ICI D1694, An Inhibitor of Thymidylate Synthase for Clinical Study

Chemistry and biology of pteridines

1956 • 1,263 citations

A potent antitumour quinazoline inhibitor of thymidylate synthetase: Synthesis, biological properties and therapeutic results in mice

1981 • 242 citations

Modulation of anti-metabolite effects

1984 • 96 citations

Quinazoline antifolate thymidylate synthase inhibitors: heterocyclic benzoyl ring modifications

1991 • 78 citations

Activity of the thymidylate synthase inhibitor 2-desamino-N10-propargyl-5,8-dideazafolic acid and related compounds in murine (L1210) and human (W1L2) systems in vitro and in L1210 in vivo.

1990 • 61 citations

Thymidylate synthase: A target for anticancer drug design

1989 • 52 citations

Thymidylate synthase inhibitors: The in vitro activity of a series of heterocyclic benzoyl ring modified 2-desamino-2-methyl-N10-substituted-5,8-dideazafolates

1991 • 42 citations

Folate analogs. 32. Synthesis and biological evaluation of 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid and related compounds

1989 • 32 citations

Relative substrate activities of structurally related pteridine, quinazoline, and pyrimidine analogs for mouse liver folylpolyglutamate synthetase.

1989 • 18 citations