Cardiac Adaptation to Hemodynamic Overload, Training and Stress

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

The Reliability of Molecular Weight Determinations by Dodecyl Sulfate-Polyacrylamide Gel Electrophoresis

1969 • 20,498 citations

Methods of Enzymatic Analysis

1975 • 20,446 citations

THE COLORIMETRIC DETERMINATION OF PHOSPHORUS

1925 • 19,115 citations

The Regulation of Rabbit Skeletal Muscle Contraction

1971 • 4,491 citations

Untersuchungen uber die Harnstoffbildung im Tierkörper

1932 • 3,104 citations

New type of cardiomyopathy associated with diabetic glomerulosclerosis

1972 • 1,725 citations

Fiber Orientation in the Canine Left Ventricle during Diastole and Systole

1969 • 1,415 citations

[α1(III)]3 Human Skin Collagen

1974 • 592 citations

Contractile State of Cardiac Muscle Obtained from Cats with Experimentally Produced Ventricular Hypertrophy and Heart Failure

1967 • 505 citations

The Importance of Adaptive Changes in Vascular Design for the Establishment and Maintenance of Primary Hypertension, as Studied in Man and in Spontaneously Hypertensive Rat

1972 • 505 citations

Coronary Arterial Smooth Muscle Contraction by a Substance Released from Platelets: Evidence That It Is Thromboxane A ₂

1976 • 504 citations

Direct evidence that the greater contractility of resistance vessels in spontaneously hypertensive rats is associated with a narrowed lumen, a thickened media, and an increased number of smooth muscle cell layers.

1978 • 461 citations

Endogenous digitalis-like substance in plasma of volume-expanded dogs

1980 • 444 citations

The action potentials of the alpha motoneurones supplying fast and slow muscles

1958 • 443 citations

Effects of long-term electrical stimulation on some contractile and metabolic characteristics of fast rabbit muscles

1973 • 422 citations

STUDIES ON THE FIRST DERIVATIVE OF THE VENTRICULAR PRESSURE PULSE IN MAN

1962 • 409 citations

Magnesium Deficiency Produces Spasms of Coronary Arteries: Relationship to Etiology of Sudden Death Ischemic Heart Disease

1980 • 392 citations

Validity of an indirect tail-cuff method for determining systolic arterial pressure in unanesthetized normotensive and spontaneously hypertensive rats.

1971 • 391 citations

Myosin isoenzymic distribution correlates with speed of myocardial contraction

1981 • 357 citations

Species- and age-dependent changes in the relative amounts of cardiac myosin isoenzymes in mammals

1981 • 354 citations

Sarcoplasmic Reticulum

1968 • 348 citations

Elevation of Adrenal Tyrosine Hydroxylase and Phenylethanolamine-N-Methyl Transferase by Repeated Immobilization of Rats

1970 • 316 citations

Molecular characterization of two myosin heavy chain genes expressed in the adult heart

1982 • 277 citations

The effects of different patterns of muscle activity on capillary density, mechanical properties and structure of slow and fast rabbit muscles

1976 • 276 citations

Increased myothermal economy of isometric force generation in compensated cardiac hypertrophy induced by pulmonary artery constriction in the rabbit. A characterization of heat liberation in normal and hypertrophied right ventricular papillary muscles.

1982 • 254 citations

The ATPase activities of rat cardiac myosin isoenzymes

1980 • 253 citations

Synthesis by Fast Muscle of Myosin Light Chains characteristic of Slow Muscle in Response to Long-term Stimulation

1973 • 242 citations

Structural differences in the heavy chains of rat ventricular myosin isoenzymes

1979 • 227 citations

Thromboxane release during pacing-induced angina pectoris: possible vasoconstrictor influence on the coronary vasculature.

1980 • 224 citations

Engineering Mechanics for Successive States in Canine Left Ventricular Myocardium

1973 • 218 citations

RNA of RNA Tumour Viruses contains Poly A

1972 • 213 citations

Altered myosin isozyme patterns from pressure-overloaded and thyrotoxic hypertrophied rabbit hearts.

1982 • 212 citations

Effect of subcortical lesions on shock-induced aggression in the rat.

1971 • 210 citations

The Problem of Central Nervous Reorganization After Nerve Regeneration and Muscle Transposition

1945 • 208 citations

Serum Magnesium in Acute Myocardial Infarction

1980 • 204 citations

The effect of motoneurone activity on the speed of contraction of striated muscle

1963 • 202 citations

AN INCREASED CALCIUM SENSITIVITY OF MESENTERIC RESISTANCE VESSELS IN YOUNG AND ADULT SPONTANEOUSLY HYPERTENSIVE RATS

1980 • 199 citations

De Novo Synthesis of Myocardial Adenine Nucleotides in the Rat

1973 • 197 citations

Slow and Fast Muscles After Cross Innervation

1967 • 187 citations

Hydrolysis of ATP and reversible binding to F-actin by myosin heavy chains free of all light chains

1981 • 185 citations

Enzymic properties of myosin in fast and slow twitch muscles of the cat following cross‐innervation

1969 • 172 citations

The growth of the muscular and collagenous parts of the rat heart in various forms of cardiomegaly

1969 • 171 citations

Short- and long-term efficacy of a calcium-antagonistic agent (nifedipine) combined with methyldopa in the treatment of severe hypertension.

1980 • 163 citations

112. The course of autoxidation reactions in polyisoprenes and allied compounds. Part IX. The primary thermal oxidation product of ethyl linoleate

1945 • 160 citations

Structure and mass of mitochondria in the process of compensatory hyperfunction and hypertrophy of the heart

1964 • 150 citations

Sodium-calcium exchange and sidedness of isolated cardiac sarcolemmal vesicles

1980 • 146 citations

The free heavy chain of vertebrate skeletal myosin subfragment 1 shows full enzymatic activity.

1982 • 145 citations

Isolation and characterization of two molecular variants of myosin heavy chain from rabbit ventricle. Change in their content during normal growth and after treatment with thyroid hormone.

1982 • 144 citations

Alterations of mechanical parameters in chemically skinned preparations of rat myocardium as a function of isoenzyme pattern of myosin

1982 • 140 citations

The adaptive changes in the isoenzyme pattern of myosin from hypertrophied rat myocardium as a result of pressure overload and physical training

1981 • 139 citations

Myosin types and fiber types in cardiac muscle. I. Ventricular myocardium.

1981 • 133 citations

Myocardial Force-Velocity Relationships in Clinical Heart Disease

1970 • 127 citations

Transmural distribution of myocardial blood flow and of coronary reserve in canine left ventricular hypertrophy

1977 • 124 citations

Decrease of calcium binding by the red blood cell membrane in spontaneously hypertensive rats and in essential hypertension

1979 • 124 citations

Human atrial and ventricular myosin light-chains subunits in the adult and during development

1980 • 122 citations

Transitions in human atrial and ventricular myosin light-chain isoenzymes in response to cardiac-pressure-overload-induced hypertrophy

1982 • 119 citations

Isomyosin distribution in normal and pressure-overloaded rat ventricular myocardium. An immunohistochemical study.

1981 • 115 citations

Separation of the α Chains of Type I and III Collagens by SDS-Polyacrylamide Gel Electrophoresis1

1979 • 114 citations

The effects of inactivity, programmed stimulation, and denervation on the histochemistry of skeletal muscle fiber types

1973 • 111 citations

Normal Myocardial Function and Energetics in Volume-Overload Hypertrophy in the Cat

1973 • 110 citations

Left ventricular function in experimental aorto-caval fistula with circulatory congestion and fluid retention

1968 • 110 citations

Effect of thyroxine on ventricular myocardial contractility and ATPase activity in guinea pigs

1974 • 99 citations

Myocardial hypertrophy and failure

1983 • 95 citations

Serum Magnesium Levels in Patients with Acute Myocardial Infarction

1977 • 92 citations

Structural and Enzymatic Comparison of Human Cardiac Muscle Myosins Isolated from Infants, Adults, and Patients with Hypertrophic Cardiomyopathy

1982 • 87 citations

Favorable effects of therapy on cardiac performance in spontaneously hypertensive rats

1982 • 85 citations

Heat, mechanics, and myosin ATPase in normal and hypertrophied heart muscle.

1982 • 83 citations

Isometric Cardiac Contraction

1977 • 81 citations

Makroskopische und mikrometrische Untersuchungen am Myokard verschieden stark gef�llter linker Kammern

1960 • 81 citations

Influence of thyroid hormone administration on myosin ATPase activity and myosin isoenzyme distribution in the heart of diabetic rats

1982 • 79 citations

Normal Contractile State of Hypertrophied Myocardium after Pulmonary Artery Constriction in the Cat

1974 • 79 citations

Cross innervation and the regulatory protein system of rabbit soleus muscle

1975 • 79 citations

Evidence for enhanced sodium transport in the tail artery of the spontaneously hypertensive rat.

1979 • 77 citations

Biochemical "Defect" in the Hypertrophied and Failing Heart

1973 • 77 citations

Aging changes in the human aortic valve in relation to dystrophic calcification

1976 • 77 citations

Adaptation of actomyosin ATPase in different types of muscle to endurance exercise

1975 • 75 citations

Regulation of protein synthesis and degradation during in vitro cardiac work

1980 • 74 citations

Atrial and ventricular cardiac myosins contain different heavy chain species

1978 • 70 citations

Enhanced synthesis of adrenal dopamine beta-hydroxylase induced by repeated immobilization in rats.

1971 • 70 citations

Relationship of phosphorylation potential and oxygen consumption in isolated perfused rat hearts

1980 • 70 citations

Structural differences in the mesentery microcirculation between normotensive and spontaneously hypertensive rats

1978 • 69 citations

Distribution of myosin isozymes within single cardiac cells. An immunohistochemical study.

1983 • 69 citations

Response of blood pressure and cardiac myosin polymorphism to swimming training in the spontaneously hypertensive rat

1982 • 69 citations

Characterization of intramuscular collagen in the mammalian left ventricle

1982 • 68 citations

Myocardial mechanical alterations during gradual onset long-term hypertension in rats

1981 • 68 citations

Attenuation of myocardial acidosis by propranolol during ischaemic arrest and reperfusion: evidence with 31P nuclear magnetic resonance

1980 • 65 citations

In vivo CO-2 buffer curves of skeletal and cardiac muscle

1966 • 64 citations

Arterial changes in Crotalaria spectabilis-induced pulmonary hypertension in rats.

1974 • 63 citations

Die Frage wozu? : Geschichte und Wiederentdeckung des teleologischen Denkens

1985 • 63 citations

Alterations in cardiac oxygen consumption under chronic pressure overload

1982 • 62 citations

Coronary artery spasm in the denervated transplanted human heart

1981 • 61 citations

A Unifying Concept for the Role of Matrix Vesicles and Lysosomes in the Formal Pathogenesis of Diseases of Connective Tissues and Blood Vessels

1977 • 60 citations

Myocardial function in different models of cardiac hypertrophy. An attempt at correlating mechanical, biochemical, and morphological parameters

1977 • 56 citations

Morphologische und physiologische Untersuchungen an Ratten w�hrend eines Lauftrainings und nach dem Training

1951 • 56 citations

Morphometric analysis of the rabbit myocardium after chronic ethanol feeding — early capillary changes

1982 • 54 citations

Occurrence of type III collagen in inflamed synovial membranes: A comparison between non rheumatoid, rheumatoid, and normal synovial collagens

1975 • 54 citations

Do Resistance Vessel Abnormalities Contribute to the Elevated Blood Pressure of Spontaneously-Hypertensive Rats?

1983 • 54 citations

Pressure-volume relations, elastic modulus, and contractile behaviour of the hypertrophied left ventricle of rats with Goldblatt II hypertension

1977 • 53 citations

Studies on the substructure of myosin in cardiac hypertrophy Characterization of light chains

1974 • 52 citations

Myocardial oxygen consumption during experimental hypertrophy and congestive heart failure

1973 • 52 citations

Digoxin-like immunoreactivity in the serum of rats with cardiac overload

1981 • 52 citations

Heat production during hypoxic contracture of rat myocardium.

1982 • 51 citations

Separation of muscle and non-muscle cells from adult rat myocardium: An application to the study of RNA polymerase

1977 • 49 citations

Effect of l-thyroxine on the primary structure of cardiac myosin

1970 • 48 citations

Studies on digitalis

1965 • 46 citations

Polymorphic myosin as the common determinant of myofibrillar ATPase in different haemodynamic and thyroid states

1982 • 43 citations

The Isolation and Some Properties of an Alkaloid from Crotalaria spectabilis Roth¹

1935 • 42 citations

Influence of Nifedipine on Ventricular Function and Myocardial Hypertrophy in Spontaneously Hypertensive Rats

1983 • 42 citations

Immunological and biochemical evidence for atrial-like isomyosin in thyrotoxic rabbit ventricle

1981 • 41 citations

Physiological and pathological changes in tissue monoamine oxidase activity

1976 • 41 citations

Regulation of rat adrenal dopamine β-hydroxylase. II. Receptor interaction in the regulation of enzyme synthesis and degradation

1976 • 38 citations

Glass electrode measurement of net Na⁺ and K⁺ fluxes in erythrocytes of the spontaneously hypertensive rat

1977 • 38 citations

Fiber orientation in hypertrophied canine left ventricle

1979 • 37 citations

Effect of phospholipid methylation on beta-adrenergic receptors in the normal and hypertrophied rat myocardium.

1980 • 37 citations

Cell-free translation of mammalian myosin heavy-chain messenger ribonucleic acid from growing and fused-L6E9 myoblasts

1979 • 33 citations

5-Hydroxytryptamine, 5-Hydroxytryptophan Decarboxylase and Monoamine Oxidase in Hearts of Normal, Thyroid-Fed and Propylthiouracil-Fed Male and Female Rats

1962 • 33 citations

Arterial blood gases, muscle fiber diameter and intercapillary distance in cardiac hypertrophy of rats with an old myocardial infarction

1978 • 32 citations

Sodium pump activity in arteries of rats with Goldblatt hypertension.

1982 • 31 citations

Cardiac hypertrophy after coronary artery ligation in rats.

1960 • 31 citations

Differential Effects of L-Thyroxine on Cardiac and Hepatic Monoamine Oxidase Activity Toward Benzylamine and Serotonin

1976 • 31 citations

Contractile Proteins of Normal and Failing Human Heart

1963 • 30 citations

Simultaneously Measured Isometric Tension and ATP Hydrolysis in Glycerinated Fibers from Normal and Hypertrophied Rabbit Heart

1972 • 28 citations

Pathophysiological Changes Associated with Stress-Induced Hypertension in the Borderline Hypertensive Rat

1980 • 27 citations

Spontaneous rhythmic contractions in isolated human coronary arteries

1981 • 27 citations

Functional evaluation of the rat heart in situ

1975 • 27 citations

A Stimulator-Regulated Rapid-Freeze Clamp for Terminating Metabolic Processes of the Heart During Normal Physiological Working Conditions

1982 • 26 citations

Isoforms of heavy and light chains of cardiac myosins from rat and rabbit

1982 • 23 citations

Phenylglyoxal modification of cardiac myosin S-1. Evidence for essential arginine residues at the active site.

1979 • 22 citations

Effects of N-ethylmaleimide on the ATPase activities of cardiac myosin from thyrotoxic rabbits

1975 • 21 citations

Effect of exercise on pre- and postcapillary resistance in the spontaneously hypertensive rat

1978 • 21 citations

Alterations in rat myocardial mechanics under Goldblatt hypertension and experimental aortic stenosis

1979 • 20 citations

Studies on the role of myosin light chain-LC2 in tension generation

1980 • 19 citations

Elastic and contractile properties of the myocardium in experimental cardiac hypertrophy of the rat Methodological and pathophysiological considerations

1980 • 18 citations

THE EFFECT OF DIFFERENT DEGREES OF SUBDIAPHRAGMATIC AORTIC CONSTRICTION ON HEART WEIGHT AND BLOOD PRESSURE OF NORMAL AND HYPOPHYSECTOMIZED RATS

1955 • 16 citations

Sodium activation of heart (Na+ + K+)-ATPase from normotensive and spontaneously hypertensive rats.

1980 • 14 citations

The Utilization of Energy by the Myocardium Hypertrophied Secondary to Pressure Overload

1981 • 14 citations

Digitalis-like biological activity and immunoreactivity in chromatographic fractions of rabbit adrenal extract.

1981 • 13 citations

Elektronenmikroskopische Untersuchungen �ber das Verhalten glatter Muskelzellen in der Arterienwand unter verschiedenen experimentellen Bedingungen

1973 • 13 citations

EFFECT OF STRESS ON CATECHOLAMINE SYNTHESIZING AND DEGRADING ENZYMES IN CONTROL AND SPONTANEOUSLY HYPERTENSIVE RATS11Supported in part by The Foundation's Fund for Research in Psychiatry, New Haven, Conn., USA, Research Grant Number G 71 – 498.

1976 • 13 citations

Alteration of the intracellular calcium pool of adipose tissue in spontaneously hypertensive rats

1981 • 13 citations

Structural variants of heavy and light chains of atrial and ventricular myosins in hypertrophied human hearts

1983 • 12 citations

Biochemical indices of cholinergic and adrenergic autonomic innervation in dog heart: Disparate alterations in chronic right heart failure

1982 • 12 citations

Cardiodigin: endogenous digitalis-like material from mammalian heart.

1982 • 10 citations

Cardiac muscle and liver ribosomes of the rat: the influence of laparotomy and laparotomy combined with adrenalectomy

1970 • 9 citations

Diastolic tension of rat cardiac muscle during deficiency of oxygen and glucose

1981 • 9 citations

Differences between transmitter depletion in human heart hypertrophy and experimental cardiac hypertrophy in Goldblatt rats

1980 • 8 citations

Comparison of the synthesis of light and heavy chains of cardiac myosin.

1976 • 8 citations

Cardiovascular effects of chronic infusion of propranolol in the conscious spontaneously hypertensive rat

1980 • 8 citations

Neurogenic Influences of Bilateral Adrenalectomy on Monoamine Oxidase

1976 • 7 citations

Failure of the aldosterone antagonist spironolactone to inhibit myocardial hypertrophy produced by experimental hyperthyroidism and accompanied by "apparent" digoxin immunoreactivity in the blood.

1980 • 6 citations

Restriction of β-adrenergic responsiveness in hypertrophied ventricular myocardium of rats

1977 • 6 citations

Distribution and Significance of Cardiac Muscle Cell Disorganization in the Left Ventricle of Patients with Hypertrophic Cardiomyopathy: Evidence of a Diffuse Cardiomyopathic Process

1982 • 6 citations

Heterogeneity of 27,000 Dalton-Light Chain of Cardiac Ventricular Myosin1

1981 • 6 citations

Blood pressure and cardiac myosin heterogeneity in the rat as influenced by swimming and emotional excitation

1983 • 5 citations

Koronare Hämodynamik und myokardialer Sauerstoffverbrauch unter Dihydralazininfusion

1980 • 4 citations

Increased resistance of the myocardium to anoxia in vitro after repeated application of isoprenalin.

1965 • 4 citations

Strukturelle Veränderungen des druck- und volumenüberlasteten Herzens

1982 • 4 citations

Morphological study of cardiac hypertrophy induced by cold stress in rats

1981 • 3 citations

Influence of catheter position on blood pressure values in the pulmonary artery of the dog

1973 • 2 citations