Increased protein kinase C activity is linked to reduced insulin receptor autophosphorylation in liver of starved rats.

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

Insulin Stimulates the Phosphorylation of the 95,000-Dalton Subunit of Its Own Receptor

1982 • 1,138 citations

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

1986 • 1,100 citations

The Complete Primary Structure of Protein Kinase C—the Major Phorbol Ester Receptor

1986 • 878 citations

[1] Assays of protein kinase

1983 • 832 citations

Phosphorylation activates the insulin receptor tyrosine protein kinase.

1983 • 558 citations

Limited Proteolysis of Protein Kinase C Subspecies by Calcium-dependent Neutral Protease (Calpain)

1989 • 470 citations

Phorbol ester-induced serine phosphorylation of the insulin receptor decreases its tyrosine kinase activity.

1988 • 315 citations

Protein kinase C directly phosphorylates the insulin receptor in vitro and reduces its protein-tyrosine kinase activity.

1986 • 275 citations

Insulin Binding to Monocytes and Insulin Action in Human Obesity, Starvation, and Refeeding

1978 • 254 citations

Decreased autophosphorylation of the insulin receptor-kinase in streptozotocin-diabetic rats.

1984 • 237 citations

Decreased kinase activity of insulin receptors from adipocytes of non-insulin-dependent diabetic subjects.

1987 • 228 citations

Differential Down-regulation of Protein Kinase C Isozymes

1989 • 219 citations

Studies on the mechanism of insulin resistance in the liver from humans with noninsulin-dependent diabetes. Insulin action and binding in isolated hepatocytes, insulin receptor structure, and kinase activity.

1986 • 214 citations

Identification of the structures of multiple subspecies of protein kinase C expressed in rat brain

1987 • 202 citations

Reversibility of defective adipocyte insulin receptor kinase activity in non-insulin-dependent diabetes mellitus. Effect of weight loss.

1988 • 195 citations

Increasing the cAMP content of IM-9 cells alters the phosphorylation state and protein kinase activity of the insulin receptor.

1986 • 182 citations

Identification of three additional members of rat protein kinase C family: gd‐, ϵ‐ and ξ‐subspecies

1987 • 173 citations

Purification of the catalytically active phosphorylated form of insulin receptor kinase by affinity chromatography with O-phosphotyrosyl-binding antibodies

1985 • 124 citations

Immunological quantitation of phospholipid/Ca2+-dependent protein kinase and its fragments. Tissue levels, subcellular distribution, and ontogenetic changes in brain and heart.

1986 • 114 citations

Relationship of insulin binding and insulin-stimulated tyrosine kinase activity is altered in type II diabetes.

1987 • 113 citations

Immunochemical identification of protein kinase C isozymes as products of discrete genes

1987 • 105 citations

Insulin binding and insulin-dependent phosphorylation of the insulin receptor solubilized from human erythrocytes.

1983 • 101 citations

Insulin receptor kinase activity in rat liver. Regulation by fasting and high carbohydrate feeding.

1985 • 96 citations

Mechanism of hepatic glycogen synthase inactivation induced by Ca2+-mobilizing hormones. Studies using phospholipase C and phorbol myristate acetate

1986 • 68 citations

Separate domains of the insulin receptor contain sites of autophosphorylation and tyrosine kinase activity

1987 • 66 citations

Calcium-activated, phospholipid-dependent protein kinases from rat liver: subcellular distribution, purification, and characterization of multiple forms

1987 • 57 citations

Fasting and refeeding alter the insulin receptor tyrosine kinase in chicken liver but fail to affect brain insulin receptors.

1986 • 48 citations

Identification of a phosphorylation site of the rat insulin receptor catalyzed by protein kinase C in an intact cell

1989 • 41 citations

Regulation of epidermal growth factor receptor number and phosphorylation by fasting in rat liver.

1986 • 38 citations

Mechanism of Defective Insulin-Receptor Kinase Activity in NIDDM: Evidence for Two Receptor Populations

1989 • 38 citations

Insulin-Sensitive Tyrosine Kinase Is Increased in Livers of Adult Obese Zucker Rats:Correction with Prolonged Fasting

1988 • 21 citations

Determination of Ca2+- and phospholipid-dependent protein kinase in rat liver membranes

1983 • 11 citations