Desmopressin (DDAVP) in the Treatment of Bleeding Disorders: The First 20 Years

Involvement of large plasma von Willebrand factor (vWF) multimers and unusually large vWF forms derived from endothelial cells in shear stress-induced platelet aggregation.

1986 • 609 citations

1-DEAMINO-8-D-ARGININE VASOPRESSIN: A NEW PHARMACOLOGICAL APPROACH TO THE MANAGEMENT OF HAEMOPHILIA AND VON WILLEBRAND'S DISEASE

1977 • 597 citations

Treatment with Desmopressin Acetate to Reduce Blood Loss after Cardiac Surgery

1986 • 517 citations

Mechanism of Plasminogen Activator and Factor VIII Increase after Vasoactive Drugs

1975 • 400 citations

Multimeric composition of factor VIII/von Willebrand factor following administration of DDAVP: implications for pathophysiology and therapy of von Willebrand's disease subtypes

1982 • 369 citations

DIABETIC KETOACIDOSIS

1974 • 363 citations

IMPROVEMENT IN THE HAEMOSTATIC DEFECT OF URAEMIA AFTER TREATMENT WITH RECOMBINANT HUMAN ERYTHROPOIETIN

1987 • 267 citations

Platelet Aggregation Induced by I-Desamino-8-D-Arginine Vasopressin (dDAVP) in Type IIb von Willebrand's Disease

1983 • 260 citations

Metaanalysis of prophylactic drug treatment in the prevention of postoperative bleeding

1994 • 248 citations

Conjugated Estrogens for the Management of Bleeding Associated with Renal Failure

1986 • 220 citations

Controlled trial of desmopressin in liver cirrhosis and other conditions associated with a prolonged bleeding time

1986 • 212 citations

Patterns of development of tachyphylaxis in patients with haemophilia and von Willebrand disease after repeated doses of desmopressin (DDAVP)

1992 • 187 citations

Hemostatic effects of tranexamic acid and desmopressin during cardiac surgery.

1991 • 184 citations

A Trial of Desmopressin (1-Desamino-8-D-Arginine Vasopressin) to Reduce Blood Loss in Uncomplicated Cardiac Surgery

1989 • 177 citations

Response of Patients with Mild and Moderate Hemophilia A and von Willebrand's Disease to Treatment with Desmopressin

1985 • 166 citations

Use of DDAVP in inherited and acquired platelet dysfunction

1990 • 164 citations

DDAVP enhances platelet adherence and platelet aggregate growth on human artery subendothelium

1984 • 163 citations

Increase in antihaemophilic globulin activity following infusion of adrenaline

1961 • 150 citations

Studies on the prolonged bleeding time in von Willebrand's disease.

1976 • 148 citations

FACTORS AFFECTING THE COAGULATION TIME OF BLOOD

1914 • 135 citations

Proceedings: The release of plasminogen activator and factor VIII to lysine vasopressin, arginine vasopressin, I-desamino-8-d-arginine vasopressin, angiotensin and oxytocin in man.

1974 • 131 citations

1-Desamino-8-D-arginine Vasopressin (Desmopressin) Decreases Operative Blood Loss in Patients Having Harrington Rod Spinal Fusion Surgery

1987 • 127 citations

Does desmopressin acetate reduce blood loss after surgery in patients on cardiopulmonary bypass?

1988 • 119 citations

Nasal Spray Desmopressin (DDAVP) for Mild Hemophilia A and von Willebrand Disease

1991 • 115 citations

The effect of desmopressin acetate (DDAVP) on postoperative blood loss after cardiac operations in children

1989 • 113 citations

Desmopressin and bleeding time in patients with cirrhosis.

1985 • 113 citations

FACTORS AFFECTING THE COAGULATION TIME OF BLOOD

1914 • 112 citations

The Effect of Desmopressin on Reducing Blood Loss in Cardiac Surgery – A Meta-Analysis of Double-Blind, Placebo-Controlled Trials

1995 • 107 citations

DDAVP: A useful alternative to blood components in moderate hemophilia A and von Willebrand disease

1983 • 100 citations

Prospective Multicenter Study on Subcutaneous Concentrated Desmopressin for Home Treatment of Patients with von Willebrand Disease and Mild or Moderate Hemophilia A

1996 • 99 citations

Plasminogen Activation In Vivo upon Intravenous Infusion of DDAVP

1992 • 90 citations

Desmopressin induces endothelial P-selectin expression and leukocyte rolling in postcapillary venules

1995 • 87 citations

Randomized controlled trial of desmopressin plus terlipressin vs. terlipressin alone for the treatment of acute variceal hemorrhage in cirrhotic patients: A multicenter, double-blind study

1993 • 87 citations

Platelet‐activating factor secreted by DDAVP‐treated monocytes mediates von willebrand factor release from endothelial cells

1993 • 80 citations

Desmopressin (DDAVP) and hemostasis

1994 • 76 citations

ABSENT FACTOR VIII RESPONSE TO SYNTHETIC VASOPRESSIN ANALOGUE (DDAVP) IN NEPHROGENIC DIABETES INSIPIDUS

1985 • 75 citations

DDAVP: Does the drug have a direct effect on the vessel wall?

1983 • 75 citations

A Trial of Desmopressin to Reduce Blood Loss in Patients Undergoing Spinal Fusion for Idiopathic Scoliosis

1992 • 75 citations

Randomized study of aprotinin and DDAVP to reduce postoperative bleeding after cardiopulmonary bypass surgery.

1994 • 66 citations

Mechanisms of platelet dysfunction and response to DDAVP in patients with congenital platelet function defects. A double-blind placebo-controlled trial.

1995 • 65 citations

Effects of desmopressin acetate on platelet aggregation, von Willebrand factor, and blood loss after cardiac surgery with extracorporeal circulation.

1990 • 63 citations

Mechanisms of Platelet Dysfunction and Response to DDAVP in Patients with Congenital Platelet Function Defects

1995 • 61 citations

Decreased postoperative drainage with addition of ϵ-aminocaproic acid before cardiopulmonary bypass

1994 • 57 citations

The hemostatic effects of desmopressin on patients who had total joint arthroplasty. A double-blind randomized trial.

1994 • 57 citations

Randomized controlled trial of desmopressin plus terlipressin vs. terlipressin alone for the treatment of acute variceal hemorrhage in cirrhotic patients: A multicenter, double-blind study

1993 • 56 citations

Evaluation of the effectiveness of DDAVP in surgery and in bleeding episodes in haemophilia and von Willebrand's disease. A study on 43 patients

2008 • 55 citations

Desmopressin stimulates the expression of P-selectin on human platelets in vitro.

1995 • 50 citations

DDAVP in type IIa von Willebrand's disease

1986 • 47 citations

DDAVP Reduces Bleeding during Continued Hirudin Administration in the Rabbit

1996 • 45 citations

Desmopressin: A Nontransfusional Hemostatic Agent

1990 • 43 citations

Factor‐VIII Activity and Antigen, Platelet Count and Biochemical Changes after Adrenoceptor Stimulation

1977 • 43 citations

DDAVP and epinephrine-induced changes in the localization of von Willebrand factor antigen in endothelial cells of human oral mucosa

1988 • 43 citations

DDAVP—The Multipotent Drug in Patients With Coagulopathies

1991 • 42 citations

DDAVP-induced release of Von Willebrand factor from endothelial cells in vitro: The effect of plasma and blood cells

1990 • 41 citations

Heparin, DDAVP and the Bleeding Time

1991 • 39 citations

Multimeric composition of factor VIII/von Willebrand factor following administration of DDAVP: implications for pathophysiology and therapy of von Willebrand's disease subtypes

1982 • 38 citations

Bleeding time prolongation with streptokinase and its reduction with 1-desamino-8-D-arginine vasopressin.

1990 • 37 citations

Desmopressin induces adhesion of normal human erythrocytes to the endothelial surface of a perfused microvascular preparation

1990 • 34 citations

Desmopressin and type II B von Willebrand disease

1996 • 27 citations

1-Deamino-8 D-arginine vasopressin decreases the production of 13-hydroxyoctadecadienoic acid by endothelial cells

1992 • 13 citations

DDAVP enhances platelet adherence and platelet aggregate growth on human artery subendothelium

1984 • 8 citations

The Influence of Infusions of 1-Desamino-8-D-Arginine Vasopressin (DDAVP) In Vivo on Thrombin Generation In Vitro

1992 • 5 citations

DDAVP in type IIa von Willebrand's disease

1986 • 5 citations

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