Human Tumor Antigens: Detection and Characterization with Monoclonal Antibodies

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma

1980 • 5,022 citations

DEMONSTRATION OF TUMOR-SPECIFIC ANTIGENS IN HUMAN COLONIC CARCINOMATA BY IMMUNOLOGICAL TOLERANCE AND ABSORPTION TECHNIQUES

1965 • 2,318 citations

Discrete stages of human intrathymic differentiation: Analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage

1980 • 1,668 citations

Reactivity of a monoclonal antibody with human ovarian carcinoma.

1981 • 1,648 citations

The differentiation and function of human T lymphocytes

1980 • 1,548 citations

Colorectal carcinoma antigens detected by hybridoma antibodies

1979 • 1,342 citations

Monoclonal antibody defining a stage-specific mouse embryonic antigen (SSEA-1).

1978 • 1,303 citations

Immunity to Methylcholanthrene-Induced Sarcomas

1957 • 1,241 citations

A monoclonal antibody-defined antigen associated with gastrointestinal cancer is a ganglioside containing sialylated lacto-N-fucopentaose II.

1982 • 885 citations

A monoclonal antibody to human acute lymphoblastic leukaemia antigen

1980 • 748 citations

Antigenic properties of methylcholanthrene-induced tumors in mice of the strain of origin.

1953 • 686 citations

Human cell surface glycoprotein related to cell proliferation is the receptor for transferrin.

1981 • 685 citations

Colorectal carcinoma-specific antigen: detection by means of monoclonal antibodies.

1979 • 638 citations

Stage-specific embryonic antigen involves αl→ 3 fucosylated type 2 blood group chains

1981 • 612 citations

Monoclonal antibodies to epithelium‐specific components of the human milk fat globule membrane: Production and reaction with cells in culture

1981 • 605 citations

GD3, a prominent ganglioside of human melanoma. Detection and characterisation by mouse monoclonal antibody.

1982 • 579 citations

A spectrum of monoclonal antibodies reactive with human mammary tumor cells.

1981 • 565 citations

Selective proliferation of normal human melanocytes in vitro in the presence of phorbol ester and cholera toxin.

1982 • 552 citations

Avian leukosis virus-induced tumors have common proviral integration sites and synthesize discrete new RNAs: oncogenesis by promoter insertion

1981 • 533 citations

Cell surface antigens of human malignant melanoma: definition of six antigenic systems with mouse monoclonal antibodies.

1980 • 522 citations

A human thymocyte antigen defined by a hybrid myeloma monoclonal antibody

1979 • 506 citations

A critique of the evidence for active host defence against cancer, based on personal studies of 27 murine tumours of spontaneous origin

1976 • 478 citations

Surface markers on leukemia and lymphoma cells: recent advances

1982 • 419 citations

SOME ASPECTS OF NORMAL AND ABNORMAL CELL SURFACE GENETICS

1969 • 415 citations

Surface markers on leukemia and lymphoma cells: recent advances

1982 • 411 citations

Cancer immunology: the search for specificity--G. H. A. Clowes Memorial lecture.

1981 • 395 citations

A Monosialoganglioside Is a Monoclonal Antibody-Defined Antigen of Colon Carcinoma

1981 • 375 citations

P-24: a human leukemia-associated and lymphohemopoietic progenitor cell surface structure identified with monoclonal antibody.

1981 • 371 citations

Intradermal Immunization of C3H Mice against a Sarcoma That Originated in an Animal of the Same Line

1943 • 363 citations

Immunopathologic Characterization of a Monoclonal Antibody that Recognizes Common Surface Antigens of Human Ovarian Tumors of Serous, Endometrioid, and Clear Cell Types

1983 • 351 citations

Study of antibodies against human melanoma produced by somatic cell hybrids.

1978 • 349 citations

Differentiation antigens expressed by epithelial cells in the lactating breast are also detectable in breast cancers

1981 • 331 citations

Surface antigens of melanocytes and melanomas. Markers of melanocyte differentiation and melanoma subsets.

1982 • 327 citations

A monoclonal antibody (B72.3) defines patterns of distribution of a novel tumor‐associated antigen in human mammary carcinoma cell populations

1982 • 324 citations

Unique glycoprotein-proteoglycan complex defined by monoclonal antibody on human melanoma cells.

1982 • 305 citations

Enemies within: the genesis of retrovirus oncogenes

1981 • 303 citations

Human melanoma-associated antigen p97 is structurally and functionally related to transferrin

1982 • 288 citations

Biochemical studies of the human thymocyte cell-surface antigens T6, T9 and T10

1981 • 283 citations

Structural features of the cell surface receptor for transferrin that is recognized by the monoclonal antibody OKT9.

1982 • 275 citations

Distribution and molecular characterization of a cell‐surface and a cytoplasmic antigen detectable in human melanoma cells with monoclonal antibodies

1981 • 269 citations

Detection of the human T cell lymphoma virus p19 in cells of some patients with cutaneous T cell lymphoma and leukemia using a monoclonal antibody.

1981 • 265 citations

Two monoclonal anticarbohydrate antibodies directed to glycosphingolipids with a lacto-N-glycosyl type II chain.

1981 • 262 citations

Distribution of common acute lymphoblastic leukemia antigen in nonhematopoietic tissues.

1981 • 261 citations

Identification of a cell surface protein, p97, in human melanomas and certain other neoplasms.

1980 • 259 citations

Generation of human monoclonal antibodies reactive with human mammary carcinoma cells.

1980 • 255 citations

Quantitative analysis of melanoma-associated antigen p97 in normal and neoplastic tissues.

1981 • 250 citations

Activation of the Transforming Potential of a Normal Cell Sequence: A Molecular Model for Oncogenesis

1981 • 246 citations

Terminal Transferase-Positive Human Bone Marrow Cells Exhibit the Antigenic Phenotype of Common Acute Lymphoblastic Leukemia

1979 • 243 citations

Antigens of human pancreatic adenocarcinoma cells defined by murine monoclonal antibodies.

1982 • 239 citations

Immunological properties of a type C retrovirus isolated from cultured human T-lymphoma cells and comparison to other mammalian retroviruses

1981 • 237 citations

Monoclonal antibody detection of a circulating tumor-associated antigen. I. Presence of antigen in sera of patients with colorectal, gastric, and pancreatic carcinoma

1982 • 237 citations

Characterization of a monoclonal antibody (5E9) that defines a human cell surface antigen of cell activation.

1981 • 232 citations

Cancer immunology: the search for specificity.

1982 • 226 citations

Expression of common acute lymphoblastic leukemia antigen (CALLA) by lymphomas of B-cell and T-cell lineage

1981 • 226 citations

Characterization of a human melanoma-associated ganglioside antigen defined by a monoclonal antibody, 4.2.

1982 • 217 citations

Heterogeneity in surface antigen and glycoprotein expression of cell lines derived from different melanoma metastases of the same patient. Implications for the study of tumor antigens.

1981 • 213 citations

Monoclonal antibodies directed against the human Leb blood group antigen.

1981 • 212 citations

Two monoclonal antiplatelet antibodies as markers of human megakaryocyte maturation: immunofluorescent staining and platelet peroxidase detection in megakaryocyte colonies and in in vivo cells from normal and leukemic patients

1982 • 209 citations

LEWIS BLOOD-TYPE MAY AFFECT THE INCIDENCE OF GASTROINTESTINAL CANCER

1982 • 207 citations

Hybrid Myelomas Producing Antibodies Against a Human Neuroblastoma Antigen Present on Fetal Brain

1979 • 206 citations

Structural characterization of human melanoma-associated antigen p97 with monoclonal antibodies.

1981 • 203 citations

Human cell-surface glycoprotein with unusual properties

1980 • 201 citations

Common human melanoma-associated antigen(s) detected by monoclonal antibodies.

1980 • 200 citations

A NEW MARKER FOR HUMAN CANCER CELLS. 1. THE Ca ANTIGEN AND THE Cal ANTIBODY

1982 • 198 citations

Human homologue of murine T200 glycoprotein.

1980 • 196 citations

The hapten structure of a developmentally regulated glycolipid antigen (SSEA-1) isolated from human erythrocytes and adenocarcinoma: A preliminary note

1981 • 189 citations

Monoclonal antibodies to the human mammary gland

1982 • 189 citations

Changes in the expression and polarization of blood group I and i antigens in post-implantation embryos and teratocarcinomas of mouse associated with cell differentiation

1981 • 188 citations

Isoantigenic expression of Forssman glycolipid in human gastric and colonic mucosa: Its possible identity with “A-like antigen” in human cancer

1977 • 181 citations

Production and Characterization of Monoclonal Antibody to a Melanoma Specific Glycoprotein

1981 • 179 citations

Stage-specific transforming genes of human and mouse B- and T-lymphocyte neoplasms

1982 • 175 citations

Cell surface antigens of human melanoma identified by monoclonal antibody.

1979 • 173 citations

Definition of a Thy-1 determinant on human neuroblastoma, glioma, sarcoma, and teratoma cells with a monoclonal antibody.

1982 • 167 citations

Monoclonal Antibody to Human Platelet Glycoprotein I I. IMMUNOLOGICAL STUDIES

1981 • 166 citations

Melanocytic and nevocytic malignant melanomas.Cellular and subcellular differentiation

1967 • 159 citations

Lipid Composition of Human Malignant Melanoma Tumors at Various Levels of Malignant Growth

1979 • 156 citations

Monoclonal antibodies that demonstrate specificity for several types of human lung cancer.

1981 • 151 citations

Monoclonal antibodies specific for carcinoembryonic antigen and produced by two hybrid cell lines.

1980 • 146 citations

Heterogeneity of B-cell leukemias demonstrated by the monoclonal antibody FMC7

1981 • 146 citations

Cell surface antigens of human renal cancer defined by mouse monoclonal antibodies: identification of tissue-specific kidney glycoproteins.

1981 • 146 citations

Monoclonal Antibodies: A Powerful New Tool in Biology and Medicine

1981 • 142 citations

Antitumour reactions of monoclonal antibody against a human osteogenic-sarcoma cell line

1981 • 141 citations

Acute lymphoblastic leukaemia associated antigen. IV Expression on non-leukaemic ‘lymphoid’ cells

1980 • 140 citations

Expression of Ia-like antigens on cultured human malignant melanoma cell lines.

1978 • 137 citations

Immunologic classification of lymphocytic leukemias based on monoclonal antibody-defined cell surface antigens

1982 • 133 citations

A small polypeptide different from β2-microglobin associated with a human cell surface antigen

1979 • 131 citations

Monoclonal antibodies directed against the sugar sequence of lacto-N-fucopentaose III are obtained from mice immunized with human tumors

1982 • 130 citations

A NEW MARKER FOR HUMAN CANCER CELLS. 2. IMMUNOHISTOCHEMICAL DETECTION OF THE Ca ANTIGEN IN HUMAN TISSUES WITH THE Ca1 ANTIBODY

1982 • 128 citations

Structures of Some New Complex Gangliosides of Fish Brain

1980 • 127 citations

Human lymphocyte markers defined by antibodies derived from somatic cell hybrids. IV. A monoclonal antibody reacting specifically with a subpopulation of human B lymphocytes.

1981 • 127 citations

Expression of HLA‐DR and common acute lymphoblastic leukemia antigens on glioma cells

1982 • 127 citations

DR (Ia-like) antigens on human melanoma cells. Serological detection and immunochemical characterization.

1979 • 126 citations

An abnormal membrane glycoprotein associated with malignancy in a wide range of different tumours

1978 • 117 citations

Sphingoglycolipids with Leb activity, and the co-presence of Lea-, Leb-glycolipids in human tumor tissue

1970 • 116 citations

HUMAN HYBRIDOMAS FROM MALIGNANT GLIOMAS

1982 • 115 citations

Human glioma-associated antigens detected by monoclonal antibodies.

1981 • 114 citations

Monoclonal antibodies to the human mammary gland

1982 • 110 citations

Protein antigens of normal and malignant human cells identified by immunoprecipitation with monoclonal antibodies.

1980 • 108 citations

VIL-A1, A monoclonal antibody reactive with common acute lymphatic leukemia cells

1982 • 105 citations

Characterization of Monoclonal Antibodies to Human Melanoma-Associated Antigens<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref><xref ref-type="fn" rid="FN4">4</xref>

1981 • 102 citations

Cell surface antigens of human astrocytoma defined by mouse monoclonal antibodies: identification of astrocytoma subsets.

1982 • 97 citations

Structural Properties and Tissue Distribution of the Antigen Recognized by the Monoclonal Antibody 653.40S to Human Melanoma Cells<xref ref-type="fn" rid="fn2">2</xref><xref ref-type="fn" rid="fn3">3</xref>

1981 • 97 citations

A 94,OOO-Dalton Glycoprotein Expressed by Human Melanoma and Carcinoma Cells<xref ref-type="fn" rid="fn2">2</xref>

1982 • 96 citations

Cell-Surface Differentiation in the Mouse

1980 • 86 citations

A monoclonal antibody recognizing a human thymus leukemia‐like antigen associated with β₂‐microglobulin

1982 • 85 citations

Direct demonstration of an HLA-DR allotypic determinant on the low molecular weight (beta) subunit using a mouse monoclonal antibody specific for DR3

1982 • 83 citations

Biochemical characterization of human melanoma cell surfaces: dissection with monoclonal antibodies.

1980 • 82 citations

Detection of a human melanoma-associated antigen, p97, in histological sections of primary human melanomas

1982 • 82 citations

Differential Binding to Human Mammary and Nonmammary Tumors of Monoclonal Antibodies Reactive with Carcinoembryonic Antigen

1983 • 79 citations

Common antigenic determinants on human melanoma, glioma, neuroblastoma, and sarcoma cells defined with monoclonal antibodies.

1981 • 78 citations

A cell-surface antigen which is present in the ganglioside fraction and shared by human melanomas

1982 • 77 citations

Monoclonal antibodies reactive with acute myelogenous leukemia cells.

1981 • 77 citations

Chapter 1 The Use of Monoclonal Antibody Techniques in the Study of Developing Cell Surfaces

1980 • 73 citations

Common neuroectodermal antigens on human melanoma, neuroblastoma, retinoblastoma, glioblastoma and fetal brain revealed by hybridoma antibodies raised against melanoma cells

1981 • 72 citations

Tissue distribution, molecular profile, and shedding of a cytoplasmic antigen identified by the monoclonal antibody 465.12S to human melanoma cells.

1982 • 72 citations

Expression of neuroectodermal antigens common to melanomas, gliomas, and neuroblastomas

1982 • 70 citations

A-like blood group antigen in gastric cancer cells of patients in blood groups Q or B.

1970 • 69 citations

Clonal variation in expression of a human melanoma antigen defined by a monoclonal antibody.

1981 • 69 citations

Monoclonal antibodies recognizing tumor-associated antigen of human ovarian mucinous cystadenocarcinomas.

1982 • 69 citations

Monoclonal antibody-defined human lung cell surface protein antigens.

1982 • 68 citations

Report of the workshop on the carcinoembryonic antigen (CEA): The present position and proposals for future investigation

1974 • 64 citations

Detection of human osteosarcoma-associated antigen(s) by monoclonal antibodies.

1982 • 60 citations

Heterogeneity of HLA-A,B, Ia-like, and melanoma-associated antigen expression by human melanoma cell lines analyzed with monoclonal antibodies and flow cytometry.

1982 • 57 citations

Cell Surface Glycoproteins of Human Tumor Cell Lines: Unusual Characteristics of Malignant Melanoma2

1979 • 55 citations

The monoclonal antibody anti‐SSEA‐1 discriminates between fucosylated type 1 and type 2 blood group chains

1981 • 53 citations

Blood group A-like glycolipid and a novel Forssman antigen in the hepatocarcinoma of a blood group O individual.

1981 • 52 citations

Use of monoclonal antibodies in detection of melanoma-associated antigens in intact human tumors.

1982 • 52 citations

Analysis of the biosynthesis of HLA-DR glycoproteins in human malignant melanoma cell lines.

1981 • 52 citations

Use of monoclonal antibodies as diagnostic and therapeutic reagents in acute lymphoblastic leukemia.

1981 • 52 citations

Rejectability of virus-induced tumors and nonrejectability of spontaneous tumors: a lesson in contrasts.

1977 • 50 citations

Human leukemia-associated antigen: relation to a family of surface glycoproteins.

1980 • 49 citations

The questionable immunogenicity of certain neoplasms

1977 • 45 citations

MONOCLONAL ANTI‐TYPE 2 H: AN ANTIBODY DETECTING A PRECURSOR OF THE A AND B BLOOD GROUP ANTIGENS

1982 • 44 citations

Serological analysis of cell surface antigens of null cell acute lymphocytic leukemia by mouse monoclonal antibodies.

1982 • 44 citations

Human prostate specific and shared differentiation antigens defined by monoclonal antibodies.

1982 • 42 citations

Monoclonal antibodies to carcinoembryonic antigen produced by somatic cell fusion.

1981 • 41 citations

Carbohydrate differences in human high molecular weight antigens of B- and T-cell lines

1982 • 40 citations

A membrane glycoprotein from human neuroblastoma cells isolated with the use of a monoclonal antibody.

1980 • 40 citations

Membrane antigens detected on human lung carcinoma cells by hybridoma monoclonal antibody

1981 • 40 citations

Two human tumor‐associated antigens, p155 and p210, detected by monoclonal antibodies

1981 • 40 citations

Derivation of human T-cell leukemias.

1981 • 39 citations

Some further information about the abnormal membrane glycoprotein associated with malignancy

1978 • 39 citations

Epstein-Barr Virus Antigens–A Challenge to Modern Biochemistry

1982 • 38 citations

Structural characterization of the ‘melanoma-specific’ antigen detected by monoclonal antibody 691I5Nu-4-B

1981 • 38 citations

Somatic-cell hybrids producing antibodies against CEA

1981 • 37 citations

Mouse Monoclonal IgM Antibody Against Human Lung Cancer Line SK-LC-3 with Specificity for H(O) Blood Group Antigen

1982 • 36 citations

Characterization of a Monoclonal Antibody Reactive With a Subset of Human Breast Tumors<xref ref-type="fn" rid="fn2">2</xref>, <xref ref-type="fn" rid="fn3">3</xref>

1982 • 30 citations

Human monoclonal antibodies to glioma cells

1981 • 30 citations

Studies on the ability of monoclonal antibodies to selectively mediate complement-dependent cytotoxicity of human myelogenous leukemia blast cells.

1982 • 28 citations

ILLEGITIMATE BLOOD GROUP ANTIGENS P₁, A, AND MN (T) IN MALIGNANCY–A POSSIBLE THERAPEUTIC APPROACH WITH ANTI‐Tja, ANTI‐A, AND ANTI‐T

1976 • 27 citations

Heterotransplantation of Human Malignant Melanoma Cell Lines in Athymic Nude Mice<xref ref-type="fn" rid="FN1">2</xref>

1979 • 27 citations

Detection of Monoclonal Antibody-Defined Colorectal Carcinoma Antigen by Solid-Phase Binding Inhibition Radioimmunoassay

1981 • 27 citations

Lymphocyte‐dependent antibodies to antigen 3.1, a cell‐surface antigen expressed by a subgroup of human melanomas

1981 • 26 citations

Human Cell Membrane Components Dominant in T Cell Lineage: Identification and Characterization of Human TL-Like Antigens

1979 • 24 citations

Monoclonal antibody against A1 Lewis d antigen produced by the hybridoma immunized with a pulmonary carcinoma.

1982 • 24 citations

Mouse monoclonal antibody to a melanoma-carcinoma-associated antigen synthesized by a human melanoma cell line propagated in serum-free medium.

1982 • 23 citations

MONOCLONAL ANTIBODY SPECIFIC FOR HUMAN T ACUTE LYMPHOBLASTIC LEUKAEMIA

1982 • 22 citations

Tumor markers for ovarian cancer.

1979 • 21 citations

Immunochemical and Biosynthetic Analysis of Monoclonal Antibody-Defined Melanoma-Associated Antigen

1982 • 19 citations

A new acute leukemia-associated blast cell antigen detected by a monoclonal antibody

1982 • 10 citations

Heteroantisera against a blast cell antigen

1979 • 8 citations

Monoclonal antibodies to tumor-associated antigens in human prostate and bladder cancer. Abstr.

1981 • 3 citations