Methodological Issues in Pharmacological Studies of Sleep

Statistical principles in experimental design.

1962 • 27,228 citations

A manual of standardized terminology, techniques and scoring system for sleep stages of human subjects

1968 • 11,801 citations

Statistical Principles in Experimental Design

1992 • 4,547 citations

Psychopharmacology: The third generation of progress

1988 • 3,403 citations

Design and Analysis of Experiments in Psychology and Education.

1954 • 2,704 citations

Psychopharmacology: The Third Generation of Progress.

1988 • 1,973 citations

Statistics for Psychologists

1966 • 1,924 citations

Experimental designs, 2nd ed.

1957 • 1,781 citations

Some Theorems on Quadratic Forms Applied in the Study of Analysis of Variance Problems, I. Effect of Inequality of Variance in the One-Way Classification

1954 • 1,494 citations

Adaptation-level theory : an experimental and systematic approach to behavior

1964 • 1,218 citations

THE FIRST NIGHT EFFECT: AN EEG STUDYOF SLEEP

1966 • 1,105 citations

An Extension of Box's Results on the Use of the $F$ Distribution in Multivariate Analysis

1958 • 1,100 citations

Sleep and wakefulness

1963 • 1,091 citations

Experimental Designs Balanced for the Estimation of Residual Effects of Treatments

1949 • 1,056 citations

Psychological and physiological differences between good and poor sleepers.

1967 • 626 citations

Some Theorems on Quadratic Forms Applied in the Study of Analysis of Variance Problems, II. Effects of Inequality of Variance and of Correlation Between Errors in the Two-Way Classification

1954 • 560 citations

Self-reports versus sleep laboratory findings in 122 drug-free subjects with complaints of chronic insomnia

1976 • 552 citations

The Crossover Experiment for Clinical Trials

1980 • 374 citations

Design and analysis of experiments in psychology and education.

1953 • 350 citations

USE OF MEDICAID DATA FOR PHARMACOEPIDEMIOLOGY

1989 • 316 citations

A multicenter, placebo-controlled study evaluating zolpidem in the treatment of chronic insomnia.

1994 • 222 citations

Vigilance: Theory, Operational Performance, and Physiological Correlates

1978 • 209 citations

Measurement of Sleep-related Breathing Disturbances in Epidemiologic Studies

1991 • 209 citations

Rebound Insomnia: A New Clinical Syndrome

1978 • 201 citations

Rebound Insomnia and Rebound Anxiety: A Review

1983 • 198 citations

Sedative-hypnotics and human performance.

1981 • 198 citations

Five Weeks to Escape the Sleeping-pill Habit

1965 • 184 citations

Sleep in patients with Parkinson's disease and normal subiects prior to and following levodopa administration

1971 • 172 citations

Evaluation and Treatment of Insomnia

1987 • 171 citations

Sleeping Pills, Insomnia and Medical Practice

1979 • 168 citations

MESAM 4: An Ambulatory Device for the Detection of Patients at Risk for Obstructive Sleep Apnea Syndrome (OSAS)

1992 • 157 citations

The Effect of Memory Load on the Circadian Variation in Performance Efficiency Under a Rapidly Rotating Shift System*

1976 • 157 citations

Amount of Dreaming: Effect of Incentive, Adaptation to Laboratory, and Individual Differences

1964 • 141 citations

Early Morning Insomnia with Rapidly Eliminated Benzodiazepines

1983 • 139 citations

Rebound insomnia. A potential hazard following withdrawal of certain benzodiazepines

1979 • 137 citations

The effects of flurazepam, lorazepam, and triazolam on sleep and memory

1980 • 135 citations

Evaluation and Treatment of Insomnia.

1984 • 124 citations

Clinical Pharmacokinetics of Hypnotics

1977 • 123 citations

Assessment of Accuracy and Analysis Time of a Novel Device to Monitor Sleep and Breathing in the Home

1995 • 117 citations

Fatigue, Circadian Rhythm, and Truck Accidents

1977 • 111 citations

Chronic hypnotic-drug use. Ineffectiveness, drug-withdrawal insomnia, and dependence.

1974 • 106 citations

Comparisons of Home Sleep Recordings and Polysomnograms in Older Adults with Sleep Disorders

1981 • 106 citations

Behavior and Brain Electrical Activity

1975 • 102 citations

Hypnotic Efficacy of Triazolam: Sleep Laboratory Evaluation of Intermediate‐Term Effectiveness

1976 • 99 citations

The Discovery of Drug-Induced Illness

1977 • 98 citations

Hypnotic Drugs and Their Effectiveness

1970 • 98 citations

Rebound Insomnia

1979 • 98 citations

Review of company postmarketing surveillance studies.

1992 • 88 citations

Discovery of adverse drug reactions. A comparison of selected phase IV studies with spontaneous reporting methods

1983 • 84 citations

Rebound Insomnia: Its Determinants and Significance

1990 • 83 citations

The Benzodiazepines: Current Standards for Medical Practice

1985 • 80 citations

Chronic Hypnotic-Drug Use

1974 • 80 citations

Comparative Effectiveness of Nine Hypnotic Drugs: Sleep Laboratory Studies

1977 • 79 citations

Can a Rapidly-eliminated Hypnotic Cause Daytime Anxiety?

1989 • 78 citations

Adverse Reactions to Benzodiazepine Hypnotics: Spontaneous Reporting System

1987 • 76 citations

Sleep laboratory studies of flurazepam: A model for evaluating hypnotic drugs

1976 • 76 citations

Effects of Hypnotics on Memory

1983 • 75 citations

Nocturnal Sleep and Wakefulness: Effects of Age and Sex in Normal Sleepers

1984 • 73 citations

Hypnotics — Methods of development and evaluation

1977 • 65 citations

Discovery of Adverse Drug Reactions

1983 • 65 citations

The role of automated record linkage in the postmarketing surveillance of drug safety: A critique

1989 • 62 citations

Sleep Laboratory Studies of Hypnotic Drugs

1983 • 61 citations

Effectiveness of Temazepam with Short‐, Intermediate‐, and Long‐Term Use: Sleep Laboratory Evaluation

1978 • 61 citations

Adverse behavioral reactions attributed to triazolam in the Food and Drug Administration's Spontaneous Reporting System.

1991 • 51 citations

Effects of placebo and flurazepam on sleep patterns in insomniac subjeets

1971 • 49 citations

The Effect of Correlation On the Repeated Measures Design

1963 • 48 citations

Clinical Pharmacokinetics of the Benzodiazepines

1985 • 48 citations

Benzodiazepine Hypnotics: Kinetic and Therapeutic Options

1982 • 48 citations

Sleep Evaluation in Chronic Insomniacs during 14-Day Use

1990 • 40 citations

Adverse Behavioral Reactions Attributed to Triazolam in the Food and Drug Administration's Spontaneous Reporting System

1991 • 37 citations

Readaptation to the Sleep Laboratory in Insomniac Subjects

1975 • 36 citations

Sleeping Pills, Insomnia, and Medical Practice

1979 • 35 citations

Sleep Studies and Rebound Insomnia

1987 • 33 citations

The use of triazolam in phase-advanced sleep

1988 • 31 citations

Investigations of an automatic screening device (MESAM) for obstructive sleep apnoea

1990 • 28 citations

Sleep laboratory evaluation of psychoactive drugs.

1970 • 21 citations

Hypnotic Efficacy in Middle Age

1982 • 20 citations

Clinical Evaluation of Hypnotic Drugs: Contributions from Sleep Laboratory Studies

1979 • 19 citations

Principles and Techniques of Human Research and Therapeutics

1986 • 18 citations

Imidazobenzodiazepines

1983 • 16 citations

Marketing Aspects of Company-Sponsored Postmarketing Surveillance Studies

1993 • 14 citations

Hypnotic Drugs

1972 • 10 citations

Role of the Sleep Laboratory in the Evaluation of Hypnotic Drugs

1979 • 10 citations

Post-marketing drug surveillance--concepts, insights and applications.

1990 • 6 citations

Sleep Profiles of Insomnia and Hypnotic Drug Effectiveness

1975 • 6 citations

Postmarketing surveillance: perspectives of a journal editor.

1993 • 2 citations

Help for House Purchase.

1974 • 1 citations