Complications Associated with Sedative and Neuromuscular Blocking Drugs in Critically Ill Patients

Low mortality associated with low volume pressure limited ventilation with permissive hypercapnia in severe adult respiratory distress syndrome

1990 • 899 citations

A Clinical Prediction Rule for Delirium After Elective Noncardiac Surgery

1994 • 846 citations

Propofol. An update on its clinical use.

1994 • 594 citations

Peripheral Nerve Function in Sepsis and Multiple Organ Failure

1991 • 579 citations

Metabolic acidosis and fatal myocardial failure after propofol infusion in children: five case reports.

1992 • 572 citations

Persistent Paralysis in Critically Ill Patients after Long-Term Administration of Vecuronium

1992 • 487 citations

Propofol

1994 • 370 citations

The neurological complications of sepsis

1993 • 342 citations

Myopathy in Severe Asthma

1992 • 291 citations

Use of Sedating Drugs and Neuromuscular Blocking Agents in Patients Requiring Mechanical Ventilation for Respiratory Failure. A National Survey

1992 • 273 citations

Continuous infusion of haloperidol controls agitation in critically ill patients

1994 • 268 citations

Propofol vs Midazolam in Short-, Medium-, and Long-term Sedation of Critically III Patients

1993 • 252 citations

Myopathy with thick filament (myosin) loss following prolonged paralysis with vecuronium during steroid treatment

1991 • 242 citations

Use of Sedating Drugs and Neuromuscular Blocking Agents in Patients Requiring Mechanical Ventilation for Respiratory Failure

1991 • 238 citations

Neuromuscular complications in patients given pavulon/sr (pancuronium bromide) during artificial ventilation

1985 • 217 citations

Acute necrotizing myopathy of intensive care: Electrophysiological studies

1994 • 200 citations

Early, routine paralysis for intracranial pressure control in severe head injury

1994 • 193 citations

Neuromuscular Blockade in the Intensive Care Unit: More than We Bargained for

1993 • 183 citations

Prolonged paralysis after treatment with neuromuscular junction blocking agents

1991 • 169 citations

Anaesthetic practice and postoperative pulmonary complications

1992 • 153 citations

Prolonged paralysis in intensive care unit patients after the use of neuromuscular blocking agents

1994 • 148 citations

Reversible neurologic abnormalities associated with prolonged intravenous midazolam and fentanyl administration

1991 • 145 citations

Pharmacokinetics of midazolam administered by continuous intravenous infusion to intensive care patients

1992 • 135 citations

UNCONSCIOUSNESS ASSOCIATED WITH MIDAZOLAM AND ERYTHROMYCIN

1990 • 132 citations

Prolonged paralysis due to nondepolarizing neuromuscular blocking agents and corticosteroids

1994 • 127 citations

Prolonged Weakness after Long-Term Infusion of Vecuronium Bromide

1992 • 126 citations

A national survey on the practice patterns of anesthesiologist intensivists in the use of muscle relaxants

1992 • 121 citations

Fatal metabolic acidosis in a pediatric patient receiving an infusion of propofol in the intensive care unit

1995 • 119 citations

Accumulation of midazolam after repeated dosage in patients receiving mechanical ventilation in an intensive care unit.

1984 • 116 citations

Prolonged Weakness After Infusion of Atracurium in Two Intensive Care Unit Patients

1994 • 105 citations

Prolonged neuromuscular blockade after long-term infusion of vecuronium bromide in the intensive care unit

1990 • 104 citations

The neuromuscular and autonomic blocking activities of pancuronium, Org NC 45, and other pancuronium analogues, in the cat

1979 • 99 citations

Patterns of prescribing and administering drugs for agitation and pain in patients in a surgical intensive care unit

1994 • 98 citations

Clinical Importance of the Interaction of Diazepam and Cimetidine

1984 • 92 citations

Relationship between posttetanic count and response to carinal stimulation during vecuronium‐induced neuromuscular blockade

1987 • 91 citations

Midazolam infusions in critically ill patients.

1991 • 90 citations

Improved Oxygenation After Muscle Relaxation in Adult Respiratory Distress Syndrome

1985 • 76 citations

Suxamethonium and Hyperkalaemia

1990 • 75 citations

Neuromuscular Disorder in Intensive Care Unit Patients Treated With Pancuronium Bromide

1994 • 70 citations

The Clinical Spectrum of Critical Illness Polyneuropathy

1994 • 64 citations

Neurological sequelae in children after prolonged propofol infusion

1992 • 60 citations

The pharmacodynamics and pharmacokinetics of the metabolite 3-desacetylvecuronium (ORG 7268) and its parent compound, vecuronium, in human volunteers.

1994 • 58 citations

Resistance to d-Tubocurarine in Lower Motor Neuron Injury Is Related to Increased Acetylcholine Receptors at the Neuromuscular Junction

1990 • 58 citations

Spinal Anesthesia

1991 • 53 citations

Central Nervous System Effects of Intrathecal Muscle Relaxants in Rats

1993 • 52 citations

Double-blind, randomized, multicenter study of doxacurium vs. pancuronium in intensive care unit patients who require neuromuscular-blocking agents

1995 • 50 citations

Adverse Reactions and Interactions of the Neuromuscular Blocking Drugs

1989 • 49 citations

Increased Requirements for Continuously Infused Vecuronium in Critically III Patients

1989 • 48 citations

Activation of Brain Acetylcholine Receptors by Neuromuscular Blocking Drugs

1994 • 47 citations

The level of neuromuscular block needed to suppress diaphragmatic movement during tracheal suction in patients with raised intracranial pressure: a study with vecuronium and atracurium

1993 • 46 citations

Prolonged Reversible Quadriparesis in Mechanically Ventilated Patients Who Received Long-term Infusions of Vecuronium

1991 • 46 citations

The comparative potency and pharmacokinetics of pancuronium and its metabolites in anesthetized man.

1978 • 46 citations

The use of neuromuscular blocking drugs in the intensive care unit: A US perspective

1993 • 45 citations

Sedation for the critically ill

1999 • 44 citations

Cumulative characteristics of atracurium and vecuronium. A simultaneous clinical and pharmacokinetic study.

1994 • 35 citations

Applied pharmacology of common neuromuscular blocking agents in critical care.

1994 • 25 citations

Lethal catatonia complicated by the development of neuroleptic malignant syndrome in a middle-aged female

1991 • 24 citations

Prolonged Neuromuscular Blockade in Two Critically Ill Patients Treated With Atracurium

1995 • 21 citations

Clinical use of peripheral nerve stimulators in anaesthesia

1987 • 21 citations

Persistent paralysis in critically ill patients after the use of neuromuscular blocking agents.

1994 • 21 citations

The Comparative Potency and Pharmacokinetics of Pancuronium and Its Metabolites in Anesthetized Man

1979 • 20 citations

ON THE SITE OF ACTION OF THE ANTI‐ADRENAL STEROIDOGENIC EFFECT OF ETOMIDATE AND MEGESTROL ACETATE

1984 • 20 citations

Muscle relaxants in critical care

1993 • 19 citations

Pharmacoeconomic issues of sedation, analgesia, and neuromuscular blockade in critical care.

1994 • 19 citations

Cumulative Characteristics of Atracurium and Vecuronium

1994 • 18 citations

Comparison of the Neuromuscular Recovery After Paralysis with Atracurium Versus Vecuronium in an ICU Patient with Renal Insufficiency

1994 • 18 citations

Pharmacokinetics, Neuromuscular Effects, and Biodisposition of 3-Desacetylvecuronium (Org 7268) in Cats

1991 • 18 citations

Changes of expression of endogenous sugar receptors by polymorphonuclear leukocytes after prolonged anaesthesia and surgery

1992 • 17 citations

Analgesia in the critically ill patient.

1994 • 14 citations

PORCINE MODEL FOR STUDYING THE PASSAGE OF NON-DEPOLARIZING NEUROMUSCULAR BLOCKERS THROUGH THE BLOOD-BRAIN BARRIER

1992 • 14 citations

Neuromuscular blockade: indications, peripheral nerve stimulation, and other concurrent interventions.

1994 • 12 citations

Neuromuscular blocking drugs: Practical aspects of research in the intensive care unit

1993 • 11 citations

An update on monitoring of neuromuscular function

1992 • 8 citations

COMPLICATIONS OF NEUROMUSCULAR BLOCKERS

1993 • 7 citations

Leucocyte migration: effects of in vitro exposure to anaesthetic agents: possible potentiation of effects by adrenaline.

1992 • 5 citations

[Effect of pancuronium bromide on the adherence of polymorphonuclear neutrophilic granulocytes in vitro].

1988 • 4 citations

Neuromuscular blocking agents in critically ill patients

1994 • 4 citations

Behaviour of leukocyte membrane fluidity in presence of anaesthetic drugs. Comparison between allergic patients and control subjects

1993 • 2 citations