Matrix Gla protein synthesis and gamma-carboxylation in the aortic vessel wall and proliferating vascular smooth muscle cells--a cell system which resembles the system in bone cells.

Spontaneous calcification of arteries and cartilage in mice lacking matrix GLA protein

1997 • 2,050 citations

Increased bone formation in osteocalcin-deficient mice

1996 • 1,692 citations

Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in bone

1989 • 1,256 citations

Warfarin Causes Rapid Calcification of the Elastic Lamellae in Rat Arteries and Heart Valves

1998 • 531 citations

Purification of bovine bone morphogenetic protein by hydroxyapatite chromatography.

1984 • 433 citations

Angiotensin-(1-7) Inhibits Vascular Smooth Muscle Cell Growth

1996 • 294 citations

Lung, heart, and kidney express high levels of mRNA for the vitamin K-dependent matrix Gla protein. Implications for the possible functions of matrix Gla protein and for the tissue distribution of the gamma-carboxylase.

1988 • 231 citations

The Role of Gla Proteins in Vascular Calcification

1998 • 165 citations

Molecular structure, chromosome assignment, and promoter organization of the human matrix Gla protein gene.

1990 • 130 citations

The potent antioxidant activity of the vitamin K cycle in microsomal lipid peroxidation

1997 • 128 citations

Assembly of the Warfarin-sensitive Vitamin K 2,3-Epoxide Reductase Enzyme Complex in the Endoplasmic Reticulum Membrane

1997 • 116 citations

Vitamin K-dependent carboxylation and vitamin K metabolism in liver. Effects of warfarin.

1985 • 99 citations

Intestinal flora is not an intermediate in the phylloquinone-menaquinone-4 conversion in the rat

1998 • 84 citations

Vitamin K counteracts the effect of warfarin in liver but not in bone

1987 • 83 citations

Vitamin K-dependent carboxylase: Requirements for carboxylation of soluble peptide substrates and substrate specificity

1979 • 83 citations

Warfarin poisoning and vitamin K antagonism in rat and human liver. Design of a system in vitro that mimics the situation in vivo

1987 • 62 citations

Warfarin Resistance Is Associated with a Protein Component of the Vitamin K 2,3-Epoxide Reductase Enzyme Complex in Rat Liver

1998 • 54 citations

Sequence of the precursor to rat bone gamma-carboxyglutamic acid protein that accumulates in warfarin-treated osteosarcoma cells.

1985 • 50 citations

Vitamin K-dependent carboxylation and vitamin K epoxidation. Evidence that the warfarin-sensitive microsomal NAD(P)H dehydrogenase reduces vitamin K1 in these reactions

1981 • 31 citations

Early processing of prothrombin and factor X by the vitamin K-dependent carboxylase.

1988 • 27 citations

Anti-oxidant/pro-oxidant reactions of vitamin K

1985 • 16 citations

Identification of vitamin K-dependent carboxylase activity in lung type II cells but not in lung macrophages

1988 • 15 citations

[33] Purification of warfarin-sensitive vitamin K epoxide reductase

1997 • 14 citations

Isolation and partial characterization of a vitamin K-dependent carboxylase from bovine aortae

1987 • 9 citations