Defective Recovery and Severe Renal Damage After Acute Hemolysis in Hemopexin-Deficient Mice

Manipulating the mouse embryo: A laboratory manual

1986 • 4,548 citations

The acute phase response

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Manipulating the mouse embryo: A laboratory manual

1986 • 2,165 citations

Ferritin: a cytoprotective antioxidant strategem of endothelium.

1992 • 1,100 citations

Heme oxygenase 1 is required for mammalian iron reutilization

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Cytokines and the hepatic acute phase response

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IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to CEBP

1990 • 637 citations

HFE gene knockout produces mouse model of hereditary hemochromatosis

1998 • 535 citations

Disruption of Krox-20 results in alteration of rhombomeres 3 and 5 in the developing hindbrain

1993 • 452 citations

Hemin: a possible physiological mediator of low density lipoprotein oxidation and endothelial injury.

1991 • 406 citations

Exposure of endothelial cells to free heme potentiates damage mediated by granulocytes and toxic oxygen species.

1991 • 305 citations

Antioxidant protection by haemopexin of haem-stimulated lipid peroxidation

1988 • 280 citations

Hemin: a possible physiological mediator of low density lipoprotein oxidation and endothelial injury.

1991 • 216 citations

Increased Susceptibility in Hp Knockout Mice During Acute Hemolysis

1998 • 208 citations

Defective iron homeostasis in beta 2-microglobulin knockout mice recapitulates hereditary hemochromatosis in man.

1996 • 197 citations

Cloning and characterization of a 23-kDa stress-induced mouse peritoneal macrophage protein.

1993 • 192 citations

Interleukin 6 induces a liver-specific nuclear protein that binds to the promoter of acute-phase genes.

1989 • 172 citations

The influence of heme-binding proteins in heme-catalyzed oxidations

1988 • 141 citations

Hemopexin-mediated transport of heme into isolated rat hepatocytes.

1981 • 128 citations

A protein of the Z class of liver cytosolic proteins in the rat that preferentially binds heme.

1985 • 120 citations

Molecular Characterization of a Newly Identified Heme-binding Protein Induced during Differentiation of urine Erythroleukemia Cells

1998 • 115 citations

Binding of heme by glutathione S-transferase: a possible role of the erythrocyte enzyme

1982 • 100 citations

Cellular Protection Mechanisms against Extracellular Heme

1999 • 94 citations

Regulation of heme oxygenase and metallothionein gene expression by the heme analogs, cobalt-, and tin-protoporphyrin.

1993 • 84 citations

Heme-hemopexin-mediated induction of metallothionein gene expression.

1992 • 78 citations

The primary structure of human hemopexin deduced from cDNA sequence: evidence for internal, repeating homology

1985 • 75 citations

Identification of the histidine residues of hemopexin that coordinate with heme-iron and of a receptor-binding region.

1993 • 72 citations

Hemopexin in the human retina: Protection of the retina against heme-mediated toxicity

1996 • 70 citations

Expression of the mRNA of Heme-Binding Protein 23 Is Coordinated with That of Heme Oxygenase-1 by Heme and Heavy Metals in Primary Rat Hepatocytes and Hepatoma Cells

1995 • 69 citations

Expression of the Protective Proteins Hemopexin and Haptoglobin by Cells of the Neural Retina

1998 • 52 citations

Inhibition of the Thiol-Specific Antioxidant Activity of Rat Liver MSP23 Protein by Hemin

1995 • 52 citations

Heme-mediated reactive oxygen species toxicity to retinal pigment epithelial cells is reduced by hemopexin

1996 • 44 citations

Hemopexin is synthesized in peripheral nerves but not in central nervous system and accumulates after axotomy.

1992 • 41 citations

Hemopexin from four species inhibits the association of heme with cultured hepatoma cells or primary rat hepatocytes exhibiting a small number of species specific hemopexin receptors

1998 • 40 citations

Specific Expression in Brain and Liver Driven by the Hemopexin Promoter in Transgenic Mice

1996 • 39 citations

Changes in expression and localization of hemopexin and its transcripts in injured nervous system: a comparison of central and peripheral tissues

1997 • 35 citations

Role of Heme–Hemopexin in Human T-Lymphocyte Proliferation

1997 • 32 citations

Hemopexin, The Heme-Binding Serum β-Glycoprotein

1974 • 27 citations

Initial heme uptake from albumin by short-term cultured rat hepatocytes is mediated by a transport mechanism differing from that of other organic anions

1998 • 23 citations

Regulation of Hemopexin Synthesis in Degenerating and Regenerating Rat Sciatic Nerve

1999 • 21 citations

Defective iron homeostasis in β2-microglobulin knockout mice recapitulates hereditary hemochromatosis in man

1997 • 20 citations