The Development of a Practical Total Synthesis of Natural and Unnatural Codeine, Morphine and Thebaine

The Pharmacological Basis of Therapeutics

1976 • 8,675 citations

Identification of two related pentapeptides from the brain with potent opiate agonist activity

1975 • 3,780 citations

The pharmacological basis of therapeutics

1981 • 2,853 citations

Opiate Receptor: Demonstration in Nervous Tissue

1973 • 2,364 citations

Stereospecific Binding of the Potent Narcotic Analgesic [ ³ H]Etorphine to Rat-Brain Homogenate

1973 • 1,055 citations

Problems of Drug Dependence

1969 • 970 citations

Characteristics of the “Receptor” for Narcotic Analgesics in Synaptic Plasma Membrane Fraction from Rat Brain

1973 • 426 citations

The Synthesis of Morphine

1956 • 307 citations

A novel opioid receptor site directed alkylating agent with irreversible narcotic antagonistic and reversible agonistic activities

1980 • 287 citations

Drug and Neurotransmitter Receptors in the Brain

1984 • 274 citations

Solubilization of active opiate receptors.

1980 • 199 citations

Central and peripheral endorphins: Basic and clinical aspects

1983 • 185 citations

THE SYNTHESIS OF MORPHINE

1952 • 172 citations

Stereospecific and Nonstereospecific Effects of (+)- and (—)-Morphine: Evidence for a New Class of Receptors?

1977 • 164 citations

Studies in the (+)-morphinan series. 5. Synthesis and biological properties of (+)-naloxone

1978 • 148 citations

Ueber das Morphium, eine neue salzfähige Grundlage, und die Mekonsäure, als Hauptbestandtheile des Opiums

1817 • 125 citations

Synthetic opium alkaloids and derivatives. A short total synthesis of (.+-.)-dihydrothebainone, (.+-.)-dihydrocodeinone, and (.+-.)-nordihydrocodeinone as an approach to a practical synthesis of morphine, codeine, and congeners

1980 • 114 citations

A rapid, high-yield conversion of codeine to morphine

1977 • 109 citations

Irreversible Ligands with High Selectivity Toward δ and μ Opiate Receptors

1983 • 108 citations

Long-acting opiate agonists and antagonists: 14-hydroxydihydromorphinone hydrazones

1980 • 103 citations

Central and Peripheral Endorphins: Basic and Clinical Aspects

1986 • 89 citations

Studies directed towards the total synthesis of morphine alkaloids

1982 • 82 citations

Identification of a M_r 58 000 glycoprotein subunit of the opiate receptor

1982 • 81 citations

Biomimetic total synthesis of (−)-codeine

1983 • 79 citations

A crystallographic examination of the structure of morphine

1955 • 68 citations

Expedient synthesis of racemic and optically active N-norreticuline and N-substituted and 6'-bromo-N-norreticulines

1980 • 59 citations

A practical synthesis of codeine from dihydrothebainone

1976 • 55 citations

Die Cyclisierung von Octahydro‐isochinolinderivaten durch Morphinan‐Ringschluß. Synthese des Dihydrothebainons

1967 • 54 citations

Codeine analogs. Synthesis of 4a-aryldecahydroisoquinolines containing nitrogen ring functionality and of octahydro-1H-indeno[1,2,3-ef]isoquinolines. A total synthesis of codeine

1983 • 51 citations

Phenol oxidation and biosynthesis. Part XII. Stereochemical studies related to the biosynthesis of the morphine alkaloids

1967 • 50 citations

XLIX.—On the action of organic acids and their anhydrides on the natural alkaloïds. Part I

1874 • 48 citations

THE SYNTHESIS OF MORPHINE

1954 • 47 citations

An Opiate Binding Site in the Rat Brain Is Highly Selective for 4,5-Epoxymorphinans

1983 • 42 citations

Studies in the (+)-morphinan series. 4. A markedly improved synthesis of (+)-morphine

1978 • 39 citations

Über die absolute Konfiguration des Morphins und verwandter Alkaloide

1955 • 38 citations

Darstellung der reinen Mohnsäure (Opiumsäure) nebst einer chemischen Untersuchung des Opiums mit vorzüglicher Hinsicht auf einen darin neu entdeckten Stoff und die dahin gehörigen Bemerkungen

1925 • 37 citations

Studies in the (+)-Morphinan Series I. An Alternative Conversion of (+)-Dihydrocodeinone into (+)-Codeine

1977 • 34 citations

XXVIII.—On the action of the organic acids and their anhydrides on the natural alkaloïds. Part V

1876 • 33 citations

Biomimetic approaches to morphine alkaloids. Total synthesis of (.+-.)-2-hydroxycodeine and (.+-.)-noroxycodone

1981 • 32 citations

Synthesis of racemic and chiral codeine and morphine via the dihydrothebainones. (Chemistry of opium alkaloids, Part XI)

1979 • 31 citations

An alternate route in the synthesis of morphine

1967 • 30 citations

The Morphine Alkaloids

1965 • 27 citations

CCCCXXXVIII.—Preliminary synthetical experiments in the morphine group. Part I

1931 • 26 citations

Pavinan and isopavinan alkaloids. Synthesis of racemic and natural thalidine, bisnorargemonine, and congeners from N-norreticuline

1980 • 26 citations

Neurotransmitter receptor binding and drug discovery

1983 • 22 citations

Investigation of the grewe codeine method. Attempts to achieve a practical synthesis

1974 • 18 citations

Teilsynthesen in der Morphinreihe: I. Der Übergang aus der Dihydrothebainonin die Dihydrokodeinon‐Reihe

1930 • 16 citations

THE SYNTHESIS OF RACEMIC β-Δ⁶-DIHYDRODESOXYCODEINE METHYL ETHER

1950 • 15 citations

Studies on the Synthesis of Morphine VI*

1983 • 10 citations

(+)-Codeine and (+)-Morphine from Sinomenine

1954 • 9 citations

The biosynthesis and synthesis of morphine alkaloids.

1963 • 9 citations

ChemInform Abstract: CODEINE ANALOGS. SYNTHESIS OF 4A‐ARYLDECAHYDROISOQUINOLINES CONTAINING NITROGEN RING FUNCTIONALITY AND OF OCTAHYDRO‐1H‐INDENO(1,2,3‐EF)ISOQUINOLINES. A TOTAL SYNTHESIS OF CODEINE

1983 • 6 citations

Colchicine Studies. II. Synthesis of 2-(2',3',4'-Trimethoxyphenyl)-cyclohept-2-enone

1954 • 5 citations

Ueber eine neue Methode zur Abscheidung des Morphiums aus dem Opium

1833 • 3 citations

V.—Hydroxycodeine: a new alkaloid from opium

1911 • 3 citations

The Opium Problem.

1928 • 1 citations