Effects of genistein, a tyrosine kinase inhibitor, on platelet functions

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Genistein, a specific inhibitor of tyrosine-specific protein kinases.

1987 • 3,773 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

Transforming gene product of Rous sarcoma virus phosphorylates tyrosine

1980 • 2,387 citations

Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate

1988 • 1,027 citations

Production of diglyceride from phosphatidylinositol in activated human platelets.

1979 • 727 citations

The Metabolism of Phosphoinositide-Derived Messenger Molecules

1986 • 717 citations

Role of phosphoinositides in transmembrane signaling.

1990 • 491 citations

Effect of genistein on topoisomerase activity and on the growth of [VAL 12]Ha-ras-transformed NIH 3T3 cells

1988 • 443 citations

[30] Use and specificity of genistein as inhibitor of protein-tyrosine kinases

1991 • 421 citations

Inositol phosphates: synthesis and degradation.

1988 • 359 citations

Blood platelets express high levels of the pp60c-src-specific tyrosine kinase activity.

1986 • 329 citations

Alkaline O→N-transacylation. A new method for the quantitative deacylation of phospholipids

1981 • 320 citations

Thrombin treatment induces rapid changes in tyrosine phosphorylation in platelets.

1989 • 276 citations

Tyrosine-specific protein phosphorylation is regulated by glycoprotein IIb-IIIa in platelets.

1989 • 250 citations

Role of platelet membrane glycoprotein IIb-IIIa in agonist-induced tyrosine phosphorylation of platelet proteins.

1990 • 237 citations

Mechanisms of action in NIH-3T3 cells of genistein, an inhibitor of EGF receptor tyrosine kinase activity

1990 • 235 citations

Platelet tyrosine-specific protein phosphorylation is regulated by thrombin.

1988 • 229 citations

[31] Use and selectivity of herbimycin A as inhibitor of protein-tyrosine kinases

1991 • 218 citations

Human platelets form 3-phosphorylated phosphoinositides in response to alpha-thrombin, U46619, or GTP gamma S.

1990 • 204 citations

Cytosolic and stored calcium antagonistically control tyrosine phosphorylation of specific platelet proteins.

1991 • 170 citations

Thrombin and collagen induce rapid phosphorylation of a common set of cellular proteins on tyrosine in human platelets

1989 • 148 citations

Genistein, a protein tyrosine kinase inhibitor, inhibits thromboxane A2-mediated human platelet responses.

1991 • 143 citations

Attenuation of sn-1,2-diacylglycerol second messengers. Metabolism of exogenous diacylglycerols by human platelets.

1986 • 106 citations

Platelet-activating factor stimulation of tyrosine kinase and its relationship to phospholipase C in rabbit platelets: studies with genistein and monoclonal antibody to phosphotyrosine.

1990 • 101 citations

Specific inhibitors of tyrosine-specific protein kinases: properties of 4-hydroxycinnamamide derivatives in vitro.

1989 • 100 citations

Elevated cytosolic Ca2+ activates phospholipase D in human platelets

1991 • 90 citations

Purification and enzymatic characterization of pp60c-src from human platelets.

1990 • 85 citations

Effect of genistein, a tyrosine kinase inhibitor, on U46619-induced phosphoinositide phosphorylation in human platelets

1990 • 68 citations

Vasopressin dependent tyrosine phosphorylation of a 38 kDa protein in human platelets

1990 • 32 citations