Cryptic Catalysis and Cholinesterase Function

A new and rapid colorimetric determination of acetylcholinesterase activity

1961 • 25,114 citations

Acetylcholinesterase: enzyme structure, reaction dynamics, and virtual transition states

1987 • 1,044 citations

Enzyme Mechanism from Isotope Effects

1991 • 574 citations

Structure and mechanism of chymotrypsin

1976 • 449 citations

Transition States of Biochemical Processes

1978 • 418 citations

Solvent Deuterium Isotope Effects on Acid-Base Equilibria

1964 • 297 citations

Rigorous least squares adjustment: Application to some non-linear equations, I

1965 • 292 citations

Effective charge on acetylcholinesterase active sites determined from the ionic strength dependence of association rate constants with cationic ligands

1980 • 189 citations

Structure of human erythrocyte acetylcholinesterase. Characterization of intersubunit disulfide bonding and detergent interaction.

1984 • 180 citations

Rigorous Least Squares Adjustment: Applications to Some Non-linear Equations, II

1965 • 151 citations

Fractional diffusion-limited component of reactions catalyzed by acetylcholinesterase

1986 • 133 citations

Cholinesterases. Structure, function, mechanism, genetics and cell biology.

1991 • 122 citations

Purification and crystallization of a dimeric form of acetylcholinesterase from Torpedo californica subsequent to solubilization with phosphatidylinositol-specific phospholipase C

1988 • 105 citations

Direct determination of acetyl-enzyme intermediate in the acetylcholinesterase-catalyzed hydrolysis of acetylcholine and acetylthiocholine.

1984 • 97 citations

A simplified procedure for the purification of large quantities of fetal bovine serum acetylcholinesterase

1986 • 87 citations

Cholinesterases : structure, function, mechanism, genetics, and cell biology

1991 • 84 citations

Catalytic Power and Transition-State Stabilization

1978 • 74 citations

Chapter 3 Structure and function of serine proteases

1987 • 54 citations

Simple general acid-base catalysis of physiological acetylcholinesterase reactions

1992 • 27 citations

Effect of reactivity on virtual transition-state structure for the acylation stage of acetylcholinesterase-catalyzed hydrolysis of aryl esters and anilides

1987 • 10 citations