Embryonic genome activation

Full-term development of mice from enucleated oocytes injected with cumulus cell nuclei

1998 • 2,257 citations

Human gene expression first occurs between the four- and eight-cell stages of preimplantation development

1988 • 1,419 citations

Cloned Transgenic Calves Produced from Nonquiescent Fetal Fibroblasts

1998 • 1,408 citations

Active demethylation of the paternal genome in the mouse zygote

2000 • 964 citations

Genomic Imprinting Disrupted by a Maternal Effect Mutation in the Dnmt1 Gene

2001 • 675 citations

The transition from maternal to embryonic control in the 2-cell mouse embryo.

1982 • 626 citations

Regulation of Transcriptional Activity during the First and Second Cell Cycles in the Preimplantation Mouse Embryo

1997 • 578 citations

Histone acetylation: chromatin in action

1997 • 475 citations

Heat shock proteins, first major products of zygotic gene activity in mouse embryo

1983 • 401 citations

Viable offspring derived from fetal and adult mammalian cells.

1997 • 347 citations

Changes in state of adenylation and time course of degradation of maternal mRNAs during oocyte maturation and early embryonic development in the mouse

1988 • 304 citations

Regulation of Gene Expression at the Beginning of Mammalian Development

1995 • 290 citations

Remodeling of Nucleoproteins during Gametogenesis, Fertilization, and Early Development

1986 • 280 citations

Quantitative analysis of protein synthesis in mouse embryos. I. Extensive reprogramming at the one- and two-cell stages

1991 • 234 citations

Casein Kinase II-mediated Phosphorylation of the C Terminus of Sp1 Decreases Its DNA Binding Activity

1997 • 231 citations

Growth-related Changes in Phosphorylation of Yeast RNA Polymerase II

1998 • 225 citations

Active Remodeling of Somatic Nuclei in Egg Cytoplasm by the Nucleosomal ATPase ISWI

2000 • 219 citations

Polyadenylated RNA of mouse ova and loss of maternal RNA in early development

1980 • 210 citations

Sp1 Is Phosphorylated and Its DNA Binding Activity Down-regulated upon Terminal Differentiation of the Liver

1995 • 210 citations

Changes in total RNA, polyadenylated RNA, and actin mRNA during meiotic maturation of mouse oocytes

1985 • 202 citations

Chromatin Transitions during Early Xenopus Embryogenesis: Changes in Histone H4 Acetylation and in Linker Histone Type

1993 • 186 citations

Chromatin Structure of Telomere Domain in Human Sperm

2000 • 181 citations

Mechanisms and Control of Embryonic Genome Activation in Mammalian Embryos

1999 • 173 citations

Activation of Endogenous Nucleases in Mature Sperm Cells upon Interaction with Exogenous DNA

1997 • 165 citations

RNA synthesis and cytoplasmic polyadenylation in the one-cell mouse embryo

1982 • 149 citations

Acquisition of a transcriptionally permissive state during the 1-cell stage of mouse embryogenesis

1992 • 139 citations

Evidence for expression of the paternal genome in the two-cell mouse embryo

1981 • 139 citations

Transcription of paternal Y-linked genes in the human zygote as early as the pronucleate stage

1994 • 139 citations

Remodeling somatic nuclei in Xenopus laevis egg extracts: molecular mechanisms for the selective release of histones H1 and H1(0) from chromatin and the acquisition of transcriptional competence.

1996 • 132 citations

Onset of paternal gene activation in early mouse embryos fertilized with transgenic mouse sperm

1994 • 130 citations

Analysis of gene expression in mouse preimplantation embryos demonstrates that the primary role of enhancers is to relieve repression of promoters.

1993 • 124 citations

Temporally restricted spatial localization of acetylated isoforms of histone H4 and RNA polymerase II in the 2-cell mouse embryo

1995 • 121 citations

Regulation of gene expression in preimplantation mouse embryos: Effects of the zygotic clock and the first mitosis on promoter and enhancer activities

1991 • 120 citations

The need for enhancers in gene expression first appears during mouse development with formation of the zygotic nucleus.

1989 • 118 citations

Structural relationship and posttranslational modification of stage-specific proteins synthesized during early preimplantation development in the mouse.

1981 • 116 citations

Repression of Gene Expression at the Beginning of Mouse Development

1995 • 111 citations

RNA synthesis at the two-cell stage of mouse development

1972 • 110 citations

Changes in the quantity of histone and actin messenger RNA during the development of preimplantation mouse embryos

1983 • 109 citations

Changes in histone synthesis and modification at the beginning of mouse development correlate with the establishment of chromatin mediated repression of transcription

1997 • 108 citations

The Unique, Complex Organization of the Transcriptionally Silent Sperm Chromatin

1996 • 107 citations

Nuclear translocation and carboxyl-terminal domain phosphorylation of RNA polymerase II delineate the two phases of zygotic gene activation in mammalian embryos

1997 • 102 citations

Effect of egg composition on the developmental capacity of androgenetic mouse embryos

1991 • 102 citations

Transcription factor mTEAD-2 is selectively expressed at the beginning of zygotic gene expression in the mouse

1997 • 91 citations

Atypical decondensation of the sperm nucleus, delayed replication of the male genome, and sex chromosome positioning following intracytoplasmic human sperm injection (ICSI) into golden hamster eggs: does ICSI itself introduce chromosomal anomalies?

2000 • 90 citations

Stage-dependent redistributions of acetylated histones in nuclei of the early preimplantation mouse embryo

1997 • 85 citations

Developmental regulation of chromatin composition during mouse embryogenesis: somatic histone H1 is first detectable at the 4-cell stage

1992 • 81 citations

DNA Organization in Human Spermatozoa

1994 • 80 citations

Amounts and modulation of actin mRNAs in mouse oocytes and embryos

1989 • 79 citations

Gene activity and cleavage arrest in human pre-embryos

1992 • 75 citations

PARTICIPATION OF DNA STRUCTURE ON SPERM CHROMATIN ORGANIZATION

2000 • 73 citations

Stage-Specific Induction and Regulation by Genomic Imprinting of the Mouse U2afbp-rs Gene during Preimplantation Development

1995 • 67 citations

Transcriptional Control of Development, Protein Synthesis, and Heat-Induced Heat Shock Protein 70 Synthesis in 2-Cell Bovine Embryos1

1999 • 64 citations

Developmental Change in TATA-Box Utilization during Preimplantation Mouse Development

2000 • 63 citations

Developmental acquisition of enhancer function requires a unique coactivator activity

1997 • 57 citations

Actin mRNA content in normal and delayed implanting mouse embryos

1985 • 55 citations

Regulation of gene expression in the preimplantation mouse embryo: Temporal and spatial patterns of expression of the transcription factor Sp1

1997 • 55 citations

Cell-Specific Organization of the 5S Ribosomal RNA Gene Cluster DNA Loop Domains in Spermatozoa and Somatic Cells1

1995 • 52 citations

Relief of a repressed gene expression state in the mouse 1-cell embryo requires DNA replication

1998 • 46 citations

Strain-specific differences in mouse oocytes and their contributions to epigenetic inheritance

1994 • 44 citations

Further evidence that sperm nuclear proteins are necessary for embryogenesis

2000 • 44 citations

Localization of fibrillarin and nucleolin in nucleoli of mouse preimplantation embryos

1995 • 44 citations

Changes in permissiveness for the expression of microinjected DNA during the first cleavages of mouse embryos

1992 • 43 citations

Temporal patterns of A-myb and B-myb gene expression during testis development.

1996 • 43 citations

Developmentally Regulated Loss and Reappearance of Immunoreactive Somatic Histone H1 on Chromatin of Bovine Morula-Stage Nuclei Following Transplantation into Oocytes1

1999 • 43 citations

Mechanistic and Developmental Aspects of Genetic Imprinting in Mammals

1995 • 37 citations

Nucleosomal domains of mouse spermatozoa chromatin as potential sites for retroposition and foreign DNA integration

2000 • 37 citations

Initiation of a chromatin-based transcriptionally repressive state in the preimplantation mouse embryo: Lack of a primary role for expression of somatic histone H1

2000 • 24 citations

Stage-specific embryonic antigens detected by an antiserum against mouse blastocysts

1980 • 21 citations

Interaction of exogenous DNA with the nuclear matrix of live spermatozoa

2000 • 17 citations

Embryonic inheritance of the chromatin organisation of the imprinted H19 domain in mouse spermatozoa

2000 • 13 citations

Chromatin and transcriptional activity in earlyXenopusdevelopment

1995 • 10 citations

Paternal transcripts for glucose‐6‐phosphate dehydrogenase and adenosine deaminase are first detectable in the human preimplantation embryo at the Three‐ to Four‐Cell stage

1997 • 2 citations

Somatic histone H1 microinjected into fertilized mouse eggs is transported into the pronuclei but does not disrupt subsequent preimplantation development

1996 • 1 citations