Nucleoside diphosphate kinases, nm23, and tumor metastasis: Possible biochemical mechanisms

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

1991 • 2,774 citations

Evidence for a Novel Gene Associated With Low Tumor Metastatic Potential

1988 • 1,304 citations

Reduced tumor incidence, metastatic potential, and cytokine responsiveness of nm3-transfected melanoma cells

1991 • 548 citations

Tumor cell instability, diversification, and progression to the metastatic phenotype: from oncogene to oncofetal expression.

1987 • 508 citations

Reduced Nm23/Awd protein in tumour metastasis and aberrant Drosophila development

1989 • 487 citations

Nucleoside diphosphate kinase from human erythrocytes. Structural characterization of the two polypeptide chains responsible for heterogeneity of the hexameric enzyme

1991 • 420 citations

Association of low nm23 RNA levels in human primary infiltrating ductal breast carcinomas with lymph node involvement and other histopathological indicators of high metastatic potential.

1989 • 398 citations

Identification of a second human nm23 gene, nm23-H2.

1991 • 357 citations

A Drosophila gene that is homologous to a mammalian gene associated with tumor metastasis codes for a nucleoside diphosphate kinase

1990 • 353 citations

Expression of the Antimetastatic Gene nm23 in Human Breast Cancer: An Association WIth Good Prognosis

1991 • 298 citations

Altered expression of NM23, a gene associated with low tumor metastatic potential, during adenovirus 2 Ela inhibition of experimental metastasis.

1988 • 264 citations

Dictyostelium Nucleoside Diphospate Kinase Highly Homologous to Nm23 and Awd Proteins Involved in Mammalian Tumor Metastasis and Drosphila Development

1990 • 231 citations

High levels of p19/nm23 protein in neuroblastoma are associated with advanced stage disease and with N-myc gene amplification.

1991 • 229 citations

Low nm23 protein expression in infiltrating ductal breast carcinomas correlates with reduced patient survival.

1991 • 166 citations

Developmental consequences of awdb3, a cell-autonomous lethal mutation of Drosophila induced by hybrid dysgenesis

1988 • 162 citations

Somatic allelic deletion of nm23 in human cancer.

1991 • 159 citations

Induction of nm23 Gene Expression in Human Colonic Neoplasms and Equal Expressions in Colon Tumors of High and Low Metastatic Potential

1991 • 157 citations

Functional cloning of a nucleoside diphosphate kinase from Dictyostelium discoideum.

1990 • 141 citations

Analysis of the lethal interaction between the prune and Killer of prune mutations of Drosophila.

1988 • 135 citations

Association of nm23-H1 allelic deletions with distant metastases in colorectal carcinoma

1991 • 135 citations

Positive Relationship Between Expression of Anti-metastatic Factor (nm23 Gene Product or Nucleoside Diphosphate Kinase) and Good Prognosis in Human Breast Cancer

1991 • 132 citations

Transphosphorylation and G protein activation

1990 • 125 citations

Conversion of GDP into GTP by nucleoside diphosphate kinase on the GTP-binding proteins.

1990 • 121 citations

Membrane-associated nucleoside diphosphate kinase from rat liver. Purification, characterization, and comparison with cytosolic enzyme.

1988 • 118 citations

Molecular consequences of awdb3, a cell-autonomous lethal mutation of Drosophila induced by hybrid dysgenesis

1988 • 98 citations

Evidence for complex formation between GTP binding protein(Gs) and membrane-associated nucleoside diphosphate kinase

1990 • 89 citations

Activation of a Small GTP-Binding Protein by Nucleoside Diphosphate Kinase

1991 • 81 citations

GDP does not mediate but rather inhibits hormonal signal to adenylate cyclase.

1983 • 77 citations

The molecular biology of breast cancer

1991 • 74 citations

A product of the prune locus of Drosophila is similar to mammalian GTPase-activating protein

1991 • 70 citations

Retinoids as modulators of tumor cells invasion and metastasis.

1991 • 57 citations

Tumor cell progression and differentiation in metastasis.

1991 • 23 citations

Altered Gene Expression in Tumor Metastasis: The nm23 Gene

1989 • 22 citations

Differential susceptibility to GTP formed from added GDP via membrane-associated nucleoside diphosphate kinase of GTP-sensitive adenylate cyclases achieved by hormone and cholera toxin

1985 • 19 citations

Genetic control of the metastatic phenotype.

1991 • 16 citations