Regulation of de novo purine synthesis in human lymphoblasts. Similar rates of de novo synthesis during growth by normal cells and mutants deficient in hypoxanthine-guanine phosphoribosyltransferase activity.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

A familial disorder of uric acid metabolism and central nervous system function

1964 • 1,448 citations

Enzyme Defect Associated with a Sex-Linked Human Neurological Disorder and Excessive Purine Synthesis

1967 • 1,210 citations

Incorporation of 3H-uridine and 3H-uracil into RNA

1974 • 485 citations

Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency in Gout

1969 • 452 citations

Human lymphoblastoid lines from lymph node and spleen

1968 • 261 citations

Biochemical Bases of Accelerated Purine Biosynthesis de Novo in Human Fibroblasts Lacking Hypoxanthine-Guanine Phosphoribosyltransferase

1968 • 251 citations

Permeation of Glucose by Simple and Facilitated Diffusion by Novikoff Rat Hepatoma Cells in Suspension Culture and Its Relationship to Glucose Metabolism

1972 • 215 citations

Abnormal Purine Metabolism and Purine Overproduction in a Patient Deficient in Purine Nucleoside Phosphorylase

1976 • 175 citations

Rate-limiting steps in the interconversion of purine ribonucleotides in Ehrlich ascites tumor cells in vitro.

1971 • 173 citations

Duncan's Diseases of Metabolism,

1975 • 165 citations

Synthesis of 5-Phosphoribosyl 1-Pyrophosphate from Glucose in Ehrlich Ascites Tumor Cells in Vitro

1965 • 157 citations

Feedback Inhibition of Purine Biosynthesis in Ascites Tumor Cells

1962 • 154 citations

Mutant feedback-resistant phosphoribosylpyrophosphate synthetase associated with purine overproduction and gout. Phosphoribosylpyrophosphate and purine metabolism in cultured fibroblasts.

1975 • 136 citations

Human Glutamine Phosphoribosylpyrophosphate Amidotransferase

1973 • 133 citations

Purine Overproduction in Man Associated with Increased Phosphoribosylpyrophosphate Synthetase Activity

1973 • 118 citations

Incorporation of glycine nitrogen into uric acid in normal and gouty man.

1952 • 108 citations

Patterns of phosphoribosylpyrophosphate and ribose-5-phosphate concentration and generation in fibroblasts from patients with gout and purine overproduction.

1976 • 104 citations

Gout and Hyperuricemia.

1977 • 98 citations

Purine nucleotide synthesis in lymphoblasts cultured from normal subjects and a patient with Lesch-Nyhan syndrome

1973 • 93 citations

Regulation of purine biosynthesis

1972 • 86 citations

The Effects of Azathioprine (Imuran) on Purine Synthesis in Clinical Disorders of Purine Metabolism*

1967 • 85 citations

Regulation of de novo purine biosynthesis in human lymphoblasts. Coordinate control of proximal (rate-determining) steps and the inosinic acid branch point.

1976 • 80 citations

Multiple mechanisms of regulation of purine biosynthesis de novo in intact tumor cells

1974 • 76 citations

Patterns of Glucose Metabolism in Normal and Virus-Transformed Chick Cells in Tissue Culture<xref ref-type="fn" rid="FN1">2</xref>

1972 • 73 citations

Mechanism of excessive purine biosynthesis in hypoxanthine-guanine phosphoribosyltransferase deficiency

1970 • 73 citations

Purine excretion by mammalian cells deficient in adenosine kinase

1973 • 70 citations

Availability of 5-Phosphoribosyl 1-Pyrophosphate for Ribonucleotide Synthesis in Ehrlich Ascites Tumor Cells in Vitro

1965 • 67 citations

De novo synthesis of purine nucleotides in human peripheral blood leukocytes. Excessive activity of the pathway in hypoxanthine-guanine phosphoribosyltransferase deficiency.

1976 • 55 citations

Phosphoribosylpyrophosphate Overproduction, a New Metabolic Abnormality in the Lesch Nyhan Syndrome

1975 • 49 citations

Expression of Purine Overproduction in a Series of 8-Azaguanine-Resistant Diploid Human Lymphoblast Lines

1974 • 47 citations

Effects of Hormones and Drugs on Phosphoribosyl Pyrophosphate Concentrations in Mouse Liver

1975 • 46 citations

Dynamics of Metabolism of Normal and Virus-Transformed Chick Cells in Culture

1973 • 45 citations

Phosphoribosylpyrophosphate Synthetase Is Elevated in Fibroblasts from Patients with the Lesch-Nyhan Syndrome

1976 • 35 citations

Regulatory Mechanisms in Carbohydrate Metabolism

1963 • 30 citations

Regulation of purine nucleotide synthesis

1976 • 29 citations

Increased PRPP synthetase activity in cultured rat hepatoma cells containing mutations in the hypoxanthine‐guanine phosphoribosyltransferase gene

1976 • 25 citations

Biochemical Characteristics of 8-Azaguanine Resistant Human Lymphoblast Mutants Selected in Vitro

1974 • 22 citations

The 'adenosine cycle' is not a significant route of purine metabolism in mammalian cells

1976 • 17 citations

Synthesis of 5-Phosphoribosyl 1-Pyrophosphate from Ribonucleosides in Ehrlich Ascites Tumor Cells in Vitro

1965 • 16 citations

Urate Kinetics in Hypoxanthine-Guanine Phosphoribosyltransferase Deficiency: Their Significance for the Understanding of Gout

1976 • 15 citations

Effects of Actinomycin D on Purine Ribonucleotide Metabolism in Ehrlich Ascites Tumor Cells In Vitro

1974 • 8 citations