian Virus 40 Hybrids for Mapping the Simian Virus 40 Genome

1973 • 243 citations

Adenovirus tripartite leader sequence enhances translation of mRNAs late after infection.

1984 • 234 citations

Adenovirus E1B proteins are required for accumulation of late viral mRNA and for effects on cellular mRNA translation and transport.

1985 • 234 citations

Isolation of deletion and substitution mutants of adenovirus type 5

1978 • 230 citations

Identification of the gene and mRNA for the adenovirus terminal protein precursor

1981 • 227 citations

Adenovirus early region 1B 58,000-dalton tumor antigen is physically associated with an early region 4 25,000-dalton protein in productively infected cells

1984 • 221 citations

The structure of replicating adenovirus 2 DNA molecules

1977 • 210 citations

Effect of route of inoculation on experimental respiratory viral disease in volunteers and evidence for airborne transmission

1966 • 185 citations

Immunization with Live Types 7 and 4 Adenovirus Vaccines. II. Antibody Response and Protective Effect against Acute Respiratory Disease Due to Adenovirus Type 7

1971 • 171 citations

Infection of eucaryotic cells by helper-independent recombinant adenoviruses: early region 1 is not obligatory for integration of viral DNA

1984 • 170 citations

Adenoviruses from Patients with AIDS: A Plethora of Serotypes and A Description of Five New Serotypes of Subgenus D (Types 43-47)

1988 • 168 citations

Cloning of a DNA fragment from the left-hand terminus of the adenovirus type 2 genome and its use in site-directed mutagenesis

1981 • 157 citations

The infectivity of adenovirus 5 DNA-protein complex

1976 • 150 citations

A Recombinant Human Adenovirus Vaccine against Rabies

1990 • 145 citations

Genome structure of incomplete particles of adenovirus

1976 • 145 citations

Construction of nondefective adenovirus type 5 bearing a 2.8-kilobase hepatitis B virus DNA near the right end of its genome

1985 • 144 citations

Generation of adenovirus by transfection of plasmids

1983 • 144 citations

Immunogenicity and efficacy testing in chimpanzees of an oral hepatitis B vaccine based on live recombinant adenovirus.

1989 • 144 citations

The adenovirus E1B-55K transforming polypeptide modulates transport or cytoplasmic stabilization of viral and host cell mRNAs.

1986 • 143 citations

Identification of the components necessary for adenovirus translational control and their utilization in cDNA expression vectors.

1985 • 142 citations

A cell line that supports the growth of a defective early region 4 deletion mutant of human adenovirus type 2.

1983 • 141 citations

A Unique Form of Terminal Redundancy in Adenovirus DNA Molecules

1972 • 139 citations

Adenovirus-2 DNA Contains an Inverted Terminal Repetition

1972 • 135 citations

Protein IX, a minor component of the human adenovirus capsid, is essential for the packaging of full length genomes.

1987 • 134 citations

Identification of a repeated sequence element required for efficient encapsidation of the adenovirus type 5 chromosome

1987 • 134 citations

Group C adenovirus DNA sequences in human lymphoid cells

1986 • 133 citations

Recombinant adenovirus induces antibody response to hepatitis B virus surface antigen in hamsters.

1987 • 130 citations

A New Animal Model for Human Respiratory Tract Disease Due to Adenovirus

1984 • 128 citations

Adenovirus E1A renders infected cells sensitive to cytolysis by tumor necrosis factor.

1989 • 125 citations

Physical mapping of a large-plaque mutation of adenovirus type 2

1979 • 125 citations

Induction by E1A oncogene expression of cellular susceptibility to lysis by TNF

1987 • 124 citations

Use of Human Adenovirus-based Vectors for Antigen Expression in Animals

1989 • 122 citations

Structure of the linkage between adenovirus DNA and the 55,000 molecular weight terminal protein

1981 • 118 citations

DNA sequence of the early E3 transcription unit of adenovirus 5

1985 • 116 citations

Development of a helper-independent human adenovirus vector and its use in the transfer of the herpes simplex virus thymidine kinase gene

1986 • 113 citations

Control of adenovirus acute respiratory disease in U.S. Army trainees.

1975 • 108 citations

Gastrointestinal Viral Infections in Homosexual Men Who were Symptomatic and Seropositive for Human Immunodeficiency Virus

1988 • 108 citations

Analysis of human tonsil and cancer DNAs and RNAs for DNA sequences of group C (serotypes 1, 2, 5, and 6) human adenoviruses

1979 • 106 citations

Mouse anti-adenovirus cytotoxic T lymphocytes. Inhibition of lysis by E3 gp19K but not E3 14.7K.

1989 • 105 citations

Processing of the adenovirus terminal protein

1981 • 99 citations

Covalently closed circles of human adenovirus DNA are infectious.

1984 • 98 citations

Downstream sequences affect transcription initiation from the adenovirus major late promoter.

1986 • 97 citations

Effect of the tripartite leader on synthesis of a non-viral protein in an adenovirus 5 recombinant

1985 • 93 citations

Tests in Hamsters for Oncogenic Quality of Ordinary Viruses Including Adenovirus Type 7.

1964 • 93 citations

Protection of mice against lethal challenge with herpes simplex virus by vaccination with an adenovirus vector expressing hsv glycoprotein B

1989 • 90 citations

Adenovirus early region 4 is essential for normal stability of late nuclear RNAs

1989 • 87 citations

Expression of SV40 T antigen under control of adenovirus promoters

1981 • 87 citations

In vitro and in vivo synthesis of the hepatitis B virus surface antigen and of the receptor for polymerized human serum albumin from recombinant human adenoviruses.

1985 • 86 citations

Detection of adenovirus nucleic acid sequences in human tonsils in the absence of infectious virus

1987 • 83 citations

Efficient transformation of human fibroblasts by adenovirus-simian virus 40 recombinants.

1984 • 80 citations

Synthesis and processing of human immunodeficiency virus type 1 envelope proteins encoded by a recombinant human adenovirus

1989 • 79 citations

Translational control of SV40 T antigen expressed from the adenovirus late promoter

1983 • 79 citations

Oncogenic Transformation of Hamster Embryo Cells in vitro by Adenovirus Type 5

1973 • 78 citations

The infectivity of adenovirus genomes lacking DNA sequences from their left-hand termini

1982 • 78 citations

Adenovirus Type 7b in a Children's Hospital

1983 • 78 citations

Interaction of human adenovirus serotype 2 with human lymphoid cells

1988 • 76 citations

Molecular epidemiology of adenoviruses: global distribution of adenovirus 7 genome types

1985 • 76 citations

Human adenovirus cloning vectors based on infectious bacterial plasmids

1986 • 75 citations

Malignant transformation of human embryo retinoblasts by cloned adenovirus 12 DNA

1982 • 75 citations

Abundant expression of herpes simplex virus glycoprotein gB using an adenovirus vector

1988 • 74 citations

Restricted replication of human adenovirus type 5 in mouse cell lines

1989 • 74 citations

Expression of hepatitis B surface antigen with a recombinant adenovirus.

1985 • 72 citations

Retinal Tumor Induced in the Baboon by Human Adenovirus 12

1980 • 66 citations

Persistent Infection with Adenovirus Types 5 and 6 in Lymphoid Cells from Humans and Woolly Monkeys

1982 • 64 citations

High-level transcription from the adenovirus major late promoter requires downstream binding sites for late-phase-specific factors

1990 • 64 citations

RNA Transcription and Splicing at Early and Intermediate Times after Adenovirus-2 Infection

1980 • 63 citations

Region E3 of human adenoviruses; differences between the oncogenic adenovirus-3 and the non-oncogenic adenovirus-2

1986 • 60 citations

Herpes simplex virus IgG Fc receptors induced using recombinant adenovirus vectors expressing glycoproteins E and I

1990 • 59 citations

Transfer of genes into hematopoietic cells using recombinant DNA viruses.

1985 • 58 citations

Altered mRNA splicing in monkey cells abortively infected with human adenovirus may be responsible for inefficient synthesis of the virion fiber polypeptide.

1984 • 57 citations

The murine cellular immune response to adenovirus type 5

1989 • 57 citations

Latent Infection of Rabbits by Adenovirus Type 5

1957 • 54 citations

Nonpermissivity of human peripheral blood lymphocytes to adenovirus type 2 infection

1988 • 54 citations

Expression of dihydrololate reductase, and of the adjacent Elb region, in an Ad5-dihydrofolate reductase recombinant virus

1984 • 53 citations

Mapping the 5′ ends, 3′ ends, and splice sites of mRNAs from the early E3 transcription unit of adenovirus 5

1985 • 53 citations

Molecular Epidemiology of Adenovirus Type 35 Infections in Immunocompromised Hosts

1987 • 52 citations

Cytotoxic T lymphocytes specific for herpes simplex virus (HSV) studied using adenovirus vectors expressing HSV glycoproteins

1990 • 50 citations

Characterization of the early region 3 and fiber genes of Ad7

1988 • 50 citations

Cloning of the herpes simplex virus ICP4 Gene in an adenovirus vector: Effects on adenovirus gene expression and replication

1989 • 48 citations

Overproduction of the protein product of a nonselected foreign gene carried by an adenovirus vector.

1985 • 47 citations

The structure and functions of the adenovirus early region 1 proteins

1987 • 44 citations

Expression of the Glycoprotein of Vesicular Stomatitis Virus by Infectious Adenovirus Vectors

1989 • 44 citations

Rescue of functional replication origins from embedded configurations in a plasmid carrying the adenovirus genome.

1984 • 44 citations

A new hamster model for adenoviral vaccination

1988 • 44 citations

Replication-induced stimulation of the major late promoter of adenovirus is correlated to the binding of a factor to sequences in the first intron

1988 • 43 citations

Overproduction of polyomavirus middle T antigen in mammalian cells through the use of an adenovirus vector

1987 • 43 citations

An adenovirus vector system used to express polyoma virus tumor antigens.

1985 • 42 citations

Characterization of middle T antigen expressed by using an adenovirus expression system

1987 • 41 citations

Infectious circular DNA of human adenovirus type 5: regeneration of viral DNA termini from molecules lacking terminal sequences.

1989 • 41 citations

Enhanced infectivity of adenovirus type 2 DNA and a DNA-protein complex

1978 • 40 citations

High level expression of the envelope glycoproteins of the human immunodeficiency virus type I in presence of rev gene using helper-independent adenovirus type 7 recombinants

1990 • 40 citations

Quantitative studies of natural and experimental adenovirus infections of human cells

1965 • 40 citations

Spread of Enteric Live Adenovirus Type 4 Vaccine in Married Couples

1969 • 39 citations

Sequence and genetic organization of adenovirus type 35 early region 3

1988 • 39 citations

Stable gene transfer and tissue-specific expression of a human globin gene using adenoviral vectors.

1986 • 38 citations

Efficient transcription, not translation, is dependent on adenovirus tripartite leader sequences at late times of infection

1988 • 38 citations

Adenovirus vaccine vectors expressing hepatitis B surface antigen: Importance of regulatory elements in the adenovirus major late intron

1990 • 36 citations

Mapping of Adenovirus Type 5 Temperature-sensitive Mutations by Marker Rescue in Enhanced Double DNA Infections

1978 • 36 citations

Gene product of region E4 of adenovirus type 5 modulates accumulation of certain viral polypeptides

1988 • 35 citations

Transcription mapping of mouse adenovirus type 1 early region 3

1990 • 35 citations

Identification of a downstream sequence and binding protein that regulate adenovirus major late promoter transcription in vitro.

1988 • 31 citations

Regulation of early adenovirus gene expression.

1987 • 31 citations

Communicability of Enteric Live Adenovirus Type 4 Vaccine in Families

1969 • 29 citations

High Level Expression in 293 Cells of the Herpes Simplex Virus Type 2 Ribonucleotide Reductase Subunit 2 Using an Adenovirus Vector

1990 • 28 citations

Cell-Type-Specific Synthesis of Murine Immunoglobulin μ RNA from an Adenovirus Vector

1986 • 28 citations

Genomic variation of adenovirus type 5 isolates recovered from bone marrow transplant recipients

1987 • 24 citations

Role of adenovirus type 2 early region 4 in the early-to-late switch during productive infection

1986 • 24 citations

The Origin of Adenovirus DNA Replication

1983 • 24 citations

Adenovirus type 7 infections in children in new South Wales, Australia

1989 • 24 citations

Resistance of human cells to the adenovirus E3 effect on class I MHC antigen expression. Implications for antiviral immunity.

1990 • 23 citations

Restricted replication of adenovirus type 2 in mouse balb/3T3 cells

1986 • 23 citations

An outbreak of respiratory disease due to a type 5 adenovirus identified as genome type 5a.

1980 • 23 citations

Current use and future directions of adenovirus vaccine.

1989 • 22 citations

Retinal Tumor Induction by Ocular Inoculation of Human Adenovirus in 3-Day-Old Rats

1975 • 19 citations

Immunization of Canadian Armed Forces personnel with live types 4 and 7 adenovirus vaccines.

1986 • 19 citations

Adenoviruses with nonidentical terminal sequences are viable

1989 • 18 citations

The creation of adenovirus genomes with viable, stable, internal redundancies centered about the E2b region

1987 • 18 citations

One-sided immunologic relation between adenovirus and infectious canine hepatitis antigens

1960 • 16 citations

EQUINE PIROPLASMOSIS--A MIXED STRAIN OF PIROPLASMA CABALLI AND PIROPLASMA EQUI ISOLATED IN FLORIDA AND STUDIED BY THE FLUORESCENT-ANTIBODY TECHNIQUE.

1964 • 16 citations

Defect of adenovirus type 12 replication in hamster cells: absence of transcription of viral virus-associated and L1 RNAs

1989 • 15 citations

Current considerations in public health of the role of animals in relation to human viral diseases.

1960 • 15 citations

Characterization of the translational defect to fiber synthesis in monkey cells abortively infected with human adenovirus: role of ancillary leaders

1989 • 14 citations

The adenovirus tripartite leader sequence can alter nuclear and cytoplasmic metabolism of a non-adenovirus mRNA within infected cells

1988 • 14 citations

CHARACTERISTICS OF VACCINE-INDUCED AND NATURAL INFECTION WITH ADENOVIRUS TYPE 4 IN NAVAL RECRUITS1

1968 • 14 citations

Adenovirus‐12 genes undetectable in human retinoblastoma

1982 • 13 citations

Two new genome types of adenovirus 7c

1988 • 12 citations

Cell-type-specific synthesis of murine immunoglobulin mu RNA from an adenovirus vector.

1986 • 12 citations

Characterization of the genome of a vaccine strain of canine adenovirus type 1

1988 • 9 citations

Human adenovirus antibody in sera of normal and tumour-bearing dogs

1979 • 8 citations

Simultaneous overexpression of avian pp60c-src and polyomavirus middle T antigen in mammalian cells

1990 • 5 citations

Secondary Serological Response to Infectious Canine Hepatitis Virus Produced by Adenovirus Type 4.

1962 • 5 citations

Incomplete human adenovirus replication in canine tumour cells and serological evidence of infections in tumour-bearing canine pets

1980 • 5 citations

PERSPECTIVES IN VIROLOGY V

1968 • 5 citations

Comparison of human and monkey cells for the ability to attenuate transcripts that begin at the adenovirus major late promoter

1989 • 4 citations

Flow Cytometric Analysis of DNA Content of Mouse Liver Cells Following in vivo Infection by Human Adenovirus Type 5

1981 • 4 citations

Lifelong persistent infection of hamster brain by human adenovirus type 6.

1988 • 2 citations