Molecular Mechanisms of Action of Calmodulin

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

1986 • 4,785 citations

Three-dimensional structure of calmodulin

1985 • 1,035 citations

Calmodulin—an intracellular calcium receptor

1980 • 964 citations

Calmodulin

1982 • 771 citations

Intraterminal injection of synapsin I or calcium/calmodulin-dependent protein kinase II alters neurotransmitter release at the squid giant synapse.

1985 • 636 citations

Structure of the calcium regulatory muscle protein troponin-C at 2.8 Å resolution

1985 • 619 citations

PROTEIN KINASES IN THE BRAIN

1985 • 559 citations

Physiological implications of the presence, distribution, and regulation of calmodulin in eukaryotic cells.

1982 • 516 citations

Control of microtubule assembly-disassembly by calcium-dependent regulator protein.

1978 • 493 citations

Physicochemical properties of rat testis Ca2+-dependent regulator protein of cyclic nucleotide phosphodiesterase. Relationship of Ca2+-binding, conformational changes, and phosphodiesterase activity

1977 • 459 citations

Calmodulin and the cell cycle: Involvement in regulation of cell-cycle progression

1982 • 414 citations

Isolation of the yeast calmodulin gene: Calmodulin is an essential protein

1986 • 400 citations

Unpolymerized tubulin modulates the level of tubulin mRNAs

1981 • 392 citations

The relationship between calmodulin binding and phosphorylation of smooth muscle myosin kinase by the catalytic subunit of 3‘:5‘ cAMP-dependent protein kinase.

1981 • 388 citations

Calmodulin binding domains: characterization of a phosphorylation and calmodulin binding site from myosin light chain kinase

1986 • 319 citations

Identification of the calmodulin-binding domain of skeletal muscle myosin light chain kinase.

1985 • 302 citations

Coordinate regulation of multiple histone mRNAs during the cell cycle in HeLa cells

1983 • 278 citations

Calcium/calmodulin-dependent protein kinase II. Characterization of distinct calmodulin binding and inhibitory domains.

1988 • 256 citations

The calmodulin binding domain of chicken smooth muscle myosin light chain kinase contains a pseudosubstrate sequence.

1987 • 241 citations

Changes in calmodulin and its mrna accompany reentry of quiescent (G0) cells into the cell cycle

1984 • 229 citations

Characterization of the Bovine Papilloma virus plasmid maintenance sequences

1984 • 224 citations

The ovalbumin gene family: Hormonal control of X and Y gene transcription and mRNA accumulation

1981 • 213 citations

Bacterial expression and characterization of proteins derived from the chicken calmodulin cDNA and a calmodulin processed gene.

1985 • 209 citations

Agonist and antagonist properties of calmodulin fragments.

1984 • 198 citations

Ca2+-dependent high-affinity complex formation between calmodulin and melittin

1983 • 191 citations

Chicken calmodulin genes. A species comparison of cDNA sequences and isolation of a genomic clone.

1983 • 187 citations

Calmodulin is involved in regulation of cell proliferation.

1987 • 183 citations

Microinjection of Ca++-calmodulin causes a localized depolymerization of microtubules.

1983 • 181 citations

Functional Analysis of a Complementary DNA for the 50-Kilodalton Subunit of Calmodulin Kinase II

1987 • 179 citations

Phosphorylation of smooth muscle heavy meromyosin by calcium-activated, phospholipid-dependent protein kinase. The effect on actin-activated MgATPase activity.

1983 • 174 citations

Bovine papilloma virus deoxyribonucleic acid: a novel eucaryotic cloning vector.

1981 • 172 citations

Analysis and in vivo disruption of the gene coding for calmodulin in Schizosaccharomyces pombe.

1987 • 169 citations

Regulation of intracellular levels of calmodulin and tubulin in normal and transformed cells.

1981 • 158 citations

Proteolysis of smooth muscle myosin light chain kinase. Formation of inactive and calmodulin-independent fragments.

1987 • 156 citations

A fluorescent probe study of Ca2+ binding to the Ca2+-specific sites of cardiac troponin and troponin C.

1980 • 153 citations

Domain organization of chicken gizzard myosin light chain kinase deduced from a cloned cDNA

1986 • 148 citations

Calcium and calmodulin in cell growth and transformation

1984 • 145 citations

Production and characterization of an antibody to myosin light chain kinase and intracellular localization of the enzyme

1981 • 137 citations

Site-specific mutagenesis of the alpha-helices of calmodulin. Effects of altering a charge cluster in the helix that links the two halves of calmodulin.

1987 • 135 citations

Protein Kinases in the Brain

1985 • 134 citations

Calmodulin and cell proliferation

1982 • 134 citations

Interaction of calmodulin and a calmodulin-binding peptide from myosin light chain kinase: major spectral changes in both occur as the result of complex formation

1985 • 133 citations

Trimethyllysine and protein function. Effect of methylation and mutagenesis of lysine 115 of calmodulin on NAD kinase activation.

1986 • 120 citations

Calcium-dependent regulatory protein of cyclic nucleotide metabolism in normal and transformed chicken embryo fibroblasts.

1976 • 119 citations

Amino acid sequence of an active fragment of rabbit skeletal muscle myosin light chain kinase

1985 • 108 citations

Genetically engineered calmodulins differentially activate target enzymes.

1986 • 99 citations

Potentiation of Bleomycin Lethality by Anticalmodulin Drugs: A Role for Calmodulin in DNA Repair

1984 • 97 citations

Tissue-specific expression of a chicken calmodulin pseudogene lacking intervening sequences.

1983 • 91 citations

Regulation of human histone gene expression during the HeLa cell cycle requires protein synthesis.

1984 • 91 citations

NMR studies of a complex of deuterated calmodulin with melittin.

1986 • 81 citations

Relationship between changes in the calcium dependent regulatory protein and adenylate cyclase during viral transformation

1979 • 64 citations

Calcium ion-dependent covalent modification of calmodulin with norchlorpromazine isothiocyanate

1983 • 58 citations

Calmodulin: Properties, Intracellular Localization, and Multiple Roles in Cell Regulation

1981 • 46 citations

Biosynthesis of calmodulin in normal and virus-transformed chicken embryo fibroblasts.

1984 • 40 citations

Identification of .beta.-endorphin residues 14-25 as a region involved in the inhibition of calmodulin-stimulated phosphodiesterase activity

1983 • 40 citations

Functional domains of chicken gizzard myosin light chain kinase.

1985 • 40 citations

Smooth muscle myosin light chain kinase. Amino acid sequence at the site phosphorylated by adenosine cyclic 3',5'-phosphate-dependent protein kinase whether or not calmodulin is bound.

1986 • 31 citations

The Nontranscribed Chicken Calmodulin Pseudogene Cross-Hybridizes with mRNA from the Slow-Muscle Troponin C Gene

1987 • 31 citations

Cell cycle-dependent expression of a stable episomal human histone gene in a mouse cell.

1986 • 24 citations

The role of calmodulin in cell transformation

1983 • 24 citations

The nontranscribed chicken calmodulin pseudogene cross-hybridizes with mRNA from the slow-muscle troponin C gene.

1987 • 21 citations

Hormonal Regulation of a Chicken Oviduct Messenger Ribonucleic Acid that Shares a Common Domain with Gizzard Myosin Light Chain Kinase*

1987 • 14 citations

Rapid automated synthesis via diisopropyl phosphoramidite in situ activation. Chemical synthesis and cloning of a calmodulin gene

1986 • 7 citations