Mechanisms of Cancer Invasion and Metastasis

Metastasis: Quantitative Analysis of Distribution and Fate of Tumor Emboli Labeled With <sup>125</sup>I-5-Iodo-2′ -deoxyuridine<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1970 • 990 citations

ENDOTHELIAL CONTRACTION INDUCED BY HISTAMINE-TYPE MEDIATORS

1969 • 841 citations

AN ENZYMATIC FUNCTION ASSOCIATED WITH TRANSFORMATION OF FIBROBLASTS BY ONCOGENIC VIRUSES

1973 • 779 citations

Antimetastatic effects associated with platelet reduction.

1968 • 695 citations

Quantitative Studies on Tissue Transplantation Immunity. III. Actively Acquired Tolerance

1956 • 693 citations

Demonstration of cell‐mediated immunity to human neoplasms of various histological types

1971 • 673 citations

Observations on the social behaviour of cells in tissue culture

1954 • 606 citations

The surface properties of cancer cells: a review.

1962 • 569 citations

Platelet—tumor‐cell interactions in mice. The role of platelets in the spread of malignant disease

1973 • 447 citations

Density Dependent Inhibition of Cell Growth in Culture

1967 • 440 citations

Basis for the Acquisition of Malignant Potential by Mouse Cells Cultivated in vitro

1968 • 425 citations

The relationship of embolic homogeneity, number, size and viability to the incidence of experimental metastasis

1973 • 406 citations

Decreased Mutual Adhesiveness, a Property of Cells from Squamous Cell Carcinomas

1944 • 391 citations

AN ENZYMATIC FUNCTION ASSOCIATED WITH TRANSFORMATION OF FIBROBLASTS BY ONCOGENIC VIRUSES

1973 • 368 citations

Cooperation of Immune Lymphoid Cells with Macrophages in Tumour Immunity

1970 • 315 citations

Pathogenesis of metastasis formation observed in vivo in the rabbit ear chamber.

1958 • 252 citations

Control of Carcinogenesis: A Possible Role for the Activated Macrophage

1972 • 223 citations

Inhibition of pulmonary metastasis by intravenous injection of specifically activated macrophages.

1974 • 205 citations

Mechanisms responsible for the origin and distribution of blood-borne tumor metastases: a review.

1953 • 201 citations

Coagulative properties of cancers

1958 • 201 citations

An Immunostimulation Theory of Tumor Development

1971 • 186 citations

Trauma and the localization of tumor cells

1967 • 155 citations

The interrelationship of hematogenous and lymphatic tumor cell dissemination.

1966 • 150 citations

Immunological resistance to pulmonary metastases in C3Hf-Bu mice bearing syngeneic fibrosarcoma of different sizes.

1974 • 149 citations

Transpulmonary passage of tumor cell emboli.

1952 • 146 citations

Adhesiveness and stickiness: two independent properties of the cell surface.

1961 • 141 citations

Principles of Pathobiology.

1972 • 138 citations

Transmigration of Lymph Nodes by Tumor Cells

1966 • 138 citations

Chemotherapy of cancer dissemination and metastasis

1973 • 136 citations

A Correlation between Electrical Surface Charge and Some Biological Characteristics During the Stepwise Progression of a Mouse Sarcoma

1958 • 134 citations

Collagenolytic activities of squamous cell carcinoma of the skin.

1973 • 132 citations

Biochemical Parameters correlated with Tumour Cell Implantation

1973 • 131 citations

The fate of circulating tumors cells. I. Passage of cells through capillaries.

1961 • 130 citations

REMOVAL OF SIALIC ACID FROM THE CELL COAT IN TUMOR CELLS AND VASCULAR ENDOTHELLUM, AND ITS EFFECTS ON METASTASIS

1962 • 128 citations

Cell Aggregation: Its Enhancement by a Supernatant from Cultures of Homologous Cells

1967 • 123 citations

On the Chemical Bonds between Animal Cells. A Mechanism for Type-Specific Association

1958 • 118 citations

Ultrastructural modifications of the cell surface and intercellular contacts of some transformed cell strains.

1969 • 118 citations

Metastasis: a review of recent advances.

1957 • 118 citations

Barrier function of lymph node to tumor cells and erythrocytes.I. Normal nodes

1967 • 117 citations

Immune stimulation-inhibition of experimental cancer metastasis.

1974 • 115 citations

Experimental studies on the spread of cancer in the lymphatic system. I. Effectiveness of the lymph node as a barrier to the passage of embolic tumor cells.

1954 • 105 citations

Studies on the mechanisms of metastasis; the distribution of tumors in various organs in relation to the distribution of arterial emboli.

1951 • 105 citations

Cortisone-Induced Metastases of Adenocarcinoma in Mice.

1952 • 101 citations

Factors affecting the number of tumor metastases; experiments with a transplantable mouse tumor.

1950 • 97 citations

Inhibition of established transplants of chemically induced sarcomas in syngeneic mice by lymphocytes from immunized donors

1972 • 95 citations

CONVERSION OF SOLID NEOPLASMS INTO ASCITES TUMORS

1956 • 93 citations

GLUCOCORTICOID-INDUCED ALTERATION OF THE SURFACE MEMBRANE OF CULTURED HEPATOMA CELLS

1970 • 93 citations

Cellular adhesiveness in relation to the invasiveness of cancer; electron microscopy of liver perfused with a chelating agent.

1954 • 83 citations

Some Chemical Factors in Cellular Adhesion and Stickiness

1962 • 81 citations

Measurement of the Ability of Cells to Infiltrate Normal Tissues in vitro

1974 • 81 citations

Clinico-Pathologic Analysis of the Surgical Curability of Breast Cancers

1961 • 74 citations

The significance of low calcium and high potassium content in neoplastic tissue

1950 • 72 citations

THE RELATIONSHIP BETWEEN THE DISSEMINATION OF TUMOR CELLS AND THE DISTRIBUTION OF METASTASES.

1964 • 70 citations

Examination of Blood for Tumor Cells<xref ref-type="fn" rid="FN1">2</xref>

1957 • 70 citations

EXPERIMENTAL STUDIES OF THE INTRAVASCULAR DISSEMINATION OF ASCITIC V2 CARCINOMA CELLS IN THE RABBIT, WITH SPECIAL REFERENCE TO FIBRINOGEN AND FIBRINOLYTIC AGENTS.

1964 • 69 citations

Studies on the mechanisms of invasion in cancer. II. In vivo effects of a factor chemotactic for cancer cells

1971 • 69 citations

Influence of cultivation, trypsinization and aggregation on the transplantability of melanoma B16 cells

1973 • 68 citations

Studies concerning the regional lymph node in cancer.IV. Tumor inhibition by regional lymph node cells

1974 • 68 citations

The invasive growth of malignant tumours as a purely mechanical process

1973 • 66 citations

The organ selectivity of experimentally induced metastases in rats

1952 • 64 citations

A study on the establishment and growth of tumor metastases with tritiated thymidine.

1960 • 62 citations

Environment of the blood-borne tumor embolus adherent to vessel wall.

1973 • 60 citations

Differential growth of metastatic tumors in liver and lung; experiments with rabbit V2 carcinoma.

1952 • 53 citations

Enhancement of pulmonary metastases by x-irradiation in rats bearing mammary cancer

1967 • 53 citations

On the Etiology of Some Human Cancers

1951 • 51 citations

The time of metastasis and release of circulating tumor cells as determined in an experimental system

1961 • 51 citations

Action of Cortisone on Disseminated Tumor Cells after Removal of the Primary Growth

1955 • 47 citations

The fate of circulating tumor cells. II. A mechanism of cortisone action in increasing metastases.

1962 • 47 citations

The invasive growth of malignant tumours: An experimental interpretation based on elastic‐jelly models

1959 • 41 citations

Cancer of the Breast and Its Treatment.

1922 • 41 citations

Influence of Immunologic Competence of the Host on Metastases Induced by the 3LL Lewis Tumor in Mice2

1974 • 40 citations

Enhancement of experimental metastasis by x-ray: a possible mechanism.

1972 • 37 citations

Immunologic Manipulation of Metastases due to Herpesvirus Transformed Cells

1973 • 36 citations

Adhesive specificity in normal and transformed mouse fibroblasts

1973 • 36 citations

Possible role of uninvolved regional nodes in preventing metastasis from breast cancer

1969 • 34 citations

Defibrination and metastasis formation

1972 • 31 citations

The rationale of anticoagulants in the treatment of cancer.

1974 • 31 citations

Humoral and cellular immune factors in the systemic control of artifically induced metastases in C3Hf mice.

1973 • 30 citations

Malignancy, electrophoretic mobilities and sialic acids at the electrokinetic surface of TA3 cells

1970 • 30 citations

Immune Surveillance Revisited

1974 • 29 citations

INTERACTIONS OF HUMORAL ANTIBODIES AND IMMUNE LYMPHOCYTES

1967 • 28 citations

Detection metastic tumor cells by intraperitoneal inoculation or organ brei from tumor-bearing mice.

1953 • 28 citations

Organ localization and the effect of trauma on the fate of circulating cancer cells.

1965 • 28 citations

Relation of glucocorticoid activity of steroids to number of metastases.

1962 • 26 citations

A New Sign of Favorable Prognosis in Mammary Cancer

1973 • 24 citations

Cell Movement in Confluent Monolayers: A Re‐Evaluation of the Causes of ‘Contact Inhibition’

1973 • 24 citations

Radiation-induced changes in established tumor immunity.

1974 • 23 citations

The study of circulating tumor cells by the formation of pulmonary embolic tumor growths in a secondary host

1969 • 23 citations

Immediate passage of tumor cell emboli through the liver and kidney.

1956 • 21 citations

CELL SURFACE CHARGE AND METASTASIS FORMATION

1972 • 21 citations

Experimental tumor cell emboli in lymph nodes.

1967 • 20 citations

Migration Inhibitory Factor and Mediators of Cellular Hypersensitivity in Vitro**Supported in part by U.S.P.H.S. Grant AI-7685 and a grant from the John A. Hartford Foundation.

1971 • 18 citations

Haemagglutinin of Rubella Virus

1967 • 17 citations

Blocking antibodies and enhancement.

1972 • 17 citations

Quantitative analysis of the mechanism of glucocorticoid enhancement of experimental metastasis.

1972 • 17 citations

Relative susceptibility of various organs to tumor transplantation.

1950 • 16 citations

Locomotion of Cancer Cells in vivo Compared with Normal Cells

1967 • 16 citations

The dissemination of cancer cells during operative procedures.

1960 • 15 citations

Lymphatico-venous communications in the albino rat.

1959 • 14 citations

Cell Adhesion and Locomotion

1973 • 14 citations

Experiences with lymphocyte immunotherapy in experimental tumor systems

1971 • 14 citations

Studies of Circulating Cancer Cells in Cancer Patients

1967 • 12 citations

Fate of Circulating Tumor Cells: III. Comparison of Metastatic Growth Produced by Tumor Cell Emboli in Veins and Lymphatics

1965 • 11 citations

Biochemical and biophysical properties of cell membranes.

1967 • 9 citations

Dormancy by dissociated thyroid cells in the lungs of mice

1968 • 8 citations

Diffusible Factors from Malignant Cells which Affect Epidermal Survival and Differentiation

1970 • 6 citations

Radiation Effect on the Barrier Function of the Lymph Node

1968 • 6 citations

Effect of irradiation on experimental metastases via lymph and blood streams.

1970 • 6 citations

FIBRINOLYTIC TREATMENT OF CANCER

1964 • 6 citations

The barrier function of lymph nodes. A review of experimental studies and their implications for cancer surgery.

1970 • 5 citations

SUPPLEMENT

1970 • 3 citations

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