Tryptophan in the central nervous system: Regulation and Significance
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References (267)
The Determination of Enzyme Dissociation Constants
1934 • 11,865 citations
EVIDENCE FOR THE EXISTENCE OF MONOAMINE-CONTAINING NEURONS IN THE CENTRAL NERVOUS SYSTEM. I. DEMONSTRATION OF MONOAMINES IN THE CELL BODIES OF BRAIN STEM NEURONS.
1964 • 5,110 citations
Brain uptake of radiolabeled amino acids, amines, and hexoses after arterial injection
1971 • 1,671 citations
Chemical Nature of Synaptic Transmission in Vertebrates
1974 • 1,613 citations
EVIDENCE FOR THE EXISTENCE OF MONOAMINE NEURONS IN THE CENTRAL NERVOUS SYSTEM. IV. DISTRIBUTION OF MONOAMINE NERVE TERMINALS IN THE CENTRAL NERVOUS SYSTEM.
1965 • 1,543 citations
Ascending Monoamine Neurons to the Telencephalon and Diencephalon
1966 • 1,205 citations
The Biochemistry of Affective Disorders
1967 • 1,183 citations
Brain Serotonin Content: Physiological Regulation by Plasma Neutral Amino Acids
1972 • 1,164 citations
Brain Serotonin Content: Physiological Dependence on Plasma Tryptophan Levels
1971 • 1,006 citations
INTENSIFICATION OF THE CENTRAL SEROTONINERGIC PROCESSES AS A POSSIBLE DETERMINANT OF THE THYMOLEPTIC EFFECT
1969 • 705 citations
STUDIES IN VIVO ON THE RELATIONSHIP BETWEEN BRAIN TRYPTOPHAN, BRAIN 5‐HT SYNTHESIS AND HYPERACTIVITY IN RATS TREATED WITH A MONOAMINE OXIDASE INHIBITOR AND L‐TRYPTOPHAN
1971 • 667 citations
The Specific Binding of l-Tryptophan to Serum Albumin
1958 • 638 citations
Partial Purification and Characterization of Tryptophan Hydroxylase from Rabbit Hindbrain
1972 • 445 citations
The Distribution of Adrenergic Nerve Fibres to the Blood Vessels in Skeletal Muscle
1965 • 412 citations
THE EFFECTS OF PRECURSOR LOADING IN THE CEREBRAL METABOLISM OF 5‐HYDROXYINDOLES
1968 • 399 citations
Free Tryptophan in Plasma and Brain Tryptophan Metabolism
1972 • 380 citations
Metabolism of the Nervous System
1957 • 372 citations
Effects of Amino Acid Feedings in Schizophrenic Patients Treated with Iproniazid
1961 • 339 citations
In Vitro and in Vivo Formation of Two New Metabolites of Melatonin
1974 • 323 citations
Enzymic Studies on the Biosynthesis of Serotonin in Mammalian Brain
1970 • 308 citations
EFFECTS OF IMMOBILIZATION AND FOOD DEPRIVATION ON RAT BRAIN TRYPTOPHAN METABOLISM
1972 • 307 citations
Kinetic analysis of blood-brain barrier transport of amino acids
1975 • 306 citations
Tryptophan Pyrrolase of Rabbit Intestine
1967 • 284 citations
Ventilation of Operating-theatres
1964 • 275 citations
TRYPTOPHAN IN THE TREATMENT OF DEPRESSION
1967 • 274 citations
L-Tryptophan in Mania
1974 • 272 citations
γ-Glutamyl Transpeptidase in Brain Capillaries: Possible Site of a Blood-Brain Barrier for Amino Acids
1974 • 269 citations
Free tryptophan in serum controls brain tryptophan level and serotonin synthesis
1973 • 266 citations
Rapid depletion of serum tryptophan, brain tryptophan, serotonin and 5-hydroxyindoleacetic acid by a tryptophan-free diet
1974 • 264 citations
Substrate specificity of steady-state amino acid transport in mouse brain slices
1965 • 263 citations
Effect of psychotropic drugs on tryptophan concentration in the rat brain.
1971 • 248 citations
The Comparative Antidepressant Value of L-Tryptophan and Imipramine With and Without Attempted Potentiation by Liothyronine
1972 • 248 citations
Brain Electrolytes and Fluid Metabolism.
1973 • 236 citations
Tryptophan hydroxylase activity and synaptosomal uptake of serotonin in discrete brain regions after midbrain raphe lesions: Correlations with serotonin levels and histochemical fluorescence
1972 • 232 citations
Daily variations of serotonin metabolism in the rat brain
1972 • 231 citations
INSULIN, PLASMA AMINOACID IMBALANCE, AND HEPATIC COMA
1975 • 224 citations
Mechanisms of Release of Biogenic Amines.
1967 • 222 citations
CALCIUM DEPRIVATION IN HYPOPARATHYROIDISM
1960 • 219 citations
Serotonin: Release in the Forebrain by Stimulation of Midbrain Raphé
1967 • 208 citations
L-tryptophan verses E.C.T.
1970 • 201 citations
Studies on Aromatic Amino Acid Uptake by Rat Brain in Vivo
1962 • 195 citations
Effect of the oral administration of tryptophan‐free amino acid mixtures on serum tryptophan, brain tryptophan and serotonin metabolism
1974 • 195 citations
Psychotomimetic N -Methylated Tryptamines: Formation in Brain in vivo and in vitro
1972 • 181 citations
5‐HYDROXYINDOLE METABOLISM IN RAT BRAIN. A STUDY OF INTERMEDIATE METABOLISM USING THE TECHNIQUE OF TRYPTOPHAN LOADING–I METHODS
1965 • 177 citations
Quantitative aspects of tryptophan metabolism in humans and other species: a review
1971 • 163 citations
TOTAL AND FREE TRYPTOPHAN CONCENTRATION IN THE PLASMA OF DEPRESSIVE PATIENTS
1973 • 163 citations
Relevance of free tryptophan in serum to tissue tryptophan concentrations
1974 • 161 citations
Unbound Amino Acid Concentrations in Human Blood Plasmas
1957 • 147 citations
Dopamine and Serotonin Metabolism in Hepatic Encephalopathy
1974 • 144 citations
Decrease of 5-Hydroxytryptamine in the Brain provoked by Hydrocortisone and its Prevention by Allopurinol
1968 • 144 citations
Short- and Long-Term Lithium Administration: Effects on the Brain's Serotonergic Biosynthetic Systems
1973 • 142 citations
EFFECTS ON PLASMA AND BRAIN TRYPTOPHAN IN THE RAT OF DRUGS AND HORMONES THAT INFLUENCE THE CONCENTRATION OF UNESTERIFIED FATTY ACID IN THE PLASMA
1974 • 141 citations
EFFECTS OF L-TRYPTOPHAN (A NATURAL SEDATIVE) ON HUMAN SLEEP
1970 • 138 citations
Studies of Alpha-methyl-para-tyrosine, L-dopa, and L-tryptophan in Depression and Mania
1971 • 137 citations
Effect of tryptophan administration on 5HIAA in cerebrospinal fluid in man.
1970 • 136 citations
Identification and Distribution of Tryptamine in the Rat
1974 • 135 citations
Tryptophan Pyrrolase—A Biochemical Factor in Depressive Illness?
1969 • 132 citations
Hyperphenylalaninemia: Disaggregation of Brain Polyribosomes in Young Rats
1970 • 131 citations
Adrenal Cortical Activity in Pathological Emotional States : A Review
1966 • 126 citations
Indole(ethyl)amine N-Methyltransferase in Human Brain
1971 • 126 citations
Indoleamines and affective disorders
1972 • 126 citations
Histochemical Fluorescence of Raphe Neurons: Selective Enhancement by Tryptophan
1971 • 120 citations
Tryptophan-Niacin Relationships in Man Studies with Diets Deficient in Riboflavin and Niacin, Together with Observations on the Excretion of Nitrogen and Niacin Metabolites
1956 • 119 citations
Duncan's Diseases of Metabolism
1970 • 119 citations
PLASMA AND BRAIN TRYPTOPHAN CHANGES IN EXPERIMENTAL ACUTE HEPATIC FAILURE
1973 • 118 citations
TRYPTOPHAN TRANSPORT ACROSS THE SYNAPTOSOMAL MEMBRANE1
1970 • 117 citations
Role of amino acid supply in regulating ribosome function.
1968 • 112 citations
l-Tryptophan in affective disorders: Indoleamine changes and differential clinical effects
1974 • 111 citations
Amine Precursors and Depression
1975 • 110 citations
Influence of drugs on the firing of serotonin-containing neurons in brain.
1972 • 110 citations
Dietary regulation of brain tryptophan metabolism by plasma ratio of free tryptophan and neutral amino acids in humans
1974 • 110 citations
Brain tryptophan hydroxylase: purification of, production of antibodies to, and cellular and ultrastructural localization in serotonergic neurons of rat midbrain.
1975 • 109 citations
COMPARISON OF 5‐HYDROXYINDOLES IN VARIOUS REGIONS OF DOG BRAIN AND CEREBROSPINAL FLUID
1968 • 108 citations
Possible Participation of Superoxide Anion in the Intestinal Tryptophan 2,3-Dioxygenase Reaction
1971 • 107 citations
Changes in brain serotonin metabolism associated with fasting and satiation in rats
1972 • 106 citations
EFFECTS OF CHRONIC PORTO‐CAVAL ANASTOMOSIS ON BRAIN TRYPTOPHAN, TYROSINE AND 5‐HYDROXYTRYPTAMINE
1975 • 106 citations
Effect of L-Tryptophan on Brain Serotonin Metabolism in Depressed Patients
1972 • 105 citations
The influx of amino acids into the brain of the rat in vivo : the essential compared with some non-essential amino acids
1973 • 104 citations
The regulation of tryptophan pyrrolase activity by tryptophan
1966 • 104 citations
Tryptophan hydroxylase. Purification and some properties of the enzyme from rabbit hindbrain
1975 • 102 citations
THE BRAIN BARRIER SYSTEM–III
1962 • 101 citations
Effects of immobilization on rat liver tryptophan pyrrolase and brain 5‐hydroxytryptamine metabolism
1969 • 100 citations
CENTRAL MONOAMINE NEURONS**Abbreviations used: A, adrenaline; CA, catecholamine(s); CNS, central nervous system; COMT, catechol-o-methyltransferase; DA, dopamine; DOPA, 3,4-dihydroxyphenylalanine; FRA, flexor reflex afferents; 5-HT, 5-hydroxytryptamine; 5-HTP, 5-hydroxytryptophan; MAO, monoamine oxidase; NA, noradrenaline.
1966 • 95 citations
A specific and sensitive enzymatic assay for tryptamine in tissues.
1972 • 95 citations
SEQUENTIAL COMPARISON OF L-TRYPTOPHAN WITH E.C.T. IN SEVERE DEPRESSION
1970 • 94 citations
Changes on recovery in the concentrations of tryptophan and the biogenic amine metabolites in the cerebrospinal fluid of patients with affective illness
1973 • 94 citations
THE SUBCELLULAR DISTRIBUTION OF β‐PHENYLETHYLAMINE, p‐TYRAMINE AND TRYPTAMINE IN RAT BRAIN
1975 • 90 citations
THE NATURE OF IN VITRO HYDROXYLATION OF <scp>l</scp>‐TRYPTOPHAN BY BRAIN TISSUE
1966 • 90 citations
EFFECT OF INCREASED RAT BRAIN TRYPTOPHAN ON 5‐HYDROXYTRYPTAMINE AND 5‐HYDROXYINDOLYL ACETIC ACID IN THE HYPOTHALAMUS AND OTHER BRAIN REGIONS
1974 • 89 citations
Dietary Carbohydrate Increases Brain Tryptophan and Decreases Free Plasma Tryptophan
1973 • 89 citations
The effect of L-tryptophan and some psychotropic drugs on the formation of 5-hydroxytryptophan in the mouse brain in vivo
1972 • 89 citations
Serotonin Metabolism in Rat Brain after Surgical Diversion of the Portal Venous Circulation
1973 • 88 citations
The effect of tryptophan metabolites on brain 5-hydroxytryptamine metabolism
1970 • 88 citations
THE EFFECTS OF MATURATION ON IN VITRO PROTEIN SYNTHESIS BY MOUSE BRAIN CELLS
1966 • 87 citations
Regulation of serotonin synthesis
1974 • 86 citations
l-Trypophan as a selective histochemical marker for serotonergic neurons in single-cell recording studies
1974 • 85 citations
The Functional Significance of Changes in Activity of the Enzymes, Tryptophan Pyrrolase and Tyrosine Transaminase, after Induction in Intact Rats and in the Isolated, Perfused Rat Liver
1969 • 84 citations
Effect of tryptophan on polyribosomes and protein synthesis in liver
1971 • 84 citations
Behavioral effects and brain amine content in rats.
1961 • 84 citations
PLASMA TRYPTOPHAN AND 5‐HT METABOLISM IN THE CNS OF THE NEWBORN RAT
1974 • 83 citations
Identification and quantitation of a new indolealkylamine in rat hypothalamus
1973 • 83 citations
Regulation of Biosynthesis of Catecholamines and Serotonin in the CNS
1974 • 81 citations
SI UNITS
1975 • 81 citations
MELANIN FORMATION BY HUMAN BRAIN IN VITRO
1975 • 77 citations
The acute effects of oral (‐)‐tryptophan in human subjects.
1975 • 76 citations
Monoamine precursors in the treatment of depression
1971 • 75 citations
Effects of lithium chloride on parameters biosynthetic capacity for 5-hydroxytryptamin in rat brain.
1975 • 75 citations
Effect of drugs on the tryptamine content of rat tissues.
1973 • 73 citations
TRANSPORT OF <scp>l</scp>‐TRYPTOPHAN INTO SLICES OF RAT CEREBRAL CORTEX1
1972 • 73 citations
POLYRIBOSOME DISAGGREGATION AND CELL‐FREE PROTEIN SYNTHESIS IN PREPARATIONS FROM CEREBRAL CORTEX OF HYPERPHENYLALANINEMIC RATS1
1971 • 72 citations
Tryptophan Transport in Neurospora crassa: a Tryptophan-Binding Protein Released by Cold Osmotic Shock
1970 • 72 citations
Hypnotic Effects of L-Tryptophan
1974 • 72 citations
Tryptophan metabolism in depression
1970 • 70 citations
Cerebral tryptophan‐2,3‐dioxygenase (pyrrolase) and its induction in rat brain
1974 • 69 citations
Free Amino Acids and Peptides in Tissues
1964 • 68 citations
Saturation of a shared mechanism which transports L‐arginine and L‐lysine into the brain of the living rat
1974 • 68 citations
SOME ENZYMIC ASPECTS OF THE PRODUCTION OF OXIDIZED OR REDUCED METABOLITES OF CATECHOLAMINES AND 5‐HYDROXYTRYPTAMINE BY BRAIN TISSUES
1974 • 67 citations
Relationships between tryptophan in serum and CSF, and 5-hydroxyindoleacetic acid in CSF of man: effect of cirrhosis of liver and probenecid administration.
1975 • 65 citations
AMINO ACID TRANSPORT BY CHOROID PLEXUS IN VITRO1
1969 • 64 citations
The effect of L-dopa on the concentrations of tryptophan, tyrosine and serotonin in rat brain
1971 • 63 citations
COMPARATIVE TRIAL OF L-TRYPTOPHAN AND E.C.T. IN SEVERE DEPRESSIVE ILLNESS
1974 • 63 citations
Simulation of biogenic amine metabolism in the brain
1974 • 62 citations
Effect of chronic lithium treatment on monoamine metabolism in rat brain
1973 • 62 citations
Nucleus ruber and L-Dopa psychosis: Biochemical post-mortem findings
1974 • 61 citations
TRYPTOPHAN CONCENTRATION IN THE CEREBROSPINAL FLUID OF DEPRESSIVE PATIENTS
1972 • 61 citations
The rate of incorporation of amino acids into brain proteins during infusion in the rat
1973 • 61 citations
Adrenal Cortical Activity Changes in Manic-Depressive Illness
1967 • 61 citations
TRANSAMINATION OF AROMATIC AMINO ACIDS IN RAT BRAIN
1964 • 60 citations
Kinetics of influx of phenylalanine, tyrosine, tryptophan, histidine and leucine into slices of brain cortex from adult and 7-day-old rats
1972 • 60 citations
Benzodiazepines: Specific competitors for the binding of l-tryptophan to human serum albumin
1975 • 59 citations
Intestinal transport of tryptophan and its derivatives
1964 • 59 citations
AN ASSAY PROCEDURE FOR TRYPTAMINE IN BRAIN AND SPINAL CORD USING ITS [3H]DANSYL DERIVATIVE
1973 • 58 citations
Some factors in the regulation of central serotonergic synapses
1974 • 57 citations
The binding of <scp>L</scp>-tryptophan to serum albumins in the presence of non-esterified fatty acids
1975 • 56 citations
Tryptophan metabolism in liver disease
1971 • 56 citations
Inhibition by albumin of tryptophan uptake by rat brain
1976 • 56 citations
Tryptophan Metabolism in Affective Psychoses
1966 • 53 citations
Transport and exchange diffusion of <scp>l</scp>-tryptophan in Ehrlich cells
1961 • 52 citations
Effect of a Tryptophan Deficient Diet on Brain Serotonin and Plasma Tryptophan Level.
1963 • 52 citations
5-Hydroxytryptamine metabolism in affective illness: the effect of tryptophan administration
1973 • 51 citations
LIVER AND BRAIN TRYPTOPHAN METABOLISM FOLLOWING HYDROCORTISONE ADMINISTRATION TO RATS AND GERBILS
1975 • 51 citations
LEVODOPA AND L-TRYPTOPHAN THERAPY IN PARKINSONISM
1972 • 51 citations
Metabolism of Tryptophan in Depressive Disease
1973 • 50 citations
Mode of Action of Antirheumatic Drugs
1971 • 50 citations
EFFECTS OF LESIONS AND DRUGS ON BRAIN TRYPTAMINE
1974 • 49 citations
Possible role of free serum tryptophan in the control of brain tryptophan level and serotonin synthesis.
1974 • 48 citations
The displacement of l-tryptophan and dipeptides from bovine albumin in vitro and from human plasma in vivo by antirheumatic drugs
1971 • 46 citations
Factors influencing effect of hydrocortisone on rat brain tryptophan metabolism
1975 • 46 citations
BIOSYNTHESIS OF SEROTONIN IN RAPHÉ NUCLEI OF RAT BRAIN: EFFECT OF p‐CHLOROPHENYLALANINE1
1973 • 46 citations
Characteristics of tryptophan accumulation by glial cells
1974 • 46 citations
TRYPTOPHAN AND 5‐HYDROXYINDOLEACETIC ACID IN HUMAN CEREBROSPINAL FLUID
1974 • 46 citations
Cerebrospinal fluid 5-hydroxyindoles and behavior after l-tryptophan and pyridoxine administration to psychiatric patients
1970 • 45 citations
Studies on the Metabolism of 5-Hydroxytryptamine (Serotonin) II. Effect of Tryptophan Deficiency in Rats
1962 • 45 citations
Regulation of tryptophan and tyrosine hydroxylase
1974 • 44 citations
On the Mechanism of the Brain Serotonin Depletion in Experimental Phenylketonuria
1965 • 44 citations
REGIONAL TRANSPORT OF TRYPTOPHAN IN RAT BRAIN
1977 • 44 citations
MENTAL DISTRUBANCES FOLLOWED BY STUPOR IN A PATIENT WITH CARCINOIDOSIS: Recovery with Tryptophan treatment
1966 • 43 citations
Control of brain serotonin levels by the diet.
1974 • 43 citations
Distribution and Metabolism of Tryptamine in Rat Brain
1973 • 42 citations
METABOLISM OF A TRYPTOPHAN LOAD IN THE HYPOTHALAMUS AND OTHER BRAIN REGIONS
1975 • 42 citations
TRYPTOPHAN MALABSORPTION IN LEVODOPA‐TREATED PARKINSONIAN PATIENTS
1973 • 42 citations
L-tryptophan metabolism in phenylketonuria
1966 • 42 citations
KINETIC ANALYSIS OF PHENYLALANINE‐INDUCED INHIBITION IN THE SATURABLE INFLUX OF TYROSINE, TRYPTOPHAN, LEUCINE AND HISTIDINE INTO BRAIN CORTEX SLICES FROM ADULT AND 7‐DAY‐OLD RATS
1975 • 42 citations
The acute effects of intravenous infusion of L‐tryptophan in normal subjects
1974 • 41 citations
TRYPTOPHAN/IMIPRAMINE IN DEPRESSION
1975 • 41 citations
On the importance of decarboxylation in the metabolism of phenylalanine, tyrosine, and tryptophan
1974 • 41 citations
RAPID EFFECTS OF ENVIRONMENTAL DISTURBANCE ON RAT PLASMA UNESTERIFIED FATTY ACID AND TRYPTOPHAN CONCENTRATIONS AND THEIR PREVENTION BY ANTILIPOLYTIC DRUGS
1975 • 41 citations
Tryptophan catabolism by tryptophan pyrrolase in rat liver. The effect of tryptophan loads and changes in tryptophan pyrrolase activity.
1975 • 40 citations
Normalization of brain serotonin by L‐tryptophan in levodopa‐treated rats
1975 • 40 citations
Decrease of cerebral serotonin and 5-hydroxyindolylacetic acid caused by (?)-?-methyltryptophan
1970 • 39 citations
Syntheses and biological evaluation of analogs of luteinizing hormone-releasing hormone (LH-RH) modified in position 2, 3, 4 or 5
1973 • 39 citations
CONVERSION OF D‐ AND L‐TRYPTOPHAN TO BRAIN SEROTONIN AND 5‐HYDROXYINDOLEACETIC ACID AND TO BLOOD SEROTONIN1
1973 • 38 citations
Effects of central alterations of serotoninergic neurons upon the sleep-waking cycle.
1974 • 38 citations
Alterations of individual free amino acids in brain during acute hepatic coma.
1970 • 38 citations
Correlations between circadian changes in serum amino acids or brain tryptophan and the contents of serotonin and 5-hydroxyindoleacetic acid in regions of the rat brain
1975 • 38 citations
Intestinal transport of <scp>l</scp>-tryptophan in vitro: inhibition by high concentrations
1960 • 37 citations
LEVEL AND AMINO ACID ACCEPTOR ACTIVITY OF MOUSE BRAIN tRNA DURING NEURAL DEVELOPMENT
1973 • 36 citations
ANTIDEPRESSANT ACTION OF TRYPTOPH AN
1974 • 36 citations
Extrapineal N-acetyltransferase activity in rat brain
1974 • 35 citations
Pial vessels transport of substances from cerebrospinal fluid to blood
1974 • 35 citations
The Binding of Indole Analogues to Defatted Human Serum Albumin at Different Chloride Concentrations
1964 • 34 citations
Amino acid uptake into human brain tumors
1974 • 34 citations
Quantitative Aspects of D- and L-Tryptophan utilization by the Young Pig
1971 • 34 citations
Melanogenesis from tryptophan. Biogenetic experiments with harding-passey mouse melanoma
1974 • 33 citations
Alpha-methyltryptophan: Effects on synthesis and degradation of serotonin in the brain
1972 • 33 citations
Influence of restraint stress, corticosterone and betamethasone on brain amine levels
1969 • 33 citations
INCORPORATION OF 14 C-TRYPTOPHAN INTO 14 C-PROTEIN BY CULTURED RAT PINEALS: STIMULATION BY l -NOREPINEPHRINE
1969 • 33 citations
Central decarboxylation and uptake of l-DOPA
1972 • 32 citations
Relationship between rat brain and cisternal CSF tryptophan concentrations.
1976 • 32 citations
Effects of l-dopa administration on the serotonergic system in rat brain: Correlation between levels of l-dopa accumulated in the brain and depletion of serotonin and tryptophan
1974 • 32 citations
INCREASE OF BRAIN TRYPTOPHAN BY ELECTROCONVULSIVE SHOCK IN RATS
1972 • 31 citations
TREATMENT OF UNIPOLAR DEPRESSION
1975 • 30 citations
AMINO ACID TRANSPORT INTO THE CEREBROSPINAL FLUID OF THE RAT1
1975 • 30 citations
Unesterified Fatty Acids and the Binding of Tryptophan in Human Plasma
1974 • 30 citations
Effects of hydrocortisone and immobilization on tryptophan metabolism in brain and liver of rats of different ages
1975 • 29 citations
Affective disorder: studies with amine precursors
1975 • 29 citations
The Effect of Inadequate Vitamin B upon Sexual Physiology in the Male
1928 • 29 citations
Whole Blood 5-Hydroxytryptamine during Treatment of Endogenous Depressive Illness
1973 • 29 citations
5-Methoxytryptamine: a possible central nervous system transmitter.
1974 • 29 citations
The relationship between the concentrations of tryptophan and 5‐hydroxyindoieacetic acid in rat brain and cerebrospinal fluid
1975 • 28 citations
Parallel variation of ventricular CSF tryptophan and free serum tryptophan in man.
1976 • 28 citations
Amino acid transport mechanisms of the cerebrospinal fluid.
1974 • 28 citations
THE EFFECT OF A LOW PROTEIN DIET AND EXOGENOUS INSULIN ON BRAIN TRYPTOPHAN AND ITS METABOLITES IN THE WEANLING RAT
1975 • 27 citations
TRANSPORT OF LYSINE FROM CEREBROSPINAL FLUID OF THE CAT
1970 • 26 citations
5-Hydroxyindoleacetic acid, homovanillic acid and tryptophan levels in CSF above and below a complete block of CSF flow.
1973 • 26 citations
Alpha-methyltryptophan and its actions on tryptophan metabolism.
1971 • 25 citations
Cerebrospinal fluid homovanillic acid, 5-hydroxyin-doleacetic acid, lactic acid, and pH before and after probenecid in hepatic coma
1974 • 24 citations
Tryptophan and tyrosine disposition and brain tryptophan metabolism in acute carbon tetrachloride poisoning
1975 • 24 citations
Inhibition of entry of some amino acids into the brain, with observations on mental retardation in the aminoacidurias
1974 • 24 citations
PARTICIPATION OF DOPAMINE‐ AND SEROTONIN‐RECEPTORS IN THE DISAGGREGATION OF BRAIN POLYSOMES BY <scp>l</scp>‐DOPA AND <scp>l</scp>‐5‐HTP
1975 • 24 citations
L-tryptophan in the treatment of levodopa induced psychiatric disorders.
1974 • 24 citations
VENTRICULO‐CISTERNAL PERFUSION OF AMINO ACIDS IN CAT BRAIN*—II
1966 • 24 citations
5‐Hydroxytryptophan pyrrolase in rat brain
1972 • 24 citations
Tryptophan Pyrrolase Induced in Human Liver by Hydrocortisone: Effect on Excretion of Kynurenine
1966 • 24 citations
Tryptophan metabolism in a patient with phenylketonuria and scleroderma: a proposed explanation of the indole defect in phenylketonuria.
1966 • 23 citations
Free and bound serum tryptophan in drug-free normal controls and chronic schizophrenic patients.
1974 • 23 citations
Plasma Trytophan and Sleep
1974 • 22 citations
Plasma tryptophan tolerance curves in drug free normal controls, schizophrenic patients and prisoner volunteers
1974 • 22 citations
Liver tryptophan pyrrolase activity and metabolism of brain 5-HT in rat
1975 • 22 citations
AMINOACIDS, INSULIN, AND HEPATIC COMA
1975 • 20 citations
Comparable therapeutic efficacy of tryptophan and imipramine: average therapeutic ratings versus "true" equivalence. An important difference.
1973 • 20 citations
Involvement of the liver in the regulation of tryptophan availability. Possible role in the responses of liver and brain to starvation
1974 • 20 citations
RELATIONSHIP BETWEEN ALTERNATE ROUTES OF TRYPTOPHAN METABOLISM FOLLOWING ADMINISTRATION OF TRYPTOPHAN PEROXIDASE INDUCERS OR STRESSORS1
1971 • 20 citations
Analysis of the effect of 5-hydroxykynurenamine,, a serotonin metabolite, on isolated cerebral arteries, aortas and atria.
1975 • 20 citations
VENTRICULO‐CISTERNAL PERFUSION OF AMINO ACIDS IN CAT BRAIN *‐I
1966 • 19 citations
Stimulation by Dibutyryl Cyclic AMP of Serotonin Synthesis and Tryptophan Transport in Brain Slices
1972 • 19 citations
Clinical Relevance of Drugs Affecting Tryptophan Transport
1975 • 19 citations
The Effect of Theophylline on Tryptophan Pyrrolase in the Hypophysectomized Rat and Some Observations on the Validity of Tryptophan Pyrrolase Assays
1974 • 19 citations
SERUM TRYPTOPHAN BINDING IN CHLORPROMAZINE-TREATED CHRONIC SCHIZOPHRENICS
1974 • 19 citations
Hormonal imputs and brain tryptophan metabolism: The effect of growth hormone
1975 • 18 citations
Multicompartmental analysis of amino acids: 1. Preliminary data on concentrations, fluxes, and flow constants of tryptophan in affective illness
1975 • 18 citations
Zur Therapie der Dopa-Psychosen mit<scp>L</scp>-Tryptophan
1974 • 18 citations
Effect of chronic administration of cortisone on the tryptophan induced changes in amine levels in the rat brain.
1968 • 17 citations
Influence of Hydrocortisone and Glucagon on Liver Tyrosine Transaminase and on Brain Tyrosine, Norepinephrine and Serotonin
1970 • 17 citations
Increase in the plasma concentration of free tryptophan caused by probenecid in humans
1973 • 17 citations
The plasma factor and transport of indoleamino acids.
1969 • 16 citations
AN EXAMINATION OF THE CATALYTIC PROPERTIES OF SEVERAL AMINOTRANSFERASES IN BRAIN AND LIVER BY MEANS OF AN IMPROVED RADIOMETRIC ASSAY WITH DINITROPHENYLHYDRAZINE
1975 • 16 citations
Effects of Various Drugs on Serum Free and Total Tryptophan Levels and Brain Tryptophan Metabolism in Rats
1975 • 16 citations
The detection of mausamine in the brain of mouse
1961 • 16 citations
Hydroxytryptamingehalt des Rattendarmes bei verschiedenem Tryptophangehalt der Nahrung
1958 • 16 citations
Eighth Symposium on Advanced Medicine.
1973 • 16 citations
Effects of the α-Hydroxy Analogues of Isoleucine, Lysine, Threonine and Tryptophan and the α-Keto Analogue of Tryptophan and the Level of the Corresponding Amino Acids on Growth of Rats
1964 • 15 citations
5-hydrotrtryptamine-O-sulfate: an alternate route of serotonin inactivation in brain
1972 • 14 citations
Hydroxylation of tryptophan and its control in brain
1975 • 14 citations
5-HYDROXYTRYPTAMINE AND HEPATIC COMA
1975 • 14 citations
The effects of diet, lipolysis and limb ischaemia on the distribution of plasma tryptophan in the rat
1975 • 14 citations
Effect of electroconvulsive therapy on plasma unesterified fatty acid and free tryptophan concentrations in man
1974 • 14 citations
L-Tryptophan: A Possible Natural Hypnotic Substance
1974 • 13 citations
Plasma Amino Acids in Experimental Acute Hepatic Failure and Their Relationship to Brain Tryptophan
1974 • 13 citations
Amino acid activation in mammalian brain. Purification and characterization of tryptophan-activating enzyme from buffalo brain
1973 • 13 citations
Relationship of dietary tryptophan and niacin to tryptophan metabolism in schizophrenics and nonschizophrenics
1974 • 12 citations
Cerebral Hydroxylases: Stimulation by a New Factor
1973 • 12 citations
Transport synaptosomal du tryptophane et de la tyrosine cerebrale. Stimulation de la vitesse de capture apres reserpine ou inhibition de la monoamine oxydase
1974 • 11 citations
Changes in the Free Amino Acid Composition of Cerebrospinal Fluid in Liver Disease
1962 • 10 citations
Automated assay of tryptophan at the nanogram level: Determination of tryptophan in cerebrospinal fluid and of total and nonprotein bound tryptophan in serum
1974 • 8 citations
EFFECT OF LITHIUM ON SERUM TRYPTOPHAN AND BRAIN SEROTONIN IN RATS
1974 • 8 citations
Book Review: Eighth Symposium on Advanced Medicine
1973 • 7 citations
The effect of the plasma factor on the uptake of amino acids by neural tissue.
1972 • 7 citations
Rat liver tryptophan oxygenase induced by neonatal corticoid administration and its effect on brain serotonin.
1973 • 6 citations
Influence of clofibrate on serum triptophan in man
1974 • 6 citations
Tryptophyl‐polypeptides in rat brain
1973 • 6 citations
SERUM-AMINOACIDS AND BRAIN TRYPTOPHAN UPTAKE
1975 • 5 citations
The transport of L‐tryptophan from cerebrospinal fluid in the dog
1973 • 5 citations
Validity of plasma factor in schizophrenia as measured by tryptophan uptake.
1975 • 3 citations
International Review of Neurobiology, Vol. 7
1965 • 1 citations
Intestinal absorption of tryptophan stereoisomers and analogs.
1974 • 1 citations
l-Dihydroxyphenylalanine: Effect on Levels of Free Amino Acids in Rat Liver
1974 • 1 citations