Clinical Pharmacokinetics of Quetiapine

Clinical pharmacokinetics; concepts and applications

1989 • 2,266 citations

Multiple fixed doses of “Seroquel” (quetiapine) in patients with acute exacerbation of schizophrenia: A comparison with haloperidol and placebo

1997 • 756 citations

Quetiapine in Patients With Schizophrenia

1997 • 487 citations

Cyclosporin A drug interactions. Screening for inducers and inhibitors of cytochrome P-450 (cyclosporin A oxidase) in primary cultures of human hepatocytes and in liver microsomes.

1990 • 423 citations

A Positron Emission Tomography Study of Quetiapine in Schizophrenia: A Preliminary Finding of an Antipsychotic Effect With Only Transiently High Dopamine D2 Receptor Occupancy

2000 • 401 citations

Age and cytochrome P450-linked drug metabolism in humans: An analysis of 226 subjects with equal histopathologic conditions*

1997 • 400 citations

A comparison of quetiapine and chlorpromazine in the treatment of schizophrenia

1997 • 253 citations

Metabolic Drug Interactions

2000 • 208 citations

Pharmacokinetic Interactions of Cimetidine 1987

1987 • 195 citations

Time course of central nervous dopamine-D 2 and 5-HT 2 receptor blockade and plasma drug concentrations after discontinuation of quetiapine (Seroquel ® ) in patients with schizophrenia

1998 • 167 citations

Pharmacokinetics, Tolerability, and Clinical Effectiveness of Quetiapine Fumarate

2000 • 137 citations

ICI 204,636, a novel, atypical antipsychotic: early indication of safety and efficacy in patients with chronic and subchronic schizophrenia

1995 • 92 citations

N-demethylation of amitriptyline in vitro: role of cytochrome P-450 3A (CYP3A) isoforms and effect of metabolic inhibitors.

1995 • 89 citations

The Effects of Concomitant Phenytoin Administration on the Steady-State Pharmacokinetics of Quetiapine

2001 • 75 citations

Prediction of the outcome of a phase 3 clinical trial of an antischizophrenic agent (quetiapine fumarate) by simulation with a population pharmacokinetic and pharmacodynamic model

2000 • 70 citations

A comparison of bd and tid dose regimens of quetiapine (Seroquel) in the treatment of schizophrenia

1998 • 70 citations

The Safety and Pharmacokinetics of Quetiapine When Coadministered With Haloperidol, Risperidone, or Thioridazine

2002 • 68 citations

[Cyclosporin A: drug interactions].

1991 • 67 citations

Single-dose pharmacokinetics of quetiapine in subjects with renal or hepatic impairment

2000 • 59 citations

ICI 204,636 (SEROQUEL™): A Dibenzothiazepine Atypical Antipsychotic. Review of Preclinical Pharmacology and Highlights of Phase II Clinical Trials

1995 • 51 citations

Effect of Fluoxetine and Imipramine on the Pharmacokinetics and Tolerability of the Antipsychotic Quetiapine

2002 • 43 citations

Determination of an antipsychotic agent (ICI 204,636) and its 7-hydroxy metabolite in human plasma by high-performance liquid chromatography and gas chromatography—mass spectrometry

1992 • 28 citations

NEW ANTIDEPRESSANT DRUGS AND THE TREATMENT OF DEPRESSION IN THE MEDICALLY ILL PATIENT

1996 • 25 citations

The Effect of Multiple Doses of Cimetidine on the Steady-State Pharmacokinetics of Quetiapine in Men With Selected Psychotic Disorders

2002 • 20 citations

The effect of zileuton on antipyrine and indocyanine green disposition*

1995 • 12 citations

Pharmacokinetics and safety of lithium co-administered with ‘seroquel’ (quetiapine)

1997 • 9 citations