Regulation of Biosynthesis of β-Lactam Antibiotics

Amino Acid Biosynthesis and its Regulation

1978 • 740 citations

Cyclic Adenosine Monophosphate in Bacteria

1970 • 503 citations

Control of antibiotic biosynthesis

1980 • 469 citations

Regulation of the Assimilation of Nitrogen Compounds

1978 • 345 citations

Advances in Biotechnology

1981 • 325 citations

Cyclic adenosine 5'-monophosphate in Escherichia coli

1976 • 324 citations

Control of antibiotic biosynthesis.

1980 • 277 citations

EFFECT OF PRIMARY METABOLITES ON SECONDARY METABOLISM

1977 • 249 citations

Genetics of Industrial Microorganisms

1979 • 208 citations

Genetics of industrial microorganisms

1978 • 200 citations

Advances in Biotechnology

2009 • 193 citations

Cyclic adenosine 5'-monophosphate in Escherichia coli.

1976 • 172 citations

Catabolite Repression and other Control Mechanisms in Carbohydrate Utilization

1969 • 169 citations

Nitrogen Metabolite Regulation of Antibiotic Biosynthesis

1980 • 157 citations

Carbon Catabolite Regulation of Cephalosporin Production in Streptomyces clavuligerus

1978 • 141 citations

Sporulation and the Production of Serine Protease and Cephamycin C by Streptomyces lactamdurans

1979 • 139 citations

Nitrogen nutrition and regulation of cephalosporin production in Streptomyces clavuligerus

1979 • 130 citations

Second International Symposium on the Genetics of Industrial Micro-organisms

1976 • 128 citations

Conversion of penicillin N to cephalosporin(s) by cell-free extracts of Cephalosporium acremonium

1976 • 122 citations

Streptomyces clavuligerus sp. nov., a -Lactam Antibiotic Producer

1971 • 116 citations

Genetics of Industrial Microorganisms

1974 • 111 citations

Microbial Technology: Current State, Future Prospects

1980 • 107 citations

Cell-free conversion of δ-(<scp>l</scp>-α-aminoadipyl)-<scp>l</scp>-cysteinyl-<scp>d</scp>-valine into an antibiotic with the properties of isopenicillin N in Cephalosporium acremonium

1979 • 104 citations

Synthesis of δ-(α-aminoadipyl)cysteinylvaline and its role in penicillin biosynthesis

1976 • 85 citations

Biosynthesis of Novobiocin by Streptomyces niveus

1972 • 83 citations

Incorporation of 3H from δ-(<scp>l</scp>-α-amino (4,5-3H)adipyl)-<scp>l</scp>-cysteinyl-<scp>d</scp>-(4,4-3H)valine into isopenicillin N

1979 • 80 citations

Lysine Inhibition of in vivo Homocitrate Synthesis in Penicillium chrysogenum

1974 • 78 citations

Inhibition and repression of homocitrate synthase by lysine in Penicillium chrysogenum

1980 • 75 citations

Isolation and nature of intracellular peptides from a cephalosporin C-producing Cephalosporium sp

1971 • 73 citations

Inhibition of penicillin formation by lysine

1957 • 72 citations

L-lysine epsilon-aminotransferase involved in cephamycin C synthesis in Streptomyces lactamdurans

1980 • 70 citations

Regulation of glutamine synthetase activity by adenylylation in the Gram-positive bacterium Streptomyces cattleya.

1981 • 69 citations

Cell-free ring expansion of penicillin N to deacetoxycephalosporin C by Cephalosporium acremonium CW-19 and its mutants.

1978 • 65 citations

Reversal of lysine inhibition of penicillin production by α-aminoadipic or adipic acid

1961 • 63 citations

Role of Methionine in Cephalosporin Synthesis

1966 • 61 citations

Streptomyces novoguineensis sp. nov., an amipurimycin producer, and antimicrobial activity of amipurimycin.

1977 • 59 citations

Incorporation of Labeled Precursors into A16886B, a Novel β-Lactam Antibiotic Produced by Streptomyces clavuligerus

1972 • 58 citations

Lysine Regulation of Penicillin Biosynthesis in Low-producing and Industrial Strains of Penicillium chrysogenum

1979 • 58 citations

Microbial Technology: Current State, Future Prospects

1979 • 54 citations

Cell-free cyclization of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine to isopenicillin N

1980 • 53 citations

A New Natural Penicillin from Penicillium Chrysogenum

1962 • 52 citations

The Effect of the Carbohydrate Nutrition on Penicillin Production by Penicillium chrysogenum Q-176

1953 • 51 citations

Biosynthesis of cephalosporin C from amino acids

1963 • 50 citations

An adenosine triphosphate-dependent carbamoylphosphate-3-hydroxymethylcephem O-carbamoyltransferase from Streptomyces clavuligerus

1980 • 48 citations

Sulphur-containing amino acids and peptides in the mycelium of Penicillium chrysogenum

1960 • 48 citations

Stimulation of the conversion of penicillin N to cephalosporin by ascorbic acid, α-ketoglutarate, and ferrous ions in cell-free extracts of strains of Cephalosporiumacremonium

1979 • 47 citations

Control of the production of cephamycin C and thienamycin by Streptomyces cattleya NRRL 8057

1981 • 47 citations

Effect of Glucose and Methionine Consumption Rates on Cephalosporin C Production by Cephalosporium acremonium

1978 • 47 citations

The biosynthesis of penicillin. 1. The incorporation of some amino acids into penicillin

1954 • 47 citations

The conversion of cephalosporins to 7 α-methoxycephalosporins by cell-free extracts of Streptomyces clavuligerus

1980 • 45 citations

Biosynthesis of peptides containing α-aminoadipic acid and cysteine in extracts of a Cephalosporium sp

1971 • 45 citations

The oxygenation of [3-methyl-3H]desacetoxycephalosporin C [7β-(5-<scp>d</scp>-aminadipamido)-3-methylceph-3-em-4-carboxylic acid] to [3-hydroxymethyl-3H]desacetylcephalosporin C by 2-oxoglutarate-linked dioxygenases from Acremonium chrysogenum and Streptomyces clavuligerus

1978 • 43 citations

Biochemistry of penicillin and cephalosporin fermentations.

1974 • 43 citations

Homocitrate Formation in Neurospora crassa

1968 • 40 citations

Role of Methionine in Cephalosporin Synthesis

1966 • 40 citations

Lysine control of penicillin biosynthesis

1972 • 39 citations

Regulation of cephalosporin synthesis in Cephalosporium acremonium by phosphate and glucose

1980 • 38 citations

Homocitrate synthase as the crucial site of the lysine effect on penicillin biosynthesis.

1977 • 36 citations

Enzymatic Hydrolysis of Cephalosporin C by an Extracellular Acetylhydrolase of Cephalosporium acremonium

1976 • 36 citations

ACCUMULATION OF INTRACELLULAR INORGANIC SULFATE BY PENICILLIUM CHRYSOGENUM

1961 • 35 citations

Control of the production of cephamycin C and thienamycin byStreptomyces cattleyaNRRL 8057

1981 • 35 citations

Mutations that affect antibiotic synthesis by Cephalosporium acremonium

1972 • 34 citations

A kinetic study of homocitrate synthetase activity in the yeast Saccharomycopsis lipolytica

1976 • 34 citations

Incorporation of 3H and 14C from (6 α-3H)penicillin N and (10-14C,6 α-3H) penicillin N into deacetoxycephalosporin C

1980 • 34 citations

Genetic and Biochemical Studies of Mutants of Penicillium chrysogenum Impaired in Penicillin Production

1979 • 34 citations

Biosynthesis of a 7-α-methoxycephalosporin. Incorporation of molecular oxygen

1979 • 34 citations

The obligatory role of methionine in the conversion of sulfate to cephalosporin C

1975 • 34 citations

Antibiotics and other secondary metabolites : biosynthesis and production

1978 • 32 citations

Further studies on microbiological ring-expansion of penicillin N.

1979 • 32 citations

Control of Lysine Biosynthesis in Yeast by a Feedback Mechanism

1967 • 30 citations

Effect of Exogenous Penicillin on Penicillin Biosynthesis

1972 • 29 citations

The Effect of the Carbohydrate Nutrition on Penicillin Production by Penicillium chrysogenum Q-1761

1953 • 29 citations

Catabolite regulation of antibiotic biosynthesis

1980 • 29 citations

Uptake and metabolism of ?-aminoadipic acid by Penicillium chrysogenum wis 54-1255

1978 • 29 citations

Production of Cephalosporin C by Single and Double Sulfur Auxotrophic Mutants of Cephalosporium acremonium

1975 • 28 citations

Use of α-aminoadipic acid for the biosynthesis of penicillin N and cephalosporin C by a Cephalosporium sp.

1967 • 28 citations

Glutamine Metabolism in Nitrogen-starved Conidia of Neurospora crassa

1979 • 27 citations

SYNTHESIS OF CEPHALOSPORIN C BY RESTING CELLS OF CEPHALOSPORIUM SP.

1963 • 27 citations

Increase in activity of β-lactam synthetases after growth ofCephalosporium acremoniumwith methionine or norleucine

1980 • 26 citations

Enzymes Involved in β-Lactam Antibiotic Biosynthesis

1977 • 25 citations

Intermediates in inorganic sulfate utilization by Penicillium chrysogenum

1963 • 25 citations

Effect of methionine on cephalosporin C and penicillin N production by a mutant of Cephalosporium acremonium.

1975 • 25 citations

Investigation of the two final steps in the biosynthesis of cephalosporin C using permeabilized cells ofCephalosporium acremonium

1980 • 23 citations

Studies on the biosynthesis of penicillin.

1947 • 23 citations

Stimulation of cephalosporin production by methionine peptides in a mutant blocked in reverse transsulfuration.

1975 • 22 citations

Lysine stimulation of cephalosporin C synthesis in Cephalosporium acremonium

1979 • 22 citations

Lysine Biosynthesis in Streptomyces lipmanii : Implications in Antibiotic Biosynthesis

1973 • 20 citations

Antibiotics IV. Biosynthesis

1982 • 20 citations

Studies on the biosynthesis of isopenicillin N with a cell-free preparation of Penicillium chrysogenum.

1980 • 19 citations

Impaired Penicillin Production in Lysine Regulatory Mutants of Penicillium chrysogenum

1974 • 19 citations

Stimulation of cell-free ring expansion of penicillin N by sonication and Triton X-100

1980 • 17 citations

beta-Lactam antibiotics and related substances.

1977 • 14 citations

Co-synthesis of Penicillin Following Treatment of Mutants of Aspergillus nidulans Impaired in Antibiotic Production with Lytic Enzymes

1980 • 14 citations

Deacetylcephalosporin C synthesis by cell-free extracts of Cephalosporium acremonium.

1977 • 13 citations

Feedback Inhibition of Lysine Biosynthesis in Yeast

1969 • 12 citations

Insensitivity of Homocitrate Synthase in Extracts of Penicillium chyrosogenum to Feedback Inhibition by Lysine

1974 • 10 citations

Control of lysine biosynthesis in yeast

1972 • 9 citations

Influence of penicillin instability on interpretation of feedback regulation experiments

1981 • 9 citations

The biosynthesis of penicillin

1957 • 9 citations

CARBON CATABOLITE REPRESSION OF PENICILLIN BIOSYNTHESIS

1981 • 5 citations

Insensitivity of Homocitrate Synthase in Extracts of Penicillium chyrosogenum to Feedback Inhibition by Lysine1

1974 • 5 citations

Influence of penicillin instability on interpretation of feedback regulation experiment

1981 • 4 citations