Protein Kinases and Phosphatases

Calmodulin Plays a Pivotal Role in Cellular Regulation

1980 • 2,441 citations

Phosphorylation-Dephosphorylation of Enzymes

1979 • 2,205 citations

Brain energy metabolism

1978 • 1,448 citations

Handbook of Neurochemistry

1972 • 1,374 citations

Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.

1980 • 1,317 citations

The neurosciences. Fourth study program

1980 • 1,165 citations

Calcium-dependent activation of a multifunctional protein kinase by membrane phospholipids.

1979 • 1,139 citations

Purification and Characterization of a Protein Inhibitor of Adenosine 3',5'-Monophosphate-dependent Protein Kinases

1971 • 892 citations

Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. II. Proenzyme and its activation by calcium-dependent protease from rat brain.

1977 • 865 citations

The distribution and dissociation of cyclic adenosine 3':5'-monophosphate-dependent protein kinases in adipose, cardiac, and other tissues.

1975 • 758 citations

Unsaturated diacylglycerol as a possible messenger for the activation of calcium-activated, phospholipid-dependent protein kinase system

1979 • 727 citations

Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. I. Purification and characterization of an active enzyme from bovine cerebellum.

1977 • 587 citations

Comparison of adenosine 3':5'-monophosphate-dependent protein kinases from rabbit skeletal and bovine heart muscle.

1975 • 569 citations

Calcium-dependent protein kinase: widespread occurrence in various tissues and phyla of the animal kingdom and comparison of effects of phospholipid, calmodulin, and trifluoperazine.

1980 • 568 citations

Cyclic AMP-dependent endogenous phosphorylation of a microtubule-associated protein.

1975 • 551 citations

Cyclic Nucleotide-dependent Protein Kinases

1969 • 551 citations

The neurosciences : fourth study program

1979 • 521 citations

Modulator protein as a component of the myosin light chain kinase from chicken gizzard

1978 • 488 citations

Studies on the properties and mode of action of the purified regulatory subunit of bovine heart adenosine 3‘:5‘-monophosphate-dependent protein kinase.

1978 • 467 citations

Inhibitory action of chlorpromazine, dibucaine, and other phospholipid-interacting drugs on calcium-activated, phospholipid-dependent protein kinase.

1980 • 464 citations

Concerted regulation of cardiac sarcoplasmic reticulum calcium transport by cyclic adenosine monophosphate dependent and calcium-calmodulin-dependent phosphorylations

1979 • 454 citations

Adenosine 3':5'-monophosphate-regulated phosphoprotein system of neuronal membranes. I. Solubilization, purification, and some properties of an endogenous phosphoprotein.

1977 • 411 citations

Depolarization-induced phosphorylation of specific proteins, mediated by calcium ion influx, in rat brain synaptosomes.

1977 • 393 citations

Ca2+-dependent protein phosphorylation system in membranes from various tissues, and its activation by "calcium-dependent regulator".

1978 • 346 citations

Stimulation of Ca ²⁺ -dependent neurotransmitter release and presynaptic nerve terminal protein phosphorylation by calmodulin and a calmodulin-like protein isolated from synaptic vesicles

1979 • 346 citations

Cyclic Nucleotide-dependent Protein Kinases

1970 • 334 citations

Identification of an activator protein for myosin light chain kinase as the Ca2+-dependent modulator protein.

1978 • 311 citations

Two calcium/calmodulin-dependent protein kinases, which are highly concentrated in brain, phosphorylate protein I at distinct sites.

1981 • 296 citations

Direct phosphorylation of brain tyrosine hydroxylase by cyclic AMP-dependent protein kinase: mechanism of enzyme activation.

1978 • 286 citations

Multiple phosphorylation sites in protein I and their differential regulation by cyclic AMP and calcium.

1979 • 284 citations

Immunohistochemical localization of cyclic GMP-dependent protein kinase in mammalian brain.

1981 • 279 citations

The Role of Calmodulin in the Structure and Regulation of Phosphorylase Kinase from Rabbit Skeletal Muscle

1979 • 267 citations

PHOSPHOLIPIDS IN SYNAPTIC FUNCTION

1979 • 235 citations

A new activator protein that activates tryptophan 5-monooxygenase and tyrosine 3-monooxygenase in the presence of Ca2+-, calmodulin-dependent protein kinase. Purification and characterization.

1981 • 234 citations

Differential phosphorylation of multiple sites in purified protein I by cyclic AMP-dependent and calcium-dependent protein kinases.

1981 • 233 citations

Cyclic Nucleotides, Phosphorylated Proteins, And Neuronal Function

1978 • 216 citations

Subcellular Distribution of Adenosine 3',5'-Monophosphate-dependent Protein Kinase in Rat Brain

1971 • 208 citations

Purification and Some Characteristics of an ACTH‐Sensitive Protein Kinase and Its Substrate Protein in Rat Brain Membranes

1980 • 202 citations

Protein Phosphorylation Catalyzed by Cyclic AMP-Dependent and Cyclic GMP-Dependent Protein Kinases

1980 • 201 citations

Subcellular distribution in cerebral cortex of two proteins phosphorylated by a cAMP-dependent protein kinase.

1979 • 200 citations

Characterization and comparison of membrane-associated and cytosolic cAMP-dependent protein kinases. Physicochemical and immunological studies on bovine cerebral cortex protein kinases.

1979 • 188 citations

Modulation of brain polyphosphoinositide metabolism by ACTH-sensitive protein phosphorylation

1980 • 178 citations

Nuclear Protein Kinases

1974 • 175 citations

Myosin light‐chain kinase, a new enzyme from striated muscle

1974 • 170 citations

Phosphoprotein Phosphatases from Rat Cerebral Cortex

1972 • 169 citations

Purification and subunit composition of guanosine 3':5'-monophosphate-dependent protein kinase from bovine lung.

1977 • 167 citations

Nuclear protein kinases. Evidence for their heterogeneity, tissue specificity, substrate specificities, and differential responses to cyclic adenosine 3':5'-monophosphate.

1974 • 167 citations

Regulation of pyruvate metabolism in mammalian tissues.

1979 • 166 citations

Mechanisms by which diazepam, muscimol, and other drugs change the content of cGMP in cerebellar cortex

1977 • 165 citations

Adenosine 3′:5′-cyclic monophosphate- and guanosine 3′:5′-cyclic monophosphate-dependent protein kinases: Possible homologous proteins

1977 • 158 citations

Recently discovered systems of enzyme regulation by reversible phosphorylation

1980 • 156 citations

Comparison of the substrate specificity of adenosine 3':5'-monophosphate- and guanosine 3':5'-monophosphate-dependent protein kinases. Kinetic studies using synthetic peptides corresponding to phosphorylation sites in histone H2B.

1979 • 152 citations

Studies on the sites in histones phosphorylated by adenosine 3':5'-monophosphate-dependent and guanosine 3':5'-monophosphate-dependent protein kinases.

1976 • 152 citations

Brain postsynaptic densities: the relationship to glial and neuronal filaments.

1980 • 146 citations

An endogenous substrate for cGMP-dependent protein kinase in mammalian cerebellum

1978 • 140 citations

Interaction of calmodulin with myosin light chain kinase and cAMP-dependent protein kinase in bovine brain.

1981 • 137 citations

Immunocytochemical localization, in synapses, of protein I, an endogenous substrate for protein kinases in mammalian brain.

1979 • 135 citations

Calmodulin and myosin light-chain kinase of rabbit fast skeletal muscle

1979 • 133 citations

Stimulation by phosphatidylserine and calmodulin of calcium-dependent phosphorylation of endogenous proteins from cerebral cortex.

1980 • 132 citations

Function of calmodulin in postsynaptic densities. II. Presence of a calmodulin- activatable protein kinase activity

1981 • 131 citations

Protein phosphorylation

1979 • 124 citations

Immunological distinction between guanosine 3':5'-monophosphate-dependent and adenosine 3':5'-monophosphate-dependent protein kinases.

1980 • 121 citations

Adenosine 3‘:5‘-monophosphate receptor proteins in mammalian brain.

1978 • 117 citations

Localization of cyclic GMP-dependent protein kinase and substrate in mammalian cerebellum.

1980 • 113 citations

Ontogeny of synaptic phosphoproteins in brain.

1978 • 113 citations

Distribution of protein I in mammalian brain as determined by a detergent-based radioimmunoassay.

1981 • 109 citations

Widespread distribution of protein I in the central and peripheral nervous systems.

1979 • 108 citations

Turnover of protein-bound phosphorylserine in membrane preparations from ox brain catalysed by intrinsic kinase and phosphatase activity

1971 • 108 citations

Brain Energy Metabolism

1979 • 107 citations

Guanosine 3':5'-monophosphate-dependent protein kinase from bovine lung. Subunit structure and characterization of the purified enzyme.

1977 • 103 citations

Identification of two subclasses of type II cAMP-dependent protein kinases. Neural-specific and non-neural protein kinases.

1980 • 102 citations

Guanosine 3':5'-monophosphate-dependent protein kinase from bovine cerebellum. Purification and characterization.

1975 • 98 citations

Adenosine 3':5'-monophosphate-regulated phosphoprotein system of neuronal membranes. II. Solubilization, purification, and some properties of an endogenous adenosine 3':5'-monophosphate-dependent protein kinase.

1977 • 95 citations

Endogenous protein kinase inhibitors. Purification, characterization, and distribution in different tissues.

1977 • 92 citations

Phosphorylation of myelin basic protein by an adenosine 3′:5′-cyclic monophosphate-dependent protein kinase (Short Communication)

1973 • 90 citations

Identification of endogenous substrate proteins for cAMP-dependent protein kinase in bovine brain.

1980 • 90 citations

GLYCOGEN PHOSPHORYLASE IN BRAIN*

1962 • 89 citations

Regulation of bovine adrenal tyrosine 3-monooxygenase by phosphorylation-dephosphorylation reaction, catalyzed by adenosine 3‘:5‘-monophosphate-dependent protein kinase and phosphoprotein phosphatase.

1979 • 83 citations

Activation of tryptophan 5-monooxygenase by calcium-dependent regulator protein

1979 • 81 citations

Trifluoperazine inhibits hippocampal long-term potentiation and the phosphorylation of a 40,000 dalton protein

1980 • 81 citations

IN VIVO CHANGES OF CEREBRAL CYCLIC ADENOSINE 3′,5′‐MONOPHOSPHATE INDUCED BY BIOGENIC AMINES: ASSOCIATION WITH PHOSPHORYLASE ACTIVATION

1974 • 79 citations

Ca2+ and cyclic AMP regulate phosphorylation of same two membrane-associated proteins specific to nerve tissue.

1979 • 77 citations

Phosphorylative and functional modifications of nucleoplasmic RNA polymerase II by homologous adenosine 3':5'-monophosphate-dependent protein kinase from calf thymus and by heterologous phosphatase.

1977 • 76 citations

Presynaptic localization of phosphoprotein B-50

1981 • 75 citations

Hormonal control of protein phosphorylation in turkey erythrocytes. Phosphorylation by cAMP-dependent and Ca2+-dependent protein kinases of distinct sites in goblin, a high molecular weight protein of the plasma membrane.

1980 • 74 citations

Activation of brain tryptophan hydroxylase by ATP-MG2+: dependence on calmodulin.

1980 • 74 citations

Immunohistochemical localization of a phosphoprotein (B-50) isolated from rat brain synaptosomal plasma membranes

1981 • 72 citations

PROTEIN PHOSPHORYLATION IN SYNAPTIC MEMBRANES REGULATED BY ADENOSINE 3′:5′‐MONOPHOSPHATE: REGIONAL AND SUBCELLULAR DISTRIBUTION OF THE ENDOGENOUS SUBSTRATES

1979 • 69 citations

Cyclic GMP-dependent protein phosphorylation in intact medial tissue and isolated cells from vascular smooth muscle.

1980 • 68 citations

Phosphorylation‐Mediated Changes in Pyruvate Dehydrogenase Activity Influence Pyruvate‐Supported Calcium Accumulation by Brain Mitochondria

1981 • 68 citations

Differences in properties of cytosol and membrane-derived protein kinases.

1976 • 68 citations

Cyclic AMP regulation of lactate dehydrogenase. Isoproterenol and N6,O2'-dibutyryl cyclic AMP increase the levels of lactate dehydrogenase-5 isozyme and its messenger RNA in rat C6 glioma cells.

1980 • 68 citations

A guanosine 3‘:5‘-monophosphate-dependent protein kinase from bovine heart muscle. Purification and phosphorylation of histone I and IIb.

1978 • 67 citations

Cyclic AMP-stimulated protein kinases at brain synaptic junctions.

1979 • 67 citations

Phosphorylation of calf thymus H1 histone by calcium-activated, phospholipid-dependent protein kinase

1980 • 66 citations

Evidence that the 40,000 Mr phosphoprotein influenced by high frequency synaptic stimulation is the alpha subunit of pyruvate dehydrogenase

1981 • 65 citations

Protein Kinase Modulator from Lobster Tail Muscle

1973 • 64 citations

Study of autophosphorylation of isoenzymes of cyclic AMP-dependent protein kinases.

1977 • 61 citations

Phosphoproteins in Postsynaptic Densities

1982 • 60 citations

Autophosphorylation of cGMP-dependent protein kinase.

1981 • 60 citations

Activation of phosphorylase kinase from brain by small amounts of calcium ion

1973 • 59 citations

Effect of Cyclic AMP‐Dependent Protein Phosphorylating Conditions on the pH‐Dependent Activity of Tyrosine Hydroxylase from Beef and Rat Striata

1981 • 57 citations

Studies on the cell location of cyclic 3′,5′-guanosine monophosphate-dependent protein kinase in cerebellum

1978 • 56 citations

Calcium ion stimulated endogenous protein kinase catalyzed phosphorylation of basic proteins in myelin subfractions and myelin-like membrane fraction from rat brain

1980 • 55 citations

The Hormonal Control of Glycogen Metabolism in Mammalian Muscle by Multivalent Phosphorylation

1979 • 55 citations

STUDIES ON PHOSPHORYLASE b KINASE FROM NEUTRAL TISSUES

1970 • 51 citations

Phosphorylase kinase phosphorylates a brain protein which is influenced by repetitive synaptic activation

1979 • 51 citations

Occurrence of Two Types of Ca2+-Dependent Protein Kinases in the Cytosol Fraction of the Brain

1981 • 50 citations

Aspects of Protein Phosphorylation in the Nervous System with Particular Reference to Synaptic Transmission

1982 • 49 citations

Membrane Phospholipid Turnover, Receptor Function and Protein Phosphorylation

1982 • 49 citations

Protein kinase translocation following beta-adrenergic receptor activation in C6 glioma cells.

1980 • 49 citations

Calf brain phosvitin kinase. II. Purification and characterization of three different fractions of phosvitin kinase

1973 • 48 citations

Molecular properties and mode of action of homogeneous preparation of stimulatory modulator of cyclic GMP-dependent protein kinase from the heart.

1978 • 47 citations

B-50 Protein Kinase and Kinase C in Rat Brain

1982 • 46 citations

CYCLIC NUCLEOTIDES IN MURINE BRAIN: EFFECT OF HYPOTHERMIA ON ADENOSINE 3′,5’ MONOPHOSPHATE, GLYCOGEN PHOSPHORYLASE, GLYCOGEN SYNTHASE AND METABOLITES FOLLOWING MAXIMAL ELECTROSHOCK OR DECAPITATION

1976 • 45 citations

Regulatory and functional compartment of three multifunctional protein kinase systems

1979 • 45 citations

Calcium-regulated phosphorylation in synaptosomal cytosol: dependence on calmodulin.

1980 • 44 citations

Solubilization of a phosphoprotein and its associated cyclic AMP-dependent protein kinase and phosphoprotein phosphatase from synaptic membrane fractions, and some kinetic evidence for their existence as a complex

1975 • 42 citations

Regulation of rat brainstem tryptophan 5-monooxygenase. Calcium-dependent reversible activation by ATP and magnesium

1979 • 42 citations

Intrinsic protein phosphorylation in synaptic plasma membrane fragments from the rat General characteristics and migration behaviour on polyacrylamide gels of the main phosphate acceptors

1982 • 41 citations

MULTIPLE FORMS OF PROTEIN KINASES IN MYELIN AND MICROSOMAL FRACTIONS OF BOVINE BRAIN

1978 • 41 citations

Molecular and Physiopathologic Aspects of Mammalian Cyclic GMP-Dependent Protein Kinase

1978 • 41 citations

Identification of the cyclic AMP-dependent protein kinase responsible for endogenous phosphorylation of substrate proteins in synaptic membrane fraction from rat brain.

1979 • 39 citations

Evidence for the presynaptic location of adenylate cyclase and the cyclic AMP-stimulated protein kinase which is bound to synaptic membranes

1977 • 38 citations

Phosphoprotein phosphatases for myelin basic protein in myelin and cytosol fractions of brain

1975 • 38 citations

Neuronal localization of specific brain phosphoproteins

1978 • 36 citations

Localization in the synaptic junction of the cyclic amp stimulated intrinsic protein kinase activity of synaptosomal plasma membranes

1976 • 35 citations

Stimulatory modulator of guanosine 3′:5′-monophosphate-dependent protein kinase from mammalian tissues

1976 • 35 citations

Calmodulin-dependent myosin light chain kinases

1981 • 35 citations

Isolation and properties of the bovine brain protein inhibitor of adenosine 3′:5′‐monophosphate‐dependent protein kinases

1978 • 34 citations

Ribosomal protein phosphorylation in rat cerebral cortex in vitro. Influence of cyclic adenosine 3‘:5‘-monophosphate.

1978 • 33 citations

Calcium ion-stimulated phosphorylation of myelin proteins

1980 • 33 citations

MYELIN BASIC PROTEIN PHOSPHATASE ACTIVITY IN RAT BRAIN

1977 • 33 citations

Ontogeny of Membrane-Bound Protein Phosphorylating Systems in the Rat

1981 • 32 citations

Regulatory Mechanisms of Synaptic Transmission

1981 • 31 citations

Protein phosphorylation in isolated plasma membranes and postsynaptic junctional structures from brain synapses

1979 • 29 citations

Nuclear translocation of cyclic AMP-dependent protein kinase subunits during the transsynaptic activation of gene expression in rat adrenal medulla.

1979 • 26 citations

Neuronal Localization of Ca²⁺‐dependent Protein Phosphorylation in Brain

1980 • 23 citations

Calf brain phosvitin kinase

1972 • 22 citations

Comparison of cAMP and cGMP-dependent protein kinases.

1978 • 21 citations

DO PHOSPHORYLATED PROTEINS REGULATE GENE ACTIVITY?

1975 • 19 citations

Phosphorylation of multiple proteins of both ribosomal subunits in rat cerebral cortex in vivo. Effect of adenosine 3′:5′-cyclic monophosphate

1979 • 19 citations

Protein phosphorylation in nuclei of adrenal medulla incubated with cyclic adenosine 3‘:5‘-monophosphate-dependent protein kinase

1977 • 18 citations

Ontogenetic studies of cGMP‐dependent protein kinase in rat cerebellum

1979 • 17 citations

The occurrence of myosin light chain kinase in non-muscle tissues

1981 • 17 citations

Studies of subunit structure of phosvitin kinase FII from bovine brain

1979 • 15 citations

Solubilization and partial characterization of a phosphoprotein phosphatase from human myelin

1978 • 15 citations

Microheterogeneity of adenosine cyclic monophosphate-dependent protein kinases from mouse brain and heart

1978 • 14 citations

Enzyme systems involved in phosphorylation and dephosphorylation of two endogenous phosphoproteins in neuronal membranes

1977 • 14 citations

Calcium, Calmodulin, and Synaptic Function: Modulation of Neurotransmitter Release, Nerve Terminal Protein Phosphorylation, and Synaptic Vesicle Morphology by Calcium and Calmodulin

1981 • 13 citations

Presence of Protein I, a Phosphoprotein Associated with Synaptic Vesicles, in Cerebellar Granule Cells

1981 • 13 citations

Translocation of cytosol protein kinase into nuclei and the induction of tyrosine hydroxylase in NBD-2 neuroblastoma cells

1979 • 12 citations

Phosphorylation of Chromatin Proteins in Cerebral Anoxia and Ischemia

1980 • 10 citations

Cyclic nucleotide-dependent phosphorylation of endogenous proteins in bovine adrenocortical cell membranes

1981 • 10 citations

<b>DEVELOPMENTAL CHANGE IN ACTIVITY OF PROTEIN KINASES IN RAT </b><b>BRAIN </b>

1980 • 8 citations

Intrinsic Protein Phosphorylation in Synaptosomal Plasma Membrane Fragments: A Comparison of Cerebral Cortex Tissue from Several Species, Including Human Biopsy Specimens

1982 • 7 citations

SUBCELLULAR DISTRIBUTION OF A HEAT‐STABLE PROTEIN INHIBITOR OF CYCLIC AMP‐DEPENDENT PROTEIN KINASE IN RAT BRAIN

1977 • 6 citations

Distribution of Protein I, a Synapse‐Specific Phosphoprotein, and Adenylate Cyclase in the Rat Spinal Cord

1981 • 6 citations

PHOSPHORYLATION OF NUCLEAR PROTEINS FROM RABBIT CEREBRUM, CEREBELLUM AND LIVER IN VITRO

1978 • 5 citations

PHOSPHOPROTEIN PHOSPHATASE OF PINEAL GLAND: SOME PROPERTIES OF THE ENZYME AND THE IDENTIFICATION OF AN ENDOGENOUS ACTIVATOR

1977 • 5 citations

Ca2+-sensitivity of Ca24 -plus-calmodulin-dependent protein kinase activity towards intrinsic proteins in synaptosomal membrane fragments from rat cerebral cortex

1982 • 3 citations

Deleted Work

1955 • 0 citations