Comparative assessment of proliferation and DNA content in breast carcinoma by image analysis and flow cytometry.

Cell cycle analysis of a cell proliferation-associated human nuclear antigen defined by the monoclonal antibody Ki-67.

1984 • 4,180 citations

Histological Grading and Prognosis in Breast Cancer

1957 • 2,897 citations

Cyclin/PCNA is the auxiliary protein of DNA polymerase-δ

1987 • 1,766 citations

Analysis of PCP-data to determine the fraction of cells in the various phases of cell cycle

1975 • 586 citations

Analysis of proliferative grade using anti-PCNA/cyclin monoclonal antibodies in fixed, embedded tissues. Comparison with flow cytometric analysis.

1989 • 582 citations

Prediction of Relapse or Survival in Patients with Node-Negative Breast Cancer by DNA Flow Cytometry

1989 • 571 citations

Expression of proliferating cell nuclear antigen (PCNA)/cyclin during the cell cycle

1986 • 529 citations

DNA content and survival in mammary carcinoma.

1980 • 372 citations

Pathologic predictors of early local recurrence in stage I and II breast cancer treated by primary radiation therapy

1984 • 360 citations

Monoclonal antibodies to proliferating cell nuclear antigen (PCNA)/cyclin as probes for proliferating cells by immunofluorescence microscopy and flow cytometry

1988 • 321 citations

DNA flow cytometry and prognostic factors in 1331 frozen breast cancer specimens

1988 • 301 citations

Flow cytometry, cellular DNA content, and prognosis in human malignancy.

1987 • 258 citations

Proliferative index in breast carcinoma determined in situ by Ki67 immunostaining and its relationship to clinical and pathological variables

1987 • 253 citations

Growth fractions in breast cancers determined in situ with monoclonal antibody Ki-67.

1986 • 249 citations

Independent prognostic significance of a nuclear proliferation antigen in diffuse large cell lymphomas as determined by the monoclonal antibody Ki-67

1988 • 227 citations

Improving the prognostic value of DNA flow cytometry in breast cancer by combining DNA index and S-phase fraction: A proposed classification of DNA histograms in breast cancer

1988 • 226 citations

Nuclear structure in cancer tissues.

1957 • 222 citations

Leukocyte common antigen—a diagnostic discriminant between hematopoietic and nonhematopoietic neoplasms in paraffin sections using monoclonal antibodies: Correlation with immunologic studies and ultrastructural localization

1985 • 214 citations

Prognostic significance of Ki-67 reactivity in soft tissue sarcomas

1989 • 198 citations

Relationship between labeling indices of KI-67 and brdurd in human malignant tumors

1988 • 177 citations

Flow cytometry of breast carcinoma: I. Relation of DNA ploidy level to histology and estrogen receptor

1981 • 170 citations

A proposed classification of breast cancer based on kinetic information derived from a comparison of risk factors in 168 primary operable breast cancers

1986 • 149 citations

Prognostic significance of dna measurements in 409 consecutive breast cancer patients

1988 • 148 citations

Thymidine labeling index and Ki-67 growth fraction in lesions of the breast.

1989 • 138 citations

Proliferative potential of meningiomas determined with the monoclonal antibody Ki-67

1987 • 128 citations

The correlation of growth fractions with histologic grading and lymph node status in human mammary carcinoma

1987 • 124 citations

Predictive value of nuclear DNA content in breast cancer in relation to clinical and morphologic factors. A retrospective study of 227 consecutive cases

1988 • 117 citations

Comparison of monoclonal antibody Ki-67 reactivity with grade and DNA flow cytometry of breast carcinomas

1988 • 113 citations

Primary breast cancer: Flow cytometric dna pattern in relation to clinical and histopathologic characteristics

1986 • 82 citations

Proliferating cell nuclear antigen (PCNA)/cyclin in activated human T lymphocytes.

1987 • 79 citations

Hydatidiform Moles: Application of Flow Cytometry in Diagnosis

1988 • 77 citations

Cell proliferation in non-Hodgkin's lymphomas. Digital image analysis of Ki-67 antibody staining.

1989 • 75 citations

Influence of systematic errors on the evaluation of the S phase portions from DNA distributions of solid tumors as shown for 328 breast carcinomas

1987 • 58 citations

Cytometry of breast carcinoma: Significance of ploïdy balance and proliferation index

1987 • 52 citations

Tumor cell growth fractions in human malignant melanomas and the correlation to histopathologic tumor grading.

1989 • 50 citations

DNA image cytometry on machine‐selected breast cancer cells and a comparison between flow cytometry and scanning cytophotometry

1985 • 45 citations

Quantitation of estrogen receptor content and Ki-67 staining in breast carcinoma by the microTICAS image analysis system.

1987 • 41 citations

Immunodetection in fine-needle aspirates and multiparametric (SAMBA) image analysis. Receptors (monoclonal antiestrogen and antiprogesterone) and growth fraction (monoclonal Ki67) evaluation in breast carcinomas

1989 • 34 citations