Expression and functional analysis of voltage-activated Na+ channels in human prostate cancer cell lines and their contribution to invasion in vitro.

LNCaP model of human prostatic carcinoma.

1983 • 1,749 citations

Establishment and characterization of a human prostatic carcinoma cell line (PC-3).

1979 • 1,595 citations

Cancer statistics, 1995

1995 • 1,434 citations

Mutation of the Androgen-Receptor Gene in Metastatic Androgen-Independent Prostate Cancer

1995 • 1,251 citations

Primary structure and functional expression of the human cardiac tetrodotoxin-insensitive voltage-dependent sodium channel.

1992 • 624 citations

Structure and function of the β2 subunit of brain sodium channels, a transmembrane glycoprotein with a CAM motif

1995 • 456 citations

Calcium-dependent interaction of N-type calcium channels with the synaptic core complex

1996 • 350 citations

Statistics in Medicine: Calculating confidence intervals for some non-parametric analyses

1988 • 314 citations

Co-localization of L-type Ca2+ channels and insulin-containing secretory granules and its significance for the initiation of exocytosis in mouse pancreatic B-cells.

1995 • 294 citations

Principal glycopeptide of the tetrodotoxin/saxitoxin binding protein from Electrophorus electricus: isolation and partial chemical and physical characterization

1983 • 264 citations

Insulin‐like growth factor I: Action and receptor characterization in human prostate cancer cell lines

1993 • 215 citations

The ?6?1 and ?6?4 integrins in human prostate cancer progression

1995 • 188 citations

Differential expression of voltage‐activated Na⁺ currents in two prostatic tumour cell lines: contribution to invasiveness in vitro

1995 • 187 citations

Cytokeratin characterization of human prostatic carcinoma and its derived cell lines.

1987 • 154 citations

Inhibition of ATP‐sensitive potassium channels causes reversible cell‐cycle arrest of human breast cancer cells in tissue culture

1995 • 153 citations

Integrin-mediated neurite outgrowth in neuroblastoma cells depends on the activation of potassium channels

1993 • 153 citations

Application of the MTT assay to human prostate cancer cell lines in vitro: Establishment of test conditions and assessment of hormone‐stimulated growth and drug‐induced cytostatic and cytotoxic effects

1988 • 151 citations

Androgen-induced inhibition of cell proliferation in an androgen-insensitive prostate cancer cell line (PC-3) transfected with a human androgen receptor complementary DNA.

1993 • 148 citations

Changes in membrane potential during the progression of MCF‐7 human mammary tumor cells through the cell cycle

1995 • 143 citations

Regulation of growth and epidermal growth factor receptor levels of LNCaP prostate tumor cells by different steroids

1988 • 139 citations

Differential Cytokeratin Expression in Normal, Hyperplastic and Malignant Epithelial Cells From Human Prostate

1990 • 127 citations

Association between Cell Membrane Potential and Breast Cancer

1994 • 119 citations

Neuronal growth factor regulation of two different sodium channel types through distinct signal transduction pathways

1993 • 117 citations

Prostate Tissue Specificity of the Prostate-Specific Antigen Promoter Isolated from a Patient with Prostate Cancer

1995 • 115 citations

Functional properties of rat and human neocortical voltage-sensitive sodium currents

1994 • 107 citations

The preclinical development of bicalutamide: pharmacodynamics and mechanism of action

1996 • 94 citations

Phosphorylation of brain sodium channels in the I--II linker modulates channel function in Xenopus oocytes

1996 • 94 citations

Oscillating activity of a Ca(2+)-sensitive K+ channel. A prerequisite for migration of transformed Madin-Darby canine kidney focus cells.

1994 • 84 citations

Effects of androgen on intracellular calcium of LNCaP cells

1991 • 76 citations

Identification of Soluble Protein Phosphatases That Dephosphorylate Voltage-sensitive Sodium Channels in Rat Brain

1995 • 73 citations

Chemotaxis and chemokinesis of human prostate tumor cell lines in response to human prostate stromal cell secretory proteins containing a nerve growth factor-like protein.

1993 • 61 citations

Response to fibronectin–integrin interaction in leukaemia cells: delayed enhancing of a K ⁺ current

1992 • 56 citations

Voltage-dependent sodium channels in human small-cell lung cancer cells: Role in action potentials and inhibition by lambert-eaton syndrome IgG

1995 • 55 citations

Voltage-activated K+ conductance and cell proliferation in small-cell lung cancer

1994 • 55 citations

Combination therapy with cisplatin and nifedipine induces apoptosis in cisplatin-sensitive and cisplatin-resistant human glioblastoma cells

1995 • 50 citations

Recombinant human insulin-like growth factor I exerts a trophic action and confers glutamate sensitivity on glutamate-resistant cerebellar granule cells.

1993 • 46 citations

Enhancement of voltage-gated Na+ channel current associated with multidrug resistance in human leukemia cells.

1987 • 44 citations

Fast Na+ current in circular smooth muscle cells of the large intestine

1993 • 43 citations

Ionic currents in cultured rat hypothalamic neurones.

1992 • 39 citations

Spontaneous metastasis of PC‐3 cells in athymic mice after implantation in orthotopic or ectopic microenvironments

1995 • 34 citations

Evidence for involvement of the voltage-dependent Na+ channel gating in depolarization-induced activation of G-proteins

1993 • 32 citations

Ion-channel activities regulate transmembrane signaling in thymocyte apoptosis and T-cell activation

1995 • 26 citations

Development of Na+- and K+-Currents in the cocheear ganglion of the chick embryo

1992 • 25 citations

In vivo andin vitro approaches to study metastasis in human prostatic cancer

1993 • 23 citations

Utilization of the Boyden chamber to further characterize in vitro migration and invasion of benign and malignant human prostatic epithelial cells.

1992 • 23 citations

Suppression of sodium channel function in differentiating C2 muscle cells stably overexpressing rat androgen receptors

1994 • 20 citations

Maitotoxin, a calcium channel activator, inhibits cell cycle progression through the G1/S and G2/M transitions and prevents CDC2 kinase activation in GH4C1 cells

1996 • 10 citations

High titer antibody to mammalian neuronal sodium channels produces sustained channel block

1995 • 7 citations

Electrophysiological characterization of sodium channel types in the HCN-1A human cortical cell line

1993 • 6 citations