Brain Hexokinase, the Prototype Ambiquitous Enzyme

Effect of Ischemia on Known Substrates and Cofactors of the Glycolytic Pathway in Brain

1964 • 2,227 citations

Allosteric proteins and cellular control systems

1963 • 2,187 citations

The kinetics of enzyme-catalyzed reactions with two or more substrates or products☆I. Nomenclature and rate equations

1963 • 2,095 citations

The kinetics of enzyme-catalyzed reactions with two or more substrates or products

1963 • 1,885 citations

Handbook of Neurochemistry

1972 • 1,374 citations

The Molecular Organization of Membranes

1974 • 1,074 citations

THE QUANTITATIVE HISTOCHEMISTRY OF THE RETINA

1956 • 928 citations

SUBSTRATE SPECIFICITY OF BRAIN HEXOKINASE

1954 • 595 citations

The Relationships between Substrates and Enzymes of Glycolysis in Brain

1964 • 551 citations

TRANSPORT OF METABOLIC SUBSTRATES THROUGH THE BLOOD‐BRAIN BARRIER¹

1977 • 525 citations

Multiple Hexokinases of Rat Tissues

1966 • 483 citations

Principles of enzyme kinetics

1976 • 468 citations

THE ASSOCIATION OF HEXOKINASE WITH PARTICULATE FRACTIONS OF BRAIN AND OTHER TISSUE HOMOGENATES

1953 • 460 citations

Mitochondrial Hexokinase

1967 • 391 citations

Metabolic Compartmentation in the Brain

1973 • 387 citations

The Concentrations of Free and Bound Magnesium in Rat Tissues

1973 • 382 citations

The intracellular distribution of glycolytic and other enzymes in rat-brain homogenates and mitochondrial preparations

1960 • 370 citations

CEREBRAL CARBOHYDRATE METABOLISM DURING ACUTE HYPOXIA AND RECOVERY¹

1972 • 363 citations

FREEZE‐BLOWING: A NEW TECHNIQUE FOR THE STUDY OF BRAIN IN VIVO

1973 • 359 citations

Ligand binding and internal equilibiums in proteins

1972 • 324 citations

Multiple forms of hexokinase in the rat: tissue distribution, age dependency, and properties.

1965 • 308 citations

The Relationship between Michaelis Constants, Maximum Velocities and the Equilibrium Constant for an Enzyme-catalyzed Reaction

1953 • 301 citations

Principles of Enzyme Kinetics

1976 • 282 citations

Space-Filling Models of Kinase Clefts and Conformation Changes

1979 • 280 citations

THE NON-COMPETITIVE INHIBITION OF BRAIN HEXOKINASE BY GLUCOSE-6-PHOSPHATE AND RELATED COMPOUNDS

1954 • 277 citations

Specificity in the Association of Glyceraldehyde 3-Phosphate Dehydrogenase with Isolated Human Erythrocyte Membranes

1973 • 242 citations

Space-Filling Models of Kinase Clefts and Conformation Changes: Comparison of the surface structures of kinase enzymes implicates closing clefts in their mechanism.

1979 • 223 citations

A rapid and sensitive method for measuring the binding of radioactive ligands to proteins

1969 • 216 citations

Brain Hexokinase

1968 • 205 citations

Quantitative Histochemistry of Retina

1961 • 183 citations

Role of inorganic phosphate in stimulating the glucose utilization of human red blood cells

1964 • 179 citations

THE QUANTITATIVE HISTOCHEMISTRY OF THE BRAIN

1958 • 179 citations

Multiple Forms of Hexokinase

1970 • 173 citations

Ambiquitous enzymes: Variation in intracellular distribution as a regulatory mechanism

1978 • 170 citations

Metabolism of Ketone Bodies by the Brain

1973 • 168 citations

The multiple forms of mammalian hexokinase and their significance to the action of insulin

1967 • 163 citations

Purification of a hexokinase-binding protein from the outer mitochondrial membrane.

1979 • 161 citations

THE ANALYSIS OF SINGLE CELLS

1956 • 156 citations

Studies on hexokinase: 1. The hexokinase activity of rat-brain extracts

1951 • 152 citations

Purification and properties of rat brain hexokinase

1972 • 151 citations

Kinetic Studies of the Brain Hexokinase Reaction

1962 • 150 citations

Interaction of the aldolase and the membrane of human erythrocytes

1977 • 141 citations

Recent Advances in Neuroanatomical Methodology

1978 • 137 citations

Kinetic evidence for a ‘mnemonical’ mechanism for rat liver glucokinase

1977 • 135 citations

Glucose 1,6-Diphosphate Formation by Phosphoglucomutase in Mammalian Tissues

1969 • 132 citations

Development of mitochondrial energy metabolism in rat brain

1977 • 127 citations

Regulation of Glycolysis in Brain, in Situ, during Convulsions

1966 • 123 citations

The functional compartmentation of mitochondrial hexokinase

1974 • 120 citations

Effects of Energy Metabolism on in Vivo Distribution of Hexokinase in Brain

1973 • 118 citations

THE QUANTITATIVE HISTOCHEMISTRY OF BRAIN

1955 • 107 citations

Reflections on Biochemistry

1976 • 107 citations

The Kinetics and Regulation of Rat Brain Hexokinase

1971 • 102 citations

Association of heart hexokinase with subcellular structure

1966 • 101 citations

Changes in allosteric properties of phosphofructokinase bound to erythrocyte membranes.

1977 • 98 citations

MECHANISMS ACTIVATING GLYCOLYSIS IN THE BRAIN IN ARTERIAL HYPOXIA

1974 • 98 citations

ENZYMES OF ENERGY-CONVERTING SYSTEMS IN INDIVIDUAL MAMMALIAN NERVE CELL BODIES

1973 • 96 citations

Studies on the Kinetic Mechanism and Allosteric Nature of Bovine Brain Hexokinase

1969 • 94 citations

Quantitative Studies of White Matter

1961 • 93 citations

Cerebral-cortex hexokinases. Elucidation of reaction mechanisms by substrate and dead-end inhibitor kinetic analysis

1971 • 82 citations

Local Cerebral Glucose Metabolism During Controlled Hypoxemia in Rats

1979 • 82 citations

Environmental impoverishment, social isolation and changes in brain chemistry and anatomy

1966 • 79 citations

The localization of latent brain hexokinase on synaptosomal mitochondria

1972 • 75 citations

Brain hexokinase: the preparation of inner and outer mitochondrial membranes

1969 • 74 citations

The surface fine structure of the choroid plexus and ependymal lining of the rat lateral ventricle

1974 • 72 citations

MICRODETERMINATION OF α-KETO ACIDS WITH SPECIAL REFERENCE TO MALIC, LACTIC, AND GLUTAMIC DEHYDROGENASES IN BRAIN

1956 • 72 citations

Studies on the mechanism of orthophosphate regulation of bovine brain hexokinase.

1975 • 71 citations

Specificity for the glucose-6-P inhibition site of hexokinase

1974 • 71 citations

Biochemistry and Neurological Disease

1977 • 71 citations

Insulin Effects on Brain Energy Metabolism and the Related Hexokinase Distribution

1974 • 70 citations

The subcellular distribution and properties of hexokinases in the guinea-pig cerebral cortex

1967 • 70 citations

Bovine Brain Mitochondrial Hexokinase

1972 • 70 citations

Regulatory Mechanisms in Carbohydrate Metabolism

1965 • 67 citations

The Isolation and Purification of Solubilized Hexokinase from Bovine Brain^*

1967 • 66 citations

Effect of neutral salts on the interaction of rat brain hexokinase with the outer mitochondrial membrane

1977 • 62 citations

Kinetic enhancement of bound hexokinase activity by mitochondrial respiration

1972 • 62 citations

Rat brain hexokinase: A kinetic comparison of soluble and particulate forms

1970 • 61 citations

Product Inhibition of the Hexokinases

1970 • 60 citations

LOCALIZATION OF HEXOKINASE IN NEURAL TISSUE: LIGHT MICROSCOPIC STUDIES WITH IMMUNOFLUORESCENCE AND HISTOCHEMICAL PROCEDURES

1977 • 59 citations

Hexokinase binding sites on mitochondrial membranes

1970 • 53 citations

The latent hexokinase activity of rat brain mitochondria

1967 • 50 citations

Cerebral-cortex hexokinase. Comparison of properties of solubilized mitochondrial and cytoplasmic activities

1970 • 50 citations

Enzymes in intracellular organelles of adult and developing rat brain

1974 • 48 citations

Bioflavonoid regulation of ATPase and hexokinase activity in ehrlich ascites cell mitochondria

1977 • 46 citations

Studies on the kinetics and mechanism of orthophosphate activation of bovine brain hexokinase

1974 • 45 citations

ANAEROBIC GLYCOLYSIS IN NERVOUS TISSUE

1945 • 42 citations

Ligand-lnduced conformations of rat brain hexokinase: Effects of glucose-6-phosphate and inorganic phosphate

1973 • 42 citations

The Association of Brain Hexokinase with Mitochondrial Membranes and its Functional Implications

1970 • 39 citations

Effect of galactose on energy and phospholipid metabolism in the chick brain

1969 • 37 citations

Hexokinase Activity in Brain

1962 • 35 citations

METABOLIC CONTROL MECHANISMS IN MAMMALIAN SYSTEMS

1972 • 35 citations

Activation and Solubilization of Particle-Bound Hexokinase in Rat Brain

1967 • 35 citations

Mitochondrial hexokinase from small-intestinal mucosa and brain

1971 • 34 citations

Studies on the molecular weight and lipoprotein nature of glucose-6-phosphate solubilized rat brain hexokinase

1973 • 33 citations

A possible interrelationship between binding of hexokinase and the site of ATP formation in Krebs ascites cells

1969 • 32 citations

Brain hexokinase: immunohistochemical localization at the light microscopic level

1969 • 32 citations

Ligand-induced conformations of rat brain hexokinase: Studies with hexoses, hexose 6-phosphates, and nucleoside triphosphates leading to development of a new model for the enzyme

1978 • 32 citations

Kinetic studies of solubilized brain hexokinase with D-fructose as a substrate

1968 • 32 citations

Ligand-induced conformational changes of rat brain hexokinase: Their role in determining the substrate specificity for hexoses and inhibitory effectiveness of hexose 6-phosphates

1979 • 31 citations

Rat brain hexokinase: Glucose and glucose-6-phosphate binding sites and C-terminal amino acid of the purified enzyme

1974 • 31 citations

A study of the sulfhydryl groups of rat brain hexokinase

1974 • 31 citations

Effect of ligands on the reactivity of essential sulfhydryls in brain hexokinase. Possible interaction between substrate binding sites

1975 • 29 citations

Comparison of type I hexokinases from pig heart and kinetic evaluation of the effects of inhibitors

1979 • 28 citations

PROPERTIES OF MEMBRANE‐BOUND HEXOKINASE IN RAT BRAIN

1968 • 28 citations

Properties of the glucose 6-phosphate-solubilized brain hexokinase

1972 • 26 citations

Sequential control of hexokinase in ascites cells

1969 • 25 citations

Intracellular and submitochondrial localization of pig heart hexokinase

1975 • 23 citations

Soluble and participate hexokinase in developing neural systems

1974 • 23 citations

The effect of anesthesia on brain mitochondrial hexokinase

1977 • 21 citations

Studies on the mode of sugar-phosphate product inhibition of brain hexokinase

1976 • 21 citations

Solubilization of brain mitochondrial hexokinase by thiopental

1977 • 21 citations

Differences in catalytic properties between cerebral cytoplasmic and mitochondrial hexokinases

1977 • 18 citations

Effect of prenatally‐induced and postnatally‐maintained ketosis on β‐hydroxybutyrate dehydrogenase and hexokinase levels in the developing rat brain

1978 • 17 citations

Reaction of brain hexokinase with tetranitromethane: Oxidation of essential thiol groups

1977 • 17 citations

RECOVERY FROM GALACTOSE‐INDUCED NEUROTOXICITY IN THE CHICK BY THE ADMINISTRATION OF GLUCOSE¹

1973 • 15 citations

Histochemical studies on the morphology of the golgi apparatus and on the distribution of hexokinase, L-gulonolactone oxidase, xylulose reductases, and ascorbic acid in the locus coeruleus of the rabbit

1971 • 14 citations

Galactose Toxicity in the Chick: Hyperosmolality or Depressed Brain Energy Reserves?

1972 • 14 citations

Histochemical studies on the morphology of the golgi apparatus and on the enzymes of carbohydrate metabolism in various nuclei of the rat mesencephalon

1976 • 13 citations

Biochemistry and Neurological Disease

1978 • 13 citations

SOME PROPERTIES OF SOLUBLE AND SOLUBILIZED PARTICLE‐BOUND HEXOKINASE¹

1971 • 12 citations

Dansylation of tyrosine: Hindrance by N-ethylmorpholine and photodegradation of O-dansylated derivatives

1977 • 12 citations

Glucose 6-phosphate-solubilized hexokinase: Some electrophoretic properties

1974 • 11 citations

On the existence of a nucleotide-binding regulatory site on brain hexokinase

1978 • 10 citations

Histochemical studies on the distribution of some enzymes concerned with carbohydrate metabolism in the locus ceruleus, nucleus tractus mesencephalicus n. trigemini, nucleus dorsalis n. vagi and nucleus n. hypoglossi of the rat.

1975 • 10 citations

Brain mitochondrial hexokinase: Solubilization by adenine nucleotides and in coupled respiration

1973 • 9 citations

Histochemical studies on the morphology of the Golgi apparatus and on the distribution of hexokinase and some enzymes concerning vitamin C synthesis in the substantia nigra of the rabbit.

1972 • 8 citations

[Anaesthesia and intracellular distribution of cerebral hexokinase (author's transl)].

1978 • 8 citations

The molecular weight of rat brain hexokinases

1972 • 8 citations

BRAIN MITOCHONDRIAL HEXOKINASE AND ADENYLATE KINASE: EFFECT OF OSMOTIC CONDITIONS ON ENZYME ACTIVITIES

1972 • 8 citations

Extraction of mitochondrial proteins by volatile anesthetics

1978 • 7 citations

EFFECT OF FATTY ACIDS ON RAT BRAIN PARTICULATE HEXOKINASE

1978 • 7 citations

Histochemical studies on the distribution of hexokinase and several enzymes related to catecholamine production in the locus coeruleus of the squirrel monkey

1977 • 6 citations

The intracellular distribution of the latent hexokinase in brain

1970 • 6 citations

Differences in the apparent molecular weight of soluble and mitochondrial hexokinases of rat brain

1972 • 6 citations

Rat brain hexokinases of two different molecular sizes

1974 • 5 citations

Mitochondrial and cytosolic hexokinases in rat brain, with special reference to the change in experimental diabetes

1975 • 4 citations

EFFECT OF UNILATERAL VISUAL DEPRIVATION AND VISUAL STIMULATION ON THE ACTIVITIES OF GLUTAMATE DECARBOXYLASE, GABA‐α KETOGLUTARATE TRANSAMINASE, ASPARTATE AMINOTRANSFERASE AND HEXOKINASE OF THE OPTIC LOBE OF THE ADULT PIGEON

1976 • 3 citations

On the lipoprotein nature of glucose-6-phosphate-solubilized hexokinase from rat brain: A reevaluation

1976 • 2 citations