HLA-A,B,C: Patterns of Polymorphism in Peptide-Binding Proteins

Structure of the human class I histocompatibility antigen, HLA-A2

1987 • 3,453 citations

The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens

1987 • 2,403 citations

ANKYLOSING SPONDYLITIS AND HL-A 27

1973 • 1,801 citations

The epitopes of influenza nucleoprotein recognized by cytotoxic T lymphocytes can be defined with short synthetic peptides

1986 • 1,723 citations

AN ANALYSIS OF THE SEQUENCES OF THE VARIABLE REGIONS OF BENCE JONES PROTEINS AND MYELOMA LIGHT CHAINS AND THEIR IMPLICATIONS FOR ANTIBODY COMPLEMENTARITY

1970 • 1,308 citations

Binding of immunogenic peptides to Ia histocompatibility molecules

1985 • 1,209 citations

LIPID NEPHROTOXICITY IN CHRONIC PROGRESSIVE GLOMERULAR AND TUBULO-INTERSTITIAL DISEASE

1982 • 1,021 citations

HLA and Disease Associations

1985 • 893 citations

Interaction between CD4 and class II MHC molecules mediates cell adhesion

1987 • 823 citations

The class II molecules of the human and murine major histocompatibility complex

1984 • 664 citations

Two mRNAs with different 3′ ends encode membrane-bound and secreted forms of immunoglobulin μ chain

1980 • 659 citations

A sequence pattern common to T cell epitopes.

1988 • 623 citations

The T Cell Receptor

1987 • 554 citations

Major histocompatibility antigens: The human (HLA-A,-B,-C) and murine (H-2K, H-2D) class I molecules

1981 • 511 citations

Iso-leuco-anticorps

1958 • 510 citations

Immunology: The ins and outs of antigen processing and presentations

1986 • 498 citations

Why do so many lymphocytes respond to major histocompatibility antigens?

1977 • 462 citations

A vector that replicates as a plasmid and can be efficiently selected in B-lymphoblasts transformed by Epstein-Barr virus.

1985 • 445 citations

NK susceptibility varies inversely with target cell class I HLA antigen expression.

1987 • 433 citations

Use of synthetic oligonucleotides as hybridization probes: isolation of cloned cDNA sequences for human beta 2-microglobulin.

1981 • 423 citations

Nature of polymorphism in HLA-A, -B, and -C molecules.

1988 • 379 citations

Isolation and partial nucleotide sequence of a cDNA clone for human histocompatibility antigen HLA-B by use of an oligodeoxynucleotide primer.

1981 • 374 citations

CLOSE GENETIC LINKAGE BETWEEN HLA AND CONGENITAL ADRENAL HYPERPLASIA (21-HYDROXYLASE DEFICIENCY)

1977 • 372 citations

LEUKOCYTE GROUPING. A METHOD AND ITS APPLICATION*

1963 • 335 citations

Antigen Presentation Pathways to Class I and Class II MHC‐Restricted T Lymphocytes

1987 • 322 citations

Genes of the T-Cell Antigen Receptor in Normal and Malignant T Cells

1987 • 321 citations

HLA-linked congenital adrenal hyperplasia results from a defective gene encoding a cytochrome P-450 specific for steroid 21-hydroxylation.

1984 • 291 citations

Murine Major Histocompatibility Complex Class-I Mutants: Molecular Analysis and Structure-Function Implications

1986 • 286 citations

The Structure of the CD4 and CD8 Genes

1987 • 276 citations

Structure, Function, and Serology of the T-Cell Antigen Receptor Complex

1987 • 264 citations

Cloning and complete sequence of an HLA-A2 gene: analysis of two HLA-A alleles at the nucleotide level.

1985 • 255 citations

Histocompatibility Testing 1984

1984 • 252 citations

Recognition of HLA-B27 and related antigen by a monoclonal antibody

1982 • 240 citations

Significance of Lyt phenotypes: Lyt2 antibodies block activities of T cells that recognize class 1 major histocompatibility complex antigens regardless of their function.

1981 • 234 citations

Transfer and expression of three cloned human non-HLA-A,B,C class I major histocompatibility complex genes in mutant lymphoblastoid cells.

1988 • 226 citations

The Antigen-Specific, Major Histocompatibility Complex-Restricted Receptor on T Cells

1986 • 225 citations

Studies on the genetic and antigenic basis of tumour transplantation Linkage between a histocompatibility gene and 'fused' in mice

1948 • 224 citations

Histocompatibility Testing

2000 • 219 citations

Structure of HLA antigens: amino-acid and carbohydrate compositions and NH2-terminal sequences of four antigen preparations.

1976 • 168 citations

An improved biochemical method for the analysis of HLA-class I antigens. Definition of new HLA-class I subtypes

1986 • 167 citations

Complete nucleotide sequence of a gene encoding a functional human class I histocompatibility antigen (HLA-CW3).

1984 • 160 citations

Complete nucleotide sequence of a functional class I HLA gene, HLA-A3: implications for the evolution of HLA genes.

1984 • 158 citations

Comparison of one-dimensional IEF patterns for serologically detectable HLA-A and B allotypes

1984 • 152 citations

Molecular cloning of a human histocompatibility antigen cDNA fragment.

1980 • 145 citations

Protein Antigenic Structures Recognized by T Cells; Potential Applications to Vaccine Design

1987 • 139 citations

Isolation, expression, and the primary structure of HLA-Cw1 and HLA-Cw2 genes: Evolutionary aspects

1987 • 138 citations

The primary structure of HLA-A32 suggests a region involved in formation of the Bw4/Bw6 epitopes.

1986 • 137 citations

Antigen processing at the molecular level

1987 • 137 citations

T‐Cell Recognition of Lysozyme: The Biochemical Basis of Presentation

1987 • 133 citations

Complete amino acid sequence of a papain-solubilized human histocompatibility antigen, HLA-B7. 2. Sequence determination and search for homologies

1979 • 130 citations

The Structure of T-Cell Epitopes

1987 • 130 citations

The Detection of Antigenic Differences in Mouse Erythrocytes by the Employment of Immune Sera

1936 • 127 citations

Exon shuffling in vivo can generate novel HLA class I molecules.

1985 • 121 citations

Isolation of HLA locus-specific DNA probes from the 3'-untranslated region.

1984 • 120 citations

Comparison of amino acid sequences of two human histocompatibility antigens, HLA-A2 and HLA-B7: location of putative alloantigenic sites.

1979 • 119 citations

The self determinants recognized by human virus-immune T cells can be distinguished from the serologically defined HLA antigens.

1980 • 112 citations

Structure of crossreactive human histocompatibility antigens HLA-A28 and HLA-A2: possible implications for the generation of HLA polymorphism.

1982 • 106 citations

Organization, Sequence and Expression of the HLA-B27 Gene: A Molecular Approach to Analyze HLA and Disease Associations

1985 • 102 citations

The HLA-AW24 gene: Sequence, surroundings and comparison with the HLA-A2 and HLA-A3 genes

1985 • 96 citations

Isolation and N-terminal amino acid sequence of membrane-bound human HLA-A and HLA-B antigens

1976 • 92 citations

Gene conversion-like mechanisms may generate polymorphism in human class I genes.

1986 • 92 citations

The complete primary structure of HLA-Bw58.

1985 • 90 citations

Mutations of class II MHC molecules

1987 • 85 citations

Molecular cloning of bovine class I MHC cDNA.

1988 • 82 citations

Multiple genetic mechanisms have contributed to the generation of the HLA-A2/A28 family of class I MHC molecules.

1987 • 81 citations

Monoclonal antibodies against two separate alloantigenic sites of HLA-1340

1981 • 79 citations

Nomenclature for factors of the HLA system 1984

1984 • 75 citations

Comparative structural analysis of HLA-A2 antigens distinguishable by cytotoxic T lymphocytes: variants M7 and DR1

1982 • 75 citations

Definition of four HLA-A2 subtypes by CML typing and biochemical analysis

1983 • 73 citations

Arginine 45 is a major part of the antigenic determinant of human beta 2-microglobulin recognized by mouse monoclonal antibody BBM.1.

1983 • 67 citations

Organization of the human class I major histocompatibility complex genes

1987 • 65 citations

Association with beta 2-microglobulin controls the expression of transfected human class I genes.

1987 • 59 citations

Complete sequence of HLA-B27 cDNA identified through the characterization of structural markers unique to the HLA-A, -B, and -C allelic series.

1986 • 58 citations

In vitro mutagenesis at a single residue introduces B and T cell epitopes into a class I HLA molecule.

1987 • 57 citations

Expression of human class I histocompatibility antigens at the surface of DNA-transformed mouse L cells

1982 • 56 citations

Identification of several functional subgroups of HLA-B27 by restriction of the activity of antiviral T killer lymphocytes

1984 • 55 citations

DNA sequence of the coding region of the HLA-B44 gene

1986 • 53 citations

Sequences of Human Repetitive DNA, Non- -globin Genes, and Major Histocompatibility Locus Genes: III. The Major Histocompatibility Complex

1983 • 53 citations

Cellular versus humoral immunity: Determinants and consequences of an epic 19th century battle

1979 • 53 citations

Absence of polymorphism between HLA-B27 genomic exon sequences isolated from normal donors and ankylosing spondylitis patients.

1986 • 52 citations

Sequences of Human Repetitive DNA, Non- -globin Genes, and Major Histocompatibility Locus Genes: I. Repeated-sequence DNA

1983 • 52 citations

Amino acid sequences in the alpha 1 domain and not glycosylation are important in HLA-A2/beta 2-microglobulin association and cell surface expression.

1987 • 51 citations

DNA sequence of HLA-A11: Remarkable homology with HLA-A3 allows identification of residues involved in epitopes recognized by antibodies and T cells

1987 • 50 citations

Structural analysis of an HLA-B7 antigen variant detected by cytotoxic T lymphocytes.

1984 • 49 citations

Site-directed mutagenesis of class I HLA genes. Role of glycosylation in surface expression and functional recognition.

1987 • 49 citations

Primary structure of papain-solubilized human histocompatibility antigen HLA-B27

1985 • 47 citations

A single amino acid substitution in the alpha 3 domain of an H-2 class I molecule abrogates reactivity with CTL.

1987 • 47 citations

A transposable epitope of HLA-137, B40 molecules

1987 • 45 citations

In vitro-isolated human cytotoxic T-lymphocyte clones detect variations in serologically defined HLA antigens

1982 • 45 citations

Structural analysis of an HLA-B27 population variant, B27f. Multiple patterns of amino acid changes within a single polypeptide segment generate polymorphism in HLA-B27.

1987 • 43 citations

Primary structure of papain-solubilized human histocompatibility antigen HLA-B40 (-Bw60). An outline of alloantigenic determinants

1983 • 43 citations

DNA sequences of the genes that encode the CTL-defined HLA-A2 variants M7 and DK1

1987 • 43 citations

Molecular cloning and DNA sequence analysis of genes encoding cytotoxic T lymphocyte-defined HLA-A3 subtypes: the E1 subtype.

1985 • 42 citations

Further studies on the epitopes of HLA-B7 defined by murine monoclonal antibodies

1986 • 39 citations

An HLA-C-specific DNA probe

1986 • 38 citations

Comparison of the structure of HLA-Bw47 to HLA-B13 and its relationship to 21-hydroxylase deficiency

1988 • 38 citations

A public HLA antigen associated with HLA-A9, Aw32, and Bw4

1980 • 37 citations

HLA membrane antigens: sequencing by intrinsic radioactivity.

1976 • 35 citations

A beginner's guide to major histocompatibility complex function

1982 • 28 citations

Antigenic determinants of the HLA-B7 molecule; Bw6- and B7-specific determinants are spatially separate

1983 • 28 citations

HLA-B locus polymorphism: studies with a specific hybridization probe.

1985 • 26 citations

Comparison of the primary structure of class I molecules

1987 • 23 citations

Immunological and chemical purity of papain-solubilized HL-A antigens.

1975 • 23 citations

Inheritance of human leukocyte antigens.

1961 • 22 citations

Inter-Locus and intea-allelic polymorphisms of HLA class I antigen gene mRNA

1984 • 14 citations

New HLA-A2 variants defined by monoclonal antibodies and cytotoxic T lymphocytes

1987 • 14 citations

Comparative structural analysis of HLA-A3 antigens distinguishable by cytotoxic T lymphocytes: variant E1.

1985 • 14 citations

Serological Studies of Cw1 and Cw3 Expressed on the Same Haplotype

1978 • 12 citations

Partial amino acid sequences of the heavy chains of human HLA histocompatibility antigens

1976 • 11 citations

Expression of an HLA-Bw6-related specificity by the HLA-Cw3 molecule

1985 • 10 citations

Tryptic peptide mapping identifies structural heterogeneity among six variants of HLA-B27

1986 • 10 citations

Primary Structure of Pooled, Papain‐solubilized HLA‐A, ‐B, and ‐C Antigens

1979 • 8 citations

Evidence for CSH1, a variant of Cw3, in an Oriental population

1987 • 5 citations

Tenth international histocompatibility conference

1987 • 4 citations

Fifty years of H-2 research

1987 • 4 citations

Localization of an epitope of beta-2 microglobulin that is shared with other members of the immunoglobulin superfamily

1987 • 3 citations

Sir Peter Medawar 1915–1987

1988 • 3 citations

Antigen Report: HLA-B8

1984 • 2 citations

John H. Humphrey (1915–1987)

1988 • 1 citations