Metallothionein and Other Low Molecular Weight Metal-Binding Proteins

Cadmium in the environment

1971 • 1,570 citations

A CADMIUM PROTEIN FROM EQUINE KIDNEY CORTEX

1957 • 1,295 citations

Metallothionein: a Cadmium- and Zinc-containing Protein from Equine Renal Cortex

1960 • 965 citations

Metallothionein: a Cadmium and Zinc-containing Protein from Equine Renal Cortex

1961 • 685 citations

Trace element metabolism in animals - 2.

1974 • 534 citations

Effects and dose-response relationships of toxic metals

1977 • 448 citations

Newer trace elements in nutrition.

1971 • 403 citations

THE DESTRUCTIVE EFFECT OF CADMIUM ION ON TESTICULAR TISSUE AND ITS PREVENTION BY ZINC

1957 • 393 citations

Equine Hepatic and Renal Metallothioneins

1974 • 384 citations

The biochemistry of copper.

1968 • 366 citations

Isolation and Some Properties of Human Metallothionein^*

1966 • 326 citations

The induction of metallothionein in rat liver by zinc injection and restriction of food intake

1975 • 319 citations

Mammalian zinc homeostasis: Requirement for RNA and metallothionein synthesis

1975 • 307 citations

Mercury, Mercurials and Mercaptans

1974 • 282 citations

A mechanism for cadmium- and zinc-induced tolerance to cadmium toxicity: Involvement of metallothionein*1, *2

1976 • 266 citations

Metal-induced formation of metallothionein in rat liver

1975 • 263 citations

Binding of cadmium ions by rat liver and kidney

1972 • 261 citations

Trace element metabolism in man and animals - 3.

1978 • 255 citations

Biological function of metallothionein. V. Its induction in rats by various stresses.

1978 • 249 citations

Separation of two forms of rabbit metallothionein by isoelectric focusing

1972 • 247 citations

Amino-acid sequence of equine renal metallothionein-1B.

1976 • 241 citations

Human hepatic metallothioneins

1974 • 238 citations

Cadmium-metallothionein-induced nephropathy

1976 • 230 citations

Comparative toxicity of cadmium-metallothionein and cadmium chloride on mouse kidney.

1975 • 208 citations

Mercury binding in the kidney and liver of rats repeatedly exposed to mercuric chloride: Induction of metallothionein by mercury and cadmium

1974 • 206 citations

Characterization of Cd, Zn‐Thionein (Metallothionein) Isolated from Rat and Chicken Liver

1973 • 199 citations

Metallothionein

1978 • 188 citations

Metallothionein and its Relationship to the Metabolism of Dietary Zinc in Rats

1976 • 177 citations

Correlation of hepatic metallothionein concentrations with acute cadmium toxicity in the mouse

1977 • 171 citations

Preparation and properties of the major copper-binding component in human fetal liver. Its identification as metallothionein.

1978 • 169 citations

Involvement of hepatic metallothioneins in hypozincemia associated with bacterial infection.

1978 • 168 citations

Distribution of Cadmium Among Protein Fractions of Mouse Liver¹)

1971 • 167 citations

Zinc accumulation and metabolism in primary cultures of adult rat liver cells. Regulation by glucocorticoids

1978 • 167 citations

Purification and some properties of Cd-binding protein from rat liver

1972 • 167 citations

Biological function of metallothionein

1975 • 160 citations

Isolation of heavy metal binding proteins from marine vertebrates

1974 • 159 citations

Zinc Binding: A Difference Between Human and Bovine Milk

1977 • 156 citations

Mechanism for cadmium and zinc antagonism of copper metabolism

1970 • 155 citations

Cadmium resistance and content of cadmium-binding protein in cultured human cells

1975 • 154 citations

Studies on metallothionein and cadmium

1978 • 149 citations

Zinc uptake by isolated rat liver parenchymal cells

1978 • 149 citations

The isolation of metallothionein and its protective role in cadmium poisoning

1974 • 148 citations

Isolation of (copper, zinc)-thioneins from the livers of copper-injected rats

1976 • 147 citations

Distribution of cadmium, zinc and copper in the musselMytilus edulis. Existence of cadmium-binding proteins similar to metallothioneins

1976 • 146 citations

Evaluation of metallothionein content in animal tissues.

1973 • 130 citations

Cadmium Toxicity in Growing Swine

1973 • 128 citations

Metabolism of intravenously injected cadmium-binding protein

1975 • 125 citations

Isolation of cadmium-binding proteins

1971 • 122 citations

Copper-thionein from fetal bovine liver

1977 • 121 citations

Circular dichroism of metallothioneins

1978 • 121 citations

Degradation of hepatic zinc-thionein after parenteral zinc administration

1976 • 121 citations

On the Distribution of Cadmium in Blood

1971 • 118 citations

Protective effect of zinc supplementation against copper toxicosis in sheep

1976 • 117 citations

The particulate half-cystine-rich copper protein of newborn liver. Relationship to metallothionein and subcellular localization in non-mitochondrial particles possibly representing heavy lysosomes

1974 • 117 citations

The biosynthesis of metallothionein in rat liver and kidney after administration of cadmium

1976 • 115 citations

Copper-chelatin: Purification and properties of a copper-binding protein from rat liver

1975 • 114 citations

Control of zinc-thionein synthesis in rat liver

1977 • 113 citations

Cadmium and Zinc in Pregnancy and Lactation

1972 • 112 citations

Distribution of copper and zinc in the liver of the developing sheep foetus

1977 • 112 citations

Hepatic copper–and zinc-binding proteins in ruminants

1974 • 109 citations

Primary structure of human hepatic metallothionein

1977 • 109 citations

Fate of 109Cd-labeled metallothionein in rats

1975 • 108 citations

Binding of mercury in the rat kidney by metallothionein

1970 • 108 citations

Cadmium and Zinc Binding in Mammalian Liver and Kidneys

1972 • 106 citations

Studies on the toxicity and metabolism of cadmium-thionein

1977 • 104 citations

Induced synthesis of metallothionein by pig kidney cells in vitro in response to cadmium

1975 • 101 citations

Isolation and purification of cadmium binding proteins from rat liver

1974 • 101 citations

Isolation of an intestinal metallothionein induced by parenteral zinc

1977 • 98 citations

Degradation of rat liver metallothioneins in vitro

1978 • 97 citations

Influence of certain metals on the level of metallothionein‐like proteins in the liver and kidneys of rats

1976 • 97 citations

Factors Influencing Metabolism and Toxicity of Metals: A Consensus Report

1978 • 96 citations

Isolation of (copper, zinc-) thioneins from pig liver

1976 • 95 citations

Conversion of metallothionein into Cu‐thionein, the possible low molecular weight form of neonatal hepatic mitochondrocuprein

1974 • 95 citations

Mouse liver metallothioneins. Complete amino acid sequence of metallothionein-I.

1977 • 95 citations

The renal toxicity of cadmium metallothionein: Morphometric and X-ray microanalytical studies

1978 • 95 citations

Placental transfer of cadmium in rats: influence of dose and gestational age.

1975 • 95 citations

Comparison of methods for estimating hepatic metallothionein in rats

1977 • 93 citations

Early cellular effects of circulating cadmium-thionein on kidney proximal tubules.

1979 • 93 citations

Biochemical changes in rat kidney on exposure to elemental mercury vapor: Effect on biosynthesis of metallothionein

1976 • 89 citations

A Naturally Occurring Cu-Thionein inSaccharomyces cerevisiae

1975 • 89 citations

The time-course of cadmium-thionein synthesis in the rat

1976 • 87 citations

Renal tubular transport of cadmium-metallothionein

1978 • 87 citations

Binding of cadmium and mercury by metallothionein in the kidneys and liver of rats following repeated administration

1974 • 86 citations

Distribution of metallothionein-bound cadmium and cadmium chloride in mice: preliminary studies.

1975 • 85 citations

Production and study of antibody produced aganist rat cadmium thionein

1978 • 85 citations

Binding of mercury and selenium in subcellular fractions of rat liver and kidneys following separate and joint administration

1977 • 84 citations

Metallothionein: Historical Review and Perspectives

1979 • 84 citations

Control of cadmium binding protein synthesis in rat liver.

1974 • 82 citations

Binding of mercury in the rat: Studies using 203HgCl2 and gel filtration

1970 • 81 citations

Synthesis of metallothionein in a polysomal cell-free system

1977 • 80 citations

Partial purification, characterization and translation in vitro of rat liver metallothionein messenger ribonucleic acid

1978 • 80 citations

Factors influencing metabolism and toxicity of metals: a consensus report

1978 • 79 citations

Zinc-binding ligands in milk and intestine: a role in neonatal nutrition?

1977 • 79 citations

Cell-free synthesis of metallothionein directed by rat liver polyadenylated messenger ribonucleic acid

1978 • 79 citations

Accumulation and Depletion of Zinc in Rat Liver and Kidney Metallothioneins

1977 • 78 citations

Gastrointestinal absorption and organ distribution of oral cadmium chloride and cadmium‐metallothionein in mice

1978 • 77 citations

Influence of parenteral zinc and actinomycin D on tissue zinc uptake and the synthesis of a zinc-binding protein

1975 • 76 citations

Hepatic copper–and zinc-binding proteins in ruminants

1974 • 75 citations

Binding of mercury and zinc to cadmium-binding protein in liver and kidney of goldfish (Carassius auratus L.)

1976 • 74 citations

Homologous copper(1)-(thiolate)2-chromophores in yeast copper thionein

1977 • 74 citations

Relative cadmium-binding capacity of metallothionein and other cytosolic fractions in various tissues of the rat.

1975 • 72 citations

Mouse liver metallothioneins. Purification, molecular weight, amino acid composition, and metal content.

1978 • 72 citations

Copper-chelatin: Isolation from various eucaryotic sources

1975 • 72 citations

Cadmium resistance and content of cadmium-binding protein in two enzyme-deficient mutants of mouse fibroblasts (L-cells)

1978 • 70 citations

Turnover of metallothioneins in rat liver

1978 • 70 citations

Nuclear 115cadmium: Uptake and disappearance correlated with cadmium-binding protein synthesis

1976 • 69 citations

Fish mercury‐binding thionein related to adaptation mechanisms

1975 • 68 citations

Cadmium as a trace element and cadmium binding components in human cells

1970 • 67 citations

Studies on the zinc content of Cd-induced thionein

1978 • 67 citations

Studies on the appearance of a hepatic copper-binding protein in normal and zinc-deficient rats

1976 • 66 citations

Kinetics of cadmium-induced hepatic and renal metallothionein synthesis in the mouse

1977 • 65 citations

A modified procedure for determination of metallothionein-like proteins in animal tissues.

1977 • 62 citations

Rabbit Liver Metallothionein. Tentative Amino Acid Sequence of Metallothionein-B

1979 • 61 citations

Studies on the Synthesis and Metabolism of Zinc-thionein in Rats

1977 • 59 citations

Studies on the binding of methylmercury by thionein

1973 • 59 citations

Degradation of cadmium‐thionein in rat liver and kidney

1978 • 55 citations

Spectroscopic Properties of Zinc-Metallothionein

1979 • 54 citations

Metallothionein in the extracellular fluids as an index of cadmium toxicity.

1979 • 54 citations

The mechanisms of hepatic and renal metallothionein biosynthesis in cadmium-exposed rats

1977 • 54 citations

Cadmium‐induced synthesis of hepatic metallothionein in chicken and rats

1973 • 54 citations

Nomenclature of multiple forms of enzymes. Recommendations (1976) IUPAC-IUB Commission on Biochemical Nomenclature (CBN).

1977 • 53 citations

Prevention by metallothionein of cadmium‐induced inhibition of vitamin D activation reaction in kidney

1974 • 53 citations

Nature of copper compounds in liver supernate and bile of rats: studies with 67 Cu

1973 • 52 citations

The Effect of Zinc Deficiency and Food Restriction on Hepatic Zinc Proteins in the Rat

1973 • 51 citations

The Effect of Chronic Copper Poisoning on the Kidneys of Sheep

1974 • 50 citations

Formation, Circular Dichroism and X-Ray Photoelectron Spectroscopy of Hepatic Zn-Thionein

1975 • 48 citations

Studies on metal-binding proteins of low molecular weight from renal tissue of rabbits exposed to cadmium or mercury.

1974 • 48 citations

Purification of low molecular weight copper proteins from copper loaded liver

1975 • 47 citations

Isolation of Low-Molecuter-Weight Lead-Binding Protein from Human Erythrocytes

1977 • 46 citations

Reabsorption of Filtered Cadmium-Metallothionein in the Rabbit Kidney

1977 • 46 citations

The effect of cadmium om intestinal copper absorption and binding in the rat

1977 • 44 citations

Binding of cadmium on metallothionein in man: an analysis of a fatal poisoning by cadmium iodide

1972 • 42 citations

Copper-induced synthesis of copper-chelatin in rat liver

1975 • 42 citations

Distribution of Cd, Zn and Cu in the mussel Mytilus edulis. Existence of Cd-binding proteins similar to metallothioneins.

1976 • 42 citations

STUDIES ON TOLERANCE AND IONIC ANTAGONISM FOR CADMIUM OR MERCURY

1967 • 41 citations

Binding of bismuth in the kidneys of the rate: The role of metallothionein-like proteins

1977 • 41 citations

BIOCHEMICAL EFFECTS OF Cd2+-INJURY IN THE RAT AND MOUSE TESTIS

1972 • 41 citations

INDUCTION OF HEPATIC ZINC-BINDING PROTEINS OF RATS BY VARIOUS METALS

1976 • 40 citations

Cross-reactivity of metallothioneins from different origins with rabbit anti-rat hepatic metallothionein antibody

1978 • 40 citations

Isolation and characterization of a hepatic metallothionein from mice.

1975 • 40 citations

Heavy metals in rat liver cadmium binding protein.

1975 • 39 citations

Neonatal hepatic mitochondrocuprein

1964 • 38 citations

The influence of selenium on the level of mercury and metallothionein in rat kidneys in prolonged exposure to different mercury compounds

1978 • 37 citations

Inhibitory Effects on Cadmium-Induced Testicular Damage by Pretreatment with Smaller Cadmium Dose

1966 • 37 citations

The Amino Acid Sequence of Equine Metallothioneins

1979 • 36 citations

Functions of Hepatic and Renal Metallothioneins in the Control of the Metabolism of Cadmium and Certain other Bivalent Cations

1979 • 35 citations

Molecular Biology of Copper. A Circular Dichroism Study on Copper Complexes of Thionein and Penicillamine

1975 • 34 citations

Cadmium toxicity studies under long term-low level exposure (LLE) conditions I. Metabolic patterns in rats exposed to present environmental dietary levels of Cd for two years

1978 • 34 citations

Metallothionein accumulation in response to cadmium in a clonal rat liver cell line*1

1978 • 34 citations

The influence of selenium on binding of inorganic mercury by metallothionein in the kidney and liver of the rat

1976 • 33 citations

Copper thionein in the kidneys of copper-poisoned sheep

1977 • 32 citations

Kinetics of cadmium transport in the isolated perfused rat liver

1976 • 31 citations

Protein binding of cadmium, zinc and copper in environmentally insulted limpets Patella vulgata

1975 • 31 citations

Structure and Function of Metalloenzymes

1971 • 30 citations

270 MHz proton magnetic resonance spectra of metallothionein

1974 • 30 citations

Induction of renal metallothionein synthesis by parenteral cadmium-thionein in rats

1978 • 30 citations

Neonatal hepatic mitochondrocuprein I. Isolation of a protein fraction containing more than 4% copper from mitochondria of immature bovine liver

1962 • 29 citations

Cadmium and mercury binding to metallothionein as influenced by selenium

1977 • 28 citations

Renal Metal Binding Proteins

1979 • 28 citations

Amino Acid Sequence of Human Hepatic Metallothioneins

1979 • 27 citations

The levels of metallothionein-like proteins in animal tissues

1977 • 25 citations

Cadmium-115 bound to nuclear and cytoplasmic proteins

1977 • 24 citations

Factors Influencing the Occurrence of Copper-Thioneins in Tissues

1979 • 23 citations

Isolation of a non-thionein copper-binding protein from liver of copper-injected rats

1977 • 23 citations

Effect of selenium on the organ distribution and binding of bismuth in rat tissues

1978 • 23 citations

A Cadmium-Binding Glycoprotein from the Liver of the Plaice (Pleuronectes platessa)

1977 • 23 citations

Small copper-binding proteins from normal and copper-loaded liver☆

1975 • 23 citations

Accumulation of cadmium in rat liver cadmium binding protein following single and repeated cadmium administration.

1975 • 23 citations

Amino-Acid Sequence of Copper-Metallothionein from Neurospora Crassa

1979 • 22 citations

Postinductive actinomycin D effects on the concentrations of cadmium thionein, and copper chelatin in rat liver

1978 • 22 citations

¹H NMR spectra of metallothioneins

1978 • 21 citations

In Vivo and Ex Vivo Induction of Rat Liver Metallothionein

1979 • 21 citations

Physiological and Chemical Characterization of Invertebrate Metallothionein-Like Proteins

1979 • 21 citations

Primary Structure of Mouse Liver Metallothionein -I and -II

1979 • 21 citations

Synthesis and Degradation of Liver Metallothionein

1979 • 19 citations

Induction and synthesis of metallothionein in isolated perfused rat liver

1978 • 19 citations

Antibodies to the low molecular weight copper binding protein from liver

1977 • 19 citations

Binding of gold in the kidney of the rat

1977 • 19 citations

Distribution of some Protein‐bound Trace Elements among Soluble Protein Fractions from Human Liver

1976 • 19 citations

Cd-metallothionein-a test object for dark-field studies of protein structure

1976 • 17 citations

A Soluble Cadmium-Binding Component in Rat and Dog Spleen

1975 • 16 citations

The Amino-Terminal Sequence of a Rat Liver Metallothionein (MT-2)

1979 • 16 citations

Copper-Thionein and Other Metal-Sulphur-Proteins

1979 • 16 citations

Metallothionein in Intestinal Copper Metabolism

1979 • 15 citations

Optically active metalloprotein chromophores I. Metallothionein

1962 • 14 citations

Influence of Inhibitors of Protein Synthesis on Zinc Metabolism

1977 • 13 citations

Copper- and zinc-binding ligands in the intestinal mucosa

1978 • 11 citations

Metabolism and Potential Toxic Effects of Metallothionein

1979 • 10 citations

Nutritional and Environmental Factors Affecting Metallothionein Levels

1979 • 10 citations

Nomenclature of Metallothionein: A Proposal

1979 • 10 citations

The Low Molecular Weight Cadmium-, Mercury- and Zinc-Binding Proteins (Metallothioneins): Biosynthesis, Metabolism, and Possible Role in Metal Toxicity

1979 • 9 citations

Strain differences in susceptibility of mice to cadmium-induced metallothionein

1978 • 9 citations

The 1H N.M.R. Spectra of Metallothioneins

1979 • 8 citations

Determination of the Charge of Horse Kidney Metallothionein by Free Boundary Electrophoresis

1979 • 7 citations

Structural Aspects and Reduction Oxidation Reactions of Metallothionein

1979 • 7 citations

Characterization of Cadmium-Induced Metallothionein in African Green Monkey Kidney Cells In Vitro

1979 • 6 citations

Partial Purification and Translation in Vitro of Metallothionein Messenger RNA

1979 • 6 citations

Renal Effects of Mercury- and Cadmium-Metallothionein

1979 • 6 citations

CADMIUM ACCUMULATION IN LIVER AND KIDNEY OF RABBIT WITH SINGLE INJECTION

1975 • 4 citations

Low Molecular Weight Copper-Binding Proteins in Cultured Human Cells

1979 • 3 citations

Structural Characterization of Metallothionein by Multinuclear NMR

1979 • 3 citations