Oxygen Intermediates and the Microbicidal Event

Superoxide Dismutase

1969 • 12,578 citations

Bulletin of the World Health Organization

1955 • 3,648 citations

Biological Defense Mechanisms. THE PRODUCTION BY LEUKOCYTES OF SUPEROXIDE, A POTENTIAL BACTERICIDAL AGENT

1973 • 2,955 citations

Oxygen-Dependent Microbial Killing by Phagocytes

1978 • 2,519 citations

The catalytic decomposition of hydrogen peroxide by iron salts

1934 • 2,483 citations

Superoxide Dismutases

1975 • 1,673 citations

The Journal of Laboratory and Clinical Medicine

2003 • 1,534 citations

The mononuclear phagocyte system: a new classification of macrophages, monocytes, and their precursor cells.

1972 • 1,102 citations

Quantitative Aspects of the Production of Superoxide Anion Radical by Milk Xanthine Oxidase

1970 • 1,037 citations

An Enzyme-Based Theory of Obligate Anaerobiosis: The Physiological Function of Superoxide Dismutase

1971 • 979 citations

Superoxide, hydrogen peroxide, and singlet oxygen in lipid peroxidation by a xanthine oxidase system.

1975 • 969 citations

Evidence for the generation of an electronic excitation state(s) in human polymorphonuclear leukocytes and its participation in bactericidal activity

1972 • 966 citations

Studies on the chlorinating activity of myeloperoxidase.

1976 • 918 citations

Physical and chemical properties of singlet molecular oxygen

1971 • 882 citations

Superoxide‐dependent production of hydroxyl radical catalyzed by iron—EDTA complex

1978 • 876 citations

Photosensitized Oxidation and Singlet Oxygen: Consequences in Biological Systems

1976 • 827 citations

Increased superoxide anion production by immunologically activated and chemically elicited macrophages

1978 • 823 citations

The role of superoxide anion generation in phagocytic bactericidal activity. Studies with normal and chronic granulomatous disease leukocytes.

1975 • 705 citations

The neutrophil: Function and clinical disorders

1978 • 670 citations

A Mechanism for the Production of Ethylene from Methional

1970 • 668 citations

Biochemical Aspects of Phagocytosis

1961 • 657 citations

Mononuclear phagocytes in immunity, infection and pathology

1976 • 653 citations

The neutrophil: Function and clinical disorders

1979 • 628 citations

Antimicrobial mechanisms in neutrophilic polymorphonuclear leukocytes.

1975 • 583 citations

Phagocytic activation of a luminol-dependent chemiluminescence in rabbit alveolar and peritoneal macrophages

1976 • 572 citations

Liposome oxidation and erythrocyte lysis by enzymically generated superoxide and hydrogen peroxide.

1977 • 509 citations

Acid dissociation constant and decay kinetics of the perhydroxyl radical

1970 • 496 citations

Hydrogen peroxide release from mouse peritoneal macrophages: dependence on sequential activation and triggering.

1977 • 488 citations

Mechanism of the disproportionation of superoxide radicals

1977 • 466 citations

Oxygen-Dependent Microbial Killing by Phagocytes

1978 • 448 citations

THE INTERACTION OF SOLUBLE HORSERADISH PEROXIDASE WITH MOUSE PERITONEAL MACROPHAGES IN VITRO

1972 • 431 citations

Oxygen Radicals, Hydrogen Peroxide, and Oxygen Toxicity

1976 • 430 citations

The production of superoxide anion radicals in the reaction of reduced flavins and flavoproteins with molecular oxygen

1969 • 419 citations

Chemiluminescence and superoxide production by myeloperoxidase-deficient leukocytes.

1976 • 373 citations

Myeloperoxidase: Contribution to the Microbicidal Activity of Intact Leukocytes

1970 • 345 citations

Proceedings of the Royal Society (London)

1893 • 343 citations

THE RELATIVE IMPORTANCE OF BLOOD MONOCYTES AND FIXED MACROPHAGES TO THE EXPRESSION OF CELL-MEDIATED IMMUNITY TO INFECTION

1970 • 326 citations

Deuterium effects on singlet oxygen lifetimes in solutions. New test of singlet oxygen reactions

1972 • 317 citations

Observations on the fine structure and peroxidase cytochemistry of normal rat liver Kupffer cells

1974 • 293 citations

The origin of the chemiluminescence of phagocytosing granulocytes.

1976 • 283 citations

Formation of singlet oxygen by the myeloperoxidase-mediated antimicrobial system.

1977 • 262 citations

Evidence for hydroxyl radical production by human neutrophils.

1977 • 257 citations

Superoxide production by phagocytic leukocytes.

1975 • 257 citations

Kinetics of the interaction of perhydroxyl and superoxide radicals with hydrogen peroxide. The Haber-Weiss reaction

1979 • 255 citations

Electron Microscopy and Cytochemistry

1975 • 254 citations

MORPHOLOGY AND PEROXIDASE CYTOCHEMISTRY OF MOUSE PROMONOCYTES, MONOCYTES, AND MACROPHAGES

1970 • 252 citations

DIFFERENTIATION OF MONOCYTES

1971 • 249 citations

Bactericidal activity of a superoxide anion-generating system. A model for the polymorphonuclear leukocyte.

1979 • 242 citations

Generation of superoxide anion and chemiluminescence by human monocytes during phagocytosis and on contact with surface-bound immunoglobulin G.

1976 • 237 citations

MONONUCLEAR PHAGOCYTES (KUPFFER CELLS) AND ENDOTHELIAL CELLS

1972 • 230 citations

THE FINE STRUCTURAL LOCALIZATION OF ENDOGENOUS AND EXOGENOUS PEROXIDASE ACTIVITY IN KUPFFER CELLS OF RAT LIVER

1970 • 230 citations

Singlet Molecular Oxygen from Superoxide Anion and Sensitized Fluorescence of Organic Molecules

1970 • 206 citations

Biological defense mechanisms. Evidence for the participation of superoxide in bacterial killing by xanthine oxidase.

1975 • 202 citations

Differences in Oxygen Metabolism of Phagocytosing Monocytes and Neutrophils

1978 • 201 citations

Human granulocyte generation of hydroxyl radical.

1978 • 191 citations

The fungicidal mechanisms of human monocytes. I. Evidence for myeloperoxidase-linked and myeloperoxidase-independent candidacidal mechanisms.

1975 • 191 citations

Singlet Excited Oxygen as a Mediator of the Antibacterial Action of Leukocytes

1974 • 190 citations

Laboratory investigation

2005 • 176 citations

Differentiation of human monocytes in bone marrow and blood. Sequential formation of two granule populations.

1973 • 158 citations

Role of the Superoxide Anion in the Myeloperoxidase-mediated Antimicrobial System

1974 • 153 citations

Evidence for hydroxyl radical generation by human Monocytes.

1977 • 152 citations

Substrate-induced chemiluminescence of xanthine oxidase and aldehyde oxidase

1970 • 149 citations

Chemiluminescence of phagocytic cells caused by N-formylmethionyl peptides

1978 • 148 citations

Superoxide dismutase and the oxygen enhancement of radiation lethality

1976 • 140 citations

A comparison of the metabolic response to phagocytosis in human granulocytes and monocytes.

1976 • 134 citations

Electron microscopical studies on the structure, phagocytic properties, and peroxidatic activity of resident and exudate peritoneal macrophages in the guinea pig

1973 • 131 citations

Iodination by human polymorphonuclear leukocytes: a re-evaluation.

1977 • 131 citations

The granulomatous inflammatory exudate.

1969 • 126 citations

THE PHYSICS, CHEMISTRY, AND BIOLOGY, OF SINGLET MOLECULAR OXYGEN*

1970 • 124 citations

Appearance of peroxidase reactivity within the rough endoplasmic reticulum of blood monocytes after surface adherence.

1977 • 123 citations

The mechanism of the activity-dependent luminescence of xanthine oxidase

1976 • 122 citations

Ethylene formation by polymorphonuclear leukocytes. Role of myeloperoxidase.

1978 • 121 citations

Stopped flow spectrophotometric observation of superoxide dismutation in aqueous solution

1976 • 118 citations

An attempt to demonstrate a reaction between superoxide and hydrogen peroxide

1976 • 116 citations

Inhibition of superoxide anion production in macrophages by anti-inflammatory drugs

1976 • 111 citations

Chemiluminescence response of phagocytizing human monocytes

1976 • 109 citations

THE EOSINOPHILIC LEUKOCYTE

1966 • 108 citations

Oxygen Metabolism in Lactobacillus plantarum

1974 • 107 citations

Catalase-dependent peroxidative metabolism in the alveolar macrophage during phagocytosis

1970 • 106 citations

IODINATING ABILITY OF VARIOUS LEUKOCYTES AND THEIR BACTERICIDAL ACTIVITY

1973 • 97 citations

Inhibition by sulfonamides of the candidacidal activity of human neutrophils

1971 • 97 citations

An attempt to evaluate the rate of the haber‐weiss reaction by using ·OH radical scavengers

1977 • 96 citations

Function of H ₂ O ₂ , Myeloperoxidase, and Hexose Monophosphate Shunt Enzymes in Phagocytizing Cells from Different Species

1970 • 91 citations

Cytochemical localization of catalase and peroxidase in sinusoidal cells of rat liver.

1976 • 88 citations

Defective Bactericidal Activity of Monocytes in Fatal Granulomatous Disease

1969 • 86 citations

BIOCHEMICAL CHARACTERISTICS OF ACTIVATED MACROPHAGES*

1975 • 86 citations

Direct spectroscopic evidence for a deuterium solvent effect on the lifetime of singlet oxygen in water

1973 • 83 citations

Macrophage accumulation, division, maturation and digestive and microbicidal capacities in tuberculous lesions. II. Rate at which mononuclear cells enter and divide in primary BCG lesions and those of reinfection.

1972 • 80 citations

Identification of exudate-resident macrophages on the basis of peroxidatic activity.

1978 • 77 citations

Isolation and Properties of Phagocytic Vesicles II. ALVEOLAR MACROPHAGES

1972 • 77 citations

Monocyte Function in Children With Neutropenia and Chronic Infections

1972 • 74 citations

Ambiguity associated with use of singlet oxygen trapping agents in myeloperoxidase-catalyzed oxidations

1978 • 70 citations

A defect in circulating mononuclear phagocytes in chronicgranulomatous disease of childhood.

1968 • 67 citations

FINE STRUCTURAL CYTOCHEMICAL LOCALIZATION OF PEROXIDASE ACTIVITY IN RAT PERITONEAL CELLS: MONONUCLEAR CELLS, EOSINOPHILS AND MAST CELLS

1971 • 67 citations

Differences between Monocyte-Derived and Tissue Macrophages

1976 • 65 citations

BIOLOGICAL EFFECTS OF HYPOCHLOROUS ACID FORMED BY “MPO”-PEROXIDATION IN THE PRESENCE OF CHLORIDE IONS

1972 • 63 citations

Ultrastructural Localization of Horseradish Peroxidase and Endogenous Peroxidase Activity in Guinea Pig Peritoneal Macrophages

1970 • 61 citations

Chemiluminescence spectra of human myeloperoxidase and polymorphonuclear leukocytes

1977 • 60 citations

Ultrastructural localization of peroxidase activity in normal human bone marrow cells

1971 • 59 citations

Differentiation of macrophages from normal human bone marrow in liquid culture. Electron microscopy and cytochemistry.

1978 • 58 citations

Ultrastructural localization of peroxidase in leukocytes of rat bone marrow and blood

1977 • 55 citations

Differences in peroxidase localization of rabbit peritoneal macrophages after surface adherence.

1978 • 52 citations

Chemiluminescence by human alveolar macrophages: stimulation with heat-killed bacteria or phorobol myristate acetate

1977 • 45 citations

Bactericidal mechanisms in rabbit alveolar macrophages: evidence against peroxidase and hydrogen peroxide bactericidal mechanisms

1976 • 44 citations

PEROXIDATIC ACTIVITY IN RESIDENT PERITONEAL MACROPHAGES AND EXUDATE MONOCYTES OF THE GUINEA PIG AFTER INGESTION OF LATEX PARTICLES

1973 • 44 citations

Chemiluminescence and bioluminescence

1974 • 44 citations

Peroxidaze Catalyzed singlet oxygen formation from hydrogen peroxide

1977 • 43 citations

Peroxidase activity of alveolar and peritoneal macrophages.

1973 • 43 citations

The Generation of Superoxide Anion by Various Types of Phagocyte

1975 • 42 citations

Superoxide generation by human monocytes and macrophages

1978 • 39 citations

Macrophage Accumulation, Division, Maturation and Digestive and Microbicidal Capacities in Tuberculous Lesions

1972 • 39 citations

Peroxidase activity of alveolar macrophages.

1976 • 39 citations

Antimicrobial Activity of Gatalase at Acid pH

1969 • 38 citations

Cytochemical distinction between azurophils and catalase-containing granules in leukocytes. I. Studies in developing neutrophils and monocytes from patients with myeloperoxidase deficiency: comparison with peroxidase-deficient chicken heterophils.

1978 • 38 citations

Generation of singlet oxygen in the reaction of superoxide anion radical with diacyl peroxides

1978 • 37 citations

Peroxidase Mediated Antimicrobial Activities of Alveolar Macrophage Granules

1973 • 36 citations

Chemical and biological aspects of singlet excited molecular oxygen.

1970 • 36 citations

Difference spectra, catalase- and peroxidase activities of isolated parenchymal and non-parenchymal cells from rat liver

1974 • 35 citations

Communications

1968 • 34 citations

Effect of Hyperoxia on Superoxide Anion and Hydrogen Peroxide Production of Polymorphonuclear Leucocytes and Alveolar Macrophages

1977 • 34 citations

Peroxidatic activity in monocytes and tissue macrophages of mice

1978 • 34 citations

Theory of electron transfer generation and quenching of singlet oxygen [1.SIGMA.g+ and 1.DELTA.g] by superoxide anion. The role of water in the dismutation of superoxide anion

1977 • 34 citations

The Interaction of Ozone and Hydrogen Peroxide in Aqueous Solution

1938 • 33 citations

Chemiluminescence associated with phagocytosis of foreign particles in rabbit alveolar macrophages

1977 • 32 citations

Mononuclear Phagocytes

2016 • 31 citations

Peroxidative Metabolism in Alveolar Macrophages

1971 • 30 citations

Fine structure and peroxidatic activity of rat blood monocytes

1977 • 28 citations

Metabolic and Functional Studies of Monocytes in Congenital Neutropenia

1974 • 27 citations

Peroxidase and Catalase in Monocytes, Macrophages, Epithelioid Cells and Giant Cells of the Rat

1980 • 27 citations

Decay of the HO₂ and O⁻₂ Radicals Catalyzed by Superoxide Dismutase. A Pulse Radiolytic Investigation

1972 • 25 citations

The Release of Hydrogen Peroxide from Mononuclear Phagocytes and its Role in Extracellular Cytolysis

1980 • 25 citations

The effects of ethanol on some metabolic features of phagocytosis in the alveolar macrophage.

1974 • 25 citations

Peroxidatic activity and morphometric analysis of alveolar macrophages in the guinea pig.

1978 • 24 citations

Oxygen metabolism in the alveolar macrophage: friend and foe?

1976 • 22 citations

Inhibition of Lecithin:Cholesterol Acyltransferase in Human Plasma by Dicarboxylic Lecithins

1978 • 21 citations

Superoxide production by rabbit pulmonary alveolar macrophages

1977 • 21 citations

The Fine Structure and Peroxidase Activity of Resident and Exudate Peritoneal Macrophages in the Guinea Pig

1971 • 20 citations

Changes in Peroxidase Distribution within Organelles of Blood Monocytes and Peritoneal Macrophages after Surface Adherence in Vitro and in Vivo

1980 • 19 citations

[Electron microscopic study of the localization of peroxidases in human bone marrow cells].

1969 • 18 citations

Oxygen in Chemiluminescence. A Competitive Pathway of Dioxetane Decomposition Catalyzed by Electron Donors

1973 • 14 citations

Hydrogen Peroxide Release by Rat Alveolar Macrophages: Comparison with Blood Neutrophils

1978 • 14 citations

Release of Superoxide Anion by Macrophages: Effect of in Vivo or in Vitro Priming

1980 • 13 citations

INTERNATIONAL REVIEW OF EXPERIMENTAL PATHOLOGY

1965 • 12 citations

Chemiluminescence of Perhydroxyl- and Carbonate-Radicals

1973 • 10 citations

Biochemical Aspects of the Function of the Reticulo-Endothelial System

1976 • 8 citations

In vivo adherence of monocytes does not lead to the appearance of peroxidatic activity in the rough endoplasmic reticulum

1978 • 8 citations

Physical properties of singlet oxygen.

1970 • 6 citations

Cytoenzymological behavior of peritoneal exudate cells of rat in vivo. I. Histochemical study of enzymatic function of peroxidase.

1971 • 5 citations

Deleted Work

1955 • 0 citations