Changes in Hypothalamic Control of ACTH and Adrenal Cortical Functions during Aging

Characterization of a 41-Residue Ovine Hypothalamic Peptide that Stimulates Secretion of Corticotropin and β-Endorphin

1982 • 3,896 citations

Thomas, Springfield, Illinois

1965 • 2,935 citations

Twenty-four Hour Pattern of the Episodic Secretion of Cortisol in Normal Subjects

1971 • 1,220 citations

Common precursor to corticotropins and endorphins

1977 • 1,106 citations

Role of brain monoamines and histamine in regulation of anterior pituitary secretion.

1978 • 700 citations

The pituitary gland

1966 • 568 citations

In Vivo Corticotropin-Releasing Factor-Induced Secretion of Adrenocorticotropin, β-Endorphin, and Corticosterone*

1982 • 557 citations

Frontiers in Neuroendocrinology

1975 • 431 citations

Effect of Clonidine on Growth Hormone, Prolactin, Luteinizing Hormone, Follicle-Stimulating Hormone, and Thyroid-Stimulating Hormone in the Serum of Normal Men

1975 • 307 citations

DEHYDROEPIANDROSTERONE AND ANDROSTERONE LEVELS IN HUMAN PLASMA. EFFECT OF AGE AND SEX; DAY-TO-DAY AND DIURNAL VARIATIONS*

1957 • 261 citations

EFFECT OF 5-HYDROXYTRYPTOPHAN (5-HTP) ON GROWTH HORMONE AND ACTH RELEASE IN MAN

1973 • 183 citations

Nycthemeral rhythm in adrenal responsiveness to ACTH

1978 • 174 citations

Effect of Gamma-Aminobutyric Acid (GABA) and GABA Antagonist Drugs on ACTH Release

1974 • 172 citations

Angiotensin II infusion increases vasopressin, ACTH, and 11-hydroxycorticosteroid secretion

1978 • 165 citations

Adrenocortical nodular hyperplasia: The ageing adrenal

1969 • 151 citations

Cortisol Secretion in Relation to Age in Major Depression1

1981 • 142 citations

Neurotransmitters and pituitary function: regulation of ACTH secretion.

1980 • 133 citations

Lipofuscin Pigment Accumulation and Distribution in Five Rat Organs as a Function of Age

1968 • 132 citations

Chemical stimulation of the brain: effect on adrenal corticoid release

1970 • 130 citations

Chronic Stress Effects on Adrenocortical Responsiveness in Young and Aged Rats

1973 • 130 citations

THE PITUITARY‐ADRENAL SYSTEM

1949 • 119 citations

Is there a brain renin-angiotensin system?

1977 • 114 citations

ADRKNOCORTICAL FUNCTION AND CORTISOL METABOLISM IN OLD AGE*

1961 • 108 citations

Characterization of pro-opiocortin, a precursor to opioid peptides and corticotropin.

1978 • 102 citations

Hypothalamic Neuron Number of Old Female Rats

1978 • 102 citations

Hypothalamic chemoreactive structures and the regulation of pituitary-adrenal function. Effects of local injections of norepinephrine, carbachol and serotonin into the brain of guinea pigs with intact brains and after mesencephalic transection

1968 • 101 citations

Adrenergic Mechanisms Involved in the Control of Pituitary-Adrenal Activity in the Rat: A β-Adrenergic Stimulatory Mechanism

1982 • 100 citations

Cortisol secretion and dexamethasone response in depression

1981 • 94 citations

Inhibition of Hypoglycemia-Induced Cortisol Secretion by the Serotonin Antagonist Cyproheptadine

1974 • 92 citations

Adrenocortical Responsiveness to Stress and ACTH in Aging Rats

1970 • 86 citations

Some age-related changes in pituitary-adrenal function in the male laboratory rat.

1978 • 84 citations

Neurotransmitter Regulation of Growth Hormone and ACTH in the Rhesus Monkey: Effects of Biogenic Amines

1976 • 84 citations

THE METABOLISM OF CORTISOL-4-C¹⁴IN YOUNG AND ELDERLY MEN. I. SECRETION RATE OF CORTISOL AND DAILY EXCRETION OF TETRAHYDROCORTISOL, ALLOTETRAHYDROCORTISOL, TETRAHYDROCORTISONE AND CORTOLONE (20α AND 20β)*

1961 • 83 citations

Human Growth Hormone and Cortisol Response to Insulin Stimulation in Aging

1975 • 81 citations

Chronic and Acute Dexamethasone Suppression of Stress Activation of the Adrenal Cortex in Young and Aged Rats

1972 • 75 citations

In Vivo Adrenocorticotropin-Releasing Activity of Neurohypophyseal Hormones and Their Analogs*

1982 • 75 citations

UNCERTAINTIES IN GERIATRIC DATA. II. ORGAN SIZE

1965 • 74 citations

A radioimmunoassay for the estimation of serum dehydroepiandrosterone sulphate in normal and pathological sera

1975 • 73 citations

GAS CHROMATOGRAPHIC-MASS SPECTROMETRIC STUDIES ON SOLVOLYZABLE STEROIDS IN HUMAN PERIPHERAL PLASMA

1966 • 71 citations

Assessment of Hypothalamic-Pituitary-Adrenal Function in the Geriatric Age Group

1969 • 69 citations

Cortisol secretion during intrapituitary infusion of angiotensin II in conscious dogs.

1977 • 68 citations

Effect of Intraventricular Histamine on Hormone Secretion in Dogs

1979 • 67 citations

Corticosteroids and ACTH are not required for compensatory adrenal growth

1975 • 66 citations

Relative insulin insensitivity and cortisol secretion in depressed patients

1981 • 63 citations

SERUM CORTICOTROPHIN, PLASMA CORTISOL AND URINARY EXCRETION OF 17-KETOGENIC STEROIDS IN THE ELDERLY (AGE GROUP: 66–94 YEARS)

1971 • 62 citations

An Endocrine Hypothesis of Brain Aging and Studies on Brain-Endocrine Correlations and Monosynaptic Neurophysiology during Aging

1978 • 61 citations

Effect of 6-hydroxydopamine on hypothalamic norepinephrine and dopamine content, ultrastructure of the median eminence, and plasma corticosterone

1974 • 60 citations

Effect of an Antiserotoninergic Drug, Metergoline, on the ACTH and Cortisol Response to Insulin Hypoglycemia and Lysine-Vasopressin in Man

1976 • 54 citations

Changes in Plasma Corticosterone and Hypothalamic CRF Levels Following Intraventricular Injection or Drug-induced Changes of Brain Biogenic Amines in the Rat

1974 • 52 citations

Structural alterations with aging in the nervous system

1956 • 52 citations

Serotonin and the regulation of the pituitary-adrenal system after deafferentation of the hypothalamus

1972 • 47 citations

Secretion of Corticotrophin and Somatotrophin by the Senescent Adenohypophysis in Man

1975 • 46 citations

Control of Bioactive Corticotropin Release from the Neuro-Intermediate Lobe of the Rat Pituitaryin Vitro

1977 • 45 citations

Diseases in Old Age

1951 • 45 citations

Effects of chronic ACTH stimulation on adrenocortical function in young and aged rats

1972 • 44 citations

THE HISTOLOGY OF THE MORE IMPORTANT HUMAN ENDOCRINE ORGANS AT VARIOUS AGES

1926 • 42 citations

Inhibition of ACTH Response to Oral and Intravenous Metyrapone by Antiserotoninergic Treatment in Man

1975 • 36 citations

SUPPRESSION OF PLASMA ACTH CONCENTRATION BY ANGIOTENSIN II INFUSION IN NORMAL HUMANS AND IN A SUBJECT WITH A STEROID 17α‐HYDROXYLASE DEFECT

1979 • 35 citations

Correlation between hypothalamic serotonin content and adrenal function during acute stress. Effect of adrenal corticosteroids on hypothalamic serotonin content.

1973 • 31 citations

Chromophobe Adenoma-Like Lesions of the Rat Hypophysis. Frequency of the Spontaneous Lesions and Characteristics of Growth of Homologous Intraocular Transplants

1944 • 30 citations

Pituitary Function in the Elderly

1970 • 26 citations

THE URINARY EXCRETION OF ETRAHYDROCORTISOL, 3α-ALLOTETRAHYDROCORTISOL AND TETRAHYDROCORTISONE IN YOUNG AND ELDERLY MEN AND WOMEN*

1958 • 25 citations

Cytology of the adrenal gland of the rat at different ages

1953 • 25 citations

Endocrines and Aging

1977 • 21 citations

Interaction of Aging with <i>in vitro </i>Adrenocortical Responsiveness to ACTH and Cyclic AMP

1979 • 19 citations

Pituitary-adrenocortical stimulation in the aged as reflected in levels of plasma cortisol and compound S.

1970 • 18 citations

Changes in Adrenocortieal Responsiveness to ACTH Infusion in Aging Goats

1968 • 18 citations

Pituitary hormones in the brain: what is their function?

1980 • 18 citations

The ultrastructure of the aged rat zona fasciculata under various stressing procedures

1970 • 18 citations

Effect of intraventricular injection and intrahypothalamic implantation of serotonin on the hypothalamo-hypophyseal-adrenal system in the rat.

1972 • 18 citations

Reduced Juxtaglomerular Cell Granularity, Pituitary Neurosecretory Material, and Width of the Zona Glomerulosa in Aging Rats

1965 • 16 citations

Peliosis of the female adrenal cortex of the aging rat

1981 • 12 citations

Basophil adenomata in the pituitary glands of 2-year-old male Long-Evans rats.

1967 • 11 citations

Inhibitory action of serotonin on hypothalamus-induced ACTH release.

1972 • 10 citations

[Sex and age dependent development of activation patterns of steroid hormone metabolism enzymes in rat liver after neonatal interference with sex differentiation].

1972 • 9 citations

Potentiation of the ACTH Response to Metyrapone by L-Dopa in the Monkey

1976 • 9 citations

Response to corticotrophin and correlation between excretion of creatinine and urinary steroids and between the clearance of creatinine and urinary steroids in ageing

1963 • 9 citations

GESCHLECHTS- UND ALTERSABHÄNGIGE ENTWICKLUNG DER AKTIVITÄTSMUSTER VON ENZYMEN DES STEROIDHORMON-STOFFWECHSELS IN DER RATTENLEBER NACH NEONATALEM EINGRIFF IN DIE SEXUELLE DIFFERENZIERUNG

1972 • 8 citations

Age changes in the relationship among endocrine glands of the beagle

1971 • 5 citations

[Diseases of old age].

1973 • 4 citations

THE ADRENAL GLANDS OF ELDERLY MEN IN RELATION TO ABNORMAL PROSTATIC GROWTH

1973 • 2 citations

Age-dependent lipolytic activity of the rat myocardium in relation to its triglyceride content. Possible new factor in Ischaemic heart disease?

1971 • 1 citations