Do Glial Gap Junctions Play a Role in Extracellular Ion Homeostasis?

Junctional intercellular communication: the cell-to-cell membrane channel.

1981 • 1,268 citations

Effect of nerve impulses on the membrane potential of glial cells in the central nervous system of amphibia.

1966 • 1,208 citations

Potassium accumulation in muscle and associated changes1

1941 • 798 citations

Ion diffusion modified by tortuosity and volume fraction in the extracellular microenvironment of the rat cerebellum.

1981 • 781 citations

Physiological properties of glial cells in the central nervous system of amphibia.

1966 • 594 citations

Gap junctions in the brain: where, what type, how many and why?

1993 • 513 citations

Gap Junctional Conductance Is a Simple and Sensitive Function of Intracellular p H

1981 • 481 citations

The physiology of neuroglial cells

1966 • 453 citations

Physiology and Pharmacology of Gap Junctions

1985 • 452 citations

Role of glial cells in the regulation of the brain ion microenvironment

1989 • 448 citations

Extracellular Potassium in the Mammalian Central Nervous System

1979 • 445 citations

The physiology of neuroglial cells

2007 • 419 citations

Gap junctions between cultured astrocytes: immunocytochemical, molecular, and electrophysiological analysis

1991 • 415 citations

Transient changes in the size of the extracellular space in the sensorimotor cortex of cats in relation to stimulus-induced changes in potassium concentration

1980 • 362 citations

Ceiling of stimulus induced rises in extracellular potassium concentration in the cerebral cortex of cat

1977 • 361 citations

Gap junctions in cultured astrocytes: Single-channel currents and characterization of channel-forming protein

1991 • 360 citations

Ion activities and potassium uptake mechanisms of glial cells in guinea‐pig olfactory cortex slices.

1987 • 322 citations

High Potassium Conductance in Astrocyte Endfeet

1986 • 295 citations

Analysis of potassium dynamics in mammalian brain tissue.

1983 • 289 citations

Extracellular K+ accumulation in the central nervous system

1983 • 282 citations

Glial cell function: Active control of extracellular K+ concentration

1972 • 233 citations

Biophysical and pharmacological characterization of inwardly rectifying K+ currents in rat spinal cord astrocytes

1995 • 223 citations

Changes in extracellular potassium concentration produced by neuronal activity in the central nervous system of the leech

1969 • 219 citations

Spatial Buffering of Light-Evoked Potassium Increases by Retinal Müller (Glial) Cells

1989 • 218 citations

Stimulus-induced changes in extracellular Na+ and Cl− concentration in relation to changes in the size of the extracellular space

1982 • 211 citations

Astroglial Gap Junction Communication Is Increased by Treatment with Either Glutamate or High K⁺ Concentration

1994 • 205 citations

Intracellular sodium homeostasis in rat hippocampal astrocytes.

1996 • 193 citations

Potassium activity in photoreceptors, glial cells and extracellular space in the drone retina: changes during photostimulation.

1979 • 192 citations

Activity-dependent shrinkage of extracellular space in rat optic nerve: a developmental study

1985 • 192 citations

Neuroscience in Medicine

1995 • 191 citations

Undershoots following stimulus-induced rises of extracellular potassium concentration in cerebral cortex of cat

1975 • 180 citations

After‐effects of nerve impulses on signalling in the central nervous system of the leech

1969 • 174 citations

Electrical coupling between astrocytes and between oligodendrocytes studied in mammalian cell cultures

1988 • 174 citations

Role of extracellular space in hyperosmotic suppression of potassium-induced electrographic seizures

1989 • 169 citations

Activity-Dependent K ⁺ Accumulation in the Developing Rat Optic Nerve

1982 • 161 citations

Regulation of the Cerebral Circulation

1981 • 161 citations

Dye-coupling between glial cells in the guinea pig neocortical slice

1981 • 157 citations

Exclusive potassium dependence of the membrane potential in cultured mouse oligodendrocytes

1983 • 149 citations

Adrenergic regulation of intercellular communications between cultured striatal astrocytes from the mouse.

1991 • 149 citations

Astrocyte Na+ channels are required for maintenance of Na+/K(+)-ATPase activity

1994 • 146 citations

A study of the mechanisms by which potassium moves through brain tissue in the rat.

1983 • 145 citations

Carrier-mediated KCl accumulation accompanied by water movements is involved in the control of physiological K+ levels by astrocytes

1985 • 143 citations

Morphology of astrocytes and oligodendrocytes during development in the intact rat optic nerve

1993 • 139 citations

Cation-coupled chloride influx in squid axon. Role of potassium and stoichiometry of the transport process.

1983 • 138 citations

Astrocytes exhibit regional specificity in gap‐junction coupling

1994 • 134 citations

Electrical coupling, without dye coupling, between mammalian astrocytes and oligodendrocytes in cell culture

1990 • 130 citations

Changes of extracellular potassium activity induced by electric current through brain tissue in the rat.

1983 • 129 citations

Ouabain‐Sensitive and Ouabain‐Resistant Net Uptake of Potassium into Astrocytes and Neurons in Primary Cultures

1982 • 128 citations

Modulation of Parallel Fiber Excitability by Postsynaptically Mediated Changes in Extracellular Potassium

1981 • 127 citations

An intense potassium uptake into astrocytes, its further enhancement by high concentrations of potassium, and its possible involvement in potassium homeostasis at the cellular level

1978 • 121 citations

Recent advances in understanding brain capillary function

1983 • 114 citations

Chapter 3: Glial modulation of neural excitability mediated by extracellular pH: a hypothesis

1992 • 111 citations

NADH fluorescence and [K+]o changes during hippocampal electrical stimulation

1975 • 106 citations

Depolarization-induced alkalinization (DIA) in rat hippocampal astrocytes

1994 • 106 citations

Clearance of extracellular potassium: evidence for spatial buffering by glial cells in the retina of the drone

1981 • 103 citations

The clearing of excess potassium from extracellular space in spinal cord and cerebral cortex

1978 • 102 citations

Postnatal development of dye‐coupling among astrocytes in rat visual cortex

1992 • 94 citations

Glial cells and extracellular potassium: Their relationship in mammalian cortex

1976 • 93 citations

Extracellular Potassium Ions Mediate Specific Neuronal Interaction

1982 • 91 citations

Heterogeneity in gap junction expression in astrocytes cultured from different brain regions

1992 • 84 citations

Intracellular ion changes of astrocytes in response to extracellular potassium

1983 • 77 citations

Relation of potassium concentration in choroidplexus fluid to that in plasma.

1965 • 75 citations

Solutions of the Hodgkin-Huxley equations modified for potassium accumulation in a periaxonal space

1975 • 74 citations

Quantitative immunohistochemical and biochemical correlates of connexin43 localization in rat brain

1992 • 74 citations

Introductory Remarks: Glial‐Interstitial Fluid Exchange

1986 • 72 citations

Factors Determining the Decay of K⁺ Potentials and Focal Potentials in the Central Nervous System

1975 • 69 citations

Nerve impulses increase glial intercellular permeability

1996 • 65 citations

ELECTROPHYSIOLOGICAL PROPERTIES OF ASTROCYTES

1986 • 63 citations

Potassium activity in leech neuropile glial cells changes with external potassium concentration

1983 • 57 citations

Extracellular potassium accumulation and transmission in frog spinal cord

1980 • 57 citations

The contribution by glial cells to surface recordings from the optic nerve of an amphibian

1970 • 56 citations

Influence of potassium ions on accumulation and metabolism of [14C]glucose by glial cells

1975 • 55 citations

Glial Cells in the Rat Optic Nerve

1991 • 55 citations

Changes of intracellular sodium and potassium ion concentrations in frog spinal motoneurons induced by repetitive synaptic stimulation

1982 • 54 citations

Extracellular K+ in the supraoptic nucleus of the rat during reflex bursting activity by oxytocin neurones.

1991 • 51 citations

A quantitative analysis of glial cell coupling in the retina of the axolotl (Ambystoma mexicanum)

1988 • 51 citations

Effects of changes in extracellular potassium, magnesium and calcium concentration on synaptic transmission in area CA1 and the dentate gyrus of rat hippocampal slices

1990 • 50 citations

Specificity of cell-cell coupling in rat optic nerve astrocytes in vitro.

1990 • 49 citations

Different types of potassium transport linked to carbachol and γ-aminobutyric acid actions in rat sympathetic neurons

1984 • 49 citations

Cl− transport in a glioma cell line: Evidence for two transport mechanisms

1984 • 43 citations

The behavior of presumed glial cells during seizure discharge in cat cerebral cortex

1974 • 43 citations

Relationship between Na+ current expression and cell-cell coupling in astrocytes cultured from rat hippocampus

1991 • 40 citations

Light-evoked changes in [K+]o in proximal portion of light-adapted cat retina

1992 • 40 citations

[K+]o clearance in cortex: a new analytical model

1977 • 35 citations

Intracellular pH shifts capable of uncoupling cultured oligodendrocytes are seen only in low HCO₃⁻ solution

1990 • 20 citations

Effects of carbon dioxide on extracellular potassium accumulation and volume in isolated frog spinal cord

1988 • 11 citations