Cytochrome P-450 — Its Function in the Oxidative Metabolism of Drugs

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 3,435 citations

Spectral studies of drug interaction with hepatic microsomal cytochrome.

1967 • 1,126 citations

DETOXICATION MECHANISMS

1960 • 760 citations

A New Cytochrome in Liver Microsomes

1962 • 658 citations

Pigments of rat liver microsomes

1958 • 634 citations

Advances in Enzymology

1963 • 606 citations

Oxidases and Related Redox Systems

1975 • 596 citations

BIOGENESIS OF ENDOPLASMIC RETICULUM MEMBRANES

1966 • 581 citations

Adaptive increases in drug-metabolizing enzymes induced by phenobarbital and other drugs.

1960 • 511 citations

Photochemical Action Spectrum of the Terminal Oxidase of Mixed Function Oxidase Systems

1965 • 503 citations

Microsomes and drug oxidation

1969 • 451 citations

A Soluble Cytochrome P-450 Functional in Methylene Hydroxylation

1968 • 438 citations

Studies on pig liver microsomes. I. Enzymic and pigment composition of different microsomal fractions

1958 • 433 citations

Evidence for a new P-450 hemoprotein in hepatic microsomes from methylcholanthrene treated rats

1966 • 418 citations

Pigments of rat liver microsomes

2002 • 416 citations

METABOLISM OF THE STEROID HORMONES

1942 • 413 citations

The metabolism of methylated aminoazo dyes. V. Evidence for induction of enzyme synthesis in the rat by 3-methylcholanthrene.

1956 • 393 citations

Drug interaction with hepatic microsomal cytochrome.

1966 • 335 citations

Studies on the induction of CO-binding pigments in liver microsomes by phenobarbital and 3-methylcholanthrene

1967 • 334 citations

The enzymatic metabolism of hexobarbital (evipal).

1955 • 295 citations

Studies on the rate of reduction of hepatic microsomal cytochrome P-450 by reduced nicotinamide adenine dinucleotide phosphate: effect of drug substrates.

1969 • 275 citations

HYDROXYLATION OF STEROIDS AT CARBON 21

1957 • 272 citations

Detoxication of Drugs and Other Foreign Compounds by Liver Microsomes

1955 • 255 citations

Cytochrome P-450 of liver microsomes—One pigment or many

1968 • 224 citations

Induction of drug metabolism. I. Differences in the mechanisms by which polycyclic hydrocarbons and phenobarbital produce their inductive effects on microsomal N-demethylating systems.

1969 • 218 citations

[12] Techniques for the assay of the respiratory enzymes

1957 • 217 citations

THE METABOLISM OF METHYLATED AMINOAZO DYES

1954 • 214 citations

Phenobarbital-induced synthesis of the oxidative demethylating enzymes of rat liver microsomes

1964 • 190 citations

THE LIGHT REVERSIBLE CARBON MONOXIDE INHIBITION OF THE STEROID C21-HYDROXYLASE SYSTEM OF THE ADRENAL CORTEX.

1963 • 189 citations

Substrate interaction with hydroxylase system in liver microsomes

1966 • 183 citations

Succinic dehydrogenase-cytochrome system of cells intracellular respiratory system catalysing aerobic oxidation of succinic acid

1940 • 148 citations

Heavy Metal Prosthetic Groups and Enzyme Action

1950 • 144 citations

Spectrophotometric properties of a triton-clarified steroid 21-Hydroxylase system of adrenocortical microsomes

1965 • 121 citations

The metabolism of methylated aminoazo dyes. VI. Intracellular distribution and properties of the demethylase system.

1957 • 121 citations

Biphasic Decrease of Radioactive Hemoprotein from Liver Microsomal CO-binding Particles

1969 • 105 citations

On the mechanism of the C-11β-hydroxylatlon of steroids; a study with H2O18 and O218

1955 • 104 citations

A Hemochromogen Component of Liver Microsomes

1952 • 103 citations

Microsomal mixed-function oxidations: the metabolism of xenobiotics.

1965 • 95 citations

The Stoichiometry of C21 Hydroxylation of Steroids by Adrenocortical Microsomes

1963 • 89 citations

An Electron Spin Resonance Study of Microsomal Electron Transport

1962 • 88 citations

The metabolic fate of phenylbutazone (butazolidin) in man.

1955 • 83 citations

CYTOCHROME b5 AND THE DIHYDROCOENZYME I-OXIDASE SYSTEM IN THE CECROPIA SILKWORM

1954 • 62 citations

EPR measurements of substrate interaction with cytochrome P-450

1966 • 55 citations

Spectrophotometric studies of interactions between various substrates in their binding to microsomal cytochrome P-450

1969 • 53 citations

KINETICS OF CYTOCHROME b5 IN RAT LIVER MICROSOMES

1954 • 51 citations

Induction of drug metabolism. 3. Further information of a new P-450 hemoprotein after treatment of rats with 3-methylcholanthrene.

1969 • 48 citations

KINETIC AND SPECTROPHOTOMETRIC STUDIES OF CYTOCHROME b5 IN MIDGUT HOMOGENATES OF CECROPIA

1954 • 43 citations

ORGANIZATION OF THE MICROSOMAL ELECTRON TRANSPORT SYSTEM

1969 • 37 citations

The Role of Cytochrome P-450 in Microsomal Mixed Function Oxidation Reactions

1968 • 36 citations

The redox potential of liver cytochrome P-450

1970 • 27 citations

[Mechanism of oxygen metabolism].

1971 • 20 citations

Cytochrome P-420: Tubular Aggregates from Hepatic Microsomes

1969 • 17 citations

Dpnh and ionic strength as positive effectors of microsomal mixed function oxidations

1970 • 4 citations

Steady state of cytochrome p 450 of liver microsomes during drug hydroxylation reactions

1970 • 2 citations