Biochemistry of Cholinergic Neurons

A new and rapid colorimetric determination of acetylcholinesterase activity

1961 • 25,114 citations

The mathematics of diffusion

1956 • 18,583 citations

Methods of Biochemical Analysis

1956 • 4,535 citations

Data for biochemical research

1987 • 3,056 citations

The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation.

1962 • 2,522 citations

Quantal components of the end‐plate potential

1954 • 2,182 citations

EVIDENCE FOR RECYCLING OF SYNAPTIC VESICLE MEMBRANE DURING TRANSMITTER RELEASE AT THE FROG NEUROMUSCULAR JUNCTION

1973 • 2,122 citations

THE PHYSIOLOGY OF SYNAPSES

1964 • 1,932 citations

THE REACTION OF ACETYLCHOLINE AND OTHER CARBOXYLIC ACID DERIVATIVES WITH HYDROXYLAMINE, AND ITS ANALYTICAL APPLICATION

1949 • 1,902 citations

Spontaneous subthreshold activity at motor nerve endings

1952 • 1,820 citations

The Physiology of Synapses

1964 • 1,239 citations

The separation of synaptic vesicles from nerve-ending particles (‘synaptosomes’)

1964 • 1,213 citations

Advances in biochemical psychopharmacology

1970 • 1,186 citations

The release of neural transmitter substances

1969 • 1,134 citations

Radiochemical micro assays for the determination of choline acetyltransferase and acetylcholinesterase activities

1969 • 1,043 citations

The statistical nature of the acetylcholine potential and its molecular components

1972 • 960 citations

TURNOVER OF TRANSMITTER AND SYNAPTIC VESICLES AT THE FROG NEUROMUSCULAR JUNCTION

1973 • 835 citations

Über humorale übertragbarkeit der Herznervenwirkung

1921 • 817 citations

CHOLINERGIC AND NON‐CHOLINERGIC NERVE ENDINGS IN RAT BRAIN–I

1962 • 784 citations

Advances in Biochemical Psychopharmacology

1970 • 760 citations

ENZYME SECRETION AND THE INCORPORATION OF P32 INTO PHOSPHOLIPIDES OF PANCREAS SLICES

1953 • 757 citations

Transport and metabolism of calcium ions in nerve

1972 • 754 citations

The Cholinergic Synapse and the Site of Memory

1972 • 741 citations

Progress in Brain Research.

1965 • 738 citations

A further study of the statistical composition of the end‐plate potential

1955 • 701 citations

Neurotransmitter Synthesis by Neuroblastoma Clones

1972 • 695 citations

Iontophoretic studies of neurones in the mammalian cerebral cortex

1963 • 659 citations

THE ACTION OF MORPHINE AND RELATED SUBSTANCES ON CONTRACTION AND ON ACETYLCHOLINE OUTPUT OF COAXIALLY STIMULATED GUINEA‐PIG ILEUM

1997 • 632 citations

The action of botulinum toxin on the neuro‐muscular junction

1949 • 618 citations

SYNAPSES IN THE CENTRAL NERVOUS SYSTEM

1956 • 612 citations

THE ACTION OF CERTAIN ESTERS AND ETHERS OF CHOLINE, AND THEIR RELATION TO MUSCARINE

1914 • 604 citations

HIGH AFFINITY TRANSPORT OF CHOLINE INTO SYNAPTOSOMES OF RAT BRAIN¹

1973 • 585 citations

SOME FEATURES OF THE SUBMICROSCOPIC MORPHOLOGY OF SYNAPSES IN FROG AND EARTHWORM

1955 • 576 citations

The binding of acetylcholine to receptors and its removal from the synaptic cleft

1973 • 576 citations

A quantitative study of end‐plate potentials in isolated human muscle.

1965 • 565 citations

The timing of calcium action during neuromuscular transmission

1967 • 564 citations

Synaptic action during and after repetitive stimulation

1960 • 555 citations

ACETYLCHOLINE METABOLISM OF A SYMPATHETIC GANGLION

1961 • 552 citations

Release of acetylcholine at voluntary motor nerve endings

1936 • 480 citations

Distribution of lipids in subcellular particles of guinea-pig brain

1964 • 476 citations

Über humorale Übertragbarkeit der Herznervenwirkung

1924 • 473 citations

The application of subcellular fractionation techniques to the study of brain function

1965 • 466 citations

Transmitter release induced by injection of calcium ions into nerve terminals

1973 • 443 citations

ISOLATION OF SYNAPTIC VESICLES AND STRUCTURAL ORGANIZATION OF THE ACETYLCHOLINE SYSTEM WITHIN BRAIN NERVE ENDINGS*

1963 • 435 citations

Acetylcholine‐sensitive cells in the cerebral cortex

1963 • 416 citations

Biological Sciences: Isolation of the Cholinergic Receptor Protein of Torpedo Electric Tissue

1971 • 407 citations

Choline uptake systems of rat brain synaptosomes

1973 • 387 citations

The spontaneous and evoked release of acetylcholine from the cerebral cortex

1963 • 386 citations

The effects of presynaptic polarization on the spontaneous activity at the mammalian neuromuscular junction

1956 • 381 citations

MICRODETERMINATION OF CHOLINE ACETYLASE IN NERVOUS TISSUE

1965 • 367 citations

Cholinesterase-Containing Systems of the Brain of the Rat

1963 • 356 citations

Synthesis, storage and release of [¹⁴C]acetylcholine in isolated rat diaphragm muscles

1970 • 353 citations

The distribution of cholinesterase in cholinergic neurons demonstrated with the electron microscope

1966 • 351 citations

THE DETERMINATION OF PICOMOLE AMOUNTS OF ACETYLCHOLINE IN MAMMALIAN BRAIN

1973 • 343 citations

Studies on cholinesterase

1943 • 339 citations

An electrophysiological investigation of neuro‐muscular transmission in myasthenia gravis

1964 • 333 citations

The Interaction of Drugs and Subcellular Components in Animal Cells

1969 • 331 citations

A SIMPLIFIED RADIOCHEMICAL ASSAY FOR CHOLINE ACETYLTRANSFERASE

1967 • 330 citations

Quantal Nature of Synaptic Transmission

1966 • 329 citations

Role of Muscarinic Cholinergic Receptors in Regulation of Guanosine 3′:5′-Cyclic Monophosphate Content in Mammalian Brain, Heart Muscle, and Intestinal Smooth Muscle

1972 • 327 citations

THE FORMATION OF ACETYLCHOLINE. A NEW ENZYME: "CHOLINE ACETYLASE"

1943 • 326 citations

Pharmacological properties of acetylcholine‐sensitive cells in the cerebral cortex

1963 • 321 citations

Micro‐electrophoretic studies of neurones in the cat hippocampus

1966 • 320 citations

Cytological Distributions and Physiological Functions of Cholinesterases

1963 • 297 citations

Intracellular distributions of acetylcholine and choline acetylase

1958 • 288 citations

Adenosine triphosphate. A constituent of cholinergic synaptic vesicles

1974 • 288 citations

The distribution of acetylcholine in the peripheral and the central nervous system

1941 • 280 citations

The chemical transmitter at synapses in a sympathetic ganglion

1934 • 279 citations

Ultrastructure and Cytochemistry of the Synaptic Region

1967 • 271 citations

The Croonian Lecture - The transmission of impulses from nerve to muscle, and the subcellular unit of synaptic action

1962 • 270 citations

THE RELEASE OF NEURAL TRANSMITTER SUBSTANCES

1969 • 261 citations

Gangliosides and acetylcholinesterase in isolated membranes of the rat-brain cortex

1967 • 255 citations

Selective release of newly synthesized norepinephrine from the cat spleen during sympathetic nerve stimulation.

1968 • 242 citations

Physiology and ultrastructure of electrotonic junctions. IV. Medullary electromotor nuclei in gymnotid fish.

1967 • 241 citations

THE MORPHOLOGY AND ACETYLCHOLINE CONTENT OF ISOLATED CEREBRAL CORTICAL SYNAPTIC VESICLES

1965 • 235 citations

The relationship between the mode of operation and the dimensions of the junctional regions at synapses and motor end-organs

1958 • 233 citations

Choline acetylase in the central nervous system of man and some other mammals

1956 • 231 citations

Changes in motor innervation and cholinesterase localization induced by botulinum toxin in skeletal muscle of the mouse: differences between fast and slow muscles.

1970 • 230 citations

QUANTITATIVE HISTOCHEMISTRY OF ACETYL‐CHOLINESTERASE IN RAT HIPPOGAMPAL REGION CORRELATED TO HISTOCHEMICAL STAINING

1970 • 227 citations

The presence of histamine and acetylcholine in the spleen of the ox and the horse

1929 • 225 citations

Velocity and intensity of bidirectional migration of acetylcholinesterase in transected nerves

1971 • 225 citations

Chemical Coding of Behavior in the Brain

1965 • 224 citations

The effect of oxotremorine and atropine on cGMP and cAMP levels in mouse cerebral cortex and cerebellum

1970 • 224 citations

Analysis of frequency‐modulated sounds by auditory neurones of echo‐locating bats.

1965 • 223 citations

Isolation of choline esters from aqueous solutions by extraction with sodium tetraphenylboron in organic solvents

1969 • 217 citations

Presynaptic action of hemicholinium at the neuromuscular junction

1965 • 215 citations

STUDIES ON CHOLINESTERASE

1950 • 211 citations

An electron-microscopic study of zinc iodide-osmium impregnation of neurons. I. Staining of synaptic vesicles at cholinergic junctions

1968 • 211 citations

Local activity at a depolarized nerve-muscle junction

1955 • 211 citations

PRESENT VIEWS ON THE MODE OF ACTION OF ACETYLCHOLINE IN THE CENTRAL NERVOUS SYSTEM

1945 • 210 citations

Introduction to Chemical Pharmacology

1955 • 210 citations

THE USE OF MICROWAVE HEATING TO INACTIVATE CHOLINESTERASE IN THE RAT BRAIN PRIOR TO ANALYSIS FOR ACETYLCHOLINE

1973 • 208 citations

CHANGES IN THE FINE STRUCTURE OF THE NEUROMUSCULAR JUNCTION OF THE FROG CAUSED BY BLACK WIDOW SPIDER VENOM

1972 • 207 citations

INHIBITION BY MORPHINE OF THE RELEASE OF ACETYLCHOLINE FROM THE INTESTINE OF THE GUINEA‐PIG

1957 • 206 citations

ACETYLCHOLINESTERASE

1951 • 205 citations

Choline acetyltransferase binding to and release from membranes

1968 • 203 citations

LACTATE DEHYDROGENASE AS A CYTOPLASMIC MARKER IN BRAIN

1963 • 202 citations

Stimulation-Dependent Alterations in Peroxidase Uptake at Lobster Neuromuscular Junctions

1971 • 202 citations

The effect of type D botulinum toxin on frog neuromuscular junctions

1971 • 200 citations

Cholinesterase and succinic dehydrogenase in the central nervous system of the dog

1951 • 198 citations

EFFECT OF ELECTRICAL STIMULATION ON THE YIELD AND COMPOSITION OF SYNAPTIC VESICLES FROM THE CHOLINERGIC SYNAPSES OF THE ELECTRIC ORGAN OF TORPEDO: A COMBINED BIOCHEMICAL, ELECTROPHYSIOLOGICAL AND MORPHOLOGICAL STUDY

1974 • 195 citations

Calcium and synaptic transmission in a sympathetic ganglion

1940 • 194 citations

Depression of Acetylcholine Release from Cerebral Cortical Slices by Cholinesterase Inhibition and by Oxotremorine

1973 • 191 citations

ACETYLCHOLINE CONTENT OF DISCRETE AREAS OF THE BRAIN OBTAINED BY A NEAR‐FREEZING METHOD*

1964 • 190 citations

ACETYLCHOLINESTERASE

1950 • 190 citations

The isolation of pure cholinergic synaptic vesicles from the electric organs of elasmobranch fish of the family Torpedinidae

1972 • 189 citations

Choline Acetyltransferase from Rat Brain

1968 • 188 citations

DRUG‐INDUCED CHANGES IN BRAIN ACETYLCHOLINE

1962 • 187 citations

Mechanism of transmitter release

1970 • 186 citations

Carrier-mediated Transport of Choline into Synaptic Nerve Endings

1969 • 186 citations

SENSITIVITY TO SUCCINYLCHOLINE IN RELATION TO SERUM-CHOLINESTERASE

1952 • 183 citations

The ‘compartmentation’ of choline acetyltransferase within the synaptosome

1967 • 182 citations

Microphysiology of vertebrate neuromuscular transmission.

1973 • 180 citations

THE SUBCELLULAR LOCALIZATION OF GANGLIOSIDES IN THE BRAIN

1967 • 177 citations

The uptake of [14C]choline into synaptosomes in vitro

1968 • 177 citations

The effect of calcium and magnesium on the spontaneous release of transmitter from mammalian motor nerve endings

1961 • 173 citations

ON THE ISOLATION OF NERVE ENDINGS AND SYNAPTIC VESICLES

1961 • 168 citations

The pharmacology of synapses

1970 • 162 citations

Research Methods in Neurochemistry

1974 • 160 citations

PURIFICATION AND PROPERTIES OF CHOLINE ACETYLTRANSFERASE FROM OX BRAIN STRIATE NUCLEI

1971 • 158 citations

[¹⁴C]ACETYLCHOLINE SYNTHESIS BY CORTEX SLICES OF RAT BRAIN¹²

1968 • 158 citations

LES COMPARTIMENTS D'ACETYLCHOLINE DE L'ORGANE ELECTRIQUE DE LA TORPILLE ET LEURS MODIFICATIONS PAR LA STIMULATION

1972 • 156 citations

The preferential release of newly synthesized transmitter by a sympathetic ganglion

1969 • 156 citations

Depression by morphine and chloralose of acetylcholine release from the cat's brain

1965 • 156 citations

Effect of magnesium and calcium ions on the release of acetylcholine

1954 • 155 citations

The effects of nerve stimulation and hemicholinium on synaptic vesicles at the mammalian neuromuscular junction

1970 • 153 citations

Organophosphorus and other inhibitors of brain ‘neurotoxic esterase’ and the development of delayed neurotoxicity in hens

1970 • 152 citations

Acetylcholine metabolism in the central nervous system

1939 • 152 citations

Acetylcholine Action: Biochemical Aspects

1969 • 152 citations

The effects of tetanus toxin on neuromuscular transmission and on the morphology of motor end‐plates in slow and fast skeletal muscle of the mouse

1973 • 151 citations

ACETYLCHOLINESTERASE

1952 • 150 citations

STANDARDIZATION OF A RADIOCHEMICAL ASSAY OF CHOLINE ACETYLTRANSFERASE AND A STUDY OF THE ACTIVATION OF THE ENZYME IN RABBIT BRAIN

1971 • 149 citations

The source of choline for acetylcholine synthesis in a sympathetic ganglion

1969 • 148 citations

SYNTHESIS AND RELEASE OF [¹⁴C]ACETYLCH0LINE IN SYNAPTOSOMES

1971 • 148 citations

Biosynthesis of acetylcholine in nervous tissue

1972 • 146 citations

METABOLISM OF PHOSPHATIDYL INOSITOL AND OTHER LIPIDS IN ACTIVE NEURONES OF SYMPATHETIC GANGLIA AND OTHER PERIPHERAL NERVOUS TISSUES. THE SITE OF THE INOSITIDE EFFECT*

1965 • 142 citations

A radiometric microassay of acetylcholinesterase.

1967 • 141 citations

Assay Methods for Cholinesterases

1957 • 140 citations

FAST AXOPLASMIC TRANSPORT OF ACETYLCHOLINESTERASE IN MAMMALIAN NERVE FIBRES

1972 • 140 citations

The osmotically sensitive potassium and sodium compartments of synaptosomes

1967 • 137 citations

Studies on the origin of choline in the brain of the rat

1971 • 136 citations

The inhibition of erythrocyte cholinesterase by tri-esters of phosphoric acid. 3

1954 • 134 citations

The release of acetylcholine and of 3‐hydroxytyramine from the caudate nucleus

1964 • 132 citations

Structure of Acetylcholine and Other Substrates of Cholinergic Systems

1966 • 131 citations

A biochemical study of brain microsomes

1959 • 131 citations

The level of free choline in plasma

1952 • 130 citations

CHEMICAL TRANSMISSION OF THE EFFECTS OF NERVE IMPULSES

1934 • 130 citations

On the action of adrenalin.

1904 • 129 citations

Choline metabolism in the cerebral cortex of guinea pigs. Stable-bound acetylcholine

1972 • 129 citations

Acetylcholine and choline acetyltransferase in the diaphragm of the rat

1964 • 129 citations

Electrophoresis of acetylcholinc, choline and related compounds

1967 • 128 citations

COMPARATIVE STUDIES ON SYNAPTOSOMES: UPTAKE OF [N‐Me‐³H]CHOLINE BY SYNAPTOSOMES FROM SQUID OPTIC LOBES

1973 • 125 citations

ACETYLCHOLINESTERASE, I. LARGE-SCALE PURIFICATION, HOMOGENEITY, AND AMINO ACID ANALYSIS

1967 • 125 citations

Cholinergic mechanisms in the caudate nucleus

1966 • 124 citations

Molecular properties of acetylcholinesterase

1969 • 124 citations

The relationship of transmitter release and storage to fine structure in a sympathetic ganglion

1974 • 122 citations

ASPECTS OF ACETYLCHOLINE METABOLISM IN THE ELECTRIC ORGAN OF TORPEDO MARMORATA

1971 • 122 citations

The release of acetylcholine in the isolated rat diaphragm

1961 • 121 citations

Acetylcholine and the Exchange of Inositol and Phosphate in Brain Phosphoinositide

1958 • 120 citations

TRANSPORT, TURNOVER AND DISTRIBUTION OF CHOLINE ACETYLTRANSFERASE AND ACETYLCHOLIN‐ESTERASE IN THE VAGUS AND HYPOGLOSSAL NERVES OF THE RABBIT

1973 • 119 citations

CHOLINERGIC AND MONOAMINIERGIC PATHWAYS IN THE HYPOTHALAMUS

1966 • 118 citations

FRACTIONNEMENT DE L'ORGANE ELECTRIQUE DE LA TORPILLE: LOCALISATION SUBCELLULAIRE DE L'ACETYLCHOLINE SUBCELLULAR FRACTIONATION OF THE ELECTRIC ORGAN OF TORPEDO MARMORATA

1970 • 117 citations

Observation par microscopie électronique des formes allongées et globulaires de l'acétylcholinestérase de gymnote (Electrophorus electricus)

1973 • 116 citations

Acetylcholine, a New Active Principle of Ergot

1914 • 115 citations

BRAIN ACETYLCHOLINE STUDIES: A NEW EXTRACTION PROCEDURE*

1966 • 114 citations

The action of blood on acetylcholine

1930 • 114 citations

UPTAKE OF CHOLINE BY MOUSE BRAIN SLICES*

1966 • 113 citations

The inhibition of erythrocyte cholinesterase by tri-esters of phosphoric acid. 3. The nature of the inhibitory process

1953 • 112 citations

Gas chromatographic microestimation of acetylcholine and related compounds

1968 • 111 citations

Cholinesterasic striatopallidal and striatonigral efferents in the cat and the monkey

1970 • 110 citations

A radiochemical method for the estimation of choline acetyltransferase

1966 • 109 citations

SERINE PHOSPHORIC ACID FROM DIISOPROPYLPHOSPHORYL DERIVATIVE OF EEL CHOLINESTERASE

1954 • 108 citations

On the relation between ATP splitting and secretion in the adrenal chromaffin cell: extrusion of ATP (unhydrolysed) during release of catecholamines

1966 • 107 citations

CONTROL OF ACETYLCHOLINE SYNTHESIS?THE INHIBITION OF CHOLINE ACETYLTRANSFERASE BY ACETYLCHOLINE

1969 • 104 citations

Exchangeability of radioactive acetylcholine with the bound acetylcholine of synaptosomes and synaptic vesicles

1968 • 101 citations

THE EFFECT OF SOME DRUGS ON THE “FREE’ AND “BOUND” ACETYLCHOLINE CONTENT OF RAT BRAIN

1968 • 101 citations

Morphological aspects of exocytosis in the adrenal medulla

1971 • 101 citations

Role of Cholinergic Mechanisms in States of Wakefulness and Sleep

1968 • 98 citations

Intracellular distribution of choline acetylase

1956 • 98 citations

THE INFLUENCE OF CENTRALLY ACTING CHOLINOLYTIC DRUGS ON BRAIN ACETYLCHOLINE LEVELS

1964 • 96 citations

SUBCELLULAR DISTRIBUTION OF ACETYL‐CoA SYNTHETASE, ATP CITRATE LYASE, CITRATE SYNTHASE, CHOLINE ACETYLTRANSFERASE, FUMARATE HYDRATASE AND LACTATE DEHYDROGENASE IN MAMMALIAN BRAIN TISSUE

1967 • 95 citations

Choline acetyltransferase

1970 • 95 citations

Localization of Choline Acetyltransferase: Histochemistry at the Light Microscope Level

1970 • 94 citations

Fermentative Azetylcholinspaltung im Blut und ihre Hemmung durch Physostigmin

1930 • 93 citations

Acetylcholine turnover estimation in brain by gas chromatography/mass spectrometry

1974 • 93 citations

The influence of atropine on the release and uptake of acetylcholine by the isolated cerebral cortex of the rat

1966 • 92 citations

SYNTHESIS OF RADIOACTIVE ACETYLCHOLINE FROM [³H]CHOLINE AND ITS RELEASE FROM CEREBRAL CORTEX SLICES IN VITRO

1971 • 92 citations

Choline acetyltransferase inhibitors: a group of styryl-pyridine analogs

1967 • 91 citations

Rapid and Complete Purification of Acetylcholinesterases of Electric Eel and Erythrocyte by Affinity Chromatography

1971 • 91 citations

An enzymatic method for measuring picomole quantities of acetylcholine and choline in CNS tissue

1973 • 91 citations

Analysis of Biogenic Amines and Their Related Enzymes

1971 • 91 citations

Acetylcholin und Cholin aus tierischen Organen. 1. Mitteilung. Darstellung aus Rinderblut.

1930 • 90 citations

The occurrence of homologues of acetylcholine in ox spleen

1953 • 90 citations

Relationship between acetylcholine content and release in the cat's cerebral cortex

1970 • 89 citations

Cholinergic mechanisms in the cerebellar cortex

1968 • 88 citations

DIFFERENT RECOVERY RATES OF THE ELECTROPHYSIOLOGICAL, BIOCHEMICAL AND MORPHOLOGICAL PARAMETERS IN THE CHOLINERGIC SYNAPSES OF THE TORPEDO ELECTRIC ORGAN AFTER STIMULATION

1974 • 88 citations

EFFECTS OF QUATERNARY BASES AND INORGANIC CATIONS ON ACETYLCHOLINE SYNTHESIS IN NERVOUS TISSUE

1967 • 88 citations

Some characteristics of binding of γ-aminobutyric acid and acetylcholine to a synaptic vesicle fraction from mouse brain

1968 • 87 citations

The subcellular fractionation of the electric organ of Torpedo

1966 • 87 citations

PURIFICATION AND PROPERTIES OF MULTIPLE FORMS OF BRAIN ACETYLCHOLINESTERASE (EC 3.1.1.7)¹

1972 • 87 citations

PURIFICATION AND SOME PROPERTIES OF CHOLINE ACETYLTRANSFERASE (EC 2.3.1.6) FROM BOVINE BRAIN

1973 • 87 citations

Multiple forms of choline acetyltransferase in several species demonstrated by isoelectric focusing

1972 • 87 citations

Effect of local pH changes caused by substrate hydrolysis on the activity of membrane-bound acetylcholinesterase.

1967 • 86 citations

Acetylcholine Release From the Cerebral and Cerebellar Cortices : Its Role in Cortical Arousal

1965 • 84 citations

Microanalytical determination of acetylcholine, other choline esters, and choline by pyrolysis-gas chromatography

1968 • 84 citations

ACETYLCHOLINE SYNTHESIS FROM [2-¹⁴C]PYRUVATE IN RAT STRIATAL SLICES

1973 • 83 citations

THE FORMATION OF CHOLINE AND OF ACETYLCHOLTNE BY BRAIN IN VITRO

1972 • 81 citations

The Reactivation of Acetylcholinesterase Inhibited by Tetraethyl Pyrophosphate and Diisopropyl Fluorophosphate¹

1955 • 80 citations

Choline acetyltransferase purification and effect of salts on the mechanism of the enzyme-catalyzed reaction

1966 • 80 citations

UTILIZATION OF ACETATE AND PYRUVATE FOR THE SYNTHESIS OF‘TOTAL’,‘BOUND’AND‘FREE’ACETYLCHOLINE IN THE ELECTRIC ORGAN OF TORPEDO

1974 • 78 citations

Cholinergic inhibition in the cerebral cortex

1967 • 77 citations

EFFECTS OF SOME DRUGS ON THE UPTAKE OF ACETYLCHOLINE IN CORTEX SLICES OF MOUSE BRAIN

1967 • 77 citations

Axonal transport of newly synthesized acetylcholine in an identified neuron ofAplysia

1972 • 77 citations

Spectrophotometric assay for choline acetyltransferase

1972 • 76 citations

THE RELEASE OF ACETYLCHOLINE FROM MAMMALIAN MOTOR NERVE ENDINGS

1960 • 76 citations

A Partial Characterization of Acetylcholinesterase^*

1964 • 76 citations

The choline acetyltransferase of human placenta

1966 • 75 citations

The Active Site of Acetylcholinesterase and Related Esterases and its Reactivity towards Substrates and Inhibitors

1963 • 73 citations

Stimulation of Hydrolysis of Phosphatidic Acid by Cholinergic Agents in Guinea Pig Synaptosomes

1974 • 73 citations

The stimulus‐induced release of acetylcholine from synaptosome beds and its calcium dependence

1972 • 73 citations

The specificity of the human erythrocyte cholinesterase

1949 • 72 citations

Methods in brain research

1976 • 72 citations

Influence of Asphyxia on Membrane Potential Level and Action Potentials of Spinal Moto‐ and Interneurons

1959 • 72 citations

The distribution and localization of cholinesterases in nerve cells.

1959 • 71 citations

Identification of Acetylcholine in Fresh Rat Brain by Combined Gas Chromatography–Mass Spectrometry

1968 • 71 citations

Action of reserpine on the osmium tetroxide zinc iodide reactive site of synaptic vesicles in the pineal nerves of the rat

1968 • 69 citations

The synthesis, turnover and release of surplus acetylcholine in a sympathetic ganglion

1971 • 69 citations

Identification of Acetylcholine and Related Esters of Biological Origin

1963 • 69 citations

Multiple forms of acetylcholinesterase from pig brain

1973 • 68 citations

Acetylcholinesterase

1972 • 68 citations

Enzymic radioassay for acetylcholine and choline in brain

1971 • 68 citations

Some effects of nerve stimulation and hemicholinium on quantal transmitter release at the mammalian neuromuscular junction

1970 • 67 citations

COMPARATIVE STUDIES IN SYNAPTOSOME FORMATION: THE PREPARATION OF SYNAPTOSOMES FROM THE HEAD GANGLION OF THE SQUID, LOLIGO PEALII

1973 • 67 citations

FORMATION, STORAGE, AND RELEASE OF ACETYLCHOLINE AT NERVE ENDINGS

1959 • 67 citations

Axoplasmic transport of acetylcholinesterase and choline acetyltransferase in the vagus and hypoglossal nerve of the rabbit

1970 • 66 citations

EVOLUTION DE LA DECHARGE DE L'ORGANE ELECTRIQUE DE LA TORPILLE ET VARIATIONS SIMULTANEES DE L'ACETYLCHOLINE AU COURS DE LA STIMULATION¹ CHANGES IN ACETYLCHOLINE LEVEL AND ELECTROPHYSIOLOGICAL RESPONSE DURING CONTINUOUS STIMULATION OF THE ELECTRIC ORGAN OF TORPEDO MARMORATA

1974 • 65 citations

Modification of the responses of brain stem neurones to transmitter substances by anaesthetic agents

1973 • 65 citations

METHODS OF NEUROCHEMISTRY, VOL. 1

1972 • 65 citations

MEMBRANE AFFINITIES AND SUBCELLULAR DISTRIBUTION OF THE DIFFERENT MOLECULAR FORMS OF CHOLINE ACETYLTRANSFERASE FROM RAT

1973 • 63 citations

EFFECTS OF ACETYLCHOLINE ON THE INCORPORATION OF [³²P]ORTHOPHOSPHATE IN VITRO INTO THE PHOSPHOLIPIDS OF NERVE‐ENDING PARTICLES FROM GUINEA PIG BRAIN

1972 • 63 citations

Slow accumulation of choline acetyltransferase in crushed sciatic nerves of the rat

1973 • 63 citations

The kinetic properties of human placental choline acetyltransferase

1971 • 62 citations

A HISTOCHEMICAL PROCEDURE FOR THE LOCALIZATION OF CHOLINE ACETYLTRANSFERASE ACTIVITY

1970 • 61 citations

Purification and properties of human serum cholinesterase

1970 • 61 citations

The heterogeneity of bound acetylcholine and synaptic vesicles

1972 • 61 citations

Destruction of Mammalian Motor Nerve Terminals by Black Widow Spider Venom

1971 • 61 citations

Determination of Activity of Cholinesterases

1971 • 60 citations

The pharmacology of synapses

1970 • 60 citations

Drug induced changes in free, labile and stable acetylcholine of guinea-pig brain

1969 • 60 citations

METABOLISME DU CALCIUM ET LIBERATION DE L'ACETYLCHOLINE DANS L'ORGANE ELECTRIQUE DE LA TORPILLE

1974 • 60 citations

An enzyme assay for acetylcholine

1969 • 60 citations

ON THE ORIGIN OF THE ACETYL MOIETY OF ACETYLCHOLINE IN BRAIN STUDIED WITH A DIFFERENTIAL LABELLING TECHNIQUE USING ³H‐¹⁴C‐MIXED LABELLED GLUCOSE AND ACETATE

1970 • 59 citations

Gangliosides and acetylcholine of the central nervous system

1964 • 58 citations

ISOLATION OF [³H]ACETYLCHOLINE POOLS BY SUBCELLULAR FRACTIONATION OF CEREBRAL CORTEX SLICES INCUBATED WITH [³H]CHOLINE

1971 • 58 citations

The conversion of 14C-choline to 14C-acetylcholine in synaptosomes in vitro

1969 • 58 citations

EFFECTS OF ACETYLCHOLINE ON THE IN CORPORATION OF [³²P]ORTHOPHOSPHATE IN VITRO INTO THE PHOSPHOLIPIDS OF SUBSYNAPTOSOMAL MEMBRANES FROM GUINEA‐PIG BRAIN

1973 • 58 citations

THE ORIGIN OF THE ACETYLCHOLINE RELEASED FROM THE SURFACE OF THE CORTEX

1972 • 58 citations

CHOLINESTERASES IN SYMPATHETIC FIBERS AND GANGLIA

1945 • 58 citations

THE MEASUREMENT OF NANOGRAM AMOUNTS OF ACETYLCHOLINE IN TISSUES BY PYROLYSIS GAS CHROMATOGRAPHY¹

1972 • 57 citations

A COMPARISON OF THE N‐ALKYL GROUP SPECIFICITY OF CHOLINE ACETYLTRANSFERASE FROM DIFFERENT SPECIES.*

1964 • 56 citations

STUDIES ON THE ACETYLCHOLINE‐STIMULATED INCORPORATION OF RADIOACTIVE INORGANIC ORTHOPHOSPHATE INTO THE PHOSPHOLIPID OF BRAIN PARTICULATE PREPARATIONS‐II.

1966 • 56 citations

THE RELATIONSHIP BETWEEN THE CHEMICAL STRUCTURE AND NEUROTOXICITY OF ALKYL ORGANOPHOSPHORUS COMPOUNDS

1960 • 56 citations

Effects of quaternary ammonium compounds on choline transport in red cells

1969 • 55 citations

Biological Sciences: Release of Protein from Mouse Motor Nerve Terminals

1972 • 55 citations

SYNTHESIS OF ACETYLCHOLINE IN DIFFERENT COMPARTMENTS OF BRAIN NERVE TERMINALS IN VIVO AS STUDIED BY THE INCORPORATION OF CHOLINE FROM PLASMA AND THE EFFECT OF PENTOBARBITAL ON THIS PROCESS

1973 • 54 citations

Substances with acetylcholine activity in normal rat brain

1962 • 54 citations

Removal of acetylcholine from a limited volume by diffusion

1955 • 53 citations

Storage and release of acetylcholine in a sympathetic ganglion

1974 • 53 citations

Inhibition of choline acetyltransferase from bovine caudate nucleus by sulfhydryl reagents and reactivation of the inhibited enzyme

1970 • 53 citations

NEUROCHEMICAL AND STRUCTURAL STUDIES ON THE MECHANISM OF ACTION OF HEMICHOLINIUM‐3 IN CENTRAL CHOLINERGIC SYNAPSES

1970 • 53 citations

The acyl-group specificity of choline acetylase

1959 • 52 citations

The conformation of acetylcholine and related compounds in aqueous solution as studied by nuclear magnetic resonance spectroscopy.

1972 • 52 citations

The effect of inhibition of specific and non-specific cholinesterase on the motility of the isolated ileum.

1950 • 52 citations

EFFECTS OF ACETYLCHOLINE ON THE INCORPORATION OF ³²P INTO VARIOUS PHOSPHOLIPIDS IN SLICES OF NORMAL AND DENERVATED SUPERIOR CERVICAL GANGLIA OF THE CAT*

1966 • 52 citations

A specific antidote against lethal alkyl phosphate intoxication. IV. Effects in brain

1957 • 50 citations

The number of catalytic sites in acetylcholinesterase

1971 • 49 citations

The metabolism of choline by a sympathetic ganglion

1969 • 49 citations

ON SUBCELLULAR LOCALIZATION AND BINDING OF CHOLINE ACETYLTRANSFERASE IN THE CHOLINERGIC NERVE ENDINGS OF THE BRAIN

1966 • 49 citations

Lack of Correspondence between the Amplitudes of Spontaneous Potentials and Unit Potentials evoked by Nerve Impulses at Regenerating Neuromuscular Junctions

1971 • 48 citations

DISTRIBUTION OF ACETYLCHOLINE IN THE BRAIN DURING VARIOUS STATES OF ACTIVITY

1963 • 48 citations

CHOLINERGIC NERVE ENDINGS IN OCTOPUS BRAIN

1968 • 48 citations

Effect of HC-3 on acetylcholine turnover.

1961 • 48 citations

Handbuch der Experimentellen Pharmakologie

1938 • 48 citations

A CHEMICAL METHOD FOR THE DETERMINATION OF ACETYLCHOLINE: ITS APPLICATION IN A STUDY OF PRESYNAPTIC RELEASE AND A CHOLINE ACETYLTRANSFERASE ASSAY¹

1969 • 47 citations

Effects of drugs on the uptake of acetylcholine in rat brain cortex slices

1969 • 47 citations

Proceedings of the Physiological Society, 15–16 February 1974, Mill Hill Meeting: Communications

1974 • 47 citations

CHANGES IN THE ACETYLCHOLINE CONTENT OF DIFFERENT BRAIN REGIONS OF THE RAT DURING A LEARNING EXPERIMENT¹

1974 • 46 citations

THE SYNTHESIS AND STORAGE OF ACETYLCHOLINE IN THE STRIATUM *

1966 • 45 citations

Human Serum Cholinesterase as a Sialo‐Protein

1961 • 44 citations

The in vivo release of acetylcholine from cat caudate nucleus after pharmacological and surgical manipulations of dopaminergic nigrostriatal neurons

1973 • 44 citations

Separation of adrenergic and cholinergic synaptosomes from immature rat brain

1973 • 44 citations

Properties and biosynthesis of a neurotoxic protein of the venoms of sea snakes Laticauda laticaudata and Laticauda colubrina

1969 • 44 citations

PRODUCTION OF ACETYLCHOLINE IN RAT BRAIN FOLLOWING THIAMINE DEPRIVATION AND TREATMENT WITH THIAMINE ANTAGONISTS¹²

1969 • 43 citations

The characteristics of acetylcholine release mechanisms in the auditory cortex

1969 • 43 citations

SEPARATION OF APPARENT MULTIPLE FORMS OF HUMAN BRAIN CHOLINE ACETYLTRANSFERASE BY ISOELECTRIC FOCUSING

1973 • 43 citations

SUBCELLULAR LOCALIZATION OF NEWLY‐FORMED [³H]ACETYLCHOLINE IN RAT CEREBRAL CORTEX IN VITRO

1973 • 42 citations

Release of neural transmitter substances

1970 • 41 citations

Uptake of acetylcholine in rat brain cortex slices

1969 • 41 citations

THE EFFECT OF SULPHYDRYL AND OTHER DISULPHIDE REDUCING AGENTS ON CHOLINE ACETYLTRANSFERASE ACTIVITY ESTIMATED WITH SYNTHETIC ACETYL‐CoA

1967 • 40 citations

Vesicular and Synaptoplasmic Synthesis of Acetylcholine

1970 • 40 citations

Spontaneous quantal transmitter release: a statistical analysis and some implications

1973 • 39 citations

Acetylcholine content of the rabbit plantaris muscle after denervation

1962 • 39 citations

The biochemistry of synaptic transmission

1973 • 39 citations

Effect of ‘Tremorine’ and some Anti-Parkinson's Disease Drugs on Acetylcholine in the Rat's Brain

1963 • 38 citations

Central nervous system : studies on metabolic regulation and function

1974 • 38 citations

Acetylcholine metabolism in the central nervous system

1939 • 38 citations

CHOLINERGIC TRANSMISSION IN THE FROG SPINAL CORD

1962 • 38 citations

Assay of the mycobactins by measurement of the growth of Mycobacterium johnei

1966 • 38 citations

Sedimentation Behaviour and Molecular Weight of Choline Acetyltransferase

1964 • 37 citations

THE ISOLATION OF CHOLINERGIC SYNAPTIC VESICLES FROM BOVINE SUPERIOR CERVICAL GANGLION AND ESTIMATION OF THEIR ACETYLCHOLINE CONTENT

1973 • 37 citations

A New Group of Psychotomimetic Agents.

1958 • 36 citations

A study on the tricarboxylic acid cycle and the synthesis of acetylcholine in the lobster nerve

1970 • 35 citations

Human Placental Choline Acetyltransferase

1971 • 35 citations

Choline acetylase in the placenta of man and other species

1962 • 35 citations

Estimation of the acetylcholine content of rat brain by gas chromatography.

1965 • 34 citations

Methyl-fluoro-phosphorylcholines. Two Synthetic Cholinergic Drugs and Their Tertiary Homologues.

1957 • 34 citations

ACYLATION REACTIONS MEDIATED BY PURIFIED ACETYLCHOLINE ESTERASE

1949 • 34 citations

Absence of adenine nucleotide release from autonomic ganglion

1974 • 33 citations

Neurosciences Research

1969 • 33 citations

Changes in acetylcholine content of rat brain by toxic doses of di-isopropyl phosphorofluoridate

1969 • 33 citations

Electrokinetic mechanism of miniature postsynaptic potentials.

1966 • 33 citations

Enzyme-catalyzed Exchange of Oxygen Atoms between Water and Carboxylate Ion¹

1954 • 33 citations

Relationship between acetylcholine synthesis and its concentration in rat cerebral cortex

1969 • 32 citations

Effects of morphine on choline acetyltransferase levels in the caudate nucleus of the rat

1971 • 31 citations

Rapid accumulation of acetylcholine in nerve above a crush

1971 • 31 citations

Tremorine and oxotremorine effects on acetylcholinesterase and choline acetylase from rat brain

1965 • 31 citations

Localization of Choline Acetyltransferase: Ultrastructural Localization in Spinal Neurones

1970 • 31 citations

Evidence for heterogeneous pools of acetylcholine in isolated cholinergic synaptic vesicles

1974 • 30 citations

The effect of narcotic analgesic drugs on the uptake and release of neurotransmitters in isolated synaptosomes.

1974 • 30 citations

Methods in brain research

1975 • 30 citations

A morphological and biochemical study of subcellular fractions of the guinea pig spinal cord

1971 • 30 citations

The physiological significance of acetylcholine

1962 • 30 citations

Studies on choline transport and metabolism in rat brain synaptosomes

1972 • 29 citations

Acetylcholine. 1. Hydrolysis by hydrogen and hydroxyl ion

1953 • 29 citations

Proteins in bioelectricity: the control of ion movements across excitable membranes.

1968 • 29 citations

THE PREPARATION OF CHOLINERGIC SYNAPTOSOMES FROM BOVINE SUPERIOR CERVICAL GANGLIA

1972 • 29 citations

Synthesis of acetylcholine in the electric organ of Torpedo

1969 • 28 citations

Nachweis von 4-Amino-n-butyrylcholin im Warmbl�tergehirn

1959 • 28 citations

THE ACCUMULATION OF RADIOACTIVE ACETYLCHOLINE BY A SYMPATHETIC GANGLION AND BY BRAIN: FAILURE TO LABEL ENDOGENOUS STORES

1973 • 28 citations

CELL FREE "CHOLINE ACETYLASE" FROM LACTOBACILLUS PLANTARUM

1954 • 28 citations

STUDIES ON ACETYLCHOLINESTERASE OF RAT BRAIN SYNAPTOSOMAL PLASMA MEMBRANES

1974 • 26 citations

Compartmentation of acetylcholine in synaptosomes

1967 • 26 citations

Gas chromatographic estimation of choline esters in tissues:

1970 • 25 citations

Association of the Acetylcholine-phosphatidyl Inositol Effect with a “Receptor” Proteolipid from Cerebral Cortex

1971 • 25 citations

THE EFFECT OF PHOSPHOLIPASES ON THE UPTAKE OF ATROPINE AND ACETYLCHOLINE BY SLICES OF MOUSE BRAIN CORTEX

1969 • 25 citations

Acetylcholine Binding by Isolated Synaptic Vesicles in vitro

1969 • 25 citations

Choline metabolism in the cerebral cortex of guinea pigs. Phosphorylcholine and lipid choline

1972 • 25 citations

Some of the dynamics of choline and acetylcholine metabolism in rat brain.

1973 • 24 citations

Effects of stimulation on synaptic vesicles in sympathetic ganglia, as shown by fixation n the presence of Mg2+.

1971 • 24 citations

Effects of morphine and levorphanol on brain acetylcholine content in mice.

1970 • 23 citations

BIOCHEMICAL ORGANIZATION OF CHOLINERGIC NERVE TERMINALS IN THE CEREBRAL CORTEX

1969 • 23 citations

Axonal transport and acetylcholine in rat preganglionic neurones

1973 • 22 citations

Inhibition of choline acetyltransferase and hexobarbitone-metabolizing enzymes by naphthylvinyl pyridine analogues

1971 • 22 citations

THE ABSENCE OF 'SURPLUS' ACETYLCHOLINE FORMATION IN PRISMS PREPARED FROM RAT CEREBRAL CORTEX

1972 • 21 citations

Acetylcholine Quanta

1964 • 20 citations

ENZYMATIC FLUOROMETRIC DETERMINATION OF ACETYLCHOLINE IN BIOLOGICAL EXTRACTS¹

1970 • 18 citations

Neuromuscular blocking activity and other pharmacologic properties of various carnitine derivatives.

1967 • 17 citations

Fluorometric enzyme assay for choline and acetylcholine

1972 • 16 citations

Immunohistochemical localization and immunoelectrophoresis of cholinergic synaptic vesicle protein constituents from theTorpedo

1974 • 16 citations

Qualitative separation of choline esters by means of high voltage paper electrophoresis

1960 • 16 citations

THE CHROMATOGRAPHIC BEHAVIOUR OF THE ACETYLCHOLINE ACTIVITY OF BRAIN EXTRACTS

1963 • 16 citations

Choline and Phospholipid-choline in a Sympathetic Ganglion and their Relationship to Acetylcholine Synthesis

1967 • 16 citations

Morphological evidence for exocytosis of acetylcholine during formation of synaptosomes from Torpedo electric organ.

1973 • 15 citations

Accumulation of acetylcholine by the rat diaphragm

1970 • 15 citations

A new paper chromatographic technique for the separation of cholesterol and cholesteryl esters

1960 • 15 citations

Factors influencing maintenance and release of acetylcholine in rat cortical brain slices

1967 • 14 citations

IMMUNOLOGICAL APPROACH TO THE CHARACTERIZATION OF CHOLINERGIC VESICULAR PROTEIN

1974 • 13 citations

The fluorometric determination of acetylcholine

1964 • 13 citations

The reaction of acetylcholinesterase (AChe) with some quaternary hydroxy aminophenols

1968 • 13 citations

STUDIES ON SOLUBLE PROTEINS RELEASED FROM THE SYNAPTIC VESICLES OF RAT BRAIN CORTEX

1971 • 12 citations

A MICRO‐SCALE PROCEDURE FOR THE PREPARATION OF SUBCELLULAR FRACTIONS FROM INDIVIDUAL AUTONOMIC GANGLIA

1971 • 12 citations

Micro-colorimetric determination of cholinesterase activity of motor end plates in the rat diaphragm

1966 • 12 citations

Action of Phospholipase A on Synaptic Vesicles. A Model for Transmitter Release?

1972 • 11 citations

INCORPORATION OF [¹⁴CICHOLINE INTO PHOSPHOLIPIDS IN THE ISOLATED PHRENIC NERVE‐DIAPHRAGM PREPARATION OF THE RAT¹

1973 • 11 citations

Choline and its Metabolic Successors in Brain

1974 • 11 citations

Isolation and Study of Synaptic Vesicles

1974 • 11 citations

Effects of some centrally acting drugs on acetylcholine synthesis by rat cerebral cortex slices

1972 • 10 citations

Immunochemical studies on cholinergic synaptic vesicles

1974 • 10 citations

Effects of Intraperitoneally Injected Botulinum Toxin on Rat Cerebral Cortex Levels of Acetylcholine

1968 • 9 citations

The incorporation of triethylcholine into isolated guinea pig cerebral cortex synaptosomal and synaptic vesicle fractions

1971 • 8 citations

Determination of femtomole levels of acetylcholine by an improved bioassay procedure

1973 • 5 citations

The Association of Recently Synthesized Acetylcholine with Synaptic Vesicles

1973 • 5 citations

Variations d'acétylcholine en relation avec l'évolution de la décharge, pendant la stimulation de l'organe électrique de la torpille.

1972 • 5 citations

Quantitative determination of acetylcholine in biological materials by polarographic analysis.

1965 • 4 citations

Effect of desmethylimipramine on acetylcholine uptake by slices of rat brain cortex

1973 • 3 citations

A specific gas chromatographic method for assaying tissue acetylcholine: present status.

1969 • 3 citations

A mathematical model of the acetylcholine compartments in synaptosomes

1972 • 2 citations

Functional Aspects of Synaptosomes

1969 • 2 citations