Hydroxylases, Monooxygenases, and Cytochrome P-450

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 3,435 citations

Some properties of a detergent-solubilized NADPH-cytochrome c(cytochrome P-450) reductase purified by biospecific affinity chromatography.

1976 • 1,180 citations

Pigments of rat liver microsomes

1958 • 634 citations

Role of Hemoprotein P-450 in Fatty Acid ω-Hydroxylation in a Soluble Enzyme System from Liver Microsomes

1968 • 625 citations

Oxidases and Related Redox Systems

1975 • 596 citations

Molecular Mechanisms of Oxygen Activation

1975 • 588 citations

Resolution of the Cytochrome P-450-containing ω-Hydroxylation System of Liver Microsomes into Three Components

1969 • 573 citations

Evidence for the participation of cytochrome b5 in hepatic microsomal mixed-function oxidation reactions

1971 • 559 citations

Properties of electrophoretically homogeneous phenobarbital-inducible and beta-naphthoflavone-inducible forms of liver microsomal cytochrome P-450

1976 • 536 citations

PHENOBARBITAL-INDUCED SYNTHESIS OF THE MICROSOMAL DRUG-METABOLIZING ENZYME SYSTEM AND ITS RELATIONSHIP TO THE PROLIFERATION OF ENDOPLASMIC MEMBRANES

1965 • 531 citations

Hydroxylation-Induced Migration: The NIH Shift

1967 • 519 citations

Photochemical Action Spectrum of the Terminal Oxidase of Mixed Function Oxidase Systems

1965 • 503 citations

Enzymatic Metabolism of Drugs and other Foreign Compounds

1958 • 501 citations

Phosphatidylcholine Requirement in the Enzymatic Reduction of Hemoprotein P-450 and in Fatty Acid, Hydrocarbon, and Drug Hydroxylation

1970 • 462 citations

Studies on pig liver microsomes. I. Enzymic and pigment composition of different microsomal fractions

1958 • 433 citations

The oxidation of drugs by liver microsomes: on the role of TPNH and oxygen.

1957 • 399 citations

Properties of hepatic reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase

1973 • 344 citations

Studies on hydroperoxide-dependent substrate hydroxylation by purified liver microsomal cytochrome P-450

1976 • 339 citations

MECHANISM OF THE PYROCATECHASE REACTION

1955 • 337 citations

The Metabolism of Aromatic Compounds in Higher Plants

1971 • 311 citations

OXYGEN TRANSFER AND ELECTRON TRANSPORT BY THE PHENOLASE COMPLEX¹

1955 • 308 citations

Studies on the rate of reduction of hepatic microsomal cytochrome P-450 by reduced nicotinamide adenine dinucleotide phosphate: effect of drug substrates.

1969 • 275 citations

Microsomes and Drug Oxidations

1978 • 256 citations

Detoxication of Drugs and Other Foreign Compounds by Liver Microsomes

1955 • 255 citations

The Structural Basis of Membrane Function

1976 • 253 citations

Biosynthesis and its Control in Plants

1973 • 232 citations

Oxytyrosinase

1974 • 200 citations

The Metabolism of Aromatic Compounds

1974 • 200 citations

Coordinated Induction and Subsequent Activity Changes of Two Groups of Metabolically Interrelated Enzymes. Light-Induced Synthesis of Flavonoid Glycosides in Cell Suspension Cultures of Petroselinum hortense

1976 • 196 citations

Microsomal-catalyzed hydroperoxide-dependent C-oxidation of amines

1973 • 193 citations

Inhibition of the TPNH-linked lipid peroxidation of liver microsomes by drugs undergoing oxidative demethylation

1964 • 191 citations

Structures and Functions of the Phenolase Complex

1956 • 187 citations

Preparation of homogeneous NADPH-cytochrome P-450 reductase from rat liver

1975 • 186 citations

Oxygenase-Catalyzed Biological Hydroxylations

1975 • 175 citations

Hydroperoxide catalyzed liver microsomal aromatic hydroxylation reactions involving cytochrome P-450

1974 • 173 citations

N-demethylation of substituted 3-(phenyl)-1-methylureas: Isolation and characterization of a microsomal mixed function oxidase from cotton

1969 • 165 citations

The role of mixed function oxidases in kaurene metabolism in Echinocystis macrocarpa greene endosperm

1969 • 148 citations

The 4-Hydroxylation of Cinnamic Acid by Sorghum Microsomes and the Requirement for Cytochrome P-450

1974 • 147 citations

Characterization of a cytochrome P-450 dependent monoterpene hydroxylase from the higher plant Vinca rosea

1976 • 144 citations

The cinnamic acid 4-hydraxylase of pea seedlings

1967 • 140 citations

Potato Phenolases

1965 • 138 citations

Properties of NADPH and oxygen-dependent zeaxanthin epoxidation in isolated chloroplasts

1975 • 136 citations

The Metabolism of the Gibberellins

1978 • 128 citations

Decarboxylation of alpha-ketoglutarate coupled to collagen proline hydroxylase.

1968 • 127 citations

Fat Metabolism in Higher Plants

1959 • 126 citations

Biosynthesis of cyanidin in cell cultures of Haplopappus gracilis

1975 • 122 citations

The P-450 Nature of the Carbon Monoxide Complex of Ferrous Chloroperoxidase

1973 • 121 citations

Studies on the Specificity and Site of Action of α-Cyclopropyl-α-[p-methoxyphenyl]-5-pyrimidine Methyl Alcohol (Ancymidol), a Plant Growth Regulator

1978 • 120 citations

Properties of a Yeast Cytochrome P‐450‐Containing Enzyme System which Catalyzes the Hydroxylation of Fatty Acids, Alkanes, and Drugs

1973 • 116 citations

The Involvement of Cytochrome P-450 in Hepatic Microsomal Steroid Hydroxylation Reactions Supported by Sodium Periodate, Sodium Chlorite, and Organic Hydroperoxides

1976 • 115 citations

Microsomal electron transport reactions

1971 • 114 citations

Role of Cytochrome b5 in Hydroxylation by a Reconstituted Cytochrome P-450-containing System

1974 • 112 citations

Hydroxylation of geraniol and nerol by a monooxygenase from Vinca rosea

1973 • 110 citations

Oxygen Fixation into Hydroxyproline of Plant Cell Wall Protein

1963 • 109 citations

Abscisic Acid Metabolism by a Cell-free Preparation from Echinocystis lobata Liquid Endoserum

1976 • 107 citations

Hydroperoxide dependent O-dealkylation reactions catalyzed by liver microsomal cytochrome P450

1975 • 107 citations

Hydroxylation catalyzed by peroxidase

1961 • 104 citations

Inhibition of ent-Kaurene Oxidation and Growth by α-Cyclopropyl-α-(p-methoxyphenyl)-5-pyrimidine Methyl Alcohol

1976 • 104 citations

Hydroxylation: the activation of oxygen by peroxidase

1957 • 99 citations

Fat Metabolism in Higher Plants

1966 • 97 citations

Fat metabolism in higher plants

1974 • 92 citations

49. The biosynthesis of the gibberellins. Part I. (—)-Kaurene as a precursor of gibberellic acid

1964 • 92 citations

Wounding-induced cinnamic acid hydroxylase in Jerusalem artichoke tuber

1977 • 91 citations

Fractional solubilization of haemoproteins and partial purification of carbon monoxide-binding cytochrome from liver microsomes

1963 • 90 citations

Mechanisms and stereochemistry in fatty acid metabolism

1970 • 90 citations

The purification and properties of a ribonucleoenzyme, o-diphenol oxidase, from potatoes

1970 • 87 citations

Purification and multiplicity of catechol oxidase from apple chloroplasts

1965 • 86 citations

Cytochrome Components of Plant Microsomes

1975 • 86 citations

The 2-hydroxylation of trans-cinnamic acid by chloroplasts from Melilotus alba desr

1974 • 85 citations

Biosynthesis of Gibberellins

1967 • 80 citations

Hydroperoxide-dependent hydroxylation involving "H2O2-reducible hemoprotein" in microsomes of pea seeds. A new type enzyme acting on hydroperoxide and a physiological role of seed lipoxygenase.

1977 • 79 citations

CYTOCHROME COMPONENTS IN THE SPADIX OF ARUM MACULATUM

1956 • 79 citations

The hydroxylation of p-coumaric acid by an enzyme from leaves of spinach beet (Beta vulgaris L.)

1969 • 79 citations

Partial purification and properties of catechol oxidases in grapes

1971 • 78 citations

Immunochemical evidence for the participation of cytochrome b5 in the NADH synergism of the NADPH-dependent mono-oxidase system of hepatic microsomes

1974 • 77 citations

Biosynthesis of Cutin ω-Hydroxylation of Fatty Acids by a Microsomal Preparation from Germinating Vicia faba

1977 • 76 citations

Cinnamic acid hydroxylase in spinach

1965 • 75 citations

Reduced diphosphopyridine nucleotide synergism of the reduced triphosphopyridine nucleotide-dependent mixed-function oxidase system of hepatic microsomes. I. Effects of activation and inhibition of the fatty acyl coenzyme A desaturation system.

1973 • 74 citations

Mixed function oxidases from germinating castor bean endosperm

1976 • 73 citations

The action of o-dihydric phenols in the hydroxylation of p-coumaric acid by a phenolase from leaves of spinach beet (Beta vulgaris L.)

1970 • 73 citations

Hydorxyproline biosynthesis in plant cells Peptidyl proline hydroxylase from carrot disks

1971 • 73 citations

Activation of vicia faba (L.) tyrosinase as effected by denaturing agents

1966 • 73 citations

The mechanism of α-oxidation in leaves

1966 • 71 citations

Evidence for conformational changes in grape catechol oxidase

1972 • 70 citations

The possible involvement of cytochrome b5 in the oxidation of lauric acid by microsomes from kidney cortex and liver of rats

1974 • 67 citations

Biosynthesis of hydroxyfatty acid polymers

1975 • 67 citations

Subcellular localization of a cytochrome P-450-dependent monogenase in vesicles of the higher plant Catharanthus roseus

1977 • 67 citations

On the heterogeneity of the tyrosinase of broad bean (Vicia faba L.)

1965 • 67 citations

A highly purified preparation of cytochrome P-450 from microsomes of anaerobically grown yeast

1977 • 63 citations

Synthesis and Secretion of Hydroxyproline-containing Macromolecules in Carrots

1970 • 63 citations

Studies on the Enzymic Browning of Apples II. Properties of Apple Polyphenoloxidase

1964 • 63 citations

Interconversion of sub-units of catechol oxidase from apple chloroplasts

1968 • 59 citations

Reduced nicotinamide adenine dinucleotide-cytochrome b5 reductase and cytochrome b5 as electron carriers in NADH-supported cytochrome P-450-dependent enzyme activities in liver microsomes

1974 • 59 citations

Properties, development and cellular-localization of cinnamic acid 4-hydroxylase in cut-injured sweet potato<xref ref-type="fn" rid="fn1"><sup>1</sup></xref>

1974 • 59 citations

Ascorbic acid requirement for biosynthesis of hydroxyproline‐containing proteins in plants

1977 • 58 citations

Biochemistry and chemistry of plant growth regulators:

1977 • 58 citations

Biochemistry of lignification

1977 • 57 citations

Liver microsomal electron transport systems. III. The involvement of cytochrome b5 in the NADPH-supported cytochrome P-450-dependent hydroxylation of chlorobenzene

1974 • 56 citations

Multiple forms of Vitis vinifera catechol oxidase

1973 • 56 citations

Properties of the System for the Mixed Function Oxidation of Kaurene and Kaurene Derivatives in Microsomes of the Immature Seed of Marah macrocarpus

1976 • 54 citations

Simultaneous incorporation of 18O into succinate and hydroxyproline catalyzed by collagen proline hydroxylase

1971 • 53 citations

The peroxidase-catalysed oxidation of a chalcone and its possible physiological significance

1972 • 52 citations

Mechanism of .alpha.-ketoglutarate oxidation in coupled enzymic oxygenations

1969 • 52 citations

The role of hydroxygeraniol and hydroxynerol in the biosynthesis of loganin and indole alkaloids

1970 • 51 citations

Reduced diphosphopyridine nucleotide synergism of the reduced triphosphopyridine nucleotide-dependent mixed-function oxidase system of hepatic microsomes. II. Role of the type I drug-binding site of cytochrome P-450.

1973 • 50 citations

The Intracellular Location of Phenol Oxidases, Peroxidase and Phosphatases in the Leaves of Spinach Beet (Beta vulgaris L. Subspecies vulgaris)

1972 • 50 citations

Liver microsomal electron transport systems

1974 • 49 citations

Metabolism of phenolic substances by the chloroplasts-II.

1966 • 49 citations

Biophysical and Enzymological Studies upon the Interaction of trans‐Cinnamic Acid with Higher Plant Microsomal Cytochromes P‐450

1977 • 43 citations

The mechanism of ricinoleic acid biosynthesis in Ricinuscommunis seeds

1967 • 43 citations

Insect cytochrome P-450

1976 • 41 citations

Microsomal hydroxylation of ethylbenzene. Stereospecificity and the effect of phenobarbital induction

1966 • 39 citations

Properties of the System for the Mixed Function Oxidation of Kaurene and Kaurene Derivatives in Microsomes of the Immature Seed of Marah macrocarpus

1976 • 38 citations

Kinetic studies on the hydroxylation of p-coumaric acid to caffeic acid by spinach-beet phenolase

1975 • 38 citations

The enzymatic conversion of p-hydroxyphenylacetaldoxime to p-hydroxymandelonitrile

1977 • 37 citations

Biochemical Studies on Drug Metabolism: Isolation of Multiple Forms of Liver Microsomal Cytochrome P-450

1977 • 37 citations

Molecular weight and amino acid composition of purified spinach beet phenolase

1975 • 35 citations

Biosynthesis of loganin and the indole alkaloids from hydroxygeraniol–hydroxynerol

1970 • 34 citations

Properties and Solubility of Phenolase in Isolated Chloroplasts

1960 • 34 citations

Effect of ageing on enzymes of phenylpropanoid metabolism in Solanum tuberosum discs

1973 • 34 citations

Metabolism of cisanilide (cis-2,5-dimethyl-1-pyrrolidinecarboxanilide) by excised leaves and cell suspension cultures of carrot and cotton

1975 • 34 citations

An indole oxidase isolated from the leaves of Tecoma stans

1964 • 32 citations

On the Rate-Limiting Step in Microsomal Hydroxylation of Steroids

1972 • 31 citations

Studies on the enzymic browning of apples—III purification of apple phenolase

1966 • 31 citations

A New Mode of Ring Cleavage of 2,3‐Dihydroxybenzoic Acid in Tecoma Stans (L.)

1975 • 30 citations

Localization of Cinnamic Acid 4-Monooxygenase and the Membrane-bound Enzyme System for Dhurrin Biosynthesis in Sorghum Seedlings

1977 • 30 citations

Haem pigments of cytoplasmic particles from non-photosynthetic plant tissues

1957 • 30 citations

Fat metabolism in higher plants: LIII. Characterization of the product of the peanut α‐oxidation system

1972 • 28 citations

The role of oxygenated cytochrome P-450 and of cytochrome b5 in hepatic microsomal drug oxidations.

1973 • 28 citations

The carbon monoxide-binding hemoprotein reducible by hydrogen peroxide in microsomal fractions of pea seeds.

1977 • 27 citations

Cytochrome P-450 and b5 in Claviceps purpurea: Interconversion of P-450 and P-420

1970 • 27 citations

Metabolism of kaurene in cell-free extracts of immature pea seeds

1971 • 26 citations

The biosynthesis of cis-4-hydroxy-L-proline in sandal (Santalum album L.)

1970 • 26 citations

Hydroxyproline Biosynthesis : Loss of Hydrogen during the Hydroxylation of Proline

1964 • 26 citations

Lipid dependence of plant microsomal cinnamic acid 4-hydroxylase

1973 • 25 citations

The Stereochemistry of α‐Oxidation of Fatty Acids in Plants

1968 • 25 citations

Electron Paramagnetic Resonance Studies of Cytochrome P-450 in Plant Microsomes

1975 • 25 citations

The properties of cinnamic acid 4-hydroxylase of aged swede root disks

1975 • 24 citations

(−)-Kaur-16-en-7β-ol-19-oic acid, an intermediate in Gibberellin biosynthesis

1971 • 23 citations

Spectral evidence for the presence of cytochrome P-450 in microsomal fractions obtained from some higher plants

1972 • 23 citations

Das auftreten des “NIH-shifts” bei der in vivo und in vitro bildung hydroxylierter zimtsäurederivate in buchweizenhypokotylen (Fagopyrum esculentum)

1969 • 23 citations

The stereochemistry of α-oxidation of fatty acids in plants: the configuration of biosynthetic long-chain 2-hydroxy acids

1971 • 23 citations

Hydroxylation-induced migration and retention of tritium on conversion of [4-3H] cinnamic acid to 4-hydroxycinnamic acid by an enzyme from pea seedlings

1968 • 22 citations

Characterization of an enzyme from Phaseolus vulgaris seeds which hydroxylates GAi to GA8

1975 • 22 citations

Copper content and amino acid composition of catechol oxidase from clairette grapes

1977 • 21 citations

The expression of catechol oxidase activity during the hydroxylation of p-coumaric acid by spinach-beet phenolase

1972 • 20 citations

Electrophoretic Separation of the Phenolases from Potato Tubers

1963 • 20 citations

Participation of noncatalytic 'carrier' protein in the metabolism of kaurene in cell-free extracts of pea seeds

1972 • 19 citations

The action of hydrogen peroxide on the hydroxylation of p-coumaric acid by spinach-beet phenolase

1975 • 18 citations

The Stereochemistry of α‐Oxidation of Fatty Acids in Leaves

1970 • 15 citations

Differential effect of phenylhydrazine on the catecholase and cresolase activities of Vitis catechol oxidase

1974 • 14 citations

Formation of phenols from aromatic subtrates by plant and animal mono-oxygenases: The effect of adjacent deuteriums on the magnitude of the NIH shift of tritium

1973 • 14 citations

Activation of 4-Hydroxycinnamate Hydroxylase in Extracts from Sorghum

1974 • 13 citations

Un cytochrome de type P450 dans le spadice d'arum

1974 • 12 citations

Phenolase of spinach roots

1976 • 11 citations

Fat metabolism in higher plants. β-hydroxylation of fatty acids by a soluble preparation from maturing avocado mesocarp

1972 • 11 citations

Constitution of inactive phenolase-inhibitor complex in spinach chloroplasts

1977 • 11 citations

Induction d'un cytochrome du type P450 et de péroxydase durant la survie du tubercule de pomme de terre

1974 • 11 citations

Enzymic cyclization of (R,S)-14,15-oxidogeranylgeranyl pyrophosphate to 3.alpha.- and 3.beta.-hydroxykaurene

1976 • 10 citations

Characteristics of a 4-Hydroxycinnamate Hydroxylase Purified from Sorghum Leaves

1976 • 9 citations

On the mechanism of light induction of plant microsomal cinnamic acid 4-hydroxylase

1975 • 9 citations

Regulation of o-diphenolase activity by auxin and abscisic acid in germinating wheat embryos

1977 • 8 citations

Transformations of a Large Aggregate of Hydroxycinnamate Hydroxylase to Lower Molecular Weight Forms by Sulfhydryl Agents in Green Leaves of Sorghum

1975 • 6 citations

Fat metabolism in higher plants: Metabolism of medium chain fatty acids

1975 • 5 citations