The LEC rat: a model for human hepatitis, liver cancer, and much more.

Spontaneous hepatic copper accumulation in Long-Evans Cinnamon rats with hereditary hepatitis. A model of Wilson's disease.

1991 • 275 citations

New mutation causing hereditary hepatitis in the laboratory rat

1987 • 217 citations

Elevated Level of 8‐Hydroxydeoxyguanosine in DNA of Liver, Kidneys, and Brain of Long‐Evans Cinnamon Rats

1993 • 85 citations

Phenotype of preneoplastic and neoplastic liver lesions during spontaneous liver carcinogenesis of LEC rats

1990 • 66 citations

Inhibition of the copper incorporation into ceruloplasmin leads to the deficiency in serum ceruloplasmin activity in Long-Evans cinnamon mutant rat.

1993 • 64 citations

Copper metabolism in the LEC rat: Involvement of induction of metallothionein and disposition of zinc and iron

1991 • 43 citations

SPONTANEOUS OCCURRENCE OF PLACENTAL GLUTATHIONE S‐TRANSFERASE‐POSITIVE FOCI IN THE LIVERS OF LEC RATS

1988 • 33 citations

Hereditary Low Level of Plasma Ceruloplasmin in LEC Rats Associated with Spontaneous Development of Hepatitis and Liver Cancer

1991 • 26 citations

Accumulation of Abnormally High Ploid Nuclei in the Liver of LEC Rats Developing Spontaneous Hepatitis

1989 • 26 citations

Genetic linkage between copper accumulation and hepatitis/hepatoma development in LEC rats

1992 • 22 citations

High sensitivity of the LEC rat liver to the carcinogenic effect of diethylnitrosamine

1990 • 21 citations

Elevation of Serum Alpha‐fetoprotein and Proliferation of Oval Cells in the Livers of LEC Rats

1988 • 20 citations

Possible involvement of c‐myc but not ras genes in hepatocellular carcinomas developing after spontaneous hepatitis in LEC rats

1991 • 17 citations

Harmful effect of administration of copper on LEC rats.

1991 • 14 citations

A new rat model for the study of hepatocarcinogenesis

1992 • 8 citations