Fatigue in multiple sclerosis: current understanding and future directions.

The Fatigue Severity Scale

1989 • 5,280 citations

The multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue

1995 • 3,198 citations

Development of a fatigue scale

1993 • 2,698 citations

Intramuscular interferon beta‐1a for disease progression in relapsing multiple sclerosis

1996 • 2,410 citations

Randomised double-blind placebo-controlled study of interferon β-1a in relapsing/remitting multiple sclerosis

1998 • 2,049 citations

Interferon beta‐1b is effective in relapsing‐remitting multiple sclerosis

1993 • 1,908 citations

Measuring the Functional Impact of Fatigue: Initial Validation of the Fatigue Impact Scale

1994 • 1,372 citations

Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. The IFNB Multiple Sclerosis Study Group.

1993 • 1,227 citations

Dimensional assessment of chronic fatigue syndrome

1994 • 1,206 citations

Sleep Apnea and Daytime Sleepiness and Fatigue: Relation to Visceral Obesity, Insulin Resistance, and Hypercytokinemia

2000 • 1,127 citations

The Impact of Fatigue on Patients with Multiple Sclerosis

1994 • 961 citations

Fatigue in Multiple Sclerosis

1988 • 954 citations

Placebo-controlled multicentre randomised trial of interferon β-1b in treatment of secondary progressive multiple sclerosis

1998 • 931 citations

Impact of aerobic training on fitness and quality of life in multiple sclerosis

1996 • 763 citations

Sleepiness in Different Situations Measured by the Epworth Sleepiness Scale

1994 • 731 citations

Measurement of human muscle fatigue

1997 • 727 citations

Contractile speed and EMG changes during fatigue of sustained maximal voluntary contractions

1983 • 537 citations

The measurement of fatigue: A new instrument

1993 • 530 citations

Symptomatic fatigue in multiple sclerosis.

1984 • 517 citations

Reduced glucose metabolism in the frontal cortex and basal ganglia of multiple sclerosis patients with fatigue

1997 • 467 citations

Efficacy and safety of modafinil (Provigil(R)) for the treatment of fatigue in multiple sclerosis: a two centre phase 2 study

2002 • 455 citations

Correlates of Fatigue in Older Adults with Rheumatoid Arthritis

1993 • 422 citations

Affective Disorders in Multiple Sclerosis Review and Recommendations for Clinical Research

1990 • 418 citations

The Measurement of Fatigue in Patients With Multiple Sclerosis

1996 • 376 citations

Fatigue therapy in multiple sclerosis

1995 • 350 citations

Fatigue of submaximal static contractions.

1986 • 337 citations

On the evaluation of disability in multiple sclerosis

1961 • 328 citations

Fatigue and declines in cognitive functioning in multiple sclerosis

2000 • 279 citations

An electrophysiological study of the mechanism of fatigue in multiple sclerosis

1997 • 255 citations

Quantitative assessment of motor fatigue and strength in MS

1999 • 233 citations

CONTROLLED TRIAL OF INTERLEUKIN-2 INFUSIONS IN PATIENTS INFECTED WITH THE HUMAN IMMUNODEFICIENCY VIRUS

1996 • 214 citations

Psychosocial correlates of fatigue in multiple sclerosis

1996 • 214 citations

Amantadine Therapy for Fatigue in Multiple Sclerosis

1985 • 212 citations

Physical activity in chronic fatigue syndrome: Assessment and its role in fatigue

1997 • 209 citations

Altered cytokine release in peripheral blood mononuclear cell cultures from patients with the chronic fatigue syndrome

1991 • 204 citations

Follow up of patients presenting with fatigue to an infectious diseases clinic.

1992 • 201 citations

Amantadine Treatment of Fatigue Associated With Multiple Sclerosis

1989 • 200 citations

Fatigue in multiple sclerosis: Cross-sectional correlation with brain MRI findings in 71 patients

1999 • 197 citations

Quantitative assessment of sustained‐release 4‐aminopyridine for symptomatic treatment of multiple sclerosis

1997 • 186 citations

Evidence of an abnormal intramuscular component of fatigue in multiple sclerosis

1995 • 162 citations

The Development, Standardization, and Initial Validation of the Chicago Multiscale Depression Inventory

1998 • 160 citations

A double‐blind, randomized, crossover trial of pemoline in fatigue associated with multiple sclerosis

1992 • 158 citations

Central fatigue as revealed by postexercise decrement of motor evoked potentials

1994 • 158 citations

Fatigue in MS is associated with specific clinical features

2009 • 154 citations

Attention related performance in two cognitively different subgroups of patients with multiple sclerosis.

1995 • 151 citations

Postexercise phosphocreatine resynthesis is slowed in multiple sclerosis

1994 • 139 citations

Extended outpatient rehabilitation: its influence on symptom frequency, fatigue, and functional status for persons with progressive multiple sclerosis

1998 • 136 citations

Sleep Disturbance, Depression, and Lesion Site in Patients With Multiple Sclerosis

1992 • 128 citations

Markers of inflammation and immune activation in chronic fatigue and chronic fatigue syndrome.

1997 • 121 citations

Facioscapulohumeral Dystrophy Natural History Study: Standardization of Testing Procedures and Reliability of Measurements

1994 • 121 citations

Changes in Immune Parameters Seen in Gulf War Veterans but Not in Civilians with Chronic Fatigue Syndrome

1999 • 116 citations

The fatigue descriptive scale (FDS): a useful tool to evaluate fatigue in multiple sclerosis

1999 • 116 citations

Biological and clinical effects of intravenous tumor necrosis factor-alpha administered three times weekly.

1991 • 112 citations

Clinical aspects of fatigue in multiple sclerosis.

1998 • 111 citations

The Effects of Fatigue on Neuropsychological Performance in Patients With Chronic Fatigue Syndrome, Multiple Sclerosis, and Depression

1997 • 110 citations

Fatigue and magnetic resonance imaging activity in multiple sclerosis

1999 • 103 citations

Cognitive and Physical Fatigue in Multiple Sclerosis: Relations Between Self-Report and Objective Performance

1998 • 99 citations

Symptom management in multiple sclerosis

1994 • 98 citations

Muscle fatigue, effects of training and disuse

1989 • 92 citations

An open-labelled clinical and electrophysiological study of 3,4 diaminopyridine in the treatment of fatigue in multiple sclerosis

1998 • 90 citations

Amantadine, Fatigue, and Multiple Sclerosis

1988 • 85 citations

Acute phase responses and cytokine secretion in chronic fatigue syndrome.

1999 • 83 citations

Fatigue in multiple sclerosis compared with chronic fatigue syndrome

1996 • 77 citations

Endurance Training in Patients With Multiple Sclerosis: Five Case Studies

1994 • 69 citations

Excessive muscular fatigue in patients with spastic paraparesis

1990 • 50 citations

Elevated levels of tumor necrosis factor alpha in postdialysis fatigue

1998 • 47 citations

Susceptibility to Immunologically Mediated Fatigue in C57BL/6 versus Balb/c Mice

1996 • 44 citations

Muscle force, perceived effort, and voluntary activation of the elbow flexors assessed with sensitive twitch interpolation in fibromyalgia.

1996 • 42 citations

The fatigue of rapid repetitive movements

1993 • 42 citations

Interleukin-1 alpha administered after autologous transplantation: a phase I/II clinical trial

1994 • 34 citations

Increased production of interleukin-6 by adherent and non-adherent mononuclear cells during 'natural fatigue' but not following 'experimental fatigue' in patients with chronic fatigue syndrome.

1999 • 20 citations

Biological markers in body fluids for activity and progression in multiple sclerosis

1999 • 19 citations

Single Institution Experience with Recombinant Gamma-Interferon in the Treatment of Patients with Metastatic Renal Cell Carcinoma

1996 • 18 citations

A Multi-Center Controlled Study of the Acute and Chronic Effects of Cooling Therapy for MS

2000 • 1 citations