Anisotropic Reentry: A Model of Arrhythmias that may Necessitate a New Approach to Antiarrhythmic Drug Development

The heart and cardiovascular system

1986 • 1,333 citations

Circus movement in rabbit atrial muscle as a mechanism of tachycardia. III. The "leading circle" concept: a new model of circus movement in cardiac tissue without the involvement of an anatomical obstacle.

1977 • 1,069 citations

Cardiac electrophysiology and arrhythmias

1985 • 937 citations

Relating extracellular potentials and their derivatives to anisotropic propagation at a microscopic level in human cardiac muscle. Evidence for electrical uncoupling of side-to-side fiber connections with increasing age.

1986 • 880 citations

The discontinuous nature of propagation in normal canine cardiac muscle. Evidence for recurrent discontinuities of intracellular resistance that affect the membrane currents.

1981 • 726 citations

Circus movement in rabbit atrial muscle as a mechanism of trachycardia.

1973 • 689 citations

Electrophysiologic and anatomic basis for fractionated electrograms recorded from healed myocardial infarcts.

1985 • 676 citations

The functional role of structural complexities in the propagation of depolarization in the atrium of the dog. Cardiac conduction disturbances due to discontinuities of effective axial resistivity.

1982 • 535 citations

Influences of anisotropic tissue structure on reentrant circuits in the epicardial border zone of subacute canine infarcts.

1988 • 513 citations

The effect of acute coronary artery occlusion on subepicardial transmembrane potentials in the intact porcine heart.

1977 • 459 citations

Structural and electrophysiological changes in the epicardial border zone of canine myocardial infarcts during infarct healing.

1985 • 433 citations

Recurrent sustained ventricular tachycardia. 2. Endocardial mapping.

1978 • 373 citations

Electrophysiologic mapping to determine the mechanism of experimental ventricular tachycardia initiated by premature impulses

1982 • 334 citations

The wavelength of the cardiac impulse and reentrant arrhythmias in isolated rabbit atrium. The role of heart rate, autonomic transmitters, temperature, and potassium.

1986 • 333 citations

Electrophysiological changes and ventricular arrhythmias in the early phase of regional myocardial ischemia.

1981 • 318 citations

Reentrant ventricular arrhythmias in the late myocardial infarction period

1984 • 274 citations

Recurrent sustained ventricular tachycardia: structure and ultrastructure of subendocardial regions in which tachycardia originates.

1983 • 259 citations

Electrophysiological Properties of Canine Purkinje Cells in One-Day-Old Myocardial Infarction

1973 • 243 citations

Spontaneous and Induced Cardiac Arrhythmias in Subendocardial Purkinje Fibers Surviving Extensive Myocardial Infarction in Dogs

1973 • 237 citations

Slow Conduction and Reentry in the Ventricular Conducting System

1972 • 226 citations

Time course for reversal of electrophysiological and ultrastructural abnormalities in subendocardial Purkinje fibers surviving extensive myocardial infarction in dogs.

1975 • 197 citations

Protracted ventricular tachcardia induced by premature stimulation of the canine heart after coronary artery occlusion and reperfusion.

1979 • 171 citations

Electrophysiologic and anatomic correlates of sustained ventricular tachyarrhythmias in a model of chronic myocardial infarction

1980 • 168 citations

Intramural reentry as a mechanism of ventricular tachycardia during evolving canine myocardial infarction.

1985 • 149 citations

Possible electrophysiological mechanisms for lethal arrhythmias accompanying myocardial ischemia and infarction.

1975 • 111 citations

Reentrant excitation as a cause of cardiac arrhythmias

1978 • 110 citations

Reentrant ventricular arrhythmias in the late myocardial infarction period. 7. Effect of verapamil and D-600 and the role of the "slow channel".

1979 • 105 citations

Long-term electrophysiological abnormalities resulting from experimental myocardial infarction in cats.

1977 • 91 citations

Propagating depolarization in anisotropic human and canine cardiac muscle: apparent directional differences in membrane capacitance. A simplified model for selective directional effects of modifying the sodium conductance on Vmax, tau foot, and the propagation safety factor.

1987 • 83 citations

Chemical energetics of single isometric tetani in mammalian smooth muscle

1978 • 72 citations

Mapping of ventricular tachycardia induced by programmed stimulation in canine preparations of myocardial infarction.

1984 • 70 citations

Effects of pressure gradients between branches of the left coronary artery on the pressure axis intercept and the shape of steady state circumflex pressure-flow relations in dogs.

1985 • 64 citations

Cardiac Arrhythmias. A Decade of Progress.

1981 • 54 citations

Structural basis of ventricular arrhythmias in human myocardial infarction: A hypothesis

1976 • 45 citations

Endocardial, intramural, and epicardial activation patterns during sustained monomorphic ventricular tachycardia in late canine myocardial infarction.

1987 • 41 citations

Activation, Metabolism and Perfusion of the Heart

1987 • 33 citations

Ventricular Tachycardia—Mechanisms and Management.

1983 • 28 citations

Alterations in endocardial activation of the canine papillary muscle early and late after myocardial infarction.

1987 • 25 citations

Pharmacology of the antiarrhythmic drugs

1983 • 17 citations

Effects of anisotropy on functional reentrant circuits: preliminary results of computer simulation studies

1987 • 13 citations