[30] Fluorescence lifetime imaging microscopy: Homodyne technique using high-speed gated image intensifier

Principles of Fluorescence Spectroscopy

1999 • 27,045 citations

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

2012 • 8,865 citations

Time-Correlated Single Photon Counting

1984 • 2,602 citations

Principles of fluorescence spectroscopy

1984 • 1,031 citations

Fluorescence lifetime imaging of free and protein-bound NADH.

1992 • 722 citations

Excited State Lifetime Measurements

1983 • 641 citations

A continuously variable frequency cross-correlation phase fluorometer with picosecond resolution

1983 • 475 citations

Optical Sectioning Microscopy: Cellular Architecture in Three Dimensions

1984 • 468 citations

Analysis of fluorescence decay kinetics from variable-frequency phase shift and modulation data

1984 • 453 citations

Fluorescence lifetime imaging

1992 • 420 citations

Determination of oxygen concentrations by luminescence quenching of a polymer-immobilized transition-metal complex

1987 • 389 citations

Applications of fluorescence in the biomedical sciences

1986 • 370 citations

The Use of a Charge-Coupled Device for Quantitative Optical Microscopy of Biological Structures

1987 • 302 citations

Resolvability of fluorescence lifetime distributions using phase fluorometry

1987 • 278 citations

Resolution of mixtures of fluorophores using variable-frequency phase and modulation data

1984 • 265 citations

Immunoassays with time-resolved fluorescence spectroscopy: Principles and applications

1988 • 265 citations

Lifetime-selective fluorescence imaging using an rf phase-sensitive camera

1991 • 251 citations

Development and biological applications of chloride-sensitive fluorescent indicators

1990 • 241 citations

Time resolved imaging microscopy. Phosphorescence and delayed fluorescence imaging

1991 • 236 citations

Construction and performance of a variable-frequency phase-modulation fluorometer

1985 • 231 citations

Correction of timing errors in photomultiplier tubes used in phase-modulation fluorometry

1981 • 220 citations

Ca2+ imaging in single living cells: Theoretical and practical issues

1990 • 215 citations

A 10-GHz frequency-domain fluorometer

1990 • 198 citations

Optical measurements of pH using fluorescence lifetimes and phase-modulation fluorometry

1993 • 167 citations

A Two-Dimensional Fluorescence Lifetime Imaging System Using a Gated Image Intensifier

1991 • 147 citations

Fluorescence lifetime imaging microscopy (flimscopy). Methodology development and application to studies of endosome fusion in single cells

1993 • 128 citations

Time-resolved laser spectroscopy in biochemistry II

1990 • 128 citations

Fluorescence lifetime imaging of calcium using Quin-2

1992 • 122 citations

Phase-sensitive fluorescence spectroscopy: A new method to resolve fluorescence lifetimes or emission spectra of components in a mixture of fluorophores

1981 • 117 citations

Fluorescence lifetime-based sensing of pH, Ca2+, K+ and glucose

1993 • 117 citations

Charge Transfer Device Detectors for Analytical Optical Spectroscopy—Operation and Characteristics

1987 • 111 citations

Fluorescence lifetime imaging of intracellular calcium in COS cells using Quin-2

1994 • 107 citations

Optical sensing of glucose using phase-modulation fluorimetry

1993 • 95 citations

Fiber optic pH sensor based on phase fluorescence lifetimes

1993 • 91 citations

Resolution of heterogeneous fluorescence from proteins and aromatic amino acids by phase-sensitive detection of fluorescence.

1981 • 86 citations

Calcium imaging using fluorescence lifetimes and long-wavelength probes

1992 • 85 citations

A New Method for Measuring Oxygen Concentration in Biological Systems

1986 • 79 citations

Alternative immunoassays

1985 • 69 citations

Nanosecond fluorescence microscopy. Emission kinetics of fura-2 in single cells

1991 • 66 citations

Changes in membrane dynamics associated with myogenic cell fusion

1978 • 62 citations

Time-Resolved Fluorescence Microscopy Using Multichannel Photon Counting

1990 • 47 citations

Optical sensing of pH and pCO2 using phase-modulation fluorimetry and resonance energy transfer

1993 • 46 citations

Fluorescence decay analysis in solution and in a microscope of DNA and chromosomes stained with quinacrine.

1979 • 43 citations

New trends in photobiology

1988 • 39 citations

Dynamic Fluorescence Measurements of Two-State Systems: Applications to Calcium-Chelating Probes

1993 • 37 citations

Construction and evaluation of a frequency-domain epifluorescence microscope for lifetime and anisotropy decay measurements in subcellular domains

1991 • 34 citations

Two-dimensional time-resolved imaging with 100-ps resolution using a resistive anode photomultiplier tube

1992 • 33 citations

Use of time-gated fluorescence imaging for diagnosis in biomedicine

1992 • 33 citations

An automatic pulsed laser microfluorometer with high spatial and temporal resolution

1984 • 32 citations

Pulsed tunable lasers in cytofluorometry

1974 • 30 citations

Characterization of low‐light‐level cameras for digitized video microscopy

1990 • 29 citations

Fluorescence lifetime measurements under a microscope by the time-correlated single-photon counting technique

1986 • 29 citations

Construction of a Nanosecond Fluorometric System for Applications to Biological Samples at Cell or Tissue Levels

1976 • 24 citations

INSTRUMENTATION FOR FLUORESCENCE MICROSCOPY WITH PICOSECOND TIME RESOLUTION

1985 • 24 citations

Development of a streak-camera-based time-resolved microscope fluorometer and its application to studies of membrane fusion in single cells

1991 • 22 citations

A NEW METHOD OF DETERMINING INTRACELLULAR FREE Ca2+CONCENTRATION USING Quin2‐FLUORESCENCE

1991 • 22 citations

Multichannel time-correlated single photon counting: Spectroscopy and time-gated imaging using a resistive anode photomultiplier tube

1991 • 21 citations

AN INSTRUMENT FOR SIMULTANEOUS ACQUISITION OF FLUORESCENCE SPECTRA AND FLUORESCENCE LIFETIMES FROM SINGLE CELLS

1987 • 20 citations

A Nanosecond Photon-Counting Fluorimetric System Using a Modified Multichannel Vernier Chronotron

1985 • 18 citations

A single-photon-counting Fourier transform microfluorometer

1986 • 13 citations

Time-resolved fluorescence microscopy for measuring specific coenzymes in methanogenic bacteria

1984 • 10 citations

Measurement of intracellular Ca2+ in BC3H-1 muscle cells with Fura-2: Relationship to acetylcholine receptor synthesis

1990 • 9 citations

Measurement of fluorescence decay time in living cells

1972 • 8 citations

Time-resolved multiphoton counting

1986 • 6 citations