What Animal Models Should Be Used to Define Antiarrhythmic Efficacy? Acute Dog Models

Delayed Development of Ventricular Ectopic Rhythms following Experimental Coronary Occlusion

1950 • 681 citations

Clinical efficacy of amiodarone as an antiarrhythmic agent

1976 • 575 citations

Survival of Subendocardial Purkinje Fibers after Extensive Myocardial Infarction in Dogs

1973 • 316 citations

Two periods of early ventricular arrhythmia in the canine acute myocardial infarction model.

1979 • 276 citations

Spontaneous and Induced Cardiac Arrhythmias in Subendocardial Purkinje Fibers Surviving Extensive Myocardial Infarction in Dogs

1973 • 237 citations

Beneficial Effects of Vagal Stimulation and Bradycardia During Experimental Acute Myocardial Ischemia

1974 • 208 citations

Effect of drugs on conduction delay and incidence of ventricular arrhythmias induced by acute coronary occlusion in dogs

1977 • 198 citations

Differing mechanisms for ventricular vulnerability during coronary artery occlusion and release

1976 • 177 citations

The Pathophysiology of Malignant Ventricular Arrhythmias During Acute Myocardial Ischemia

1974 • 173 citations

Subendocardial origin of ventricular arrhythmias in 24-hour-old experimental myocardial infarction.

1976 • 128 citations

Reperfusion ventricular tachyarrhythmias: Correlation with antecedent coronary artery occlusion tachyarrhythmias and duration of myocardial ischemia

1981 • 128 citations

ANTIARRHYTHMIC EFFECTS OF BETA ADRENERGIC BLOCKING AGENTS*

1967 • 93 citations

Ventricular fibrillation during and after coronary artery occlusion

1960 • 91 citations

Distinctive time course of ventricular vulnerability to fibrillation during and after release of coronary ligation

1974 • 91 citations

Failure of antiarrhythmic drugs to prevent experimental reperfusion ventricular fibrillation.

1981 • 77 citations

Effects of the phenothiazine analog, EN-313, on ventricular arrhythmias in the dog

1977 • 60 citations

Nitroglycerin-induced reduction in the incidence of spontaneous ventricular fibrillation during coronary occlusion in dogs

1974 • 52 citations

Validity of myocardial infarction models.

1975 • 39 citations

Early arrhythmias following experimental coronary occlusion in conscious dogs and their modification by beta-adrenoceptor blocking drugs

1973 • 37 citations

The antiarrhythmic and antifibrillatory actions of bretylium and its o-iodobenzyl trimethylammonium analog, UM-360.

1975 • 34 citations

Effect of Propranolol, Procainamide, and Lidocaine on Ventricular Automaticity and Reentry in Experimental Myocardial Infarction

1972 • 33 citations

Relative effectiveness of three antiarrhythmic agents in the treatment of ventricular arrhythmias in experimental acute myocardial ischemia

1971 • 31 citations

The Effects of Intravenous Procaine and Procaine Amide (Pronestyl) upon Ectopic Ventricular Tachycardia Accompanying Acute Myocardial Infarction

1952 • 26 citations

Cardiovascular and antiarrhythmic effects of aprindine (AC 1802) during partial occlusion of a coronary artery in the pig

1977 • 21 citations

Effects of lignocaine and propranolol on experimental cardiac arrhythmias

1971 • 20 citations

The effect of quinidine on ventricular fibrillation induced by coronary ligation

1950 • 5 citations