Cyclic AMP and Protein Phosphorylation in the Central Nervous System in Relation to Synaptic Function

AN ELECTRON-TRANSPORT SYSTEM ASSOCIATED WITH THE OUTER MEMBRANE OF LIVER MITOCHONDRIA

1967 • 2,311 citations

Handbook of Neurochemistry

1972 • 1,374 citations

The effect of adenosine and adenine nucleotides on the cyclic adenosine 3', 5'-phosphate content of guinea pig cerebral cortex slices.

1970 • 860 citations

Purification and Properties of Rabbit Skeletal Muscle Adenosine 3',5'-Monophosphate-dependent Protein Kinases

1971 • 810 citations

Cyclic Nucleotide-dependent Protein Kinases

1969 • 551 citations

The influence of chemical agents on the accumulation of adenosine 3',5'-Phosphate in slices of rabbit cerebellum.

1968 • 435 citations

Dopamine-Sensitive Adenyl Cyclase: Possible Role in Synaptic Transmission

1971 • 415 citations

The action of norepinephrine in the rat hippocampus. I. Iontophoretic studies

1974 • 380 citations

Activation of the pathway from locus coeruleus to rat cerebellar Purkinje neurons: pharmacological evidence of noradrenergic central inhibition.

1973 • 370 citations

Regulation of Endogenous Phosphorylation of Specific Proteins in Synaptic Membrane Fractions from Rat Brain by Adenosine 3′:5′-Monophosphate

1973 • 341 citations

THE EFFECT OF ELECTRICAL STIMULATION UPON THE ACCUMULATION OF ADENOSINE 3′,5′‐PHOSPHATE IN ISOLATED CEREBRAL TISSUE

1969 • 294 citations

Practical Neurochemistry

1963 • 272 citations

ISOLATION AND STRUCTURAL STUDIES ON SYNAPTIC COMPLEXES FROM RAT BRAIN

1972 • 267 citations

Studies on norepinephrine-containing afferents to Purkinje cells of rat cerebellum. III. Evidence for mediation of norepinephrine effects by cyclic 3′, 5′-adenosine monophosphate

1971 • 257 citations

Adenosine 3′,5′-Monophosphate: Electrophysiological Evidence for a Role in Synaptic Transmission

1972 • 243 citations

Dopamine as a Synaptic Transmitter and Modulator in Sympathetic Ganglia: A Different Mode of Synaptic Action

1970 • 238 citations

Some evidence for the existence of dopaminergic neurons in the rat cortex

1973 • 230 citations

Studies on adenosine 3',5'-phosphate in rabbit cerebral cortex.

1968 • 224 citations

Reversible Phosphate Transfer between Yolk Phosphoprotein and Adenosine Triphosphate

1960 • 220 citations

Role of cyclic AMP in synaptic transmission in the mammalian peripheral nervous system.

1974 • 212 citations

The Role of Cyclic AMP and Calcium in Cell Activatio

1972 • 209 citations

Subcellular Distribution of Adenosine 3',5'-Monophosphate-dependent Protein Kinase in Rat Brain

1971 • 208 citations

Cyclic Adenosine 3′:5′-Monophosphate-Stimulated Phosphorylation of Isolated Neurotubule Subunits

1970 • 206 citations

Adenosine 3′,5′-Monophosphate in Nervous Tissue: Increase Associated with Synaptic Transmission

1971 • 205 citations

Metabolism of [14C]adenine and derivatives by cerebral tissues, superfused and electrically stimulated

1972 • 193 citations

Phosphorylation of Endogenous Protein of Rat Brain by Cyclic Adenosine 3′,5′-Monophosphate-dependent Protein Kinase

1971 • 192 citations

Characterization of the adrenergic receptors mediating a rise in cyclic 3'-5'-adenosine monophosphate in rat cerebral cortex.

1973 • 184 citations

Phosphoprotein Phosphatases from Rat Cerebral Cortex

1972 • 169 citations

Regulation of Adenosine 3′:5′-Cyclic Monophosphate Concentration in Cultured Human Astrocytoma Cells by Catecholamines and Histamine

1971 • 168 citations

Noradrenergic axon terminals in the cerebral cortex of rat. II. Quantitative data revealed by light and electron microscope radioautography of the frontal cortex

1973 • 147 citations

Stimulation by Cyclic AMP of Intrinsic Protein Kinase Activity in Ox Brain Membrane Preparations

1970 • 145 citations

ACCUMULATION OF CYCLIC ADENOSINE 3′, 5′‐MONOPHOSPHATE IN CEREBRAL CORTICAL SLICES FROM RAT AND MOUSE: STIMULATORY EFFECT OF α‐ AND β‐ADRENERGIC AGENTS AND ADENOSINE

1973 • 144 citations

Cyclic Adenosine 3′,5′-Monophosphate in Guinea Pig Cerebral Cortical Slices

1973 • 143 citations

α- and β-Adrenergic Receptors as Mediators of Accumulation of Cyclic Adenosine 3',5'-Monophosphate in Specific Areas of Guinea Pig Brain

1971 • 143 citations

Regulation of Nucleoside Cyclic 3′:5′-Monophosphate Phosphodiesterase Activity from Rat Brain by a Modulator and Ca ²⁺

1973 • 142 citations

Adenylate‐Cyclase Receptors for Adrenergic Neurotransmitters in Rat Cerebral Cortex

1973 • 133 citations

Protein Kinases: Aspects of Their Regulation and Diversity

1973 • 129 citations

Effect of nerve degeneration by 6-hydroxydopamine on catecholamine-stimulated adenosine 3',5'-monophosphate formation in rat cerebral cortex.

1973 • 124 citations

Protein kinases and protein kinase substrates.

1973 • 118 citations

Enhanced release of dopamine -hydroxylase and norepinephrine from sympathetic nerves by dibutyryl cyclic adenosine 3', 5'-monophosphate and theophylline.

1973 • 111 citations

Turnover of protein-bound phosphorylserine in membrane preparations from ox brain catalysed by intrinsic kinase and phosphatase activity

1971 • 108 citations

Role of the beta adrenergic receptor in the elevation of adenosine cyclic 3',5'-monophosphate and induction of serotonin N-acetyltransferase in rat pineal glands.

1973 • 107 citations

Can mitochondria and synaptosomes of guinea-pig brain synthesize phospholipids?

1972 • 105 citations

Isolation of rat brain myelin, monitored by polyacrylamide gel electrophoresis of dodecyl sulfate-extracted proteins

1972 • 104 citations

Effects of Drugs on Cellular Control Mechanisms

1971 • 102 citations

Preparation and Characterization of Nerve Cell Perikaryon from Rat Cerebral Cortex

1966 • 97 citations

The action of noradrenaline on cortical neurons: effects of pH

1971 • 93 citations

Protein kinase activity in membrane preparations from ox brain. Stimulation of intrinsic activity by adenosine 3′:5′-cyclic monophosphate

1973 • 93 citations

The incorporation of phosphate into cerebral phosphoprotein promoted by electrical impulses

1957 • 89 citations

ADENOSINE 3′,5′‐MONOPHOSPHATE IN GUINEA PIG CEREBRAL CORTICAL SLICES: EFFECTS OF α‐ AND β‐ADRENERGIC AGENTS, HISTAMINE, SEROTONIN AND ADENOSINE

1973 • 85 citations

Role of adenosine 3',5'-monophosphate (cyclic AMP) in actions of catecholamines.

1972 • 81 citations

Isolation of synaptic junctional complexes from rat brain

1973 • 80 citations

Pharmacological analysis of synaptically mediated increase in cyclic adenosine monophosphate in rabbit superior cervical ganglion.

1974 • 76 citations

On the mechanism of action of cyclic AMP and its role in synaptic transmission.

1972 • 76 citations

Effect of depolarizing agents on accumulation of cyclic adenosine 3′, 5′-monophosphate in cerebral cortical slices

1972 • 74 citations

Cyclic Adenosine 3′,5′-Monophosphate in Guinea Pig Cerebral Cortical Slices

1973 • 72 citations

Accumulation of adenosine cyclic 3',5'-monophosphate in rat cerebral cortical slices. Stimulatory effect of alpha and beta adrenergic agents after treatment with 6-hydroxydopamine, 2,3,5-trihydroxyphenethylamine, and dihydroxytryptamines.

1973 • 69 citations

The effects of dibutyryl cyclic adenosine 3',5'-monophosphate, theophylline and aminophylline on neuromuscular transmission in the rat.

1974 • 68 citations

Accumulation of cyclic adenosine monophosphate in incubated slices of brain tissue. 1. Structure-activity relation of agonists and antagonists of biogenic amines and of tricyclic tranquilizers and antidepressants

1972 • 65 citations

Cytochemical and pharmacological studies on polysensory neurons in the primate frontal cortex

1973 • 65 citations

Factors influencing the accumulation of cyclic AMP in brain tissue.

1970 • 64 citations

Cyclic Adenosine 3′,5′-Monophosphate in Guinea Pig Cerebral Cortical Slices

1973 • 64 citations

CHARACTERISTICS OF THE CATECHOLAMINE AND HISTAMINE RECEPTOR SITES MEDIATING ACCUMULATION OF CYCLIC ADENOSINE 3′,5′‐MONOPHOSPHATE IN GUINEA PIG BRAIN¹

1973 • 64 citations

The role of calcium in the central effects of biogenic amines

1974 • 63 citations

Norepinephrine-sensitive properties of C-6 astrocytoma cells.

1974 • 61 citations

Probenecide sensitive 3′‐5′‐cyclic AMP secretion by isoproterenol stimulated glial cells in culture

1974 • 57 citations

Calcium antagonism and its effect on the inhibitory actions of biogenic amines on cerebral cortical neurones

1974 • 47 citations

Evidence against cyclic adenosine 3′,5′-monophosphate (AMP) mediation of noradrenaline depression of cerebral cortical neurones

1973 • 45 citations

Evaluation of electrical pulses and elevated levels of potassium ions as stimulants of adenosine 3', 5'-monophosphate (cyclic AMP) accumulation in guinea-pig brain.

1973 • 45 citations

Neuroendocrine control of the cyclic AMP system of brain and pineal gland.

1972 • 43 citations

Adenyl cyclase, cyclic nucleotide phosphodiesterase and axoplasmic flow

1971 • 42 citations

Phosphorylserine and cerebral phosphoprotein

1958 • 41 citations

Enzyme transfer of phosphate from adenosine triphosphate to protein-bound serine residues in cerebral microsomes

1966 • 39 citations

Central nervous system : studies on metabolic regulation and function

1974 • 38 citations

THE SUBCELLULAR LOCALIZATION OF CEREBRAL PHOSPHOPROTEINS SENSITIVE TO ELECTRICAL STIMULATION

1965 • 37 citations

Turnover of protein-bound serine phosphate in respiring slices of guinea-pig cerebral cortex. Effects of putative transmitters, tetrodotoxin and other agents

1973 • 34 citations

Methods for Studying Protein Phosphorylation in Cerebral Tissues

1975 • 31 citations

The role of bound potassium ions in the hydrolysis of low concentrations of adenosine triphosphate by preparations of membrane fragments from ox brain cerebral cortex

1970 • 31 citations

The effect of chemical agents on the turnover of the bound phosphate associated with the sodium-and-potassium ion-stimulated adenosine triphosphatase in ox brain microsomes

1970 • 30 citations

SUBCELLULAR LOCALIZATION OF [¹⁴C]ADENINE DERIVATIVES NEWLY‐FORMED IN CEREBRAL TISSUES AND THE EFFECTS OF ELECTRICAL EXCITATION

1973 • 27 citations

Evidence for a role for protein phosphorylation in synaptic function in the cerebral cortex mediated through a β-noradrenergic receptor

1974 • 26 citations

CYCLIC AMP AND PHOSPHODIESTERASE IN SYNAPTIC VESICLES FROM MOUSE BRAIN

1973 • 25 citations

Stimulation of protein phosphorylation in brain slices by electrical pulses: speed of response and evidence for net phosphorylation

1975 • 24 citations

Neurohumoral Mechanisms in the Brain Slice

1971 • 24 citations

Effect of Psychoactive Drugs on Dopamme(3,4-Dihydroxyphenethylamine)-Sensitive Adenylate Cyclase Activity in Corpus Striatum of Rat Brain

1974 • 23 citations

Adenosine in Neurohumoral and Regulatory Roles in the Brain

1974 • 23 citations

Effects of Drugs on Cellular Control Mechanisms.

1973 • 21 citations

SUBCELLULAR SITE OF THE PHOSPHATIDYLINOSITOL EFFECT. DISTRIBUTION ON DENSITY GRADIENTS OF LABELLED LIPIDS FROM RESTING AND ACTIVE SYMPATHETIC GANGLIA OF THE RAT¹

1973 • 19 citations

The state of phosphorylation in vivo of membrane-bound phosphoproteins in rat brain

1973 • 19 citations

TURNOVER OF PROTEIN PHOSPHORUS IN RESPIRING SLICES OF GUINEA PIG CEREBRAL CORTEX: CELLULAR LOCALIZATION OF PHOSPHOPROTEIN SENSITIVE TO ELECTRICAL STIMULATION

1974 • 17 citations

LARGE SCALE PREPARATION OF A CRUDE MEMBRANE FRACTION FROM OX BRAIN

1969 • 17 citations

Absence of an effect of histamine, noradrenaline and depolarizing agents on the levels of adenosine 3', 5'-monophosphate in nerve endings isolated from cerebral cortex

1974 • 16 citations

Protein kinase activity stimulated by adenosine 3′:5′-cyclic monophosphate in synaptic-membrane fragments from ox brain. Inhibition of intrinsic activity by free and membrane-bound calcium ions

1974 • 16 citations

A theoretical treatment of the turnover of protein-bound phosphate in the presence of both protein kinase and phosphatase activities

1974 • 15 citations

Separation at neutral pH value of 32P-labelled proteins in a membrane preparation from ox brain. Partial characterization of a component of the sodium-plus-potassium ion-activated adenosine triphosphatase

1974 • 15 citations

Studies on the mechanism of action of cyclic AMP in nervous and other tissues

1971 • 14 citations

Cellular Localization of Phosphoproteins in Guinea-Pig Cerebral-Cortex Slices Sensitive to Noradrenaline, Histamine and 5-Hydroxytryptamine

1974 • 13 citations

STUDIES ON THE FUNCTION OF CENTRAL NORADRENERGIC NEURONS

1973 • 11 citations

The effect of putative transmitters and other agents on phosphoprotein turnover in respiring slices of guinea-pig cerebral cortex

1972 • 7 citations