Molecular Targets of Anti-Glutamine Therapy with Acivicin in Cancer Cells

Parts I and II

1982 • 912 citations

Enzymology of Cancer Cells

1977 • 641 citations

Biochemical strategy of cancer cells and the design of chemotherapy: G. H. A. Clowes Memorial Lecture.

1983 • 552 citations

Role of ribonucleotide reductase in expression of the neoplastic program

1981 • 136 citations

Purine and pyrimidine nucleotide patterns of normal, differentiating, and regenerating liver and of hepatomas in rats.

1980 • 104 citations

Effects of acivicin and dipyridamole on hepatoma 3924A cells.

1983 • 83 citations

Mechanism of inactivation of glutamine amidotransferases by the antitumor drug L-(alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125).

1980 • 67 citations

Biochemical and pharmacological effects of the fermentation-derived antitumor agent, (alphaS,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125).

1979 • 63 citations

Multi-enzyme-targeted chemotherapy by acivicin and actinomycin

1982 • 47 citations

L-[alphaS, 5S]-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (NSC-163501): a new amino acid antibiotic with the properties of an antagonist of L-glutamine.

1975 • 45 citations

Salvage capacity of hepatoma 3924A and action of dipyridamole

1983 • 44 citations

Biochemical pharmacology of acivicin in rat hepatoma cells

1982 • 35 citations

In vivo inactivation by acivicin of carbamoylphosphate synthetase II in rat hepatoma

1982 • 35 citations

Phase I and pharmacological study of acivicin by 24-hour continuous infusion.

1982 • 34 citations

Studies of the biochemical pharmacology of the fermentation-derived antitumor agent, (αS, 5S) -α-amino-3-chloro-4, 5-dihydro-5-isoxazoleacetic acid (at-125)

1979 • 30 citations

Rapid in vivo inactivation by acivicin of CTP synthetase, carbamoyl-phosphate synthetase II, and amidophosphoribosyltransferase in hepatoma

1982 • 28 citations

Transcriptionally active RNA polymerases from Morris hepatomas and rat liver. Elucidation of the mechanism for the preferential increase in the tumour RNA polymerase I

1980 • 27 citations

Deleted Work

1955 • 0 citations