Pharmacokinetic Models for Antineoplastic Agents

Combination Chemotherapy in the Treatment of Advanced Hodgkin's Disease

1970 • 1,450 citations

Biopharmaceutics and Relevant Pharmacokinetics

1970 • 617 citations

Methotrexate Pharmacokinetics

1971 • 481 citations

Carrier-mediated Transport of the Folic Acid Analogue, Methotrexate, in the L1210 Leukemia Cell

1968 • 384 citations

Shortcomings in Pharmacokinetic Analysis by Conceiving the Body to Exhibit Properties of a Single Compartment

1968 • 383 citations

Kinetics of pharmacologic response I. Proposed relationships between response and drug concentration in the intact animal and man

1968 • 303 citations

Implications of biochemical, cytokinetic, pharmacologic, and toxicologic relationships in the design of optimal therapeutic schedules.

1970 • 285 citations

Invariants in Experimental Data on Linear Kinetics and the Formulation of Models

1956 • 280 citations

Kinetics of distribution of substances administered to the body, II : The intravascular modes of administration

1937 • 262 citations

Pharmacodynamics of Chemotherapeutic Effects: Dose-Time-Response Relationships for Phase-Nonspecific Agents

1971 • 162 citations

Activation of cyclophosphamide in man and animals

1971 • 142 citations

ABSORPTION AND DISTRIBUTION OF DRUGS

1963 • 123 citations

Evidence That Drugs in Multiple Combinations Have Materially Advanced the Treatment of Human Malignancies

1969 • 114 citations

Preliminary Model for Methotrexate Pharmacokinetics

1970 • 111 citations

Modes of uptake of methotrexate by normal and leukemic human leukocytes in vitro and their relation to drug response.

1968 • 101 citations

In vitro-in vivo correlation of drug metabolism-deamination of 1-β-d-arabinofuranosylcytosine

1972 • 96 citations

Antibiotics Alter Methotrexate Metabolism and Excretion

1969 • 81 citations

Absorption and Distribution of Drugs

1963 • 71 citations

A postulate to aid in model building

1963 • 67 citations

Drug Synergism in Antineoplastic Chemotherapy

1964 • 67 citations

On the role of drug penetration in amethopterin resistance of Sarcoma-180 cells in vitro

1965 • 66 citations

Multicompartment Pharmacokinetic Models and Pharmacologic Effects

1969 • 62 citations

The Role of the Therapeutic Regimen in Dosage Design. Part I

1965 • 60 citations

An Improved Method of Digitoxin Therapy

1970 • 55 citations

Generalized solution to linear, two-compartment, open model for drug distribution

1970 • 46 citations

Irreversible enzyme inhibitors. CXLIX. Tissue-specific irreversible inhibitors of dihydrofolic reductase

1969 • 44 citations

Physico-Chemical Aspects of Drug Action

1968 • 40 citations

Some Pharmacokinetic Aspects of 5-(Dimethyltriazeno)-imidazole-4-carboxamide in the Dog

1968 • 37 citations

Methotrexate Tissue Distribution: Prediction by a Mathematical Model<xref ref-type="fn" rid="FN2">2</xref>

1971 • 36 citations

Metabolic and therapeutic effects of allopurinol in patients with leukemia and gout

1966 • 35 citations

A computer model for tumor growth and chemotherapy, and its application to L1210 leukemia treated with cytosine arabinoside (NSC-63878).

1970 • 34 citations

Prediction of the distribution of methotrexate in the sting rays Dasyatidae sabina and sayi by use of a model developed in mice

1972 • 32 citations

PHARMACOKINETIC ASPECTS OF DRUG METABOLISM

1971 • 28 citations

Folate antagonists as chemotherapeutic agents

1971 • 27 citations

The study of antimalarials and antimalarial activity in the human malarias.

1945 • 25 citations

PHARMACOKINETICS AND DOSE-CONCENTRATION RELATIONSHIPS

1968 • 23 citations

The distribution volume of some antibiotics.

1957 • 20 citations

CHEMOTHERAPY OF NEOPLASTIC DISEASE WITH FOLATE ANTAGONISTS

1971 • 14 citations

Models, Inference, and Strategy

1969 • 14 citations

Riboflavin-methotrexate interactions

1970 • 14 citations

Advances in chemotherapy

1965 • 11 citations