Insulin resistance syndrome: interaction with coagulation and fibrinolysis

Role of Insulin Resistance in Human Disease

1988 • 12,099 citations

Biochemistry and molecular cell biology of diabetic complications

2001 • 8,707 citations

Insulin signalling and the regulation of glucose and lipid metabolism

2001 • 4,995 citations

Role of Oxidative Stress in Development of Complications in Diabetes

1991 • 3,774 citations

HAEMOSTATIC FUNCTION AND ISCHAEMIC HEART DISEASE: PRINCIPAL RESULTS OF THE NORTHWICK PARK HEART STUDY

1986 • 1,989 citations

Hemostatic Factors and the Risk of Myocardial Infarction or Sudden Death in Patients with Angina Pectoris

1995 • 1,807 citations

PLASMINOGEN ACTIVATOR INHIBITOR IN PLASMA: RISK FACTOR FOR RECURRENT MYOCARDIAL INFARCTION

1987 • 1,516 citations

Insulin resistance and cardiovascular disease

2000 • 1,280 citations

New drug targets for type 2 diabetes and the metabolic syndrome

2001 • 995 citations

Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance.

1990 • 938 citations

Signaling pathways in insulin action: molecular targets of insulin resistance

2000 • 932 citations

Advanced Glycosylation End Products in Patients with Diabetic Nephropathy

1991 • 925 citations

Prevalence of insulin resistance in metabolic disorders: the Bruneck Study.

1998 • 843 citations

Plasminogen-Activator Inhibitor Type 1 and Coronary Artery Disease

2000 • 791 citations

Orally absorbed reactive glycation products (glycotoxins): An environmental risk factor in diabetic nephropathy

1997 • 774 citations

Fibrinolytic activity, clotting factors, and long-term incidence of ischaemic heart disease in the Northwick Park Heart Study

1993 • 727 citations

Insulin Sensitivity and Atherosclerosis

1996 • 726 citations

Free Fatty Acids and Pathogenesis of Type 2 Diabetes Mellitus

2000 • 623 citations

High Plasminogen Activator Inhibitor and Tissue Plasminogen Activator Levels in Plasma Precede a First Acute Myocardial Infarction in Both Men and Women

1998 • 594 citations

Fibrinogen and factor VII in the prediction of coronary risk. Results from the PROCAM study in healthy men.

1994 • 572 citations

Hyperinsulinemia, Hyperglycemia, and Impaired Hemostasis

2000 • 537 citations

Role of Insulin in Endogenous Hypertriglyceridemia*

1967 • 523 citations

An agent cleaving glucose-derived protein crosslinks in vitro and in vivo

1996 • 466 citations

Nutritional and toxicological aspects of the Maillard browning reaction in foods

1989 • 464 citations

Globalization, coca-colonization and the chronic disease epidemic: can the Doomsday scenario be averted?

2000 • 449 citations

Associations of Factor VIII and von Willebrand Factor with Age, Race, Sex, and Risk Factors for Atherosclerosis

1993 • 432 citations

Clustering of Procoagulation, Inflammation, and Fibrinolysis Variables with Metabolic Factors in Insulin Resistance Syndrome

2000 • 422 citations

Effects of Pioglitazone on Adipose Tissue Remodeling Within the Setting of Obesity and Insulin Resistance

2001 • 347 citations

Population correlates of plasma fibrinogen and factor VII, putative cardiovascular risk factors

1991 • 334 citations

SERUM-INSULIN IN ESSENTIAL HYPERTENSION AND IN PERIPHERAL VASCULAR DISEASE

1966 • 328 citations

Diabetes epidemiology as a tool to trigger diabetes research and care

1999 • 317 citations

T0070907, a Selective Ligand for Peroxisome Proliferator-activated Receptor γ, Functions as an Antagonist of Biochemical and Cellular Activities

2002 • 295 citations

Haemostatic variables associated with diabetes and its complications.

1979 • 290 citations

Tissue-type plasminogen activator antigen and plasminogen activator inhibitor in diabetes mellitus.

1988 • 280 citations

Association of a Common Polymorphism in the Factor XIII Gene with Myocardial Infarction

1998 • 264 citations

Relative Contribution of Insulin and Its Precursors to Fibrinogen and PAI-1 in a Large Population With Different States of Glucose Tolerance

1999 • 258 citations

Plasma concentration of cross-linked fibrin degradation product (D-dimer) and the risk of future myocardial infarction among apparently healthy men.

1994 • 250 citations

Blood pressure lowering by pioglitazone. Evidence for a direct vascular effect.

1995 • 236 citations

Proneness to Formation of Tight and Rigid Fibrin Gel Structures in Men with Myocardial Infarction at a Young Age

1996 • 226 citations

Coronary thrombosis: Pathogenesis and clinical manifestations

1991 • 212 citations

The Insulin Resistance Syndrome: Impact on Lipoprotein Metabolism and Atherothrombosis

2000 • 206 citations

The role of the fibrinolytic system in deep vein thrombosis.

1985 • 201 citations

The relationships of concentrations of insulin, intact proinsulin and 32?33 split proinsulin with cardiovascular risk factors in Type 2 (non-insulin-dependent) diabetic subjects

1990 • 198 citations

Very-Low-Density Lipoprotein Response Element in the Promoter Region of the Human Plasminogen Activator Inhibitor-1 Gene Implicated in the Impaired Fibrinolysis of Hypertriglyceridemia

1998 • 191 citations

Thiazolidinediones Down-Regulate Plasminogen Activator Inhibitor Type 1 Expression in Human Vascular Endothelial Cells: A Possible Role for PPARγ in Endothelial Function

1999 • 151 citations

Plasminogen Activator Inhibitor Type 1 Is Increased in the Arterial Wall of Type II Diabetic Subjects

2001 • 150 citations

Comparative effects of pioglitazone, glibenclamide, and voglibose on urinary endothelin-1 and albumin excretion in diabetes patients

2000 • 143 citations

Inhibition of Platelet-Collagen Interaction

2002 • 140 citations

Regional differences in intramyocellular lipids in humans observed by in vivo ¹H-MR spectroscopic imaging

2001 • 137 citations

Intercorrelations among plasma high density lipoprotein, obesity and triglycerides in a normal population

1980 • 130 citations

Effect of weight change and metformin on fibrinolysis and the von Willebrand factor in obese nondiabetic subjects: the BIGPRO1 Study. Biguanides and the Prevention of the Risk of Obesity.

1998 • 123 citations

Insulin Directly Reduces Platelet Sensitivity to Aggregating Agents: Studies In Vitro and In Vivo

1988 • 121 citations

Impaired fibrinolysis in coronary artery disease

1988 • 118 citations

Association of FXIII Val34Leu with decreased risk of myocardial infarction in Finnish males

1999 • 115 citations

Insulin Therapy in Type 2 Diabetic Subjects Suppresses Plasminogen Activator Inhibitor (PAI‐1) Activity and Proinsulin‐like Molecules Independently of Glycaemic Control

1993 • 113 citations

Circulating Levels of Factor VII, Fibrinogen, and von Willebrand Factor and Features of Insulin Resistance in First-Degree Relatives of Patients With NIDDM

1996 • 102 citations

Abnormally high circulation levels of tissue plasminogen activator and plasminogen activator inhibitor-1 in patients with a history of ischemic stroke.

1994 • 100 citations

Plasma Lipoproteins Support Prothrombinase and Other Procoagulant Enzymatic Complexes

1998 • 99 citations

The Effect of Dimethylbiguanide on Thrombin Activity, FXIII Activation, Fibrin Polymerization, and Fibrin Clot Formation

2002 • 99 citations

Relationship of Proinsulin and Insulin to Cardiovascular Risk Factors in Nondiabetic Subjects

1993 • 98 citations

Insulin, Intact and Split Proinsulin, and Coronary Artery Disease in Young Men

1995 • 93 citations

Increased Expression of Tissue Plasminogen Activator and Its Inhibitor and Reduced Fibrinolytic Potential of Human Endothelial Cells Cultured in Elevated Glucose

1992 • 91 citations

Alcohol and the risk of myocardial infarction

2001 • 90 citations

Clinical efficacy of new thiazolidinediones and glinides in the treatment of type 2 diabetes mellitus

2000 • 87 citations

Plasminogen Activator Inhibitor–1, Tissue-Type Plasminogen Activator, and Fibrinogen

1996 • 84 citations

Factor XIII val34leu and the risk of myocardial infarction.

2000 • 80 citations

The platelet insulin receptor: Detection, partial characterization, and search for a function

1988 • 80 citations

Regulation of tissue factor gene expression in obesity

2001 • 77 citations

Glucose and insulin independently reduce the fibrinolytic potential of human vascular smooth muscle cells in culture

1996 • 75 citations

Genotype-Specific Transcriptional Regulation of PAI-1 Expression by Hypertriglyceridemic VLDL and Lp(a) in Cultured Human Endothelial Cells

1997 • 58 citations

Factor VII Gene Polymorphisms, Factor VII:C Levels and Features of Insulin Resistance in Non-Insulin-Dependent Diabetes mellitus

1996 • 53 citations

Prevalence of Three Common Polymorphisms in the A-subunit Gene of Factor XIII in Patients with Coronary Artery Disease

1999 • 53 citations

Impaired fibrinolysis and increased fibrinogen levels in South Asian subjects

2001 • 46 citations

Cardiovascular Risk Factors Associated With Insulin Resistance Cluster in Families With Early-Onset Coronary Heart Disease

2001 • 43 citations

Proinsulin-like molecules and plasminogen activator inhibitor type 1 (PAI-1) activity in diabetic and non-diabetic subjects with and without myocardial infarction

1997 • 40 citations

Coagulation Factor XIII and Cardiovascular Disease in UK Asian Patients Undergoing Coronary Angiography

2001 • 38 citations

Long-term effects of troglitazone: open-label extension studies in type 2 diabetic patients.

2000 • 38 citations

Reduction of platelet aggregation induced by euglycaemic insulin clamp

1987 • 37 citations

Insulin Sensitivity and Hemostatic Factors in Clinically Healthy 58-year-old Men

2000 • 28 citations

Therapeutic perspectives for type 2 diabetes mellitus: molecular and clinical insights.

2001 • 24 citations

Diabetes and its Complications

1987 • 23 citations

Lipoproteins and thrombosis: effects of lipid lowering

1995 • 22 citations

Levels of von Willebrand Factor, Insulin Resistance Syndrome, and a Common vWF Gene Polymorphism in Non-insulin-dependent (Type 2) Diabetes Mellitus

1996 • 15 citations

Increased prothrombin fragment 1+2 and D-dimer in first-degree relatives of type 2 diabetic patients

1996 • 13 citations

Intervening in Atherogenesis: Lessons from Diabetes

2000 • 12 citations