The SPOT-synthesis technique

Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide

1963 • 7,266 citations

Use of peptide synthesis to probe viral antigens for epitopes to a resolution of a single amino acid.

1984 • 1,467 citations

Applications of Combinatorial Technologies to Drug Discovery. 1. Background and Peptide Combinatorial Libraries

1994 • 1,130 citations

Applications of Combinatorial Technologies to Drug Discovery. 2. Combinatorial Organic Synthesis, Library Screening Strategies, and Future Directions

1994 • 1,126 citations

Spot-synthesis: an easy technique for the positionally addressable, parallel chemical synthesis on a membrane support

1992 • 1,052 citations

Methods in molecular biology

1991 • 938 citations

Strategies for epitope analysis using peptide synthesis

1987 • 887 citations

A priori delineation of a peptide which mimics a discontinuous antigenic determinant

1986 • 499 citations

Chemical genetics: ligand-based discovery of gene function

2000 • 417 citations

SPOT Synthesis: Epitope Analysis with Arrays of Synthetic Peptides Prepared on Cellulose Membranes

2003 • 262 citations

Simultaneous multiple peptide synthesis under continuous flow conditions on cellulose paper discs as segmental solid supports

1988 • 218 citations

Noninvasive continuous monitoring of solid-phase peptide synthesis by acid-base indicator

1988 • 203 citations

A new general approach for the simultaneous chemical synthesis of large numbers of oligonucleotides: segmental solid supports

1983 • 181 citations

Spot synthesis: observations and optimizations

1999 • 130 citations

A novel and comprehensive synthetic approach for the elucidation of protein antigenic structures. Determination of the full antigenic profile of the α-chain of human haemoglobin

1980 • 114 citations

Parallel Personal Comments on “Classical” Papers in Combinatorial Chemistry

1998 • 90 citations

The simultaneous multiple production of solution phase peptides; assessment of the geysen method of simultaneous peptide synthesis.

1990 • 87 citations

Gas phase cleavage of Peptides from a solid support with ammonia vapour. Application in simultaneous multiple Peptide Synthesis.

1991 • 67 citations

Long-chain polystyrene-grafted polyethylene film matrix: a new support for solid-phase peptide synthesis

1989 • 61 citations

Simultaneous synthesis of peptide libraries on single resin and continuous cellulose membrane supports: examples for the identification of protein, metal and DNA binding peptide mixtures.

1993 • 58 citations

Screening chemically synthesized peptide libraries for biologically-relevant molecules

1993 • 58 citations

Synthesis of an Array Comprising 837 Variants of the hYAP WW Protein Domain

2001 • 57 citations

A new safety-catch peptide-resin linkage for the direct release of peptides into aqueous buffers

1994 • 38 citations

Glycolamidic ester group as labile linkage in solid phase peptide synthesis: use with FMOC‐protected amino acids

1986 • 33 citations

A general route to fingerprint analyses of peptide-antibody interactions using a clustered amino acid peptide library: Comparison with a phage display library

1995 • 31 citations

Stepwise transformation of a cholera toxin and a p24 (HIV-1) epitope into D-peptide analogs

1998 • 22 citations

Peptide Arrays on Membrane Supports. Synthesis and Applications

2002 • 13 citations

Combinatorial Synthesis Hits The Spot

2000 • 6 citations

Highly complex combinatorial cellulose-bound peptide libraries for the detection of antibody epitopes

1995 • 6 citations

Self-deciphering, orthogonal combinatorial libraries of soluble organic compounds: Discovery of a potent V2 vasopressin antagonist

1995 • 4 citations

Identification of miniproteins using cellulose-bound duotope scans

2006 • 4 citations

Positional scanning synthetic peptide combinatorial libraries

1993 • 1 citations