From the Growth Cone to the Synapse

The Fluid Mosaic Model of the Structure of Cell Membranes

1972 • 8,835 citations

CHEMOAFFINITY IN THE ORDERLY GROWTH OF NERVE FIBER PATTERNS AND CONNECTIONS

1963 • 1,947 citations

Axo-somatic and axo-dendritic synapses of the cerebral cortex: an electron microscope study.

1959 • 1,751 citations

THE ORGANIZATION OF PROTEINS IN THE HUMAN RED BLOOD CELL MEMBRANE

1974 • 1,554 citations

Neurobiology of cerebellar evolution and development

1971 • 1,500 citations

Neuronal migration, with special reference to developing human brain: a review

1973 • 1,239 citations

Actin And Myosin And Cell Movemen

1974 • 1,018 citations

FUNCTIONS OF COATED VESICLES DURING PROTEIN ABSORPTION IN THE RAT VAS DEFERENS

1967 • 825 citations

Membrane Structure: Some General Principles

1973 • 825 citations

ULTRASTRUCTURE AND FUNCTION OF GROWTH CONES AND AXONS OF CULTURED NERVE CELLS

1971 • 769 citations

The formation of synaptic junctions in developing rat brain: A quantitative electron microscopic study

1967 • 665 citations

ELECTRON MICROSCOPE OBSERVATIONS ON THE CARBOHYDRATE-RICH CELL COAT PRESENT AT THE SURFACE OF CELLS IN THE RAT

1967 • 660 citations

The outgrowth of the nerve fiber as a mode of protoplasmic movement

1910 • 615 citations

Observations on the living developing nerve fiber

1906 • 573 citations

AXON GROWTH: ROLES OF MICROFILAMENTS AND MICROTUBULES

1970 • 522 citations

Membrane ultrastructure at mammalian intercellular junctions

1973 • 516 citations

Preferential selection of central pathways by regenerating optic fibers

1963 • 514 citations

Haptotaxis and the Mechanism of Cell Motility

1967 • 509 citations

A quantitative investigation of the development of collateral reinnervation after partial deafferentation of the septal nuclei

1973 • 496 citations

The cell surface in development

1975 • 493 citations

Observations of the living developing nerve fiber

1907 • 487 citations

Structure and Function of Synapses.

1972 • 472 citations

Ultrastructural visualization of cellular carbohydrate components by means of concanavalin A

1971 • 464 citations

FINE STRUCTURE OF NERVE FIBERS AND GROWTH CONES OF ISOLATED SYMPATHETIC NEURONS IN CULTURE

1973 • 444 citations

The outgrowth of the nerve fiber as a mode of protoplasmic movement

1959 • 443 citations

The formation of nerve connections

1970 • 429 citations

Selective dissociation of histones from calf thymus nucleoprotein

1967 • 392 citations

Surface Movements during the Growth of Single Explanted Neurons

1970 • 372 citations

Fine structural and cytochemical analysis of the staining of synaptic junctions with phosphotungstic acid

1968 • 366 citations

OPTIC NERVE REGENERATION WITH RETURN OF VISION IN ANURANS

1944 • 356 citations

EVIDENCE FOR CELL-SURFACE GLYCOSYLTRANSFERASES

1971 • 339 citations

THE FINE STRUCTURE OF THE AXON AND GROWTH CONE OF THE DORSAL ROOT NEUROBLAST OF THE RABBIT EMBRYO

1970 • 335 citations

The specificity of cell surfaces

1967 • 330 citations

MIGRATION OF GLYCOPROTEIN FROM THE GOLGI APPARATUS TO THE SURFACE OF VARIOUS CELL TYPES AS SHOWN BY RADIOAUTOGRAPHY AFTER LABELED FUCOSE INJECTION INTO RATS

1974 • 324 citations

Studies on vertebrate neurogenesis

1960 • 306 citations

THE STRUCTURE OF ERYTHROCYTE MEMBRANES STUDIED BY FREEZE-ETCHING

1972 • 301 citations

Polysaccharides associated with the exterior surface of epithelial cells: Kidney, intestine, brain

1966 • 278 citations

ISOLATION AND STRUCTURAL STUDIES ON SYNAPTIC COMPLEXES FROM RAT BRAIN

1972 • 267 citations

Morphological changes in the neuritic growth cone and target neuron during synaptic junction development in culture.

1976 • 267 citations

ISOLATION OF POSTSYNAPTIC DENSITIES FROM RAT BRAIN

1974 • 235 citations

BRANCHING PATTERNS OF INDIVIDUAL SYMPATHETIC NEURONS IN CULTURE

1973 • 234 citations

Fine structure of dendritic and axonal growth cones in embryonic chick spinal cord

1974 • 234 citations

Studies of living nerves. II. Activities of ameboid growth cones, sheath cells, and myelin segments, as revealed by prolonged observation of individual nerve fibers in frog tadpoles

1933 • 231 citations

Further experimental evidence against “neurotropism” in nerve regeneration

1944 • 231 citations

A QUANTITATIVE STUDY OF SYNAPSES ON MOTOR NEURON DENDRITIC GROWTH CONES IN DEVELOPING MOUSE SPINAL CORD

1974 • 228 citations

Electron Microscopy of Excitatory and Inhibitory Synapses: A Brief Review

1969 • 224 citations

Histophysiology of Synapses and Neurosecretion

1964 • 216 citations

The onset of synapse formation in spinal cord cultures as studied by electron microscopy

1967 • 214 citations

The fine structure of freeze-fractured presynaptic membranes

1972 • 192 citations

The specification of the retino‐tectal projection in the chick

1974 • 173 citations

Studies on the developing cerebellums. Ultrastructure of the growth cones

1968 • 169 citations

Contribution to the problem of structural organization of the presynaptic area

1969 • 169 citations

Dissociated dorsal root ganglia in tissue culture

1956 • 162 citations

Differences in membrane structure between excitatory and inhibitory synapses in the cerebellar cortex

1974 • 157 citations

Coated vesicles and synaptogenesis. A developmental study in the cerebellar cortex of the rat

1971 • 151 citations

The Cell surface in development

1974 • 151 citations

The growth of embryonic neurites; a study of cultures of chick neural tissues.

1953 • 150 citations

FREEZE-FRACTURING OF NERVE GROWTH CONES AND YOUNG FIBERS

1974 • 150 citations

Contributions of New Impregnation Methods and Freeze Etching to the Problems of Synaptic Fine Structure

1969 • 148 citations

Fracture faces of frozen myelin

1967 • 142 citations

The neuronal membrane.

1968 • 133 citations

Differences in membrane structure between excitatory and inhibitory components of the reciprocal synapse in the olfactory bulb

1974 • 131 citations

Cellular Dynamics of the Neuron

1969 • 123 citations

Selective growth of sympathetic nerve fibers to explants of normally densely innervated autonomic effector organs in tissue culture

1973 • 122 citations

Development of fine structure of spinal cord in monkey fetuses. II. Pre‐reflex period to period of long intersegmental reflexes

1968 • 118 citations

LOCALIZATION AND CHARACTERIZATION OF CONCANAVALIN A RECEPTORS IN THE SYNAPTIC CLEFT

1974 • 114 citations

Reconstruction of dendritic growth cones in neonatal mouse olfactory bulb

1972 • 114 citations

An intercellular substance in rat cerebral cortex: Submicroscopic distribution of ruthenium red

1967 • 112 citations

PHOSPHOTUNGSTIC ACID AS A SPECIFIC ELECTRON STAIN FOR COMPLEX CARBOHYDRATES

1970 • 110 citations

Dynamic ultrastructure of presynaptic membranes at nerve terminals in the spinal cord of rats. Anesthetized and unanesthetized preparations compared

1972 • 108 citations

Electron microscopical studies of the synapse in the developing chick spinal cord

1964 • 106 citations

Synaptic Macromolecules: Identification and Metabolism

1974 • 102 citations

Synaptic junction development in the spinal cord of an amphibian embryo: An electron microscope study

1973 • 102 citations

Problems of Interpreting the Fine Structure of Vertebrate and Invertebrate Synapses

1966 • 100 citations

Ultrastructure of growth cones in the cerebellar cortex of the neonatal rat and cat

1971 • 97 citations

Studies on the mechanism determining the course of nerve fibers in tissue culture

1959 • 96 citations

Early stages of synaptogenesis in the cervical spinal cord of the chick embryo

1973 • 95 citations

Stimulation- and calcium-dependence of vesicle attachment sites in the presynaptic membrane; A freeze-cleave study on the lamprey spinal cord

1974 • 92 citations

Particle aggregations at specialized sites in freeze-etched postsynaptic membranes

1972 • 91 citations

Fine structure of synapses in the cerebral cortex

1963 • 90 citations

Studies on the mechanism determining the course of nerve fibers in tissue culture

1960 • 88 citations

The distribution of protein-bound N-acetylneuraminic acid in subcellular fractions of rat brain

1967 • 85 citations

Renewal of synaptic proteins

1973 • 82 citations

Mutual contact inhibition of extension of chick sensory nerve fibres in vitro

1971 • 79 citations

The distribution of gangliosides in subcellular fractions of guinea-pig cerebral cortex

1961 • 78 citations

Binding of concanavalin A and ricin to synaptic junctions of rat brain

1974 • 78 citations

Histophysiology of Synapses and Neurosecretion.

1965 • 77 citations

Synaptogenesis in the Chick Embryo Spinal Cord

1972 • 77 citations

Morphological and cytochemical studies of synapses formed in culture between isolated rat superior cervical ganglion neurons

1974 • 77 citations

STUDIES OF LIVING NERVES

1935 • 72 citations

Cytoplasmic Actin: A Comparative Study

1973 • 71 citations

Synaptogenesis in guinea-pig cerebral cortex: A glutaraldehyte-PTA study

1974 • 70 citations

Synaptic morphology and cytochemistry

1973 • 70 citations

The cultivation of sympathetic nerves from the intestine of chick embryos in saline solutions

1912 • 68 citations

The desmosome: Fine structural studies with freeze-fracture replication and tannic acid staining of sectioned epidermis

1976 • 63 citations

The cytochemistry of synaptic densities. I. An analysis of the bismuth iodide impregnation method

1971 • 63 citations

The cytochemistry of synaptic densities. II. Proteinaceous components and mechanism of synaptic connectivity

1971 • 61 citations

Synaptic Morphology and Cytochemistry

1973 • 59 citations

Association of glial cells with the terminal parts of neurite bundles extending from chick spinal cord in vitro

1970 • 59 citations

Anatomical observations on the specificity of synapse formation in tissue culture

1973 • 53 citations

Extracellular distribution of ruthenium red-positive substance in the cerebral cortex

1971 • 52 citations

Isolation and characterization of insoluble proteins of the synaptic plasma membrane

1968 • 51 citations

Visual recovery following regeneration of the optic nerve through the oculomotor nerve root in Xenopus

1967 • 45 citations

Morphogenesis of synaptic junctions in layers I and II of the somatic sensory cortex

1972 • 45 citations

Cytochemistry of synaptosomes

1969 • 44 citations

The organization of paramembranous densities during postnatal maturation of synaptic junctions in the cerebral cortex

1972 • 40 citations

[Quantitative correlation of structure and function on biomembranes (author's transl)].

1973 • 38 citations

SYNAPTIC FINE STRUCTURE AND NEURAL DYNAMICS**Supported by Grant No. 4356 of the Swiss National Foundation for Scientific Research.

1969 • 35 citations

Methods for the freeze-fracturing of nerve tissue cultures and cell monolayers.

1975 • 34 citations

Selectivity in fasciculation of nerve fibersin Vitro

1965 • 31 citations

Synaptic fine structure.

1971 • 30 citations

Afar and Iran

1972 • 27 citations

Axonal transport in embryonic neurons. The possibility of a proximo-distal axolemmal transfer of glycoproteins

1975 • 26 citations

Evidence for a rapid phase of axoplasmic transport at early stages in the development of the visual system of the chick and frog

1974 • 24 citations

Axonal transport in growing and mature retinal ganglion cells

1973 • 16 citations

The surface coats of chick dorsal root ganglion cellsin vitro

1972 • 15 citations

Radioautographic analysis of 3H-fucose labelled glycoproteins transported along the optic pathway of chick embryos

1974 • 8 citations

University of California, Los Angeles

1979 • 2 citations